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Article ; Online: Less Invasive Surfactant Applications in Newborns

Sadık YURTTUTAN / Mehmet Yekta ÖNCEL / Ramazan ÖZDEMİR

Forbes Tıp Dergisi, Vol 3, Iss 1, Pp 10-

2022 Volume 17

Abstract: Respiratory distress syndrome is the most significant cause of respiratory distress in premature infants, and its treatment with exogenous surfactant has reshaped infant care, providing a longer life expectancy for early-born neonates. In addition, with ... ...

Abstract	Respiratory distress syndrome is the most significant cause of respiratory distress in premature infants, and its treatment with exogenous surfactant has reshaped infant care, providing a longer life expectancy for early-born neonates. In addition, with the higher survival rate of extremely premature infants, more cases of bronchopulmonary dysplasia (BPD) and prolonged mechanical ventilation are being observed. In recent years, it has been reported that favoring non-invasive methods of ventilation along with minimally invasive methods of surfactant administration has positive effects against the development of BPD and other premature morbidities. In this article, we aim to discuss several subjects regarding the use of minimally invasive surfactant.
Keywords	preterm ; rds ; minimally invasive surfactant ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
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Article: A national survey on use of less invasive surfactant administration in Turkey.

Öncel, Mehmet Yekta / Erdeve, Ömer

The Turkish journal of pediatrics

2020 Volume 62, Issue 5, Page(s) 787–794

Abstract: Background: The aim of the study was to assess the rate of utilization, policy of premedication, technique, equipment, experience on safety and efficacy for less invasive surfactant administration or minimally invasive surfactant therapy (LISA/MIST) use ...

Abstract	Background: The aim of the study was to assess the rate of utilization, policy of premedication, technique, equipment, experience on safety and efficacy for less invasive surfactant administration or minimally invasive surfactant therapy (LISA/MIST) use in Turkey. Methods: An online survey was designed and distributed via Google Forms tool to 350 neonatologists from 173 units through NICU-Turk mailing list of the Turkish Neonatal Society. Participants were asked to answer the survey for their own neonatal intensive care unit (NICU). Results: LISA/MIST use rate was 81.6% among 87 NICUs which responded (response rate was 50.2%). LISA was used regularly in 23 of the units (26.4%), occasionally in 35 (40.2%), rarely in 12 (13.8%), and only for clinical trials in 1 (1.1%). LISA/MIST has been never applied in 16 units (18.4%). Conclusions: LISA/MIST is widely used in Turkey similar to several regions in Europe but unlike the USA. Future studies are expected to further clarify some questions about LISA/MIST procedure, especially on its efficacy and safety.
MeSH term(s)	Humans ; Infant, Newborn ; Infant, Premature ; Pulmonary Surfactants/therapeutic use ; Respiratory Distress Syndrome, Newborn ; Surface-Active Agents/therapeutic use ; Turkey
Chemical Substances	Pulmonary Surfactants ; Surface-Active Agents
Language	English
Publishing date	2020-10-27
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	0041-4301
ISSN	0041-4301
DOI	10.24953/turkjped.2020.05.010
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Article: Social and Medical Characteristics of Neonates Who Were Abandoned in a Tertiary Maternity Hospital in Turkey.

Sattarova, Shahla / Öncel, Mehmet Yekta / Üstün, Hüseyin / Karabulut Gencay, Sakine / Engür, Defne

Turkish archives of pediatrics

2023 Volume 58, Issue 5, Page(s) 480–484

Abstract: Objective: This study aimed to investigate the characteristics of neonates who were aban- doned in a tertiary maternity hospital and to determine the accompanying morbidities.: Materials and methods: This hospital-based, retrospective descriptive ... ...

