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Article ; Online: Retraction Notice. No Difference Between One-shot Co-injection of Corticosteroids and Hyaluronic Acid in a Three-injection Regimen for Knee Osteoarthritis: A Randomized, Double-blind Trial.

Hsieh, Ru-Lan / Lee, Wen-Chung

Clinical orthopaedics and related research

2024 Volume 482, Issue 3, Page(s) 570

Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	80301-7
ISSN	1528-1132 ; 0009-921X
ISSN (online)	1528-1132
ISSN	0009-921X
DOI	10.1097/CORR.0000000000002997
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Article ; Online: No Difference Between One-shot Co-injection of Corticosteroids and Hyaluronic Acid in a Three-injection Regimen for Knee Osteoarthritis: A Randomized, Double-blind Trial [RETRACTED].

Hsieh, Ru-Lan / Lee, Wen-Chung

publication RETRACTED

Clinical orthopaedics and related research

2023

Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	80301-7
ISSN	1528-1132 ; 0009-921X
ISSN (online)	1528-1132
ISSN	0009-921X
DOI	10.1097/CORR.0000000000002793
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Article ; Online: Effects of Intra-articular Coinjections of Hyaluronic Acid and Hypertonic Dextrose on Knee Osteoarthritis: A Prospective, Randomized, Double-Blind Trial.

Hsieh, Ru-Lan / Lee, Wen-Chung

Archives of physical medicine and rehabilitation

2022 Volume 103, Issue 8, Page(s) 1505–1514

Abstract: Objective: To determine whether intra-articular coinjection with hypertonic dextrose improves the outcome of hyaluronic acid (HA) prolotherapy for knee osteoarthritis (OA).: Design: Prospective, randomized, double-blind trial.: Setting: Medical ... ...

Abstract	Objective: To determine whether intra-articular coinjection with hypertonic dextrose improves the outcome of hyaluronic acid (HA) prolotherapy for knee osteoarthritis (OA). Design: Prospective, randomized, double-blind trial. Setting: Medical center in Taiwan. Participants: In total, 104 participants who fulfilled the American College of Rheumatology clinical and radiographic criteria for knee OA with a Kellgren-Lawrence score of 2 or 3 were recruited (N=104). Interventions: The participants were blocked randomized to the treatment (HA and hypertonic dextrose) or control (HA and normal saline) group. Ultrasound-guided knee intra-articular injections were administered once a week for 3 weeks. Main outcome measures: The primary outcomes were performance-based physical function measures (regular and fastest walking speed, stair climbing time, and chair rising time), and the secondary outcomes were the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee Injury and Osteoarthritis Outcome Score (KOOS). The outcome measures were assessed before the injections and at 1 week and 1, 3, and 6 months after the injections. The data were analyzed through repeated-measures analysis of covariance. Results: Significant intergroup difference-in-differences favoring the treatment group were observed for improvements in stair climbing time (-1.6; 95% confidence interval, -8.56 to 4.16; P=.38) and WOMAC physical function (-21.2; 95% confidence interval, -126.05 to 103.83; P = .045) at 6 months. The group×time interaction effects favored the treatment group for regular (P=.001) and fastest walking speed (P=.001) and chair rising time (P=.038); WOMAC stiffness (P < .001) and physical function (P = .003); and KOOS for pain (P = .035), other symptoms (P=.022), and quality of life (P=.012). Conclusions: Compared with HA plus normal saline coinjections, HA plus dextrose coinjections resulted in more significant improvements in stair climbing time and physical function at 6 months, effectively decreased pain, and improved physical function and physical functional performance from 1 week to 6 months. HA plus dextrose coinjections could be a suitable adjuvant therapy for patients with knee OA.
MeSH term(s)	Double-Blind Method ; Glucose ; Humans ; Hyaluronic Acid/therapeutic use ; Injections, Intra-Articular ; Osteoarthritis, Knee ; Pain/drug therapy ; Prospective Studies ; Quality of Life ; Saline Solution/therapeutic use ; Treatment Outcome
Chemical Substances	Saline Solution ; Hyaluronic Acid (9004-61-9) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-04-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	80057-0
ISSN	1532-821X ; 0003-9993
ISSN (online)	1532-821X
ISSN	0003-9993
DOI	10.1016/j.apmr.2022.04.001
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Article ; Online: Letter to the Editor Regarding "Effects of Trunk Stabilization Exercise While Wearing a Pelvic Compression Belt on Walking and Balancing Abilities in Patients With Stroke: An Assessor Blinded, Preliminary, Randomized, Controlled Study".

