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  1. Article ; Online: Evidence Favors Ponseti Management of Clubfoot: Commentary on an article by James A.F. Recordon, MBCHB, et al.: "A Prospective, Median 15-Year Comparison of Ponseti Casting and Surgical Treatment of Clubfoot".

    Kuo, Ken N / Smith, Peter A

    The Journal of bone and joint surgery. American volume

    2021  Volume 103, Issue 21, Page(s) e87

    MeSH term(s) Casts, Surgical ; Clubfoot/surgery ; Humans ; Orthopedic Procedures ; Prospective Studies
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.21.00738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: A new technique for separating radioulnar synostosis with vascularized flap: a case report.

    Chen, Yi-Chih / Kuo, Ken N / Takagi, Takehiko / Takayama, Shinichiro / Shih, Po-Jen / Chang, Chia-Hsieh

    JSES international

    2023  Volume 7, Issue 4, Page(s) 709–713

    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Case Reports
    ISSN 2666-6383
    ISSN (online) 2666-6383
    DOI 10.1016/j.jseint.2023.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Cby3/ciBAR1 complex positions the annulus along the sperm flagellum during spermiogenesis.

    Hoque, Mohammed / Li, Feng-Qian / Weber, William David / Chen, Jun Jie / Kim, Eunice N / Kuo, Pao-Lin / Visconti, Pablo E / Takemaru, Ken-Ichi

    The Journal of cell biology

    2024  Volume 223, Issue 3

    Abstract: Proper compartmentalization of the sperm flagellum is essential for fertility. The annulus is a septin-based ring that demarcates the midpiece (MP) and the principal piece (PP). It is assembled at the flagellar base, migrates caudally, and halts upon ... ...

    Abstract Proper compartmentalization of the sperm flagellum is essential for fertility. The annulus is a septin-based ring that demarcates the midpiece (MP) and the principal piece (PP). It is assembled at the flagellar base, migrates caudally, and halts upon arriving at the PP. However, the mechanisms governing annulus positioning remain unknown. We report that a Chibby3 (Cby3)/Cby1-interacting BAR domain-containing 1 (ciBAR1) complex is required for this process. Ablation of either gene in mice results in male fertility defects, caused by kinked sperm flagella with the annulus mispositioned in the PP. Cby3 and ciBAR1 interact and colocalize to the annulus near the curved membrane invagination at the flagellar pocket. In the absence of Cby3, periannular membranes appear to be deformed, allowing the annulus to migrate over the fibrous sheath into the PP. Collectively, our results suggest that the Cby3/ciBAR1 complex regulates local membrane properties to position the annulus at the MP/PP junction.
    MeSH term(s) Animals ; Male ; Mice ; Cilia ; Cytoskeleton ; Semen ; Sperm Tail ; Spermatogenesis/genetics ; Nuclear Proteins/genetics ; Carrier Proteins/genetics
    Chemical Substances Nuclear Proteins ; Carrier Proteins
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202307147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Definition of hip displacement and dislocation by acetabular dysplasia in children with cerebral palsy.

    Wang, Nai Kuang / Shen, Shih Hsien / Chen, Brian Po Jung / Chang, Chia Hsieh / Kuo, Ken N

    Journal of children's orthopaedics

    2023  Volume 17, Issue 4, Page(s) 315–321

    Abstract: Purpose: The acetabulum interacts with the femoral head in daily activities and may exhibit structural changes in the presence of hip disorders. This study aims to redefine hip disorders in children with cerebral palsy by structural characteristics of ... ...

    Abstract Purpose: The acetabulum interacts with the femoral head in daily activities and may exhibit structural changes in the presence of hip disorders. This study aims to redefine hip disorders in children with cerebral palsy by structural characteristics of the acetabulum in relation to the degree of the migration percentage.
    Methods: The clinical and radiographic data of 70 patients (36 males, 34 females; mean age 8.2 years) with spastic cerebral palsy were retrospectively analyzed. The acetabular structure was measured by the acetabular index on reconstructed three-dimensional computerized tomography for precision of measurement. Any significant change in acetabular index measured on the reconstructive computerized tomography related to every 10% increment of migration percentage was regarded as clinically significant in hip disorders.
    Results: The acetabular index measured on the reconstructive computerized tomography showed an increasing trend with the increment of migration percentage. The most significant acetabular index measured on the reconstructive computerized tomography change occurred between the 20%-29% and 30%-39% migration percentage groups (p < 0.001), suggesting that a migration percentage of 30% is the starting point of hip disorder. A significant increase in the posterolateral acetabular index measured on the reconstructive computerized tomography occurred in migration percentages >50%, indicating posterolateral acetabular dysplasia. Hips with migration percentages from 80% to 100% had consistent acetabular indexes measured on the reconstructive computerized tomography values, suggesting complete dislocation and no more contact and interaction between the femoral head and acetabular fossa.
    Conclusion: Structural characteristics in the acetabulum reflect hip dysfunction and potentially classify hip disorders. Results suggest the migration percentage 30% as a starting point of hip disorder and 80% as a turning point of hip dislocation in children with cerebral palsy.
    Level of evidence: level IV, diagnostic study.
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2279410-4
    ISSN 1863-2548 ; 1863-2521
    ISSN (online) 1863-2548
    ISSN 1863-2521
    DOI 10.1177/18632521231185294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CORR Insights ®: Can selective soft tissue release and cuboid osteotomy correct neglected clubfoot?

