Result 1 - 10 of total 258
Towards the re-use of routinely collected data
2022
| Keywords | Life Science |
|---|---|
| Language | English |
| Publisher | Wageningen University |
| Publishing country | nl |
| Document type | Thesis ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2023 Volume 130, Issue 17, Page(s) 174001
Abstract: We report results on the instantaneous drag force on plates that are accelerated in a direction normal to the plate surface, which show that this force scales with the square root of the acceleration. This is associated with the generation and advection ... ...
| Abstract | We report results on the instantaneous drag force on plates that are accelerated in a direction normal to the plate surface, which show that this force scales with the square root of the acceleration. This is associated with the generation and advection of vorticity at the plate surface. A new scaling law is presented for the drag force on accelerating plates, based on the history force for unsteady flow. This scaling avoids previous inconsistencies in using added mass forces in the description of forces on accelerating plates. |
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| Language | English |
| Publishing date | 2023-05-12 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 208853-8 |
| ISSN | 1079-7114 ; 0031-9007 |
| ISSN (online) | 1079-7114 |
| ISSN | 0031-9007 |
| DOI | 10.1103/PhysRevLett.130.174001 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Z 4' 58/153: Show issues |
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Healthcare Analytics
A Systematic Literature Review”
2023 Volume 4
Abstract: The publisher regrets to inform that Declaration of Competing Interest statement was not included in the published version of this article. The publisher would like to apologise for any inconvenience caused. The appropriate Declaration/Competing Interest ...
| Abstract | The publisher regrets to inform that Declaration of Competing Interest statement was not included in the published version of this article. The publisher would like to apologise for any inconvenience caused. The appropriate Declaration/Competing Interest statements, provided by the Authors, is included below. |
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| Keywords | Life Science |
| Language | English |
| Publishing country | nl |
| Document type | Article ; Online |
| ISSN | 2772-4425 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
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2024 Volume 24, Issue 1, Page(s) 462
Abstract: Background: Stakeholder engagement in evaluation of medical devices is crucial for aligning devices with stakeholders' views, needs, and values. Methods for these engagements have however not been compared to analyse their relative merits for medical ... ...
| Abstract | Background: Stakeholder engagement in evaluation of medical devices is crucial for aligning devices with stakeholders' views, needs, and values. Methods for these engagements have however not been compared to analyse their relative merits for medical device evaluation. Therefore, we systematically compared these three methods in terms of themes, interaction, and time-investment. Methods: We compared focus groups, interviews, and an online survey in a case-study on minimally invasive endoscopy-guided surgery for patients with intracerebral haemorrhage. The focus groups and interviews featured two rounds, one explorative focussing on individual perspectives, and one interactive focussing on the exchange of perspectives between participants. The comparison between methods was made in terms of number and content of themes, how participants interact, and hours invested by all researchers. Results: The focus groups generated 34 themes, the interviews 58, and the survey 42. Various improvements for the assessment of the surgical procedure were only discussed in the interviews. In focus groups, participants were inclined to emphasise agreement and support, whereas the interviews consisted of questions and answers. The total time investment for researchers of focus groups was 95 h, of interviews 315 h, and survey 81 h. Conclusions: Within the context of medical device evaluation, interviews appeared to be the most appropriate method for understanding stakeholder views since they provide a scope and depth of information that is not generated by other methods. Focus groups were useful to rapidly bring views together. Surveys enabled a quick exploration. Researchers should account for these methodological differences and select the method that is suitable for their research aim. |
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| MeSH term(s) | Humans ; Focus Groups ; Investments ; Marital Status ; Research Personnel ; Social Participation |
| Language | English |
| Publishing date | 2024-04-12 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2050434-2 |
| ISSN | 1472-6963 ; 1472-6963 |
| ISSN (online) | 1472-6963 |
| ISSN | 1472-6963 |
| DOI | 10.1186/s12913-024-10887-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 32, Issue 10, Page(s) 2887–2897
Abstract: Purpose: During counseling and management of patients with vestibular schwannoma (VS), the emphasis is shifting from tumour control and nerve preservation towards maintaining or improving health-related quality of life (HRQoL). Understanding the ... ...
