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  1. Article: Cell Membrane Sialome: Sialic Acids as Therapeutic Targets and Regulators of Drug Resistance in Human Cancer Management.

    Jastrząb, Patrycja / Narejko, Karolina / Car, Halina / Wielgat, Przemyslaw

    Cancers

    2023  Volume 15, Issue 20

    Abstract: A cellular sialome is a physiologically active and dynamically changing component of the cell membrane. Sialylation plays a crucial role in tumor progression, and alterations in cellular sialylation patterns have been described as modulators of ... ...

    Abstract A cellular sialome is a physiologically active and dynamically changing component of the cell membrane. Sialylation plays a crucial role in tumor progression, and alterations in cellular sialylation patterns have been described as modulators of chemotherapy effectiveness. However, the precise mechanisms through which altered sialylation contributes to drug resistance in cancer are not yet fully understood. This review focuses on the intricate interplay between sialylation and cancer treatment. It presents the role of sialic acids in modulating cell-cell interactions, the extracellular matrix (ECM), and the immunosuppressive processes within the context of cancer. The issue of drug resistance is also discussed, and the mechanisms that involve transporters, the tumor microenvironment, and metabolism are analyzed. The review explores drugs and therapeutic approaches that may induce modifications in sialylation processes with a primary focus on their impact on sialyltransferases or sialidases. Despite advancements in cellular glycobiology and glycoengineering, an interdisciplinary effort is required to decipher and comprehend the biological characteristics and consequences of altered sialylation. Additionally, understanding the modulatory role of sialoglycans in drug sensitivity is crucial to applying this knowledge in clinical practice for the benefit of cancer patients.
    Language English
    Publishing date 2023-10-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15205103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2 Attacks in the Brain: Focus on the Sialome.

    Wielgat, Przemyslaw / Narejko, Karolina / Car, Halina

    Cells

    2022  Volume 11, Issue 9

    Abstract: The epidemiological observations suggest that respiratory and gastrointestinal symptoms caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) are accompanied by short- and long-term neurological manifestations. There is increasing evidence that ... ...

    Abstract The epidemiological observations suggest that respiratory and gastrointestinal symptoms caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) are accompanied by short- and long-term neurological manifestations. There is increasing evidence that the neuroinvasive potential of SARS-CoV-2 is closely related to its capacity to interact with cell membrane sialome. Given the wide expression of sialylated compounds of cell membranes in the brain, the interplay between cell membrane sialoglycans and the virus is crucial for its attachment and cell entry, transport, neuronal damage and brain immunity. Here, we focus on the significance of the brain sialome in the progress of coronavirus disease 2019 (COVID-19) and SARS-CoV-2-induced neuropathology.
    MeSH term(s) Brain ; COVID-19 ; Humans ; Nervous System Diseases/etiology ; Neurons ; SARS-CoV-2
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11091458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 Attacks in the Brain

    Przemyslaw Wielgat / Karolina Narejko / Halina Car

    Cells, Vol 11, Iss 1458, p

    Focus on the Sialome

    2022  Volume 1458

    Abstract: The epidemiological observations suggest that respiratory and gastrointestinal symptoms caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) are accompanied by short- and long-term neurological manifestations. There is increasing evidence that ... ...

    Abstract The epidemiological observations suggest that respiratory and gastrointestinal symptoms caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) are accompanied by short- and long-term neurological manifestations. There is increasing evidence that the neuroinvasive potential of SARS-CoV-2 is closely related to its capacity to interact with cell membrane sialome. Given the wide expression of sialylated compounds of cell membranes in the brain, the interplay between cell membrane sialoglycans and the virus is crucial for its attachment and cell entry, transport, neuronal damage and brain immunity. Here, we focus on the significance of the brain sialome in the progress of coronavirus disease 2019 (COVID-19) and SARS-CoV-2-induced neuropathology.
    Keywords SARS-CoV-2 ; sialic acid ; COVID-19 ; brain ; neurons ; inflammation ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Sialic Acid-Modified Nanoparticles-New Approaches in the Glioma Management-Perspective Review.

    Wielgat, Przemyslaw / Niemirowicz-Laskowska, Katarzyna / Wilczewska, Agnieszka Z / Car, Halina

    International journal of molecular sciences

    2021  Volume 22, Issue 14

    Abstract: The cell surface is covered by a dense and complex network of glycans attached to the membrane proteins and lipids. In gliomas, the aberrant sialylation, as the final stage of glycosylation, is an important regulatory mechanism of malignant cell behavior ...