Fu, Yu-Shan / Hsieh, Ru-Lan

American journal of physical medicine & rehabilitation

2021 Volume 100, Issue 9, Page(s) e135–e136

MeSH term(s)	Humans ; Pelvis ; Stroke ; Torso ; Walking
Language	English
Publishing date	2021-08-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000001726
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Article ; Online: Feasibility of Family-Centered Workshops for Children Aged 18-36 Months with Language Developmental Delay.

Hsieh, Wen-Huei / Chen, Yi-Kuang / Lee, Wen-Chung / Hsieh, Ru-Lan

Pediatric neurology

2023 Volume 143, Page(s) 26–33

Abstract: Background: Family-centered workshops' effects on children with language developmental delay remain unknown. This study assessed the feasibility of workshops for children with language developmental delay.: Methods: A total of 122 children aged 18-36 ...

Abstract	Background: Family-centered workshops' effects on children with language developmental delay remain unknown. This study assessed the feasibility of workshops for children with language developmental delay. Methods: A total of 122 children aged 18-36 months with language developmental delays and their parents participated in six sessions of 2-h family-centered multidisciplinary workshops for 6 weeks. The Mandarin-Chinese Communicative Development Inventory, Peabody Developmental Motor Scale, Emotional Competency Rating Scales, Pediatric Outcomes Data Collection Instrument, Child Health Questionnaire, Pediatric Quality of Life Inventory, Caregiver Strain Index, Impact on Family Scale, PedsQL Family Impact Module, and World Health Organization Quality of Life (QOL) were administered to the children and their parents before and after the workshop. Results: We found improvement of emotion (P = 0.037), upper extremity and physical function (P = 0.038), and transfer and basic mobility (P = 0.019) in children and parental QOL related to children's conditions (P = 0.049), with no effect on communication ability and QOL in children and family strain and function. We also noted more significant improvement in children with pure developmental language delay than in children with nonpure developmental language delay concerning the success rates (from delayed to normal development) for expressive vocabulary (P < 0.001) and word combination (P = 0.002). Satisfaction levels toward the workshop were high. Conclusions: Family-centered workshops improved children's emotions, functional performance, and parental QOL. Although the samples were too small to test different conditions of the developmental delay, the workshops for children with language developmental delays are acceptable and feasible.
MeSH term(s)	Child ; Humans ; Quality of Life ; Feasibility Studies ; Language Development Disorders/therapy ; Parents/psychology ; Language ; Language Development
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2023.02.018
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Article ; Online: Effects of Repeated Co-Injections of Corticosteroids and Hyaluronic Acid on Knee Osteoarthritis: A Prospective, Double-Blind Randomized Controlled Trial.

Wang, Chun-Ping / Lee, Wen-Chung / Hsieh, Ru-Lan

The American journal of medicine

2021 Volume 135, Issue 5, Page(s) 641–649

Abstract: Background: We compared the effects of repeated co-injections of corticosteroids plus hyaluronic acid (HA) with the effects of HA injections alone in patients with knee osteoarthritis.: Methods: A double-blind randomized controlled trial was ... ...

Abstract	Background: We compared the effects of repeated co-injections of corticosteroids plus hyaluronic acid (HA) with the effects of HA injections alone in patients with knee osteoarthritis. Methods: A double-blind randomized controlled trial was conducted between October 2016 and July 2017 at a medical center. Patients (n = 57) who fulfilled the clinical and radiographic criteria for knee osteoarthritis established by the American College of Rheumatology with a Kellgren-Lawrence score of 2 or 3 were included. They were assigned to either the HA group (n = 29) or corticosteroids plus HA group (n = 28), and injections were administered under ultrasound guidance once a week for 3 consecutive weeks. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were the primary outcomes. Physical functional performance (10-m fast walking and chair-rising time) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) were secondary outcomes. The assessment was performed prior to injections, 1 week, and 1, 3, and 6 months after injections. Data were analyzed through repeated-measures analysis of covariance. Results: Both groups experienced decreased pain and improved physical function and physical functional performance over time. We found significant group × time interaction effects favoring the corticosteroids plus HA group in WOMAC-pain (P = .005) and physical function (P = .005), chair-rising time (P = .032), and KOOS-pain (P = .001). Conclusions: Repeated co-injections of corticosteroids plus HA more effectively decreased pain and improved physical function and physical functional performance than injections of HA alone from 1 week through 6 months posttreatment.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Double-Blind Method ; Humans ; Hyaluronic Acid/therapeutic use ; Injections, Intra-Articular ; Osteoarthritis, Knee/complications ; Pain/drug therapy ; Prospective Studies ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2021-12-24
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2021.11.016
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Article ; Online: Short-term multidisciplinary family-centered workshop for preschool children with global developmental delays.