    Kuo, Ken N

    Clinical orthopaedics and related research

    2013  Volume 471, Issue 8, Page(s) 2666–2667

    MeSH term(s) Clubfoot/surgery ; Humans ; Ligaments, Articular/surgery ; Osteotomy/methods ; Tarsal Bones/surgery ; Tendons/surgery ; Tenotomy/methods
    Language English
    Publishing date 2013-06-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-013-3092-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.188: Show issues Location:
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  6. Article ; Online: The favorable outcome of Bernese periacetabular osteotomy for the hip osteoarthritis in multiple epiphyseal dysplasia.

    Chang, Yao-Yuan / Lee, Chia-Che / Lin, Sheng-Chieh / Kuo, Ken N / Chang, Jia-Feng / Wu, Kuan-Wen / Wang, Ting-Ming

    Orphanet journal of rare diseases

    2023  Volume 18, Issue 1, Page(s) 340

    Abstract: Background: Multiple epiphyseal dysplasia (MED) is a rare congenital bone dysplasia. Patients with MED develop secondary hip osteoarthritis as early as the third to the fourth decade. Currently, there is no consensus on the prevention of the progressive ...

    Abstract Background: Multiple epiphyseal dysplasia (MED) is a rare congenital bone dysplasia. Patients with MED develop secondary hip osteoarthritis as early as the third to the fourth decade. Currently, there is no consensus on the prevention of the progressive hip osteoarthritis secondary to MED. The Bernese periacetabular osteotomy (PAO) is a joint-preserving surgery to reshape acetabulum and extend femoral head coverage. However, there is no documentary evidence for the effect of the procedure on MED hips.
    Patients and methods: We analyzed the preliminary outcomes following the Bernese PAO in 6 MED hips. The average age at the time of surgery was 14.3 years (range from 11.4 to 17.2 years). For our study interest of time efficiency, radiographic parameters were analyzed preoperatively and 1 year postoperatively. The hip function was evaluated by the Harris Hip Score (HHS) before and after surgery.
    Results: The mean follow-up time was 1.7 years. The mean lateral center-edge angle increased from 3.8° to 47.1° (p = 0.02), anterior center-edge angle increased from 7.3° to 35.1° (p = 0.02), and acetabulum index decreased from 27.8° to 14.6° (p = 0.04). The femoral head coverage ratio increased from 66.8% to 100% (p = 0.02). The post-operative anteroposterior pelvic radiograph demonstrated all preoperative broken Shenton lines were reversed. The mean HHS improved from 67.3 to 86.7 (p = 0.05).
    Conclusion: Bernese PAO is a feasible treatment for hip disorders in MED patients. It reshapes acetabular and femoral morphology efficiently. In our study, the preliminary results showed the procedure not only improved radiographic outcomes but also hip function.
    MeSH term(s) Humans ; Child ; Adolescent ; Osteoarthritis, Hip/etiology ; Osteoarthritis, Hip/surgery ; Osteochondrodysplasias ; Retrospective Studies ; Acetabulum/surgery ; Acetabulum/abnormalities ; Osteotomy/adverse effects ; Osteotomy/methods ; Treatment Outcome ; Hip Dislocation/etiology ; Hip Dislocation/surgery
    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-023-02920-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association of age in motor function outcomes after multilevel myofascial release in children with cerebral palsy.

    Chang, Chia-Hsieh / Chen, Chia-Ling / Yeh, Kuo-Kuang / Kuo, Ken N

    Biomedical journal

    2020  Volume 43, Issue 6, Page(s) 469–475

    Abstract: Background: Many recommend deferring orthopedic surgery for cerebral palsy-related disorders in young children. However, age is correlated with musculoskeletal deterioration, and deferral may affect surgical outcomes. We aimed to clarify the ... ...

