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Article: Cloud Computing and its Need in Life Science's R & D

Chavali, L. N / Prashanthi, N. Lakshmi / Sujatha, K / Kishor, P. B. Kavi

Current trends in biotechnology and pharmacy. 2017 July, v. 11, no. 3

2017

Abstract: ... the IT services are delivered to customers at a lower cost. The research and development (R&D) in life sciences is ...

Abstract	The cloud computing is driven by factors such as aging of the current information technology (IT) infrastructure and changes in IT landscape. Virtualization and cloud computing have transformed the way the IT services are delivered to customers at a lower cost. The research and development (R&D) in life sciences is on cusp of change. The new opportunities and challenges must focus on renewing the existing systems and processes for efficacy and adopting advancements in new technologies to gain value. This paper briefly outlines various cloud computing trends in life sciences.
Keywords	biotechnology ; cloud computing ; consumers (people) ; infrastructure ; landscapes ; paper ; research and development
Language	English
Dates of publication	2017-07
Size	p. 294-299.
Publishing place	Association of Biotechnology and Pharmacy
Document type	Article
Note	NAL-light
ISSN	2230-7303
Database	NAL-Catalogue (AGRICOLA)

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Article: Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET.

Kannan, Sujatha / Saadani-Makki, Fadoua / Muzik, Otto / Chakraborty, Pulak / Mangner, Thomas J / Janisse, James / Romero, Roberto / Chugani, Diane C

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2007 Volume 48, Issue 6, Page(s) 946–954

Abstract: ... in the fetal brain that can be monitored in vivo by (11)C-(R)-PK11195 (1-[2-chlorophenyl]-N-methyl-N-[1 ... 31 d) and were scanned using small-animal PET after intravenous administration of (11)C-(R)-PK11195 ... lectin.: Results: There was increased brain retention of (11)C-(R)-PK11195--as determined ...

Abstract	Unlabelled: Intrauterine infection can lead to a fetal inflammatory response syndrome that has been implicated as one of the causes of perinatal brain injury leading to periventricular leukomalacia (PVL) and cerebral palsy. The presence of activated microglial cells has been noted in autopsy specimens of patients with PVL and in models of neonatal hypoxia and ischemia. Activated microglial cells can cause oligodendrocyte damage and white matter injury by release of inflammatory cytokines and production of excitotoxic metabolites. We hypothesized that exposure to endotoxin in utero leads to microglial activation in the fetal brain that can be monitored in vivo by (11)C-(R)-PK11195 (1-[2-chlorophenyl]-N-methyl-N-[1-methylpropyl]-3-isoquinoline carboxamide)--a positron-emitting ligand that binds peripheral benzodiazepine receptor sites in activated microglia--using small-animal PET. Methods: Pregnant New Zealand White rabbits underwent laparotomy and were injected with 20 and 30 microg/kg of Escherichia coli lipopolysaccharide along the length of the uterus on day 28 of gestation. The pups were born spontaneously at term (31 d) and were scanned using small-animal PET after intravenous administration of (11)C-(R)-PK11195 and by MRI on postnatal day 1. The standard uptake values (SUVs) of the tracer were calculated for the whole brain at 10-min intervals for 60 min after tracer injection. The pups were euthanized after the scan, and brains were fixed, sectioned, and stained for microglial cells using biotinylated tomato lectin. Results: There was increased brain retention of (11)C-(R)-PK11195--as determined by a significant difference in the slope of the SUV over time--in the endotoxin-treated pups when compared with that of age-matched controls. Immunohistochemical staining showed dose-dependent changes in activated microglia (increased number and morphologic changes) in the periventricular region and hippocampus of the brain of newborn rabbit pups exposed to endotoxin in utero. Conclusion: Intrauterine inflammation leads to activation of microglial cells that may be responsible for the development of brain injury and white matter damage in the perinatal period. PET with the tracer (11)C-(R)-PK11195 can be used as a noninvasive, sensitive tool for determining the presence and progress of neuroinflammation due to perinatal insults in newborns.
MeSH term(s)	Animals ; Animals, Newborn ; Brain/diagnostic imaging ; Brain/pathology ; Carbon Radioisotopes ; Endometritis/complications ; Endometritis/immunology ; Endotoxins ; Female ; Isoquinolines/chemistry ; Isoquinolines/pharmacokinetics ; Magnetic Resonance Imaging/methods ; Microglia/diagnostic imaging ; Microglia/pathology ; Positron-Emission Tomography/methods ; Pregnancy ; Pregnancy Complications, Infectious/immunology ; Rabbits ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/pharmacokinetics ; Stereoisomerism
Chemical Substances	Carbon Radioisotopes ; Endotoxins ; Isoquinolines ; Radiopharmaceuticals ; endotoxin, Escherichia coli (67924-63-4) ; PK 11195 (YNF83VN1RL)
Language	English
Publishing date	2007-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80272-4
ISSN	1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0161-5505 ; 0097-9058 ; 0022-3123
DOI	10.2967/jnumed.106.038539
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Article ; Online: Selmer groups in Iwasawa theory and congruences.