    Abstract The cell surface is covered by a dense and complex network of glycans attached to the membrane proteins and lipids. In gliomas, the aberrant sialylation, as the final stage of glycosylation, is an important regulatory mechanism of malignant cell behavior and correlates with worse prognosis. Better understanding of the role of sialylation in cellular and molecular processes opens a new way in the development of therapeutic tools for human brain tumors. According to the recent clinical observation, the cellular heterogeneity, activity of brain cancer stem cells (BCSCs), immune evasion, and function of the blood-brain barrier (BBB) are attractive targets for new therapeutic strategies. In this review, we summarize the importance of sialic acid-modified nanoparticles in brain tumor progression.
    MeSH term(s) Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Blood-Brain Barrier/drug effects ; Brain Neoplasms/drug therapy ; Glioma/drug therapy ; Glioma/pathology ; Glycosylation ; Humans ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Polysaccharides/chemistry
    Chemical Substances Antineoplastic Agents ; Polysaccharides
    Language English
    Publishing date 2021-07-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22147494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tamoxifen Modulates the Immune Landscape of the Tumour Microenvironment: The Paired Siglec-5/14 Checkpoint in Anti-Tumour Immunity in an In Vitro Model of Breast Cancer.

    Wielgat, Przemyslaw / Rogowski, Karol / Czarnomysy, Robert / Wawrusiewicz-Kurylonek, Natalia / Narejko, Karolina / Bielawski, Krzysztof / Car, Halina

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Since the role of sialome-Siglec axis has been described as a regulatory checkpoint of immune homeostasis, the promotion of stimulatory or inhibitory Siglec-related mechanisms is crucial in cancer progression and therapy. Here, we investigated the effect ...

    Abstract Since the role of sialome-Siglec axis has been described as a regulatory checkpoint of immune homeostasis, the promotion of stimulatory or inhibitory Siglec-related mechanisms is crucial in cancer progression and therapy. Here, we investigated the effect of tamoxifen on the sialic acid-Siglec interplay and its significance in immune conversion in breast cancer. To mimic the tumour microenvironment, we used oestrogen-dependent or oestrogen-independent breast cancer cells/THP-1 monocytes transwell co-cultures exposed to tamoxifen and/or β-estradiol. We found changes in the cytokine profiles accompanied by immune phenotype switching, as measured by the expression of arginase-1. The immunomodulatory effects of tamoxifen in THP-1 cells occurred with the altered
    MeSH term(s) Humans ; Tamoxifen/pharmacology ; Antigens, CD/metabolism ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism ; THP-1 Cells ; Estrogens/pharmacology ; Neoplasms
    Chemical Substances Tamoxifen (094ZI81Y45) ; Antigens, CD ; Sialic Acid Binding Immunoglobulin-like Lectins ; Estrogens
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Coronaviruses: Is Sialic Acid a Gate to the Eye of Cytokine Storm? From the Entry to the Effects.

    Wielgat, Przemyslaw / Rogowski, Karol / Godlewska, Katarzyna / Car, Halina

    Cells

    2020  Volume 9, Issue 9

    Abstract: Coronaviruses (CoVs) are a diverse family of the enveloped human and animal viruses reported as causative agents for respiratory and intestinal infections. The high pathogenic potential of human CoVs, including SARS-CoV, MERS-CoV and SARS-CoV-2, is ... ...

    Abstract Coronaviruses (CoVs) are a diverse family of the enveloped human and animal viruses reported as causative agents for respiratory and intestinal infections. The high pathogenic potential of human CoVs, including SARS-CoV, MERS-CoV and SARS-CoV-2, is closely related to the invasion mechanisms underlying the attachment and entry of viral particles to the host cells. There is increasing evidence that sialylated compounds of cellular glycocalyx can serve as an important factor in the mechanism of CoVs infection. Additionally, the sialic acid-mediated cross-reactivity with the host immune lectins is known to exert the immune response of different intensity in selected pathological stages. Here, we focus on the last findings in the field of glycobiology in the context of the role of sialic acid in tissue tropism, viral entry kinetics and immune regulation in the CoVs infections.
    MeSH term(s) Animals ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Cytokines/metabolism ; Humans ; Mice ; Middle East Respiratory Syndrome Coronavirus/physiology ; N-Acetylneuraminic Acid/metabolism ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Receptors, Pattern Recognition/metabolism ; Severe acute respiratory syndrome-related coronavirus/physiology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/virology ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism ; Toll-Like Receptors/metabolism ; Virus Internalization
    Chemical Substances Cytokines ; Receptors, Pattern Recognition ; Sialic Acid Binding Immunoglobulin-like Lectins ; Toll-Like Receptors ; N-Acetylneuraminic Acid (GZP2782OP0)
    Keywords covid19
    Language English
    Publishing date 2020-08-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9091963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Coronaviruses