| Abstract | Purpose: During counseling and management of patients with vestibular schwannoma (VS), the emphasis is shifting from tumour control and nerve preservation towards maintaining or improving health-related quality of life (HRQoL). Understanding the patients' perspective and impact of VS is, therefore, of utmost importance. The current study aimed to identify treatment outcomes preferred by patients and to explore the patient-reported VS symptoms and management-related side effects and their impact on HRQoL. Methods: Patients with VS were contacted through the Dutch VS association Stichting Hoormij and questioned using a semi-structured, cross-sectional online survey. Patients were asked to report and rank symptoms and side effects, with their impact on HRQoL and frequency of occurrence. Results were structured through qualitative content analysis. Coded symptoms, side effects, impacts, frequencies, and patient-preferred outcomes were analysed and summarized with descriptive statistics. Results: Of the 231 respondents, 71% were actively treated. Hearing (symptoms vs. side effects: 78.8% vs. 63.6%), balance (62.3%; 48.8%), and energy issues (33.8%; 32.6%) were the most frequently mentioned symptoms and management-related side effects. Fatigue, deafness, headaches, and hearing loss had the highest impact on HRQoL. The majority of patients identified hearing preservation (61%), balance preservation (38.5%), and reduced tinnitus (34.6%) to be the patient-preferred outcomes. Conclusion: This qualitative study demonstrates that in this population many patients with VS encounter participation difficulties in their daily physical and social activities and value hearing and balance preservation, reduced tinnitus, and restored energy as preferred outcomes as they are hampered by symptoms and side effects related to hearing, balance, and energy. Healthcare professionals should consider these key points and use these and the patient-preferred outcomes in consultation, shared decision making, treatment, and follow-up to optimize patient-centred care. |
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| MeSH term(s) | Humans ; Neuroma, Acoustic/diagnosis ; Neuroma, Acoustic/pathology ; Neuroma, Acoustic/therapy ; Tinnitus/etiology ; Quality of Life/psychology ; Cross-Sectional Studies ; Hearing ; Treatment Outcome ; Drug-Related Side Effects and Adverse Reactions ; Retrospective Studies |
| Language | English |
| Publishing date | 2023-05-31 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 1161148-0 |
| ISSN | 1573-2649 ; 0962-9343 |
| ISSN (online) | 1573-2649 |
| ISSN | 0962-9343 |
| DOI | 10.1007/s11136-023-03433-x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3796: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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BMC medical informatics and decision making
2021 Volume 21, Issue 1, Page(s) 210
Abstract: Background: Healthcare relies on health information systems (HISs) to support the care and receive reimbursement for the care provided. Healthcare providers experience many problems with their HISs due to improper architecture design. To support the ... ...
| Abstract | Background: Healthcare relies on health information systems (HISs) to support the care and receive reimbursement for the care provided. Healthcare providers experience many problems with their HISs due to improper architecture design. To support the design of a proper HIS architecture, a reference architecture (RA) can be used that meets the various stakeholder concerns of HISs. Therefore, the objective of this study is to develop and analyze an RA following well-established architecture design methods. Methods: Domain analysis was performed to scope and model the domain of HISs. For the architecture design, we applied the views and beyond approach and designed the RA's views based on the stakeholders and features from the domain analysis. We evaluated the RA with a case study. Results: We derived the following four architecture views for HISs: The context diagram, decomposition view, layered view, and deployment view. Each view shows the architecture of the HIS from a different angle, suitable for various stakeholders. Based on a Japanese hospital information system study, we applied the RA and derived the application architecture. Conclusion: We demonstrated that the methods of the software architecture design community could be used in the healthcare domain effectively and showed the applicability of the RA. |
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| MeSH term(s) | Delivery of Health Care ; Health Information Systems ; Hospital Information Systems ; Humans |
| Language | English |
| Publishing date | 2021-07-08 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 1472-6947 |
| ISSN (online) | 1472-6947 |
| DOI | 10.1186/s12911-021-01570-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Archives of gynecology and obstetrics
2023 Volume 308, Issue 5, Page(s) 1531–1541
Abstract: Purpose: Patients often undergo repeat surgery for endometriosis, due to recurrent or residual disease. Previous surgery is often considered a risk factor for worse surgical outcome. However, data are scarce concerning the influence of subsequent ... ...