Sujatha, Ramdorai

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

2019 Volume 378, Issue 2163, Page(s) 20180442

Abstract: This article outlines the behaviour of ... ...

Abstract	This article outlines the behaviour of Iwasawa
Language	English
Publishing date	2019-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	208381-4
ISSN	1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
ISSN (online)	1471-2962
ISSN	0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
DOI	10.1098/rsta.2018.0442
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Article ; Online: GEOMORPHOLOGICAL AND SEDIMENTOLOGICAL CHANGES DURING AND AFTER THE DECEMBER-2004 INDIAN OCEAN TSUNAMI NEAR THE VELLAR RIVER AND THE M.G.R. ISLAND AREA OF THE CENTRAL TAMIL NADU COAST, INDIA

S. R. Singarasubramanian / M. V. Mukesh / K. Manoharan / P. Seralathan / K. Sujatha / D. Bakkiaraj

Science of Tsunami Hazards, Vol 28, Iss 1, Pp 67-

2009 Volume 74

Abstract: ... the M.G.R. island in the Cuddalore District, of Tamilnadu, India, caused by the 26th December, 2004 ...

Abstract	The present study reviews geomorphic changes and sediment characteristics in the Vellar river and the M.G.R. island in the Cuddalore District, of Tamilnadu, India, caused by the 26th December, 2004 Indian Ocean Tsunami. The island has an area of about 12,000 m2 and it is separated from the mainland by a channel. It is bounded to the east by the Vellar River and to the north and south by the Muzhukkuthurai lagoon. A vegetated coastal dune with a length of about 1.5 km protected the island. Tsunami waves ranging in height from 4 to 6 meters breached the dunes, caused erosion and carried debris of destroyed coastal buildings westward to more than 50 m inland. The tsunami run up was up to 1.3 m. Very fine sand with a thickness of one meter filled the Muzhukkuthurai lagoon in the west. Heavy erosion resulted in a steep beach gradient. Sediments transported from the SE and the SSE direction resulted in greater accretion along the intertidal region. The sediment layer exhibited trampled and load structures, indicating deposition by the flooding and receding motion of the water, moving at high velocity. The sediments ranged from fine to medium in size and were well sorted.
Keywords	2004 Indian Ocean Tsunami ; breaching ; sedimentation ; trampled and load structures ; Oceanography ; GC1-1581 ; Geography. Anthropology. Recreation ; G ; DOAJ:Oceanography ; DOAJ:Earth and Environmental Sciences
Subject code	910
Language	English
Publishing date	2009-01-01T00:00:00Z
Publisher	Tsunami Society International
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Implementing deep‐learning techniques for accurate fruit disease identification

Sujatha, R. / Mahalakshmi, K. / Chatterjee, Jyotir Moy

Plant Pathology. 2023 Dec., v. 72, no. 9 p.1726-1734

2023

Abstract: To overcome the problems of manual identification of fruit disease, this work proposes a deep‐learning model to analyse fruit images to detect diseases in the fruit. We are proposing here a convolutional neural network (CNN)‐based model for fruit disease ...

