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  1. Article: Coronavirus: Impact on Stock Prices and Growth Expectations

    Gormsen, Niels J / Koijen, Ralph S J

    The Review of Asset Pricing Studies

    Abstract: We use data from aggregate stock and dividend futures markets to quantify how investors’ expectations about economic growth evolved across horizons following the outbreak of the novel coronavirus (COVID-19) and subsequent policy responses until July 2020 ...

    Abstract We use data from aggregate stock and dividend futures markets to quantify how investors’ expectations about economic growth evolved across horizons following the outbreak of the novel coronavirus (COVID-19) and subsequent policy responses until July 2020 Dividend futures, which are claims to dividends on the aggregate stock market in a particular year, can be used to directly compute a lower bound on growth expectations across maturities or to estimate expected growth using a forecasting model We show how the actual forecast and the bound evolve over time As of July 20th, our forecast of annual growth in dividends points to a decline of 8% in both the United States and Japan and a 14% decline in the European Union compared to January 1 Our forecast of GDP growth points to a decline of 2% in the United States and Japan and 3% in the European Union The lower bound on the change in expected dividends is -17% in the United States and Japan and -28% in the European Union at the 2-year horizon News about U S monetary policy and the fiscal stimulus bill around March 24 boosted the stock market and long-term growth but did little to increase short-term growth expectations Expected dividend growth has improved since April 1 in all geographies
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #756959
    Database COVID19

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  2. Article ; Online: Coronavirus

    Gormsen, Niels Joachim / Koijen, Ralph S J

    The Review of Asset Pricing Studies ; ISSN 2045-9920 2045-9939

    Impact on Stock Prices and Growth Expectations

    2020  

    Abstract: Abstract We use data from aggregate stock and dividend futures markets to quantify how investors’ expectations about economic growth evolved across horizons following the outbreak of the novel coronavirus (COVID-19) and subsequent policy responses until ... ...

    Abstract Abstract We use data from aggregate stock and dividend futures markets to quantify how investors’ expectations about economic growth evolved across horizons following the outbreak of the novel coronavirus (COVID-19) and subsequent policy responses until July 2020. Dividend futures, which are claims to dividends on the aggregate stock market in a particular year, can be used to directly compute a lower bound on growth expectations across maturities or to estimate expected growth using a forecasting model. We show how the actual forecast and the bound evolve over time. As of July 20th, our forecast of annual growth in dividends points to a decline of 8% in both the United States and Japan and a 14% decline in the European Union compared to January 1. Our forecast of GDP growth points to a decline of 2% in the United States and Japan and 3% in the European Union. The lower bound on the change in expected dividends is -17% in the United States and Japan and -28% in the European Union at the 2-year horizon. News about U.S. monetary policy and the fiscal stimulus bill around March 24 boosted the stock market and long-term growth but did little to increase short-term growth expectations. Expected dividend growth has improved since April 1 in all geographies. (JEL G12, G31) Received May 23, 2020; editorial decision August 12, 2020 by Editor Nikolai Roussanov.
    Keywords covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/rapstu/raaa013
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate.

    Gopalasingam, Nigopan / Moeslund, Niels / Christensen, Kristian Hylleberg / Berg-Hansen, Kristoffer / Seefeldt, Jacob / Homilius, Casper / Nielsen, Erik Nguyen / Dollerup, Mie Ringgaard / Alstrup Olsen, Aage K / Johannsen, Mogens / Boedtkjer, Ebbe / Møller, Niels / Eiskjær, Hans / Gormsen, Lars Christian / Nielsen, Roni / Wiggers, Henrik

    Journal of the American Heart Association

    2024  Volume 13, Issue 8, Page(s) e033628

    Abstract: Background: The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output (CO) by 35% to 40% in healthy people and people with heart failure. The mechanisms underlying the effects of 3-OHB on myocardial contractility and loading conditions as well ... ...