Hsieh, Wen-Huei / Huang, Pei Chen / Tsai, Pei-Chieh / Lee, WanTing / Hu, YiJung / Lee, Wen-Chung / Hsieh, Ru-Lan

Pediatric research

2023 Volume 94, Issue 2, Page(s) 707–714

Abstract: Background: Children with developmental delays have a great impact on their families. Educating families on how to interact with their children is an important task. Therefore, we assessed the short-term effectiveness of the workshop for children with ... ...

Abstract	Background: Children with developmental delays have a great impact on their families. Educating families on how to interact with their children is an important task. Therefore, we assessed the short-term effectiveness of the workshop for children with global developmental delays. Methods: In total, 101 children aged 18-36 months with global developmental delays, all with language delay along with other developmental delays, and their parents participated in six 2-h family-centered workshop sessions for six weeks. Measures were taken before and after the workshop, including the Mandarin-Chinese Communicative Developmental Inventory, Peabody Developmental Motor Scales, Emotional Competency Rating Scales, Pediatric Outcomes Data Collection Instrument, Pediatric Evaluation of Disability Inventory, Pediatric Daily Occupation Scale, Pediatric Quality of Life Inventory (PedsQL), Caregiver Strain Index, and PedsQL-Family Impact Module. Results: Significant improvements with a small or intermediate effect size in emotions, upper extremity and physical functioning and global functioning, daily occupation performance in sensorimotor, communication, cognitive autonomy, and psychosocial domains, and parental quality of life and family impact were noted with high workshop satisfaction. Conclusion: Short-term family-centered workshop is effective for children with global developmental delays. However, due to the lack of follow-up after the intervention, it should be careful in inferring the developmental gain effect. Impact: The effectiveness of short-term family-centered workshops on children with global developmental delays remains uncertain. Short-term family-centered workshops improved the children's emotions, physical functional performance, and occupational performance in daily life. The short-term family-centered workshop is practical and effective for children with global developmental delays. Further long-term, large-scale, prospective, randomized trials are warranted to confirm these results. Clinical trial registration: ClinicalTrials.gov ID: NCT05418933.
MeSH term(s)	Child, Preschool ; Humans ; Infant ; Communication ; Emotions ; Language Development Disorders ; Prospective Studies ; Quality of Life/psychology
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-02507-3
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Article ; Online: Active video games for knee osteoarthritis improve mobility but not WOMAC score: A randomized controlled trial.

Lin, Yu-Ting / Lee, Wen-Chung / Hsieh, Ru-Lan

Annals of physical and rehabilitation medicine

2020 Volume 63, Issue 6, Page(s) 458–465

Abstract: Background: Active video games (AVGs) have become popular and have been investigated for their therapeutic purposes. However, the effect of AVGs on patients with knee osteoarthritis (OA) remains uncertain.: Objective: We aimed to compare the effects ... ...

Abstract	Background: Active video games (AVGs) have become popular and have been investigated for their therapeutic purposes. However, the effect of AVGs on patients with knee osteoarthritis (OA) remains uncertain. Objective: We aimed to compare the effects of AVGs with those of traditional therapeutic exercise on patients with knee OA. Method: This was a prospective single-blind, randomized controlled trial. Participants (n=80) with knee OA were allocated to the AVGs group (n=40) or therapeutic exercise group (n=40). Both groups received treatment 3 times a week for 4 weeks. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and secondary outcome measures were the World Health Organization Quality of Life-Brief Vision, Hospital Anxiety and Depression Scale, Multidimensional Fatigue Inventory, physical functional performance (including time for 10-m walking and for ascending and descending stairs), Biodex Stability System, Chronic Pain Grade Questionnaire, and Work Ability Index. The patients were evaluated at baseline, 2 and 4 weeks after treatment, and 1 and 3 months after treatment completion. Results: Both groups showed significant time effect in the pain subcategory of the WOMAC (P=0.047). However, we found no significant group×time interaction effect between the groups at any follow-up assessments for pain (P=0.066), stiffness (P=0.284), or physical function (P=0.179) for the WOMAC. Among the secondary outcomes, we found significant group×time effects favoring the AVG group in dynamic balance (P=0.020), and physical functional performance including 10-m walking time (P=0.002) and stair ascent time (P=0.005), and the physical domain of health (P=0.032). Conclusions: Therapeutic exercises and playing AVGs similarly improved the pain of patients with knee OA; however, playing AVGs improved dynamic balance, physical functional performance, and physical health more than therapeutic exercises did.
MeSH term(s)	Adult ; Aged ; Exercise Therapy/methods ; Female ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee/physiopathology ; Osteoarthritis, Knee/rehabilitation ; Pain Measurement ; Physical Functional Performance ; Prospective Studies ; Quality of Life ; Severity of Illness Index ; Single-Blind Method ; Stair Climbing ; Treatment Outcome ; Video Games ; Walking
Language	English
Publishing date	2020-01-22
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2480363-7
ISSN	1877-0665 ; 1877-0657
ISSN (online)	1877-0665
ISSN	1877-0657
DOI	10.1016/j.rehab.2019.11.008
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Article ; Online: Associations between Plasma Folate and Vitamin B