    Przemyslaw Wielgat / Karol Rogowski / Katarzyna Godlewska / Halina Car

    Cells, Vol 9, Iss 1963, p

    Is Sialic Acid a Gate to the Eye of Cytokine Storm? From the Entry to the Effects

    2020  Volume 1963

    Abstract: Coronaviruses (CoVs) are a diverse family of the enveloped human and animal viruses reported as causative agents for respiratory and intestinal infections. The high pathogenic potential of human CoVs, including SARS-CoV, MERS-CoV and SARS-CoV-2, is ... ...

    Abstract Coronaviruses (CoVs) are a diverse family of the enveloped human and animal viruses reported as causative agents for respiratory and intestinal infections. The high pathogenic potential of human CoVs, including SARS-CoV, MERS-CoV and SARS-CoV-2, is closely related to the invasion mechanisms underlying the attachment and entry of viral particles to the host cells. There is increasing evidence that sialylated compounds of cellular glycocalyx can serve as an important factor in the mechanism of CoVs infection. Additionally, the sialic acid-mediated cross-reactivity with the host immune lectins is known to exert the immune response of different intensity in selected pathological stages. Here, we focus on the last findings in the field of glycobiology in the context of the role of sialic acid in tissue tropism, viral entry kinetics and immune regulation in the CoVs infections.
    Keywords coronavirus ; MERS-CoV ; SARS-CoV ; SARS-CoV-2 ; sialic acid ; Siglec ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  8. Article ; Online: Sialic Acid—Modified Nanoparticles—New Approaches in the Glioma Management—Perspective Review

    Przemyslaw Wielgat / Katarzyna Niemirowicz-Laskowska / Agnieszka Z. Wilczewska / Halina Car

    International Journal of Molecular Sciences, Vol 22, Iss 7494, p

    2021  Volume 7494

    Abstract: The cell surface is covered by a dense and complex network of glycans attached to the membrane proteins and lipids. In gliomas, the aberrant sialylation, as the final stage of glycosylation, is an important regulatory mechanism of malignant cell behavior ...

    Abstract The cell surface is covered by a dense and complex network of glycans attached to the membrane proteins and lipids. In gliomas, the aberrant sialylation, as the final stage of glycosylation, is an important regulatory mechanism of malignant cell behavior and correlates with worse prognosis. Better understanding of the role of sialylation in cellular and molecular processes opens a new way in the development of therapeutic tools for human brain tumors. According to the recent clinical observation, the cellular heterogeneity, activity of brain cancer stem cells (BCSCs), immune evasion, and function of the blood–brain barrier (BBB) are attractive targets for new therapeutic strategies. In this review, we summarize the importance of sialic acid-modified nanoparticles in brain tumor progression.
    Keywords sialic acid ; nanoparticles ; Siglecs ; blood–brain barrier ; glioma ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  9. Article ; Online: Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy.

    Wielgat, Przemyslaw / Rogowski, Karol / Niemirowicz-Laskowska, Katarzyna / Car, Halina

    International journal of molecular sciences

    2020  Volume 21, Issue 12

    Abstract: The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and ... ...

    Abstract The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and immunoregulatory Siglec receptors promotes foreign antigens hiding and immunosurveillance impairment. Therefore, molecular targeting of immune checkpoints, including sialic acid-Siglec axis, is a promising new field of inflammatory disorders and cancer therapy. However, the conventional drugs used in regular management can interfere with glycome machinery and exert a divergent effect on immune controlling systems. Here, we focus on the known effects of standard therapies on the sialoglycan-Siglec checkpoint and their importance in diagnosis, prediction, and clinical outcomes.
    MeSH term(s) Animals ; Humans ; Immune System/metabolism ; Immunotherapy ; Inflammation/drug therapy ; Inflammation/metabolism ; Molecular Mimicry ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Polysaccharides/metabolism ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism
    Chemical Substances Polysaccharides ; Sialic Acid Binding Immunoglobulin-like Lectins
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21124361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Selective H3 Antagonist (ABT-239) Differentially Modifies Cognitive Function Under the Impact of Restraint Stress.

    Trofimiuk, Emil / Wielgat, Przemysław / Car, Halina

    Frontiers in systems neuroscience

    2021  Volume 14, Page(s) 614810

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2020.614810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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