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  1. Article ; Online: Sensitizing methicillin-resistant

    Ersoy, Selvi C / Proctor, Richard A / Rose, Warren E / Abdelhady, Wessam / Fan, Sook-Ha / Madrigal, Sabrina L / Elsayed, Ahmed M / Chambers, Henry F / Sobral, Rita G / Bayer, Arnold S

    Antimicrobial agents and chemotherapy

    2024  Volume 68, Issue 3, Page(s) e0162723

    Abstract: Methicillin- ... ...

    Abstract Methicillin-resistant
    MeSH term(s) Humans ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Cefuroxime/pharmacology ; Bicarbonates/pharmacology ; Staphylococcus aureus ; beta-Lactams/pharmacology ; Endocarditis, Bacterial/drug therapy ; Microbial Sensitivity Tests ; Staphylococcal Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Cefuroxime (O1R9FJ93ED) ; Bicarbonates ; beta-Lactams
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01627-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
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  2. Article ; Online: Role of the NaHCO

    Fan, Sook-Ha / Proctor, Richard A / Ersoy, Selvi C / Manna, Adhar C / Cheung, Ambrose L / Götz, Friedrich / Chambers, Henry F / Bayer, Arnold S

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0014123

    Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing concern due to their intrinsic resistance to most standard-of-care β-lactam antibiotics. Recent studies of clinical isolates have documented a novel phenotype, termed ... ...

    Abstract Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing concern due to their intrinsic resistance to most standard-of-care β-lactam antibiotics. Recent studies of clinical isolates have documented a novel phenotype, termed NaHCO
    MeSH term(s) Methicillin-Resistant Staphylococcus aureus/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; beta-Lactams/pharmacology ; Staphylococcus aureus/metabolism ; Carbon Dioxide/metabolism ; Oxacillin/pharmacology ; Phenotype ; Microbial Sensitivity Tests ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams ; 3-mercaptopyridine-2-sulfonamide (99780-72-0) ; Carbon Dioxide (142M471B3J) ; Oxacillin (UH95VD7V76) ; Bacterial Proteins
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00141-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Impacts of NaHCO

    Ersoy, Selvi C / Chan, Liana C / Yeaman, Michael R / Chambers, Henry F / Proctor, Richard A / Ludwig, Kevin C / Schneider, Tanja / Manna, Adhar C / Cheung, Ambrose / Bayer, Arnold S

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Methicillin- ... ...

    Abstract Methicillin-resistant
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11040462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The NaHCO

    Ersoy, Selvi C / Manna, Adhar C / Proctor, Richard A / Chambers, Henry F / Harrison, Ewan M / Bayer, Arnold S / Cheung, Ambrose

    Antimicrobial agents and chemotherapy

    2022  Volume 66, Issue 6, Page(s) e0025222

    Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) strains are a leading cause of many invasive clinical syndromes, and pose treatment difficulties due to ... ...

    Abstract Methicillin-resistant Staphylococcus aureus (MRSA) strains are a leading cause of many invasive clinical syndromes, and pose treatment difficulties due to their
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Genotype ; Methicillin-Resistant Staphylococcus aureus/genetics ; Microbial Sensitivity Tests ; Oxacillin ; Penicillin-Binding Proteins/genetics ; Phenotype ; Sodium Bicarbonate ; beta-Lactams
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Penicillin-Binding Proteins ; beta-Lactams ; Sodium Bicarbonate (8MDF5V39QO) ; Oxacillin (UH95VD7V76)
    Language English
    Publishing date 2022-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.00252-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
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  5. Article ; Online: Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant

    Ersoy, Selvi C / Chambers, Henry F / Proctor, Richard A / Rosato, Adriana E / Mishra, Nagendra N / Xiong, Yan Q / Bayer, Arnold S

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 5

    Abstract: Certain methicillin- ... ...

    Abstract Certain methicillin-resistant
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02621-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article: A Combined Phenotypic-Genotypic Predictive Algorithm for In Vitro Detection of Bicarbonate: β-Lactam Sensitization among Methicillin-Resistant

    Ersoy, Selvi C / Rose, Warren E / Patel, Robin / Proctor, Richard A / Chambers, Henry F / Harrison, Ewan M / Pak, Youngju / Bayer, Arnold S

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 9

    Abstract: Antimicrobial susceptibility testing (AST) is routinely used to establish predictive antibiotic resistance metrics to guide the treatment of bacterial pathogens. Recently, a novel phenotype termed "bicarbonate ( ... ...

    Abstract Antimicrobial susceptibility testing (AST) is routinely used to establish predictive antibiotic resistance metrics to guide the treatment of bacterial pathogens. Recently, a novel phenotype termed "bicarbonate (NaHCO
    Language English
    Publishing date 2021-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10091089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of Bicarbonate-β-Lactam Exposures on Methicillin-Resistant

    Ersoy, Selvi C / Hanson, Blake M / Proctor, Richard A / Arias, Cesar A / Tran, Truc T / Chambers, Henry F / Bayer, Arnold S

    Genes

    2021  Volume 12, Issue 11

    Abstract: Methicillin- ... ...

