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Article ; Online: Oral hormonal therapy as treatment option for abnormal uterine bleeding.

Selmi, Chiara / La Marca, Antonio

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

2023 Volume 28, Issue 6, Page(s) 285–294

Abstract: Background: abnormal uterine bleeding is a very frequent reason for referral to gynaecologists and can deeply influence the quality of life. Once organic causes requiring surgical treatment are ruled out, clinicians should be able to manage these ... ...

Abstract	Background: abnormal uterine bleeding is a very frequent reason for referral to gynaecologists and can deeply influence the quality of life. Once organic causes requiring surgical treatment are ruled out, clinicians should be able to manage these patients conservatively in the most effective way. Materials and methods: a search in PubMed/MEDLINE database was conducted in order to find relevant and recent meaningful sources for this narrative review. Results: LNG-IUS 52 mg is the first-line treatment for non-organic causes. Nevertheless, it could be contraindicated or declined by the patient. Combined oral contraceptives (COC) and progestin-only pills inhibit the hypothalamic-pituitary-ovarian axis, preventing ovulation, and induce endometrial atrophy. Consequently, they are effective in treating AUB. Moreover, brand new pills containing a combination of oestrogens, progestins and GnRH antagonists are now available for the management of AUB related to uterine fibroids. Conclusions: In daily clinical practice, oral hormonal therapies are convenient and reversible tools to manage AUB when LNG-IUS 52 mg is contraindicated or turn down by the patient. Many oral hormonal therapies are prescribed to treat AUB, but only a few have been approved with this specific indication, therefore further large well-designed studies are necessary in order to compare the efficacy of different pills for treating AUB.
MeSH term(s)	Female ; Humans ; Quality of Life ; Progestins/therapeutic use ; Menorrhagia/drug therapy ; Contraceptives, Oral, Combined/therapeutic use ; Leiomyoma ; Uterine Hemorrhage/drug therapy ; Levonorgestrel/therapeutic use
Chemical Substances	Progestins ; Contraceptives, Oral, Combined ; Levonorgestrel (5W7SIA7YZW)
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1397560-2
ISSN	1473-0782 ; 1362-5187
ISSN (online)	1473-0782
ISSN	1362-5187
DOI	10.1080/13625187.2023.2270098
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Zs.A 4819: Show issues

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Article ; Online: Greetings from the new Editor-in-Chief.

La Marca, Antonio

Minerva obstetrics and gynecology

2020 Volume 73, Issue 1, Page(s) 2–3

Language	English
Publishing date	2020-11-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062815-5
ISSN	2724-6450
ISSN (online)	2724-6450
DOI	10.23736/S2724-606X.20.04746-2
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Article ; Online: Vasorin: a new molecule in human reproduction?

La Marca, Antonio / De Carlini, Serena / Liuzzi, Francesca

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

2023 Volume 39, Issue 1, Page(s) 2273282

MeSH term(s)	Humans ; Cell Line, Tumor ; Signal Transduction ; Reproduction
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639237-4
ISSN	1473-0766 ; 0951-3590
ISSN (online)	1473-0766
ISSN	0951-3590
DOI	10.1080/09513590.2023.2273282
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Zs.A 2284: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Extended LH administration as a strategy to increase the pool of recruitable antral follicles in hypothalamic amenorrhea: evidence from a case series.

La Marca, Antonio / Longo, Maria

Human reproduction (Oxford, England)

2022 Volume 37, Issue 11, Page(s) 2655–2661

Abstract: New evidence is indicating a growing role of LH in promoting ovarian follicular growth and maturation, even at the early stages. LH seems to enhance the transition of follicles to the antral stage hence leading to an increase in the so-called functional ... ...

