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  1. Book ; Online ; E-Book: Thoracic radiology

    Carbone, Iacopo / Anzidei, Michele

    a guide for beginners

    2020  

    Abstract: Thoracic anatomy -- Glossary -- Lung nodules -- Lung cancer staging -- Mediastinal masses -- Imaging of the lung after surgercy, radiation therapy and chemotherapy -- Pneumonia and bronchiolitis -- Interstitial lung disease -- Pleural pathology -- Chest ... ...

    Author's details Iacopo Carbone, Michele Anzidei editors
    Abstract Thoracic anatomy -- Glossary -- Lung nodules -- Lung cancer staging -- Mediastinal masses -- Imaging of the lung after surgercy, radiation therapy and chemotherapy -- Pneumonia and bronchiolitis -- Interstitial lung disease -- Pleural pathology -- Chest x-ray interpretation.

    This book offers a comprehensive overview of all major pathologic conditions involving the lung and mediastinum and the related diagnostic procedures. Oncologic and non-oncologic conditions are reviewed and described in detail, featuring, besides normal anatomy, also high quality images from several modalities (including X-ray, CT, MR and PET), as well as b/w and color illustrations and line drawings. Complications associated with surgical and oncological treatments are also presented in detail with extensive imaging examples. The book provides a thorough coverage of the topic of thoracic imaging, yet considering a concise and synthetic approach essential to optimal learning. The book will be a useful reference guide for the everyday clinical practice of young radiologists, residents and medical students
    Keywords Chest / Radiography ; Chest ; Radiography
    Language English
    Size 1 Online-Ressource (xiv, 174 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Note Includes bibliographical references
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021460951
    ISBN 978-3-030-35765-8 ; 9783030357641 ; 3-030-35765-1 ; 3030357643
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: This special volume of mesothelioma is dedicated to my friend Adi Gazdar.

    Carbone, Michele

    Translational lung cancer research

    2020  Volume 9, Issue Suppl 1, Page(s) S1–S2

    Language English
    Publishing date 2020-03-18
    Publishing country China
    Document type Editorial
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr.2020.01.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transitional Mesothelioma and Artificial Intelligence: Do We Need One More Subtype? and Do We Need Computers to Identify Them?

    Carbone, Michele

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2020  Volume 15, Issue 6, Page(s) 884–887

    MeSH term(s) Artificial Intelligence ; Computers ; Humans ; Lung Neoplasms ; Mesothelioma ; Reproducibility of Results
    Language English
    Publishing date 2020-05-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2020.03.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6664: Show issues Location:
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  4. Article ; Online: Just a handful of publications can collect the prize.

    Carbone, Michele

    Nature

    2018  Volume 561, Issue 7724, Page(s) 464

    MeSH term(s) Achievement ; Bibliometrics ; Efficiency ; Professional Competence/standards ; Professional Competence/statistics & numerical data ; Research Personnel/standards ; Research Personnel/statistics & numerical data ; Reward
    Language English
    Publishing date 2018-09-26
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-018-06816-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: Did the Ban on Asbestos Reduce the Incidence of Mesothelioma?

    Carbone, Michele / Yang, Haining / Pass, Harvey I / Taioli, Emanuela

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 18, Issue 6, Page(s) 694–697

    MeSH term(s) Humans ; Incidence ; Lung Neoplasms/epidemiology ; Lung Neoplasms/prevention & control ; Lung Neoplasms/complications ; Mesothelioma/epidemiology ; Mesothelioma/prevention & control ; Mesothelioma/etiology ; Mesothelioma, Malignant ; Asbestos/adverse effects ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Does the Amount of Asbestos Exposure Influence Prognosis?

    Yang, Haining / Gaudino, Giovanni / Bardelli, Fabrizio / Carbone, Michele

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2022  Volume 17, Issue 8, Page(s) 949–952

    MeSH term(s) Asbestos/adverse effects ; Humans ; Lung Neoplasms/etiology ; Mesothelioma/etiology ; Occupational Exposure/adverse effects ; Prognosis
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2022.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: State-of-the-art Review on the Antiparasitic Activity of Benzimidazolebased Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis.

    Francesconi, Valeria / Rizzo, Marco / Schenone, Silvia / Carbone, Anna / Tonelli, Michele

    Current medicinal chemistry

    2023  Volume 31, Issue 15, Page(s) 1955–1982

    Abstract: Protozoan parasites represent a significant risk for public health worldwide, afflicting particularly people in more vulnerable categories and cause large morbidity and heavy economic impact. Traditional drugs are limited by their toxicity, low efficacy, ...

    Abstract Protozoan parasites represent a significant risk for public health worldwide, afflicting particularly people in more vulnerable categories and cause large morbidity and heavy economic impact. Traditional drugs are limited by their toxicity, low efficacy, route of administration, and cost, reflecting their low priority in global health management. Moreover, the drug resistance phenomenon threatens the positive therapy outcome. This scenario claims the need of addressing more adequate therapies. Among the diverse strategies implemented, the medicinal chemistry efforts have also focused their attention on the benzimidazole nucleus as a promising pharmacophore for the generation of new drug candidates. Hence, the present review provides a global insight into recent progress in benzimidazole-based derivatives drug discovery against important protozoan diseases, such as malaria, leishmaniasis and trypanosomiasis. The more relevant chemical features and structure-activity relationship studies of these molecules are discussed for the purpose of paving the way towards the development of more viable drugs for the treatment of these parasitic infections.
    MeSH term(s) Humans ; Antiparasitic Agents/therapeutic use ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use ; Antiprotozoal Agents/chemistry ; Malaria/drug therapy ; Trypanosomiasis/drug therapy ; Leishmaniasis/drug therapy ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use
    Chemical Substances Antiparasitic Agents ; Antiprotozoal Agents ; Benzimidazoles
    Language English
    Publishing date 2023-09-16
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867331666230915093928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4432: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Preventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma.