    Abstract Background: The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output (CO) by 35% to 40% in healthy people and people with heart failure. The mechanisms underlying the effects of 3-OHB on myocardial contractility and loading conditions as well as the cardiovascular effects of its enantiomeric forms, D-3-OHB and L-3-OHB, remain undetermined.
    Methods and results: Three groups of 8 pigs each underwent a randomized, crossover study. The groups received 3-hour infusions of either D/L-3-OHB (racemic mixture), 100% L-3-OHB, 100% D-3-OHB, versus an isovolumic control. The animals were monitored with pulmonary artery catheter, left ventricle pressure-volume catheter, and arterial and coronary sinus blood samples. Myocardial biopsies were evaluated with high-resolution respirometry, coronary arteries with isometric myography, and myocardial kinetics with D-[
    Conclusions: 3-OHB increased CO by reducing afterload. L-3-OHB exerted a stronger hemodynamic response than D-3-OHB due to higher circulating 3-OHB levels. There was a dissocitation between the myocardial metabolism and hemodynamic effects of the enantiomers, highlighting L-3-OHB as a potent cardiovascular agent with strong hemodynamic effects.
    MeSH term(s) Humans ; Swine ; Animals ; 3-Hydroxybutyric Acid/pharmacology ; Cross-Over Studies ; Tomography, X-Ray Computed ; Hydroxybutyrates/pharmacology ; Heart ; Ketone Bodies/metabolism
    Chemical Substances 3-Hydroxybutyric Acid (TZP1275679) ; Hydroxybutyrates ; Ketone Bodies
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.033628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 3-Hydroxybutyrate administration elevates plasma parathyroid hormone in a pilot human randomized, controlled, cross over trial.

    Svart, Mads / Gormsen, Lars Christian / Espersen, Rasmus / Rittig, Nikolaj / Starup-Linde, Jakob / Møller, Niels / Rejnmark, Lars

    Bone

    2021  Volume 153, Page(s) 116166

    Abstract: Content: Ketone bodies, in particular 3-hydroxybutyrate (3OHB), are known to possess important energetic and signaling capacities. There is a growing block of evidence, that ketogenic dieting (KD), fasting, and sodium glucose transporter 2 inhibitor ( ... ...

    Abstract Content: Ketone bodies, in particular 3-hydroxybutyrate (3OHB), are known to possess important energetic and signaling capacities. There is a growing block of evidence, that ketogenic dieting (KD), fasting, and sodium glucose transporter 2 inhibitor (SGLT2i) treatment are associated with hyperparathyroidism and negative bone health.
    Objective: We aimed to study the effect of exogenous 3OHB administration on bone metabolism, specifically the effect on parathyroid hormone (PTH) and calcium/phosphate homeostasis.
    Design: A randomized, controlled, cross over study with two arms: i) saline infusion and ii) 3OHB infusion.
    Setting: The study was conducted at Aarhus University Hospital.
    Participants: We examined eight healthy human subjects aged 50-70 years.
    Intervention: Continuous intravenous DL-3OHB-NaCl infusion or 0.9% NaCl was administered for 390 min.
    Main outcome measures: The study was designed to test the impact of 3OHB on PTH, calcium-phosphate, C-terminal Telopeptide (CTX), and Procollagen I N-terminal Propeptide (PINP). The study was a post hoc study.
    Results: The PTH concentration increased by 25% with a concomitant drop in phosphate of 30% in the 3OHB group. 3OHB infusion increased concentrations of CTX by 5%, without changes in PINP and albumin corrected calcium concentrations.
    Conclusion: In conclusion, 3OHB administration increases PTH concentration and markers of bone resorption. These findings suggest a possible negative effect on bone health, which needs to be determined in future studies.
    MeSH term(s) 3-Hydroxybutyric Acid ; Biomarkers ; Calcium ; Collagen Type I ; Cross-Over Studies ; Humans ; Parathyroid Hormone ; Procollagen
    Chemical Substances Biomarkers ; Collagen Type I ; Parathyroid Hormone ; Procollagen ; Calcium (SY7Q814VUP) ; 3-Hydroxybutyric Acid (TZP1275679)
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2021.116166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Coronary Artery Stenosis Evaluation by Angiography-Derived FFR: Validation by Positron Emission Tomography and Invasive Thermodilution.