Abstract	Objective: This study aimed to investigate the characteristics of neonates who were aban- doned in a tertiary maternity hospital and to determine the accompanying morbidities. Materials and methods: This hospital-based, retrospective descriptive study was conducted by evaluating the medical records between 2012 and 2019 in a tertiary hospital in İzmir. Results: During the study period, there were 76 women who left their babies in the hospital following delivery. Median age of the mothers was 23 (range 12-44) years. Among them, 31.5% (n = 24) were below 18 years of age. Seventy-three of the pregnancies (96%) were unwanted, 67 of the mothers were unmarried (88.16%), of which 17 revealed a history of rape (22.36%), and 2 of them were victims of incest (2.63%). Thirty-six (47.36%) neonates were female and 36 of them (47.36%) were delivered by cesarean section. The mean gestational age was 37.3 ± 2.2 weeks and the mean birth weight was 2927 ± 572 g. Twenty-one (27.63%) babies were born prematurely and 15 (19.73%) had low birth weight. Four babies (5.26%) had hypoglycemia, 3 (3.94%) had hyponatremia, 5 (6.57%) had hypocalcemia, and 3 (3.94%) had hypomagnesemia. Conclusion: Unwanted pregnancies were found to be one of the key reasons for newborn aban- donment and linked to a higher risk of complications for both mother and child. To prevent unintended pregnancy and its negative effects, it is important to ensure that all adolescents have access to high-quality education in a safe and supportive learning environment, school- based health services, and increase access to contraceptive services, including emergency contraception and safe and legal abortion services.
Language	English
Publishing date	2023-08-09
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2023.23040
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Book ; Online: Neo-Covid Study from Turkey

Mehmet Yekta Oncel (9446403)

2020

Abstract: A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Data were collected through an online data registry system via electronic case report forms. ...

Abstract	A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Data were collected through an online data registry system via electronic case report forms.
Keywords	Database ; covid19
Publishing date	2020-07-08T04:02:42Z
Publishing country	us
Document type	Book ; Online
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Book ; Online: Neo-Covid Study from Turkey

Mehmet Yekta Oncel (9446403)

2020

Abstract	A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Data were collected through an online data registry system via electronic case report forms.
Keywords	Database ; covid19
Publishing date	2020-07-08T02:53:56Z
Publishing country	us
Document type	Book ; Online
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Book ; Online: Neo-Covid Study from Turkey

Mehmet Yekta Oncel (9446403)

2020

Abstract	A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Data were collected through an online data registry system via electronic case report forms.
Keywords	Database ; covid19
Publishing date	2020-07-08T04:01:32Z
Publishing country	us
Document type	Book ; Online
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Article ; Online: Sprinkled water drops on the skin in newborns: congenital miliaria crystallina.

Sahin, Aslihan / Karadag Oncel, Eda / Ozkul, Mustafa Taha / Oncel, Mehmet Yekta

Archives of disease in childhood. Fetal and neonatal edition

2020 Volume 105, Issue 5, Page(s) 562

MeSH term(s)	Humans ; Infant, Newborn ; Male ; Miliaria/congenital ; Miliaria/pathology ; Photography ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2020-04-20
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2007331-8
ISSN	1468-2052 ; 1359-2998
ISSN (online)	1468-2052
ISSN	1359-2998
DOI	10.1136/archdischild-2020-319008
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Article ; Online: Postnatal surgery for myelomeningocele in neonates: neurodevelopmental outcomes.

Akar, Melek / Çetin, Gülşah / İnal, Mine / Helvaci, Mehmet / Dündar, Nihal Olgaç / Ergin, Firat / Uygur, Özgün / Akbay, Sinem / Özdemir, Nail / Arslan, Meltem Koyuncu / Öncel, Mehmet Yekta

Turkish journal of medical sciences

2023 Volume 53, Issue 1, Page(s) 88–93

Abstract: Background: The study aims to evaluate the neurodevelopmental outcomes of neonates with myelomeningocele (MMC) operated in the postnatal period.: Methods: This is a prospective follow-up study in a tertiary neonatal intensive care unit. ... ...