Hsieh, Ru-Lan / Huang, Ya-Li / Chen, Wei-Jen / Chen, Hsi-Hsien / Shiue, Horng-Sheng / Lin, Ying-Chin / Hsueh, Yu-Mei

Nutrients

2022 Volume 14, Issue 4

Abstract: This study hypothesized that plasma folate and vitamin ... ...

Abstract	This study hypothesized that plasma folate and vitamin B
MeSH term(s)	Adult ; Aged ; Bone Density ; Folic Acid ; Homocysteine ; Humans ; Lead ; Vitamin B 12 ; Vitamins
Chemical Substances	Vitamins ; Homocysteine (0LVT1QZ0BA) ; Lead (2P299V784P) ; Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2022-02-21
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14040911
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Article ; Online: Effects of a family-centered workshop for children with developmental delays.

Hsieh, Wen-Huei / Lee, Wen-Chung / Hsieh, Ru-Lan

Medicine

2018 Volume 97, Issue 36, Page(s) e12106

Abstract: This study investigated the effects of a short-term family-centered workshop for children with developmental delays.This study was conducted in a rehabilitation outpatient clinic of a teaching hospital. We recruited 30 children with developmental delays ... ...

Abstract	This study investigated the effects of a short-term family-centered workshop for children with developmental delays.This study was conducted in a rehabilitation outpatient clinic of a teaching hospital. We recruited 30 children with developmental delays and their parents as the study group and 57 age- and sex-matched children with typical development and their parents as the control group. The workshop was conducted for the children with developmental delays and their parents in the form of one 2-hour session per week for 6 weeks by health and education professionals by using a family-centered multidisciplinary approach. The Mandarin-Chinese Communicative Developmental Inventory and Peabody Developmental Motor Scales-Second Edition were used to assess the communication and motor skills of the children with developmental delays. The parent form of the Pediatric Outcomes Data Collection Instrument, Child Health Questionnaire, Pediatric Quality of Life (PedsQL) Inventory, and PedsQL Family Impact Module were administered to the parents of both groups.On study commencement, no significant differences were noted in functional performance and family impact between the children with developmental delays and those without delays. The children with developmental delays had lower health and health-related quality of life (HRQOL) scores than the children with typical development. Following the workshop, the study group exhibited significant improvements in physical health (94.2 vs 80.2, effect size: 1.00, P = .026), global function (94.8 vs 78.7, effect size: 0.88, P = .006), impact of the child's health on parental HRQOL (85.0 vs 70.4, effect size: 0.81, P = .043), and parental HRQOL (81.3 vs 65.0, effect size: 0.81, P = .015). No significant differences were recorded in function, health, HRQOL, or family impact between the children with developmental delays and those with typical development after 6 weeks.The multidisciplinary short-term family-centered workshop for children with developmental delays improved the children's physical health and global functional skills, and it reduced the impact of the child's health on parental HRQOL while also improving parental HRQOL.
MeSH term(s)	Ambulatory Care ; Child, Preschool ; Communication ; Cost of Illness ; Developmental Disabilities/physiopathology ; Developmental Disabilities/psychology ; Developmental Disabilities/rehabilitation ; Female ; Humans ; Infant ; Male ; Motor Skills ; Parents/education ; Parents/psychology ; Prospective Studies ; Quality of Life ; Treatment Outcome
Language	English
Publishing date	2018-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000012106
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