    Westra, Jelmer / Rasmussen, Laust Dupont / Eftekhari, Ashkan / Winther, Simon / Karim, Salma Raghad / Johansen, Jane Kirk / Hammid, Osama / Søndergaard, Hanne Maare / Ejlersen, June Anita / Gormsen, Lars C / Mogensen, Lone Juul Hune / Bøttcher, Morten / Holm, Niels Ramsing / Christiansen, Evald Høj

    JACC. Cardiovascular imaging

    2023  Volume 16, Issue 10, Page(s) 1321–1331

    Abstract: Background: Fractional flow reserve (FFR) derived from invasive coronary angiography (QFR) is promising for evaluation of intermediate coronary artery stenosis.: Objectives: The authors aimed to compare the diagnostic performance of QFR and the ... ...

    Abstract Background: Fractional flow reserve (FFR) derived from invasive coronary angiography (QFR) is promising for evaluation of intermediate coronary artery stenosis.
    Objectives: The authors aimed to compare the diagnostic performance of QFR and the guideline-recommended invasive FFR using
    Methods: This is a prospective, observational study of symptomatic patients with suspected obstructive coronary artery disease on coronary computed tomography angiography (≥50% diameter stenosis in ≥1 vessel). All patients were referred to
    Results: A total of 250 patients (320 vessels) with indication for invasive physiological assessment were included. The continuous relationship of
    Conclusions: With
    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Fractional Flow Reserve, Myocardial/physiology ; Constriction, Pathologic ; Thermodilution ; Coronary Vessels/diagnostic imaging ; Predictive Value of Tests ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/therapy ; Coronary Angiography/methods ; Positron-Emission Tomography ; Severity of Illness Index
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2023.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study on optimal diagnostic strategy.

    Winther, Simon / Dupont Rasmussen, Laust / Westra, Jelmer / Abdulzahra, Salma Raghad Karim / Dahl, Jonathan Nørtoft / Gormsen, Lars Christian / Christiansen, Evald Høj / Brix, Gitte Stokvad / Mortensen, Jesper / Ejlersen, June Anita / Søndergaard, Hanne Maare / Hansson, Nicolaj Christopher Lyng / Holm, Niels Ramsing / Knudsen, Lars Lyhne / Eftekhari, Ashkan / Møller, Peter L / Rohde, Palle Duun / Nyegaard, Mette / Böttcher, Morten

    Open heart

    2023  Volume 10, Issue 2

    Abstract: Introduction: Current guideline recommend functional imaging for myocardial ischaemia if coronary CT angiography (CTA) has shown coronary artery disease (CAD) of uncertain functional significance. However, diagnostic accuracy of selective myocardial ... ...

    Abstract Introduction: Current guideline recommend functional imaging for myocardial ischaemia if coronary CT angiography (CTA) has shown coronary artery disease (CAD) of uncertain functional significance. However, diagnostic accuracy of selective myocardial perfusion imaging after coronary CTA is currently unclear. The Danish study of Non-Invasive testing in Coronary Artery Disease 3 trial is designed to evaluate head to head the diagnostic accuracy of myocardial perfusion imaging with positron emission tomography (PET) using the tracers
    Methods and analysis: This prospective, multicentre, cross-sectional study will include approximately 1000 symptomatic patients without previous CAD. Patients are included after referral to coronary CTA. All patients undergo a structured interview and blood is sampled for genetic and proteomic analysis and a coronary CTA. Patients with possible obstructive CAD at coronary CTA are examined with both
    Ethics and dissemination: Ethical approval was obtained from Danish regional committee on health research ethics. Written informed consent will be provided by all study participants. Results of this study will be disseminated via articles in international peer-reviewed journal.
    Trial registration number: NCT04707859.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Cross-Sectional Studies ; Denmark ; Fractional Flow Reserve, Myocardial ; Prospective Studies ; Proteomics ; Water ; Multicenter Studies as Topic
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2023-002328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: Reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial.

    Svart, Mads / Gormsen, Lars C / Hansen, Jakob / Zeidler, Dora / Gejl, Michael / Vang, Kim / Aanerud, Joel / Moeller, Niels

    PloS one

    2018  Volume 13, Issue 2, Page(s) e0190556

    Abstract: Ketone bodies are neuroprotective in neurological disorders such as epilepsy. We randomly studied nine healthy human subjects twice-with and without continuous infusion of 3-hydroxybutyrate-to define potential underlying mechanisms, assessed regionally ( ... ...