    Carbone, Michele / Minaai, Michael / Takinishi, Yasutaka / Pagano, Ian / Yang, Haining

    Journal of translational medicine

    2023  Volume 21, Issue 1, Page(s) 749

    Abstract: Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy and cell survival, and to the ... ...

    Abstract Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy and cell survival, and to the extracellular space where HMGB1 promotes chronic inflammation and mesothelioma growth. Targeting HMGB1 inhibited asbestos carcinogenesis and the growth of mesothelioma. It is hoped that targeting HMGB1 will be a novel therapeutic strategy that benefits mesothelioma patients. Severe restrictions and/or a complete ban on the use of asbestos were introduced in the 80 and early 90s in the Western world. These measures have proven effective as the incidence of mesothelioma/per 100,000 persons is decreasing in these countries. However, the overall number of mesotheliomas in the Western world has not significantly decreased. There are several reasons for that which are discussed here: (1) the presence of asbestos in old constructions; (2) the development of rural areas containing asbestos or other carcinogenic mineral fibers in the terrain; (3) the discovery of an increasing fraction of mesotheliomas caused by germline genetic mutations of BAP1 and other tumor suppressor genes; (4) mesotheliomas caused by radiation therapy; (5) the overall increase in the population and of the fraction of older people who are much more susceptible to develop all types of cancers, including mesothelioma. In summary, the epidemiology of mesothelioma is changing, the ban on asbestos worked, there are opportunities to help mesothelioma patients especially those who develop in a background of germline mutations and there is the opportunity to prevent a mesothelioma epidemic in the developing world, where the use of asbestos is increasing exponentially. We hope that restrictive measures similar to those introduced in the Western world will soon be introduced in developing countries to prevent a mesothelioma epidemic.
    MeSH term(s) Humans ; Asbestos/toxicity ; Carcinogenesis ; HMGB1 Protein ; Lung Neoplasms/genetics ; Mesothelioma/epidemiology ; Mesothelioma/therapy ; Mesothelioma, Malignant/complications ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ubiquitin Thiolesterase/genetics
    Chemical Substances Asbestos (1332-21-4) ; BAP1 protein, human ; HMGB1 Protein ; Tumor Suppressor Proteins ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-023-04614-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Preventive and therapeutic opportunities

    Michele Carbone / Michael Minaai / Yasutaka Takinishi / Ian Pagano / Haining Yang

    Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-

    targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma

    2023  Volume 9

    Abstract: Abstract Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy and cell survival, and to ... ...

    Abstract Abstract Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy and cell survival, and to the extracellular space where HMGB1 promotes chronic inflammation and mesothelioma growth. Targeting HMGB1 inhibited asbestos carcinogenesis and the growth of mesothelioma. It is hoped that targeting HMGB1 will be a novel therapeutic strategy that benefits mesothelioma patients. Severe restrictions and/or a complete ban on the use of asbestos were introduced in the 80 and early 90s in the Western world. These measures have proven effective as the incidence of mesothelioma/per 100,000 persons is decreasing in these countries. However, the overall number of mesotheliomas in the Western world has not significantly decreased. There are several reasons for that which are discussed here: (1) the presence of asbestos in old constructions; (2) the development of rural areas containing asbestos or other carcinogenic mineral fibers in the terrain; (3) the discovery of an increasing fraction of mesotheliomas caused by germline genetic mutations of BAP1 and other tumor suppressor genes; (4) mesotheliomas caused by radiation therapy; (5) the overall increase in the population and of the fraction of older people who are much more susceptible to develop all types of cancers, including mesothelioma. In summary, the epidemiology of mesothelioma is changing, the ban on asbestos worked, there are opportunities to help mesothelioma patients especially those who develop in a background of germline mutations and there is the opportunity to prevent a mesothelioma epidemic in the developing world, where the use of asbestos is increasing exponentially. We hope that restrictive measures similar to those introduced in the Western world will soon be introduced in developing countries to prevent a mesothelioma epidemic.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Constipation-Predominant Irritable Bowel Syndrome (IBS-C): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms.

    Di Rosa, Claudia / Altomare, Annamaria / Terrigno, Vittoria / Carbone, Florencia / Tack, Jan / Cicala, Michele / Guarino, Michele Pier Luca

    Nutrients

    2023  Volume 15, Issue 7

    Abstract: Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits. The pathogenesis of IBS is not completely clear, but it is known to be multifactorial ...

    Abstract Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits. The pathogenesis of IBS is not completely clear, but it is known to be multifactorial and complex. Endogenous and exogenous factors such as abnormal GI motility, low-grade inflammation, increased epithelial permeability and visceral hypersensitivity, but diet and psychosocial aspects are also recognized as important actors. Furthermore, the interaction between diet and gut microbiota has gained interest as a potential contributor to the pathophysiology of IBS. To date, there is no specific diet for IBS with constipation (IBS-C); however, many studies show that fiber intake, especially soluble fiber such as inulin, could have a positive effect on symptoms. This review aims to evaluate the effects of some nutritional components such as fibers but also functional foods, prebiotics, probiotics and symbiotics on symptoms and microbiota in IBS-C subjects.
    MeSH term(s) Humans ; Irritable Bowel Syndrome ; Dysbiosis/complications ; Constipation/etiology ; Probiotics/therapeutic use ; Prebiotics
    Chemical Substances Prebiotics
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15071647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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