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  1. Article ; Online: Syndromic testing for the diagnosis of infectious diseases: the right test if used for the right patient.

    Fox, Amy S / Rao, Sonia N

    The Journal of antimicrobial chemotherapy

    2021  Volume 76, Issue Suppl 3, Page(s) iii2–iii3

    MeSH term(s) Communicable Diseases/diagnosis ; Humans
    Language English
    Publishing date 2021-09-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab248
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  2. Article ; Online: Syndromic diagnostic testing: a new way to approach patient care in the treatment of infectious diseases.

    Dumkow, Lisa E / Worden, Lacy J / Rao, Sonia N

    The Journal of antimicrobial chemotherapy

    2021  Volume 76, Issue Suppl 3, Page(s) iii4–iii11

    Abstract: Advanced microbiology technologies such as multiplex molecular assays (i.e. syndromic diagnostic tests) are a novel approach to the rapid diagnosis of common infectious diseases. As the global burden of antimicrobial resistance continues to rise, the ... ...

    Abstract Advanced microbiology technologies such as multiplex molecular assays (i.e. syndromic diagnostic tests) are a novel approach to the rapid diagnosis of common infectious diseases. As the global burden of antimicrobial resistance continues to rise, the judicious use of antimicrobials is of utmost importance. Syndromic panels are now being recognized in some clinical practice guidelines as a 'game-changer' in the diagnosis of infectious diseases. These syndromic panels, if implemented thoughtfully and interpreted carefully, have the potential to improve patient outcomes through improved clinical decision making, optimized laboratory workflow, and enhanced antimicrobial stewardship. This paper reviews the potential benefits of and considerations regarding various infectious diseases syndromic panels, and highlights how to maximize impact through collaboration between clinical microbiology laboratory and antimicrobial stewardship programmes.
    MeSH term(s) Anti-Infective Agents ; Antimicrobial Stewardship ; Communicable Diseases/diagnosis ; Communicable Diseases/drug therapy ; Diagnostic Tests, Routine ; Humans ; Patient Care
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab245
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  3. Article: Treatment gap for mental and behavioral disorders in Punjab.

    Garg, Rohit / Chavan, Bir Singh / Das, Subhash / Puri, Sonia / Banavaram, Arvind A / Benegal, Vivek / Rao, Girish N / Varghese, Mathew / Gururaj, Gopalkrishna

    Indian journal of psychiatry

    2023  Volume 65, Issue 12, Page(s) 1269–1274

    Abstract: Background and aims: There is no data on the treatment gap and health care utilization for mental disorders from Punjab. The present study reports on the same by using the data collected during the National Mental Health Survey.: Settings and design: ...

    Abstract Background and aims: There is no data on the treatment gap and health care utilization for mental disorders from Punjab. The present study reports on the same by using the data collected during the National Mental Health Survey.
    Settings and design: Multisite, multistage, stratified, random cluster sampling study conducted in four districts, namely Faridkot, Moga, Patiala, and Ludhiana (for urban metro areas). Data were collected from October 2015 to March 2016.
    Materials and methods: Mini International Neuropsychiatric Interview 6.0.0 and Adapted Fagerstrom Nicotine Dependence Scale were used to diagnose mental and behavioral disorders and tobacco use disorder, respectively. Pathways Interview Schedule of the World Health Organization was applied to persons having any disorder to assess treatment gap and health care utilization. Exploratory focused group discussions (FGDs) were conducted to understand the community perceptions regarding mental and behavioral disorders.
    Results: The treatment gap for mental and behavioral disorders was 79.59%, and it was higher for common mental disorders than severe mental disorders and higher for alcohol and tobacco use disorders as compared to opioid use disorders. The median treatment lag was 6 months. Only seven patients out of 79 were taking treatment from a psychiatrist, and the average distance traveled by the patient for treatment was 37.61 ± 45.5 km. Many attitudinal, structural, and other barriers leading to high treatment gaps were identified during FGDs in the community, such as stigma, poor knowledge about mental health, deficiency of psychiatrists, and distance from the hospital.
    Conclusions: Vertical as well as horizontal multisectoral integration is required to reduce the treatment gap and improve healthcare utilization. Increasing mental health literacy, providing high-quality mental health services at the primary-healthcare level and human resources development are the need of the hour.
    Language English
    Publishing date 2023-12-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_839_23
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  4. Article ; Online: Association of Hepatic Triglyceride Content With Cardiac Structure and Function Among Community-Dwelling Adults.

    Saha, Srishti / Keshvani, Neil / Segar, Matthew W / Patel, Kershaw V / Fudim, Marat / Rohatgi, Anand / Ayers, Colby / VanWagner, Lisa B / Rao, Vishal N / Drazner, Mark H / Garg, Sonia / Singal, Amit G / Rich, Nicole E / Browning, Jeffrey D / Neeland, Ian J / Pandey, Ambarish

    JACC. Heart failure

    2023  

    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Letter
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.10.016
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  5. Article: Systematic Review on the Correlation Between SARS-CoV-2 Real-Time PCR Cycle Threshold Values and Epidemiological Trends.