    Abstract Ketone bodies are neuroprotective in neurological disorders such as epilepsy. We randomly studied nine healthy human subjects twice-with and without continuous infusion of 3-hydroxybutyrate-to define potential underlying mechanisms, assessed regionally (parietal, occipital, temporal, cortical grey, and frontal) by PET scan. During 3-hydroxybutyrate infusions concentrations increased to 5.5±0.4 mmol/l and cerebral glucose utilisation decreased 14%, oxygen consumption remained unchanged, and cerebral blood flow increased 30%. We conclude that acute 3-hydroxybutyrate infusion reduces cerebral glucose uptake and increases cerebral blood flow in all measured brain regions, without detectable effects on cerebral oxygen uptake though oxygen extraction decreased. Increased oxygen supply concomitant with unchanged oxygen utilisation may contribute to the neuroprotective effects of ketone bodies.
    MeSH term(s) 3-Hydroxybutyric Acid/administration & dosage ; 3-Hydroxybutyric Acid/blood ; Aged ; Biological Transport, Active/drug effects ; Brain/diagnostic imaging ; Brain/drug effects ; Brain/metabolism ; Cerebrovascular Circulation/drug effects ; Cross-Over Studies ; Female ; Glucose/metabolism ; Healthy Volunteers ; Humans ; Infusions, Intravenous ; Ketone Bodies/administration & dosage ; Ketone Bodies/blood ; Male ; Middle Aged ; Neuroprotective Agents/administration & dosage ; Oxygen Consumption/drug effects ; Positron-Emission Tomography
    Chemical Substances Ketone Bodies ; Neuroprotective Agents ; Glucose (IY9XDZ35W2) ; 3-Hydroxybutyric Acid (TZP1275679)
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0190556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Metformin is distributed to tumor tissue in breast cancer patients in vivo: A

    Sundelin, Elias Immanuel Ordell / Al-Suliman, Nidal / Vahl, Pernille / Vendelbo, Mikkel / Munk, Ole Lajord / Jakobsen, Steen / Pedersen, Steen Bønløkke / Frøkiær, Jørgen / Gormsen, Lars C / Jessen, Niels

    Breast cancer research and treatment

    2020  Volume 181, Issue 1, Page(s) 107–113

    Abstract: Purpose: Epidemiological studies and randomized clinical trials suggest that the antidiabetic drug, metformin, may have anti-neoplastic effects. The mechanism that mediates these beneficial effects has been suggested to involve direct action on cancer ... ...

    Abstract Purpose: Epidemiological studies and randomized clinical trials suggest that the antidiabetic drug, metformin, may have anti-neoplastic effects. The mechanism that mediates these beneficial effects has been suggested to involve direct action on cancer cells, but this will require distribution of metformin in tumor tissue. The present study was designed to investigate metformin distribution in vivo in breast and liver tissue in breast cancer patients.
    Methods: Seven patients recently diagnosed with ductal carcinoma were recruited. Using PET/CT, tissue distribution of metformin was determined in vivo for 90 min after injection of a carbon-11-labeled metformin tracer. After surgery, tumor tissue was investigated for gene expression levels of metformin transporter proteins.
    Results: Tumor tissue displayed a distinct uptake of metformin compared to normal breast tissue AUC
    Conclusion: This study confirms that metformin is transported into tumor tissue in women with breast cancer. This finding support that metformin may have direct anti-neoplastic effects on tumor cells in breast cancer patients. However, distribution of metformin in tumor tissue is markedly lower than in liver, an established metformin target tissue.
    MeSH term(s) Aged ; Biomarkers, Tumor/genetics ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carbon Radioisotopes/pharmacokinetics ; Female ; Follow-Up Studies ; Gene Expression Profiling ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacokinetics ; Metformin/administration & dosage ; Metformin/pharmacokinetics ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Prognosis ; Tissue Distribution
    Chemical Substances Biomarkers, Tumor ; Carbon Radioisotopes ; Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2020-04-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-020-05621-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial.