Abstract	Background: The study aims to evaluate the neurodevelopmental outcomes of neonates with myelomeningocele (MMC) operated in the postnatal period. Methods: This is a prospective follow-up study in a tertiary neonatal intensive care unit. Neurodevelopmental outcomes of term neonates operated for MMC and healthy term newborns were compared with the Bayley Scales of Infant and Toddler Development -Third Edition (BSID III) at 12-18 months. Results: A total of 57 cases were included in the study (patient group = 27; control group = 30). Demographic data between the groups were similar. Cognitive, linguistic, and motor composite scores of the patient group were lower than those of the control group (p < 0.001). In the patient group, those who underwent ventriculoperitoneal shunt had lower cognitive, language and motor scores than those without shunt (p < 0.05). The cognitive, linguistic, and motor composite scores in the patient group who underwent surgery before 72 h were better than those who underwent surgery after 72 h. Discussion: In our study, it was found that the neurodevelopmental prognosis of MMC cases requiring ventriculoperitoneal shunt in the postnatal period was significantly worse than those without shunt. It is the first study in which the neurodevelopment of patients with MMC who were operated in the postnatal period was evaluated with BSID III evaluated and delays in all areas were shown in cases with MMC compared to normal cases. Better neurodevelopmental outcomes in patients operated in the first 72 h suggest that early surgery will improve neurodevelopmental outcomes in patients with MMC.
MeSH term(s)	Infant ; Humans ; Infant, Newborn ; Meningomyelocele/surgery ; Follow-Up Studies ; Prospective Studies ; Ventriculoperitoneal Shunt
Language	English
Publishing date	2023-02-22
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.55730/1300-0144.5561
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Article ; Online: Bilirubin Measurement Through a Smartphone Application in Preterm Infants.

Ustun, Huseyin / Oncel, Mehmet Yekta / Kefeli, Melike / Akar, Melek / Engür, Defne

Klinische Padiatrie

2022 Volume 235, Issue 5, Page(s) 265–269

Abstract: Backround: Aim of the present study is to evaluate the feasibility and reliability of an smartphone application for monitore of bilirubin levels in preterm infants.: Methods: Preterm infants hospitalized in the neonatal intensive care unit with ... ...

Title translation	Bilirubin-Bestimmung mittels Smartphone-App bei Frühgeborenen.
Abstract	Backround: Aim of the present study is to evaluate the feasibility and reliability of an smartphone application for monitore of bilirubin levels in preterm infants. Methods: Preterm infants hospitalized in the neonatal intensive care unit with gestational age of<35 weeks were included. Exclusion criteria were parental reluctance and requirement of phototherapy in the last 12 hours. Measurements were obtained through a smartphone application (BiliScan) along with simultaneous transcutaneous device (Dräger JM 105) and venous blood biochemistry. Results: Mean gestational age was 30.8±2.4 weeks and birth weight was 1622±566 g. Measurements were obtained at a median of 4 (1-21) days of life. Twenty-five infants (19.4%) had ABO and/or Rh incompatibility and 39 infants (30.2%) required phototherapy. None of the cases required exchange transfusion. Mean total serum bilirubin (TSB) level was 8.16±2.60 mg/dL, mean transcutaneous bilirubin (TcB) level was 8.60±2.70 mg/dL, and the mean bilirubin level measured by BiliScan was 7.26±2.68 mg/dL. For TSB and TcB measurements, the intraclass correlation coefficient (ICC) was found to be 0.915 (95% confidence interval 0.835-0.951; p<0.001) and a strong positive correlation was found between these two measurements. When TSB and BiliScan measurements were compared, ICC was found to be significant as 0.512 (95% confidence interval 0.353-0.638; p<0.001), with a moderate correlation. Conclusions: In this study, we evaluated the feasibility and reliability of a smartphone application for monitoring bilirubin levels in preterm infants. Although BiliScan measurements reported to display high correlation in term infants, a moderate correlation was found in the preterm infants. It is an emerging low-cost, non-invasive alternative for neonatal jaundice monitoring, however, results should be interpreted with caution in preterm infants.
MeSH term(s)	Infant, Newborn ; Humans ; Infant ; Infant, Premature ; Skin ; Reproducibility of Results ; Smartphone ; Bilirubin ; Jaundice, Neonatal/diagnosis ; Jaundice, Neonatal/therapy ; Neonatal Screening/methods
Chemical Substances	Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2022-12-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120650-3
ISSN	1439-3824 ; 0300-8630
ISSN (online)	1439-3824
ISSN	0300-8630
DOI	10.1055/a-1816-5878
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Article ; Online: Epidemiology and Outcomes of Neonatal Meningitis: Results of the Turkish Neo-Meningitis Nationwide Study.