| Abstract | Purpose: Patients often undergo repeat surgery for endometriosis, due to recurrent or residual disease. Previous surgery is often considered a risk factor for worse surgical outcome. However, data are scarce concerning the influence of subsequent endometriosis surgery. Methods: A retrospective study in a centre of expertise for endometriosis was conducted. All endometriosis subtypes and intra-operative steps were included. Detailed information regarding surgical history of patients was collected. Surgical time, intra-operative steps and major post-operative complications were obtained as outcome measures. Results: 595 patients were included, of which 45.9% had previous endometriosis surgery. 7.9% had major post-operative complications and 4.4% intra-operative complications. The patient journey showed a median of 3 years between previous endometriosis surgeries. Each previous therapeutic laparotomic surgery resulted on average in 13 additional minutes (p = 0.013) of surgical time. Additionally, it resulted in more frequent performance of adhesiolysis (OR 2.96, p < 0.001) and in a higher risk for intra-operative complications (OR 1.81, p = 0.045), however no higher risk for major post-operative complications (OR 1.29, p = 0.418). Previous therapeutic laparoscopic endometriosis surgery, laparotomic and laparoscopic non-endometriosis surgery showed no association with surgical outcomes. Regardless of previous surgery, disc and segmental bowel resection showed a higher risk for major post-operative complications (OR 3.64, p = 0.017 respectively OR 3.50, p < 0.001). Conclusion: Previous therapeutic laparotomic endometriosis surgery shows an association with longer surgical time, the need to perform adhesiolysis, and more intra-operative complications in the subsequent surgery for endometriosis. However, in a centre of expertise with experienced surgeons, no increased risk of major post-operative complications was observed. |
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| MeSH term(s) | Female ; Humans ; Endometriosis/surgery ; Retrospective Studies ; Dissection ; Intraoperative Complications ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Treatment Outcome |
| Language | English |
| Publishing date | 2023-08-28 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 896455-5 |
| ISSN | 1432-0711 ; 0932-0067 |
| ISSN (online) | 1432-0711 |
| ISSN | 0932-0067 |
| DOI | 10.1007/s00404-023-07193-4 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Um I Zs.55: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Computers in biology and medicine
2021 Volume 137, Page(s) 104785
Abstract: Background: Currently many healthcare systems are supported by an increasing set of Health Information Sys-tems (HISs), which assist the activities for multiple stakeholders. The literature on HISs is, however, fragmented and a solid overview of the ... ...
| Abstract | Background: Currently many healthcare systems are supported by an increasing set of Health Information Sys-tems (HISs), which assist the activities for multiple stakeholders. The literature on HISs is, however, fragmented and a solid overview of the current state of HISs is missing. This impedes the understanding and characterization of the required HISs for the healthcare domain. Methods: In this article, we present the results of a Systematic Literature Review (SLR) that identifies the HISs, their domains, stakeholders, features, and obstacles. Results: In the SLR, we identified 1340 papers from which we selected 136 studies, on which we performed a full-text analysis. After the synthesis of the data, we were able to report on 33 different domains, 41 stakeholders, 73 features, and 69 obstacles. We discussed how these domains, features, and obstacles interact with each other and presented suggestions to overcome the identified obstacles. We recognized five groups of obstacles: technical problems, operational functionality, maintenance & support, usage problems, and quality problems. Obstacles from all groups require to be solved to pave the way for further research and application of HISs. Conclusion: This study shows that there is a plentitude of HISs with unique features and that there is no consensus on the requirements and types of HISs in the literature. |
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| MeSH term(s) | Delivery of Health Care ; Health Information Systems |
| Language | English |
| Publishing date | 2021-08-27 |
| Publishing country | United States |
| Document type | Journal Article ; Review ; Systematic Review |
| ZDB-ID | 127557-4 |
| ISSN | 1879-0534 ; 0010-4825 |
| ISSN (online) | 1879-0534 |
| ISSN | 0010-4825 |
| DOI | 10.1016/j.compbiomed.2021.104785 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 653: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Healthcare Analytics
A Systematic Literature Review
2022 Volume 2
Abstract: In the field of healthcare, as well as many others, textual descriptions of events are logged. With the use of Natural Language Processing (NLP), these texts are used to train event prediction machine learning algorithms. In this review the aim was to ... ...