Abstract	To overcome the problems of manual identification of fruit disease, this work proposes a deep‐learning model to analyse fruit images to detect diseases in the fruit. We are proposing here a convolutional neural network (CNN)‐based model for fruit disease classification. By including many layers, the proposed CNN model extracts numerous features from the fruit, deals with the large data set and finally evaluates it. With the MobileNetv2 model, the disease prediction accuracy for papaya, guava and citrus was 99.4%, 98.8% and 95.8% and the recall values were 99.4%, 98.8% and 93.8%, respectively. With VGG16, the disease prediction accuracy for papaya, guava and citrus was 97.7%, 99.6% and 94.2% and the recall values were 96.5%, 99.6% and 89.2%, respectively. Finally, with DenseNet121, the disease prediction accuracy for papaya, guava and citrus was 99.4%, 97.6% and 99.2%, and the recall values were 98.8%, 97.6% and 99.2%, respectively.
Keywords	Citrus ; data collection ; fruits ; guavas ; neural networks ; plant pathology ; prediction
Language	English
Dates of publication	2023-12
Size	p. 1726-1734.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	415941-x
ISSN	1365-3059 ; 0032-0862
ISSN (online)	1365-3059
ISSN	0032-0862
DOI	10.1111/ppa.13783
Database	NAL-Catalogue (AGRICOLA)

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Article: Comparative Evaluation of Analgesic Efficacy of Ultrasound-Guided Pericapsular Nerve Group Block and Femoral Nerve Block During Positioning of Patients With Hip Fractures for Spinal Anesthesia: A Prospective, Double-Blind, Randomized Controlled Study.

Jeevendiran, Annamale / Suganya, Srinivasan / Sujatha, Chinthavali / Rajaraman, Jayashridevi / R, Surya / Asokan, Arthi / A, Radhakrishnan

Cureus

2024 Volume 16, Issue 3, Page(s) e56270

Abstract: Introduction: Hip fractures cause severe pain during positioning for spinal anesthesia (SA). Intravenous systemic analgesics can lead to various complications in elderly patients, hence peripheral nerve blocks are emerging as a standard of care in pain ... ...

Abstract	Introduction: Hip fractures cause severe pain during positioning for spinal anesthesia (SA). Intravenous systemic analgesics can lead to various complications in elderly patients, hence peripheral nerve blocks are emerging as a standard of care in pain management for hip fractures, among which femoral nerve block (FNB) is widely known and practiced. Pericapsular nerve group (PENG) block is a recently described technique that blocks the articular nerves of the hip with motor-sparing effects and is used to manage positional pain in hip fractures. This study aims to evaluate the analgesic efficacy of PENG block over FNB in managing pain during positioning before SA in hip fractures. Materials and methods: This was a prospective, randomized, double-blinded study. After ethical clearance, 70 patients undergoing hip fracture surgery under SA in a tertiary-care hospital were recruited and randomized to receive either ultrasound-guided PENG block or FNB with 20 ml of 0.25% bupivacaine before performing SA. We compared pain severity using the visual analog scale (VAS) 15 and 30 minutes after the block and during positioning. The sitting angle, requirement of rescue analgesia for positioning, and anesthesiologist and patient satisfaction scores were also analyzed. Continuous data were analyzed with an unpaired t-test while the chi-square test was used for categorical data. Results: There was a significant reduction in VAS scores after PENG block (PENG: 0.66 ± 1.05 and FNB: 1.94 ± 1.90; p = 0.001) with lesser requirement of rescue analgesia for positioning compared to FNB. The anesthesiologist and patient satisfaction scores were also significantly better in the PENG group. Conclusion: PENG block offers better analgesia for positioning before SA than FNB without any significant side effects, and improves patient and anesthesiologist satisfaction, thus proving to be an effective analgesic alternative for painful hip fractures.
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56270
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Article ; Online: Long-term follow-up of tobacco cessation intervention in a dental setting: A randomized trial.