    Abstract Methicillin-resistant
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Typing Techniques ; Bicarbonates/pharmacology ; Drug Resistance, Multiple, Bacterial/drug effects ; Drug Resistance, Multiple, Bacterial/genetics ; Gene Expression Regulation, Bacterial/drug effects ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/genetics ; Microbial Sensitivity Tests ; RNA-Seq ; Regulon/drug effects ; Regulon/genetics ; beta-Lactam Resistance/drug effects ; beta-Lactam Resistance/genetics ; beta-Lactams/pharmacology
    Chemical Substances Bacterial Proteins ; Bicarbonates ; beta-Lactams
    Language English
    Publishing date 2021-10-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12111650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO

    Ersoy, Selvi C / Gonçalves, Barbara / Cavaco, Gonçalo / Manna, Adhar C / Sobral, Rita G / Nast, Cynthia C / Proctor, Richard A / Chambers, Henry F / Cheung, Ambrose / Bayer, Arnold S

    Microbiology spectrum

    2022  Volume 10, Issue 6, Page(s) e0342222

    Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under ... ...

    Abstract Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under standard
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; beta-Lactams/pharmacology ; Cefuroxime/pharmacology ; Cell Wall/metabolism ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/genetics ; Microbial Sensitivity Tests ; Monobactams/pharmacology ; Sodium Bicarbonate/pharmacology ; Staphylococcus aureus/metabolism ; Teichoic Acids/biosynthesis
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactams ; Cefuroxime (O1R9FJ93ED) ; Monobactams ; Sodium Bicarbonate (8MDF5V39QO) ; Teichoic Acids
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03422-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bicarbonate Resensitization of Methicillin-Resistant

    Ersoy, Selvi C / Abdelhady, Wessam / Li, Liang / Chambers, Henry F / Xiong, Yan Q / Bayer, Arnold S

    Antimicrobial agents and chemotherapy

    2019  Volume 63, Issue 7

    Abstract: Endovascular infections caused by methicillin- ... ...

    Abstract Endovascular infections caused by methicillin-resistant
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Cationic Peptides/pharmacology ; Bacterial Proteins/genetics ; Bicarbonates/pharmacokinetics ; Bicarbonates/pharmacology ; Cefazolin/pharmacology ; Culture Media/chemistry ; Culture Media/pharmacology ; Drug Synergism ; Endocarditis, Bacterial/drug therapy ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Microbial Sensitivity Tests ; Oxacillin/pharmacology ; Penicillin-Binding Proteins/genetics ; Rabbits ; Salicylic Acid/pharmacology ; Staphylococcal Infections/drug therapy ; beta-Lactams/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Antimicrobial Cationic Peptides ; Bacterial Proteins ; Bicarbonates ; Culture Media ; Penicillin-Binding Proteins ; SarA protein, Staphylococcus aureus ; beta-Lactams ; mecA protein, Staphylococcus aureus ; ropocamptide (3DD771JO2H) ; Cefazolin (IHS69L0Y4T) ; Salicylic Acid (O414PZ4LPZ) ; Oxacillin (UH95VD7V76)
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00496-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Impact of Bicarbonate-β-Lactam Exposures on Methicillin-Resistant Staphylococcus aureus (MRSA) Gene Expression in Bicarbonate-β-Lactam-Responsive vs. Non-Responsive Strains

    Ersoy, Selvi C. / Hanson, Blake M. / Proctor, Richard A. / Arias, Cesar A. / Tran, Truc T. / Chambers, Henry F. / Bayer, Arnold S.

    Genes. 2021 Oct. 20, v. 12, no. 11

    2021  

    Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) infections represent a difficult clinical treatment issue. Recently, a novel phenotype was discovered amongst selected MRSA which exhibited enhanced β-lactam susceptibility in vitro in the presence of ... ...

    Abstract Methicillin-resistant Staphylococcus aureus (MRSA) infections represent a difficult clinical treatment issue. Recently, a novel phenotype was discovered amongst selected MRSA which exhibited enhanced β-lactam susceptibility in vitro in the presence of NaHCO₃ (termed ‘NaHCO₃-responsiveness’). This increased β-lactam susceptibility phenotype has been verified in both ex vivo and in vivo models. Mechanistic studies to-date have implicated NaHCO₃-mediated repression of genes involved in the production, as well as maturation, of the alternative penicillin-binding protein (PBP) 2a, a necessary component of MRSA β-lactam resistance. Herein, we utilized RNA-sequencing (RNA-seq) to identify genes that were differentially expressed in NaHCO₃-responsive (MRSA 11/11) vs. non-responsive (COL) strains, in the presence vs. absence of NaHCO₃-β-lactam co-exposures. These investigations revealed that NaHCO₃ selectively repressed the expression of a cadre of genes in strain 11/11 known to be a part of the sigB-sarA-agr regulon, as well as a number of genes involved in the anchoring of cell wall proteins in MRSA. Moreover, several genes related to autolysis, cell division, and cell wall biosynthesis/remodeling, were also selectively impacted by NaHCO₃-OXA exposure in the NaHCO₃-responsive strain MRSA 11/11. These outcomes provide an important framework for further studies to mechanistically verify the functional relevance of these genetic perturbations to the NaHCO₃-responsiveness phenotype in MRSA.
    Keywords autolysis ; biosynthesis ; cell division ; cell walls ; gene expression ; methicillin-resistant Staphylococcus aureus ; phenotype ; regulon ; sequence analysis
    Language English
    Dates of publication 2021-1020
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12111650
    Database NAL-Catalogue (AGRICOLA)

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