    Sala, Ester / Shah, Isheeta S / Manissero, Davide / Juanola-Falgarona, Marti / Quirke, Anne-Marie / Rao, Sonia N

    Infectious diseases and therapy

    2023  Volume 12, Issue 3, Page(s) 749–775

    Abstract: ... relevant for inclusion. RT-PCR Ct values were measured from national (n = 3), local (n = 7), single-unit (n ... 5), or closed single-unit (n = 1) samples. All studies retrospectively examined the correlation ...

    Abstract Background: The ability to proactively predict the epidemiological dynamics of infectious diseases such as coronavirus disease 2019 (COVID-19) would facilitate efficient public health responses and may help guide patient management. Viral loads of infected people correlate with infectiousness and, therefore, could be used to predict future case rates.
    Aim: In this systematic review, we determine whether there is a correlation between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) real-time reverse-transcription polymerase chain reaction (RT-PCR) cycle threshold (Ct) values (a proxy for viral load) and epidemiological trends in patients diagnosed with COVID-19, and whether Ct values are predictive of future cases.
    Methods: A PubMed search was conducted on August 22 2022, based on a search strategy of studies reporting correlations between SARS-CoV-2 Ct values and epidemiological trends.
    Results: Data from 16 studies were relevant for inclusion. RT-PCR Ct values were measured from national (n = 3), local (n = 7), single-unit (n = 5), or closed single-unit (n = 1) samples. All studies retrospectively examined the correlation between Ct values and epidemiological trends, and seven evaluated their prediction model prospectively. Five studies used the temporal reproduction number (R
    Conclusion: Ct values are negatively correlated with epidemiological trends and may be useful in predicting subsequent peaks in variant waves of COVID-19 and other circulating pathogens.
    Language English
    Publishing date 2023-02-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-023-00772-7
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  6. Article: Correction to: A Systematic Review of the Clinical Utility of Cycle Threshold Values in the Context of COVID-19.

    Rao, Sonia N / Manissero, Davide / Steele, Victoria R / Pareja, Josep

    Infectious diseases and therapy

    2020  Volume 9, Issue 3, Page(s) 587

    Abstract: The original article can be found online. ...

    Abstract The original article can be found online.
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country New Zealand
    Document type Journal Article ; Published Erratum
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-020-00328-z
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  7. Article ; Online: Is Increasing Parity Associated with Adverse Perinatal Outcomes in Dichorionic Twin Gestations?

    Rao, Manasa G / Debolt, Chelsea A / Wang, Kelly / Khurana, Sonia G / Mills, Alexandra N / Paul, Keisha / Vieira, Luciana / Rebarber, Andrei / Fox, Nathan S / Stone, Joanne

    American journal of perinatology

    2023  

    Abstract: Objective:  Dichorionic twins have increased risk of preterm birth and hypertensive disorders of pregnancy. Grand multiparity may be associated with adverse perinatal outcomes in singleton pregnancies, although the effect of increasing parity in twins ... ...

    Abstract Objective:  Dichorionic twins have increased risk of preterm birth and hypertensive disorders of pregnancy. Grand multiparity may be associated with adverse perinatal outcomes in singleton pregnancies, although the effect of increasing parity in twins is unclear. This study aimed to elucidate whether grand multiparity leads to adverse outcomes in dichorionic twins compared with multiparity and nulliparity.
    Study design:  This was a retrospective review of dichorionic twins at a single institution between January 2008 and December 2019 comparing pregnancy outcomes among grand multiparity, multiparity, and nulliparity. Primary outcome was preterm birth less than 37 weeks. Multivariable regression controlled for differing demographics, prior preterm birth, use of reproductive technologies, and hypertensive disorders of pregnancy. Chi square and Fisher's exact were used for categorical variables and Kruskal-Wallis was used for continuous variables.
    Results:  A total of 843 (60.3%) pregnancies were nulliparous, 499 (35.7%) multiparous, and 57(4.1%) grand multiparous. Univariate analysis indicated that multiparous women had lower incidence of preterm birth less than 37, 34, and 32 weeks (57 vs. 51%,
    Conclusion:  Grand multiparity is not associated with adverse perinatal outcomes compared with nulliparity or multiparity in dichorionic twins. Increasing parity may protect against incidence of preterm birth and hypertensive disorders of pregnancy even among grand multiparous women.
    Key points: · Incidence of preterm birth may decrease with increasing parity in twins.. · Hypertensive disorders of pregnancy may decrease with increasing parity in twins.. · Grand multiparity is not associated with adverse perinatal outcomes in twins..
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/a-2107-1755
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  8. Article: A Systematic Review of the Clinical Utility of Cycle Threshold Values in the Context of COVID-19.