Sujatha, S / Iyengar, Asha / Pruthvish, S / Prashanth, Radha

Journal of cancer research and therapeutics

2023 Volume 19, Issue Supplement, Page(s) S0

Abstract: Aims and objectives: Tobacco dependence is widely prevalent and a harmful chronic disorder. Achieving long-term tobacco abstinence is an important public health goal. This study aims to assess the long-term effectiveness of moderate-intensity treatment ... ...

Abstract	Aims and objectives: Tobacco dependence is widely prevalent and a harmful chronic disorder. Achieving long-term tobacco abstinence is an important public health goal. This study aims to assess the long-term effectiveness of moderate-intensity treatment for tobacco cessation in the dental clinic setting. Materials and methods: Out of 1206 subjects registered to the Tobacco cessation clinic (TCC) during this time period, only 999 of them completed the 1-year follow-up period. The mean age was 45.9 ± 9 years. Six hundred and three (60.3%) of these subjects were male and 396 (39.6%) of them were females. Five hundred and fifty-eight (55.8%) used smoking tobacco and 441 (44.1%) used smokeless tobacco. Patients received tailored behavioral counseling, educational material, and pharmacotherapy consisting of nicotine replacement therapy (NRT) and\or NON-NRT. Patients were monitored by phone or clinic visits for 11 months. Results: Outcomes assessed were complete abstinence, harm reduction (>50% reduction), no change and lost to follow-up. At the end of 12 months the tobacco quit rate was180 (18%), tobacco reduction >50% was 342 (34.2%), no change 415 (41.5%) and relapse 62 (6.2%). Conclusions: Our study has identified adequate quit-rates in a cohort of dental patients attending a hospital-based TCC.
MeSH term(s)	Female ; Humans ; Male ; Adult ; Middle Aged ; Tobacco Use Cessation ; Smoking Cessation ; Nicotine/therapeutic use ; Follow-Up Studies ; Tobacco Use Cessation Devices ; Chronic Disease
Chemical Substances	Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2023-05-08
Publishing country	India
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.JCRT_1029_20
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Article ; Online: Sustainable remediation of pesticide pollutants using covalent organic framework - A review on material properties, synthesis methods and application.

S, Sujatha / Rajamohan, Natarajan / S, Sanjay / R, Abhishek / M, Rajasimman

Environmental research

2024 Volume 246, Page(s) 118018

Abstract: Covalent organic frameworks (COF) have emerged as a potential class of materials for a variety of applications in a wide number of sectors including power storage, environmental services, and biological applications due to their ordered and controllable ... ...