| Abstract | In the field of healthcare, as well as many others, textual descriptions of events are logged. With the use of Natural Language Processing (NLP), these texts are used to train event prediction machine learning algorithms. In this review the aim was to assess the state-of-the-art within current literature concerning prediction of events on textual records. Thus, this study follows a standard Systematic Literature Review (SLR) process. Primary articles are selected from PubMed, IEEE and WebOfScience with a search query, and then exclusion and quality assessment criteria are used to select the articles that are relevant to this study. Published performance metrics for the prediction algorithms used in the studies were then extracted from the included articles and used to assess the different methods. The general-purpose neural network algorithms: Convolutional Neural Networks (CNNs), Long Short-Term Memory (LSTM) and Conditional Random Fields (CRF) demonstrate the highest F1-scores amongst all the methods in this review, of 98.5%, 98% and 90.13% respectively. The algorithms that were designed specifically for NLP such as word2vec and BERT also performed well with F1-scores of 88.93% and 91.50%. This review does not give a comparison between methods but gives an indication about which machine learning methods perform well according to the authors of the selected studies. Not enough performance results are published under comparable circumstances to give conclusive results about which methods perform the best. More research needs to be done in comparing algorithms on the same dataset to proof the performance of the methods. |
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| Keywords | Life Science |
| Subject code | 006 |
| Language | English |
| Publishing country | nl |
| Document type | Article ; Online |
| ISSN | 2772-4425 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Translational lung cancer research
2023 Volume 12, Issue 10, Page(s) 2015–2029
Abstract: Background: Varied outcomes on the relation between time-to-treatment and survival in early-stage non-small cell lung cancer (NSCLC) patients are reported. We examined this relation in a large multicentric retrospective cohort study and identified ... ...
| Abstract | Background: Varied outcomes on the relation between time-to-treatment and survival in early-stage non-small cell lung cancer (NSCLC) patients are reported. We examined this relation in a large multicentric retrospective cohort study and identified factors associated with extended time-to-treatment. Methods: We included 9,536 patients with clinical stage I-II NSCLC, diagnosed and treated in 2014-2019, from the Netherlands Cancer Registry that includes nation-wide data. Time-to-treatment was defined as the number of days between first outpatient visit for suspected lung cancer and start of treatment. The effect of extended time-to-treatment beyond the first quartile and survival was studied with Cox proportional hazard regression. Analyses were stratified for stage and type of therapy. Time-to-treatment was adjusted for multiple covariates including performance status and socioeconomic status. Factors associated with treatment delay were identified by multilevel logistic regression. Results: Median time-to-treatment was 47 days [interquartile range (IQR): 34-65] for stage I and 46 days (IQR: 34-62) for stage II. The first quartile extended to 33 days for both stages. Risk of death increased significantly with extended time-to-treatment for surgical treatment of clinical stage II patients [adjusted hazard ratio (aHR) >33 days: 1.36, 95% confidence intervals (CI): 1.09-1.70], but not in stage II patients treated with radiotherapy or in stage I patients. Causes of prolonged time-to-treatment were multifactorial including diagnostic tests, such as endoscopic ultrasound (EUS) or endobronchial ultrasound (EBUS). Conclusions: Clinical stage II patients benefit from fast initiation of surgical treatment. Surprisingly this appears to be accounted for by patients who are clinically stage II but pathologically stage I. Further study is needed on characterizing these patients and the significance of lymph node- or distant micrometastasis in guiding time-to-treatment and treatment strategy. |
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| Language | English |
| Publishing date | 2023-10-09 |
| Publishing country | China |
| Document type | Journal Article |
| ZDB-ID | 2754335-3 |
| ISSN | 2226-4477 ; 2218-6751 |
| ISSN (online) | 2226-4477 |
| ISSN | 2218-6751 |
| DOI | 10.21037/tlcr-23-256 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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