Abstract	New evidence is indicating a growing role of LH in promoting ovarian follicular growth and maturation, even at the early stages. LH seems to enhance the transition of follicles to the antral stage hence leading to an increase in the so-called functional ovarian reserve (recruitable antral follicles). Hypogonadotropic hypogonadism is characterized by low, and sometimes undetectable, serum LH and FSH levels, which may indeed explain the low anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) found in patients affected by this condition. We report here the cases of two young women affected by hypothalamic amenorrhea (HA) that presented for fertility treatment with very low functional ovarian reserve. The two patients were treated with exogenous LH for 1 and 2 months (extended LH administration: ELHA) at the dose of 187.5 IU LH every day and 150 IU LH every other day, respectively. In both the cases there was an increase in serum AMH levels and in the AFC. In one patient, the AMH and AFC increased from a baseline 1.3 ng/ml and 8 to 2.3 ng/ml and 14 at end of treatment, respectively. In the second case, serum AMH and AFC increased from 0.4 ng/ml and 6 to 1.6 ng/ml and 13, respectively. One patient underwent ovarian stimulation before and after ELHA, showing an increase in the number of mature oocytes recruited (3 versus 8 metaphase II (MII) oocytes before and after, respectively). The second patient underwent an IVF cycle after ELHA resulting in the retrieval of six MII oocytes and an ongoing pregnancy following transfer of a single blastocyst. Women with HA are characterized by chronic, low levels of gonadotrophins, which may impact not only on the cyclic recruitment of follicles but also the progression of small growing follicles through the first stages of folliculogenesis. Some women with HA may in fact show very low serum AMH and AFC. Our case series shows that the administration of LH at a dose of at least 150-187.5 IU every day or every other day may contribute to a clinically evident increase in the functional ovarian reserve (AFC), and probably accounts for a positive effect of LH on the progression of follicles throughout the early stages of folliculogenesis.
MeSH term(s)	Pregnancy ; Humans ; Female ; Amenorrhea ; Ovarian Follicle/physiology ; Anti-Mullerian Hormone ; Ovarian Reserve ; Ovulation Induction/methods ; Ovarian Diseases
Chemical Substances	Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	632776-x
ISSN	1460-2350 ; 0268-1161 ; 1477-741X
ISSN (online)	1460-2350
ISSN	0268-1161 ; 1477-741X
DOI	10.1093/humrep/deac195
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Article ; Online: Free your patients and yourself from day 2-3: start ovarian stimulation any time in freeze-all cycles.

Ata, Baris / La Marca, Antonio / Polyzos, Nikolaos P

Reproductive biomedicine online

2023 Volume 47, Issue 4, Page(s) 103305

Abstract: Ovarian stimulation for assisted reproductive technology is traditionally started in the early follicular phase. The essential rationale is to allow timely follicle growth and oocyte retrieval to ensure synchronization of the in-vitro cultured embryos ... ...

Abstract	Ovarian stimulation for assisted reproductive technology is traditionally started in the early follicular phase. The essential rationale is to allow timely follicle growth and oocyte retrieval to ensure synchronization of the in-vitro cultured embryos with the receptive period of the endometrium in a fresh transfer cycle. In addition, conventional thought suggested that follicle recruitment happened only once, around menstruation. A deeper understanding of folliculogenesis, advances in cryobiology and an increasing proportion of freeze-all cycles provide a unique opportunity here. Experience from oncofertility patients as well as infertile women and oocyte donors who underwent ovarian stimulation in different phases of the menstrual cycle, dubbed 'random start' cycles, suggests that the number of oocytes collected and their reproductive potential do not depend on the time of starting ovarian stimulation, although the duration of stimulation and gonadotrophin consumption can vary slightly. It may be time to free both patients and clinics from the obsession with starting ovarian stimulation in the early follicular phase in planned freeze-all cycles. The flexibility provided by random start cycles is one aspect of individualizing treatment to patients' needs.
MeSH term(s)	Female ; Humans ; Infertility, Female/therapy ; Ovulation Induction ; Reproductive Techniques, Assisted ; Oocytes ; Ovarian Follicle
Language	English
Publishing date	2023-07-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2023.103305
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Zs.A 5792: Show issues

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Article ; Online: POvaStim: An online tool for directing individualized FSH doses in ovarian stimulation.

Xu, Huiyu / Feng, Guoshuang / Han, Yong / La Marca, Antonio / Li, Rong / Qiao, Jie

Innovation (Cambridge (Mass.))

2023 Volume 4, Issue 2, Page(s) 100401

Language	English
Publishing date	2023-02-18
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2666-6758
ISSN (online)	2666-6758
DOI	10.1016/j.xinn.2023.100401
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Article ; Online: Ovarian antimüllerian hormone system: more complex than was thought.

La Marca, Antonio

Fertility and sterility

2019 Volume 112, Issue 1, Page(s) 42–43

MeSH term(s)	Anti-Mullerian Hormone ; Biomarkers ; Female ; Humans ; Ovarian Reserve ; Polycystic Ovary Syndrome
Chemical Substances	Biomarkers ; Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2019-09-13
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2019.04.042
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Article ; Online: The metrics maze in science: navigating academic evaluation without journalistic pressures.

Alviggi, Carlo / Nappi, Rossella E / La Marca, Antonio / Ubaldi, Filippo Maria / Vaiarelli, Alberto

Reproductive biomedicine online

2024 , Page(s) 103935

Abstract: In recent years a troubling trend has emerged in the medical research field, notably in reproductive medicine, manifesting an increased emphasis on quantity over quality in articles published. The pressure to collect copious publication records risks ... ...