Oncel, Mehmet Yekta / Cizmeci, Mehmet N / Karadag-Oncel, Eda / Elvan-Tuz, Aysegul / Canpolat, Fuat Emre / Akin, Mustafa Ali / Uslu, Sinan / Cetinkaya, Merih / Erdeve, Omer / Koc, Esin

The Pediatric infectious disease journal

2023 Volume 43, Issue 4, Page(s) 365–370

Abstract: Objective: To investigate the incidence and etiology of neonatal meningitis and to assess the associated risk factors, complications and outcomes in a nationwide multicenter retrospective descriptive study.: Method: Twenty-seven centers from 7 ... ...

Abstract	Objective: To investigate the incidence and etiology of neonatal meningitis and to assess the associated risk factors, complications and outcomes in a nationwide multicenter retrospective descriptive study. Method: Twenty-seven centers from 7 geographical regions participated in the study. Newborns with a positive cerebrospinal fluid culture and/or cerebrospinal fluid polymerase chain reaction were included in the study. Demographic characteristics, clinical, laboratory and neuroimaging findings and mortality characteristics were analyzed. Results: A total of 634 confirmed cases of neonatal meningitis were included in the final analysis. The incidence was 2.51 per 1000 intensive care unit hospitalizations and mortality was observed in 149 (23.5%). Gram-positive bacteria were the predominant pathogens (54.5%), with coagulase-negative Staphylococci accounting for 45.3% of the cases, followed by Gram-negative organisms (37.3%). Viral and fungal organisms were isolated in 3.2% and 1.7% of the infants, respectively. Gram-negative culture growth was more common in infants who died (51% vs. 34.6%; P < 0.001). In the multivariable model, the odds of mortality was higher in those with respiratory distress requiring invasive ventilatory support [odds ratio (OR): 10.3; 95% confidence interval (CI): 4.9-21.7; P < 0.01], hypotension requiring inotropes (OR: 4.4; 95% CI: 2.7-7.1; P < 0.001), low birth weight status (OR: 2.5; 95% CI: 1.4-4.6; P = 0.002), lack of exposure to antenatal steroids (OR: 2.4; 95% CI: 1.3-4.4; P = 0.005) and the presence of concomitant sepsis (OR: 1.9; 95% CI: 1.1-3.2; P = 0.017). Conclusions: In this nationwide study, neonatal meningitis was found to be associated with high mortality. Coagulase-negative Staphylococci was the most common causative microorganism followed by Gram-negative bacteria. Severe clinical presentation with invasive mechanical ventilation and inotrope requirement, as well as concomitant sepsis, low birth weight status and lack of exposure to antenatal steroids, were found to be independent risk factors for mortality.
MeSH term(s)	Pregnancy ; Infant ; Humans ; Infant, Newborn ; Female ; Retrospective Studies ; Coagulase ; Meningitis ; Staphylococcus ; Sepsis/microbiology ; Infant, Newborn, Diseases ; Risk Factors ; Steroids
Chemical Substances	Coagulase ; Steroids
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004197
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