    Rao, Sonia N / Manissero, Davide / Steele, Victoria R / Pareja, Josep

    Infectious diseases and therapy

    2020  Volume 9, Issue 3, Page(s) 573–586

    Abstract: ... including increased lactate dehydrogenase (n = 4), decreased lymphocytes (n = 3) and increased high ... sensitivity troponin I (n = 2). Two studies reporting on the correlation with infectivity showed that lower Ct ...

    Abstract Background: The ability to predict likely prognosis and infectiousness for patients with COVID-19 would aid patient management decisions. Diagnosis is usually via real-time PCR, and it is unclear whether the semi-quantitative capability of this method, determining viral load through cycle threshold (Ct) values, can be leveraged.
    Objectives: We aim to review available knowledge on correlations between SARS-COV-2 Ct values and patient- or healthcare-related outcomes to determine whether Ct values provide useful clinical information.
    Sources: A PubMed search was conducted on 1 June 2020 based on a search strategy of (Ct value OR viral load) AND SARS-CoV-2. Data were extracted from studies reporting on the presence or absence of an association between Ct values, or viral loads determined via Ct value, and clinical outcomes.
    Content: Data from 18 studies were relevant for inclusion. One study reported on the correlation between Ct values and mortality and one study reported on the correlation between Ct values and progression to severe disease; both reported a significant association (p < 0.001 and p = 0.008, respectively). Fourteen studies reported on the correlation between Ct value or viral loads determined via Ct value and disease severity, and an association was observed in eight (57%) studies. Studies reporting on the correlation of viral load with biochemical and haematological markers showed an association with at least one marker, including increased lactate dehydrogenase (n = 4), decreased lymphocytes (n = 3) and increased high-sensitivity troponin I (n = 2). Two studies reporting on the correlation with infectivity showed that lower Ct values were associated with higher viral culture positivity.
    Implications: Data suggest that lower Ct values may be associated with worse outcomes and that Ct values may be useful in predicting the clinical course and prognosis of patients with COVID-19; however, further studies are warranted to confirm clinical value.
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-020-00324-3
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  9. Article: District-level differences in the distribution of mental and substance use disorders in Assam.

    Gogoi, Vijay / Abhishek, Priyadarshee / Sengupta, Soumik / Banerjee, Indrajeet / Sarma, Samir / Sobhana, H / Deuri, Sonia P / Pathak, Kangkan / Sukumar, Gautham M / Benegal, Vivek / Rao, Girish N / Varghese, Mathew / Gururaj, Gopalkrishna

    Indian journal of psychiatry

    2023  Volume 65, Issue 12, Page(s) 1282–1288

    Abstract: Background: The lifetime prevalence of mental morbidity in Assam is estimated at 8% (NMHS 2015-16). Understanding the distribution patterns of different types of mental disorders among persons with mental morbidity in different districts would ... ...

    Abstract Background: The lifetime prevalence of mental morbidity in Assam is estimated at 8% (NMHS 2015-16). Understanding the distribution patterns of different types of mental disorders among persons with mental morbidity in different districts would facilitate evidence-driven district mental health programming in Assam. Given the varied socio-geopolitical situation across districts in Assam, significant variations in the distribution of mental disorders are expected.
    Aims: To assess interdistrict differentials in common mental disorders (CMDs), severe mental disorders (SMDs), socioeconomic impact, healthcare utilization, and mental disability across three districts sampled in NMHS in Assam.
    Materials and methods: This cross-sectional study used stratified random cluster sampling to identify and study eligible adult participants in Dibrugarh, Barpeta, and Cachar districts. Standardized scales and validated questionnaires were used to assess mental morbidity, disability, socioeconomic impact, and healthcare utilization. The distribution of different mental disorders among persons with mental disorders and their interdistrict differentials were tested using the Chi-square test of significance.
    Results: Among persons with mental morbidity, the most common disorder was CMDs (79%). The proportional distribution of CMDs among persons with mental morbidity was significantly higher in the Dibrugarh district (79%), whereas the distribution of SMDs was higher in the Cachar district (55%). The distribution of alcohol use disorder was the highest in the Dibrugarh district (71.6%). Significant differences in disability and healthcare utilization were observed between the districts.
    Conclusions: NMHS 2015-16 Assam indicates significant differentials in the distribution of CMDs and SMDs, healthcare utilization, and associated disability between the three districts. The differentials necessitate further research to understand socio-ethnocultural, religious, geopolitical, and other factors influencing the distribution. These differences need to be accounted for during the implementation of mental health programs in the state.
    Language English
    Publishing date 2023-12-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_844_23
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  10. Article: Systematic Review on the Correlation of Quantitative PCR Cycle Threshold Values of Gastrointestinal Pathogens With Patient Clinical Presentation and Outcomes.

    Bonacorsi, Stéphane / Visseaux, Benoit / Bouzid, Donia / Pareja, Josep / Rao, Sonia N / Manissero, Davide / Hansen, Glen / Vila, Jordi

    Frontiers in medicine

    2021  Volume 8, Page(s) 711809

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-23
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.711809
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