    Abstract Background: Many recommend deferring orthopedic surgery for cerebral palsy-related disorders in young children. However, age is correlated with musculoskeletal deterioration, and deferral may affect surgical outcomes. We aimed to clarify the relationships among age, degree of musculoskeletal disorder, and postoperative motor function change in children with cerebral palsy.
    Methods: We prospectively evaluated children with cerebral palsy and a knee flexion gait disorder who underwent multilevel myofascial release between June 2010 and July 2014. The children were divided into younger (<10 years of age) and older (>10 years of age) groups. Outcome measures included the Gross Motor Function Measure (GMFM), range of motion, spasticity, and physical capacity. Preoperative factors and postoperative changes were compared between the groups using the chi-squared, independent t-, and Mann-Whitney tests. Significant factors were plotted by participant age to identify the relationships between age and other variables.
    Results: We analyzed 20 patients who underwent multilevel myofascial release (12 and 8 in the younger and older groups, respectively). Whereas most preoperative factors were comparable between the two groups, the older group had a higher range of motion limitation score (44.4 vs. 36.1, p < 0.05). The older group also showed less improvement in the GMFM (-0.3 vs. +3.0, p < 0.05) and physical capacity (+0 vs. +1, p < 0.05) scores after 6 months of postoperative rehabilitation.
    Conclusions: Age was positively correlated with the range of motion limitation and negatively correlated with postoperative GMFM improvement. The less favored postoperative rehabilitation course in older children needs to be considered for parents whose children are amenable to surgeries.
    MeSH term(s) Cerebral Palsy ; Child ; Child, Preschool ; Female ; Gait ; Humans ; Male ; Muscle Spasticity ; Range of Motion, Articular ; Treatment Outcome
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2019.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Increasing retractions of meta-analyses publications for methodological flaw.

    Chen, Chia-Yun / Kang, Yi-No / Kuo, Ken N / Glasziou, Paul / Chen, Kee-Hsin

    Systematic reviews

    2021  Volume 10, Issue 1, Page(s) 267

    Abstract: Purpose of this letter was to explore the trends regarding methodological flaws of systematic review and meta-analyses (SRMAs) based on retraction notes in the past decades, and the categories of reasons for the retractions. Content analysis with ... ...

    Abstract Purpose of this letter was to explore the trends regarding methodological flaws of systematic review and meta-analyses (SRMAs) based on retraction notes in the past decades, and the categories of reasons for the retractions. Content analysis with descriptive statistics, Cochran Q test, and multinomial logistic regression were used. Based on 187 records of retracted SRMAs, retraction announcements can be categorized into academic ethical violation, methodological flaw, and writing or reporting problem. The numbers of academic ethical violation were significantly higher than those with methodological flaw (z = 3.51; p < 0.01) or writing problem (z = 8.58; p < 0.001). The numbers of methodological flaw were also higher than that with writing problem (z = 6.47; p < 0.001). Moreover, an increased proportion of methodological flaw was observed since 2006, and the retraction year was significantly associated with increased proportion of methodological flaw when academic ethical violation as the reference group.
    MeSH term(s) Humans ; Meta-Analysis as Topic ; Systematic Reviews as Topic
    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Letter
    ZDB-ID 2662257-9
    ISSN 2046-4053 ; 2046-4053
    ISSN (online) 2046-4053
    ISSN 2046-4053
    DOI 10.1186/s13643-021-01822-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Choosing wisely in health care.

    Chen, Chiehfeng / Tam, Ka-Wai / Kuo, Ken N

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2018  Volume 117, Issue 9, Page(s) 754–755

    MeSH term(s) Clinical Decision-Making ; Delivery of Health Care/economics ; Humans ; Medical Overuse/prevention & control ; Practice Patterns, Physicians' ; Publications/statistics & numerical data ; Publications/trends ; Taiwan
    Language English
    Publishing date 2018-07-03
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2018.06.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Tibial Lengthening along Submuscular Plate with Simultaneous Acute Tibial Deformity Correction by High-Energy Osteotomy: A Comparative Study.

    Liu, Kuei-Yu / Wu, Kuan-Wen / Lee, Chia-Che / Lin, Sheng-Chieh / Kuo, Ken N / Wang, Ting-Ming

    Journal of clinical medicine

    2022  Volume 11, Issue 18

    Abstract: Submuscular plating and osteotomy using power saw have shown the benefits in certain situations of limb lengthening. However, no previous studies combining both procedures have been conducted for acute tibial deformity correction and limb lengthening. ... ...

    Abstract Submuscular plating and osteotomy using power saw have shown the benefits in certain situations of limb lengthening. However, no previous studies combining both procedures have been conducted for acute tibial deformity correction and limb lengthening. Nineteen cases were enrolled in this study. Ten patients received tibial lengthening with acute knee angular deformity correction using high-energy osteotomy (Group 1), and nine patients received tibial lengthening only with osteotomy using multiple drills and osteotome (Group 2). Radiographic parameters retrieved before and after the operation included leg-length discrepancy, tibial length, length gained, mechanical lateral distal femoral angle (mLDFA), medial proximal tibial angle (MPTA), and mechanical axis deviation (MAD). There were significant differences between groups in terms of external fixator index (EFI) (
    Language English
    Publishing date 2022-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11185478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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