Abstract	In recent years a troubling trend has emerged in the medical research field, notably in reproductive medicine, manifesting an increased emphasis on quantity over quality in articles published. The pressure to collect copious publication records risks compromising meticulous expertise and impactful contributions. This tendency is exemplified by the rise of 'hyper-prolific researchers' publishing at an extraordinary rate (i.e. every 5 days), prompting a deeper analysis of the reasons underlying this behaviour. Prioritizing rapid publication over Galileo Galilei's systematic scientific principles may lead to a superficial approach driven by quantitative targets. Thus, the overreliance on metrics to facilitate academic careers has shifted the focus to numerical quantification rather than the real scientific contribution, raising concerns about the effectiveness of the evaluation systems. The Hamletian question is: are we scientist or journalist? Addressing these issues could necessitate a crucial re-evaluation of the assessment criteria, emphasizing a balance between quantity and quality to foster an academic environment that values meaningful contributions and innovation.
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2024.103935
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Article: Use of AMH in the Differential Diagnosis of Anovulatory Disorders Including PCOS.

Capuzzo, Martina / La Marca, Antonio

Frontiers in endocrinology

2021 Volume 11, Page(s) 616766

Abstract: Since the historical use of gonadotrophin and estradiol levels to define the different anovulatory disorders has shown some limitations, the use of other markers such as anti-müllerian hormone (AMH) has been proposed. This review addresses the role of ... ...

Abstract	Since the historical use of gonadotrophin and estradiol levels to define the different anovulatory disorders has shown some limitations, the use of other markers such as anti-müllerian hormone (AMH) has been proposed. This review addresses the role of AMH in the differential diagnosis of anovulatory disorders, especially focusing on its value in the prognostic characterization of their severity. Current limitations and future clinical applications are discussed.
MeSH term(s)	Anovulation/blood ; Anovulation/diagnosis ; Anti-Mullerian Hormone/blood ; Diagnosis, Differential ; Female ; Humans ; Ovary/metabolism ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/diagnosis
Chemical Substances	Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2021-02-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2020.616766
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Article ; Online: Fertility preservation for genetic diseases leading to premature ovarian insufficiency (POI).

La Marca, Antonio / Mastellari, Elisa

Journal of assisted reproduction and genetics

2021 Volume 38, Issue 4, Page(s) 759–777

Abstract: Purpose: The current review aims to summarize the data available concerning the applicability of fertility preservation techniques to genetic conditions at risk of premature ovarian insufficiency (POI).: Methods: A literature review through the ... ...

Abstract	Purpose: The current review aims to summarize the data available concerning the applicability of fertility preservation techniques to genetic conditions at risk of premature ovarian insufficiency (POI). Methods: A literature review through the PubMed Database was carried out. Results: About 10% of cases of POI is related to genetic diseases. The most frequent conditions associated with POI are Turner syndrome and fragile X pre-mutation; mutation of BRCA 1-2 genes and several other mutations and genetic syndromes have recently been highlighted, although they rarely occur. If a diagnosis is issued before POI onset, counseling on currently available fertility preservation techniques is advisable. In case of spontaneous menarche (this can occur variably depending on the mutation) established techniques like embryo or oocyte cryopreservation can be proposed, even if, in some cases, their effectiveness may be reduced by ovarian alterations connected to the mutation. Ovarian tissue cryopreservation has recently been defined as an established medical procedure for fertility preservation in young cancer patients and may be an option for prepubertal patients. However, it is still experimental in special populations with genetic diseases causing POI. New innovative experimental techniques, like in vitro maturation of immature oocytes (IVM) and vitro activation (IVA) of immature follicles on ovarian tissue, have shown limited but encouraging data and they will be probably available in the near future. For a correct risk-benefit evaluation, the following aspects should be considered: actual knowledge about the pathology-specific efficacy of the various techniques, the average age of onset of POI, the possible risks associated with the procedure in relation to the underlying pathology, the probability of spontaneous conception, as well as the health implications of a possible future pregnancy.. Conclusions: Fertility preservation techniques represent a crucial opportunity for patients with genetic risk of POI. Early diagnosis increases the chances to apply these techniques. No specific recommendations concerning fertility preservation for each genetic pathology are available, and clinicians should first counsel the patient and her relatives about known risks and benefits of the available techniques, both those established and those considered as experimental.
MeSH term(s)	BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Cryopreservation ; Female ; Fertility Preservation ; Fragile X Syndrome/complications ; Fragile X Syndrome/genetics ; Fragile X Syndrome/pathology ; Humans ; Oocytes/growth & development ; Pregnancy ; Primary Ovarian Insufficiency/complications ; Primary Ovarian Insufficiency/genetics ; Primary Ovarian Insufficiency/pathology ; Primary Ovarian Insufficiency/prevention & control ; Turner Syndrome/complications ; Turner Syndrome/genetics ; Turner Syndrome/pathology
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human
Language	English
Publishing date	2021-01-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1112577-9
ISSN	1573-7330 ; 1058-0468
ISSN (online)	1573-7330
ISSN	1058-0468
DOI	10.1007/s10815-021-02067-7
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