Abstract	Covalent organic frameworks (COF) have emerged as a potential class of materials for a variety of applications in a wide number of sectors including power storage, environmental services, and biological applications due to their ordered and controllable porosity, large surface area, customizable structure, remarkable stability, and diverse electrical characteristics. COF have received a lot of attention in recent years in the field of environmental remediation, It also find its way to eliminate the emerging pollutant from the environment notably pesticide from polluted water. This review more concentrated on the application of COF in pesticide removal by modifying COF structure, COF synthesis and material properties. To increase the adsorption ability and selectivity of the material towards certain pesticides removal, the synthesis of COF involves organic linkers with various functional groups such as amine, carboxylic acid groups etc. The COF have a high degree of stability and endurance make them suitable for intermittent usage in water treatment applications. This review manifests the novel progress where modified COFs employed in a prominent manner to remove pesticides from polluted water. Some examples of COF application in the eradication of pesticides are triformyl phenylene framework functionalized with amine groups has capacity to remove up to 50 mg/l of Organophosphorus - chlorpyrifos. COF modified to improve their photocatalytic capacity to breakdown the pesticide under visible light irradiation. COF tetraphenyl ethylene linked with carboxylic acid group shows efficient photocatalytic degradation of 90% of organochlorine insecticide endosulfan when subjected to visible light. Atrazine and imidacloprid are reduced from 100 ppm to 1 ppm in aqueous solutions by COF based on high adsorption capacity. In addition, the strategies, technique, synthesis and functional group modification design of COF are discussed.
MeSH term(s)	Pesticides ; Metal-Organic Frameworks ; Amines ; Carboxylic Acids ; Environmental Pollutants
Chemical Substances	Pesticides ; Metal-Organic Frameworks ; Amines ; Carboxylic Acids ; Environmental Pollutants
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.118018
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Article: Efficacy of a levothyroxine dosage regimen based on serum thyrotropin level, for primary hypothyroidism. An open label dose finding study.

Nair, Abilash / Chellamma, Jayakumari / Gopi, Anjana / Sujatha, Chintha / Sarayu, Soumya / Jabbar, P K

Journal of family medicine and primary care

2024 Volume 13, Issue 1, Page(s) 70–76

Abstract: ... patients pre-treatment TSH level (r = 0.81), T4 level (r = 0.61), and body weight (r = 0.19) correlated ...

Abstract	Background: There are no guidelines on individualized initial levothyroxine dosage in primary hypothyroidism. This prospective observational study was done to assess whether a predetermined dose of levothyroxine based on Thyroid Stimulating Hormone (TSH) levels would be able to make the patient euthyroid during a period of six weeks and to find other factors which influence the levothyroxine requirement. Materials and methods: Newly diagnosed patients with primary hypothyroidism or those patients who were not on levothyroxine therapy were divided into TSH-based groups-Group 1, 5-9.99, Group 2, 10-29.99, Group 3, 30-99.99 and Group 4, >100 μIU/ml and treated with an initial levothyroxine dose of 25,50,75 and100 μg/day for next six weeks. Factors correlating with levothyroxine requirement were determined. Results: Of the 171 patients who were included 142 completed the study, 34,46,28 and 34 patients were included in groups 1 to 4, respectively. Normalization of TSH with the above criteria was achieved in 111 (78.7%) out of 141 patients, and 91%, 67%, 75%, and 82% respectively in the 4 groups. Among adequately replaced patients pre-treatment TSH level (r = 0.81), T4 level (r = 0.61), and body weight (r = 0.19) correlated with the levothyroxine requirement. Based on these factors predicted initial dose (μg/day) was found to be 0.54 (Body Weight [Kg]) +0.47 (TSH [μIU/m]) - 1.4 (Total T4 [μg/dl]) +17.79 or 0.27 (Body Weight) +0.553 (TSH) +21. Conclusion: Serum thyrotropin-based categorization for initial levothyroxine dose leads to euthyroidism in nearly four of five patients with primary hypothyroidism. The dose required for adequate replacement of levothyroxine has correlation with pre-treatment serum TSH levels serum thyroxine levels and body weight.
Language	English
Publishing date	2024-02-08
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_654_23
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Article ; Online: NIH HIV Reagent Program: A Valuable Resource for HIV Research.

Timani, Khalid / Rashid, Sujatha / Bradford, Rebecca / Leonelli, Joseph

Current HIV research

2024 Volume 21, Issue 4, Page(s) 277–278

MeSH term(s)	Humans ; HIV Infections/diagnosis ; HIV Infections/prevention & control ; Biomedical Research ; National Institutes of Health (U.S.)
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2192348-6
ISSN	1873-4251 ; 1570-162X
ISSN (online)	1873-4251
ISSN	1570-162X
DOI	10.2174/1570162X2104231226194230
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