    Lauritsen, Katrine M / Nielsen, Bent R R / Tolbod, Lars P / Johannsen, Mogens / Hansen, Jakob / Hansen, Troels K / Wiggers, Henrik / Møller, Niels / Gormsen, Lars C / Søndergaard, Esben

    Diabetes

    2020  Volume 70, Issue 3, Page(s) 800–808

    Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibition reduces cardiovascular morbidity and mortality in individuals with type 2 diabetes. Beneficial effects have been attributed to increased ketogenesis, reduced cardiac fatty acid oxidation, and diminished ... ...

    Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibition reduces cardiovascular morbidity and mortality in individuals with type 2 diabetes. Beneficial effects have been attributed to increased ketogenesis, reduced cardiac fatty acid oxidation, and diminished cardiac oxygen consumption. We therefore studied whether SGLT2 inhibition altered cardiac oxidative substrate consumption, efficiency, and perfusion. Thirteen individuals with type 2 diabetes were studied after 4 weeks' treatment with empagliflozin and placebo in a randomized, double-blind, placebo-controlled crossover study. Myocardial palmitate and glucose uptake were measured with
    MeSH term(s) Benzhydryl Compounds/therapeutic use ; Blood Pressure/physiology ; Body Composition/physiology ; Cross-Over Studies ; Diabetes Mellitus, Type 2/metabolism ; Double-Blind Method ; Energy Metabolism/physiology ; Fatty Acids/metabolism ; Glucose/metabolism ; Glucosides/therapeutic use ; Humans ; Myocardium/metabolism ; Oxygen Consumption/physiology ; Positron Emission Tomography Computed Tomography ; Randomized Controlled Trials as Topic ; Sodium-Glucose Transporter 2/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Benzhydryl Compounds ; Fatty Acids ; Glucosides ; SLC5A2 protein, human ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; empagliflozin (HDC1R2M35U) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db20-0921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparison of quantitative flow ratio and fractional flow reserve with myocardial perfusion scintigraphy and cardiovascular magnetic resonance as reference standard. A Dan-NICAD substudy.

    Sejr-Hansen, Martin / Westra, Jelmer / Winther, Simon / Tu, Shengxian / Nissen, Louise / Gormsen, Lars / Petersen, Steffen E / Ejlersen, June / Isaksen, Christin / Bøtker, Hans Erik / Bøttcher, Morten / Christiansen, Evald H / Holm, Niels Ramsing

    The international journal of cardiovascular imaging

    2019  Volume 36, Issue 3, Page(s) 395–402

    Abstract: Quantitative flow ratio (QFR) and fractional flow reserve (FFR) have not yet been compared head to head with perfusion imaging as reference for myocardial ischemia. We aimed to compare the diagnostic accuracy of QFR and FFR with myocardial perfusion ... ...

    Abstract Quantitative flow ratio (QFR) and fractional flow reserve (FFR) have not yet been compared head to head with perfusion imaging as reference for myocardial ischemia. We aimed to compare the diagnostic accuracy of QFR and FFR with myocardial perfusion scintigraphy (MPS) or cardiovascular magnetic resonance (CMR) as reference. This study is a predefined post hoc analysis of the Dan-NICAD study (NCT02264717). Patients with suspected coronary artery disease by coronary computed tomography angiography (CCTA) were randomized 1:1 to MPS or CMR and were referred to invasive coronary angiography with FFR and predefined QFR assessment. Paired data with FFR, QFR and MPS or CMR were available for 232 vessels with stenosis in 176 patients. Perfusion defects were detected in 57 vessel territories (25%). For QFR and FFR the diagnostic accuracy was 61% and 57% (p = 0.18) and area under the receiver operating curve was 0.64 vs. 0.58 (p = 0.22). Stenoses with absolute indication for stenting due to diameter stenosis > 90% by visual estimate were not classified as significant by either QFR or MPS/CMR in 21% (7 of 34) of cases. The diagnostic performance of QFR and FFR was similar but modest with MPS or CMR as reference. Comparable performance levels for QFR and FFR are encouraging for this pressure wire-free diagnostic method.
    MeSH term(s) Aged ; Computed Tomography Angiography ; Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/physiopathology ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/physiopathology ; Denmark ; Female ; Fractional Flow Reserve, Myocardial ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myocardial Perfusion Imaging ; Predictive Value of Tests ; Radionuclide Imaging ; Reproducibility of Results ; Severity of Illness Index
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-019-01737-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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