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  1. Article ; Online: Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models.

    Li, Tian / Mao, Na / Xie, Zihao / Wang, Jianing / Jin, Fuyu / Li, Yaqian / Liu, Shupeng / Cai, Wenchen / Gao, Xuemin / Wei, Zhongqiu / Yang, Fang / Xu, Hong / Liu, Heliang / Zhang, Haibo / Xu, Dingjie

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Volume 129, Page(s) 155616

    Abstract: ... to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key ...

    Abstract Background: Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue. However, the precise effects and mechanisms of TCM in treating silicosis remain uncertain and subject to debate.
    Objective: The study aims to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key component, paeoniflorin, in silicosis using a murine model.
    Methods: Silicotic mice were treated with YYQFD, pirfenidone (PFD), or paeoniflorin. RAW264.7 cells and mouse lung fibroblasts (MLF) were stimulated with silica, matrix metalloproteinase-12 (MMP-12), or TGF-β1, followed by treatment with paeoniflorin, PFD, or relevant inhibitors. YYQFD constituents were characterized using High-Performance Liquid Chromatography (HPLC). Lung fibrosis severity was assessed via histopathological examination, micro-CT imaging, lung functions, and Western blot analysis. Transcriptome sequencing and bioinformatics analysis were employed to delineate the gene expression profile and target genes modulated by YYQFD in silicosis.
    Results: Treatment with YYQFD ameliorated silica-induced lung fibrosis. Transcriptome sequencing identified MMP-12 as a potential common target of YYQFD and PFD. Additionally, a potential pro-inflammatory role of MMP-12, regulated by silica-induced TLR4 signaling pathways, was revealed. Paeoniflorin, one of the most distinctive compounds in YYQFD, attenuated silica-induced MMP-12 increase and its derived inflammatory factors in macrophages through a direct binding effect. Notably, paeoniflorin treatment exerted anti-fibrotic effects by inhibiting MMP-12-derived inflammatory factors and TGF-β1-induced myofibroblast differentiation in silica-exposed mice.
    Conclusions: This study underscores paeoniflorin as one of the most principal bioactive compounds in YYQFD, highlighting its capacity to attenuate lung inflammation driven by macrophage-derived MMP-12 and reduce lung fibrosis both in vivo and in vitro.
    Language English
    Publishing date 2024-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
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  2. Article ; Online: Correction: Liu, Y.; Yang, J. Hydrophobic Modification of ZrO

    Liu, Yan / Yang, Jing

    Gels (Basel, Switzerland)

    2022  Volume 9, Issue 1

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2022-12-30
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9010031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Innen Nährendes Qigong - Nei Yang Gong

    Yafei, Liu

    2015  

    Author's details Liu Yafei
    Keywords Inneres Qigong ; Prophylaxe mit Qigong ; Ch'i-kung
    Subject Qigong ; Qi-gong ; Chi Kung ; Qi Gong ; Hui Chun Gong ; Chi Gong
    Language German
    Size XIV, 297 S. : zahlr. Ill., 307 schw.-w. Ill., 240 mm x 170 mm
    Edition 2. Aufl.
    Publisher Urban & Fischer in Elsevier
    Publishing place München
    Publishing country Germany
    Document type Book
    Note Aus dem Chines. übers.
    HBZ-ID HT018598025
    ISBN 978-3-437-57131-2 ; 3-437-57131-1 ; 9783437297410 ; 3437297414
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 1234 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: Kidney Yang Deficiency Syndrome Exacerbates Aβ

    Jiang, Xia / Chen, Lin / Fu, Qing / Ma, Dan Li / Liu, Xue Ting / Wang, Xiao Yi

    Current Alzheimer research

    2023  Volume 20, Issue 1, Page(s) 48–58

    Abstract: ... considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical ... for 14 days was used to produce KDS-Yang. On the 15th day, Aβ: Results: Hyperphosphorylation of tau ... in Aβ: Conclusion: KDS-Yang might exacerbate AD pathological lesions. Importantly, G-Re is ...

    Abstract Background: Traditional Chinese medicine (TCM) indicates that Alzheimer's disease (AD) is considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical characteristics to glucocorticoid withdrawal syndrome. Ginsenoside Re (G-Re) has been found to ameliorate the symptoms and pathological impairments of AD. However, it's not clear whether G-Re could protect memory and synapse lesions against kidney deficiency dementia.
    Methods: Subcutaneous injection of hydrocortisone for 14 days was used to produce KDS-Yang. On the 15th day, Aβ
    Results: Hyperphosphorylation of tau in Aβ
    Conclusion: KDS-Yang might exacerbate AD pathological lesions. Importantly, G-Re is a potential ingredient for protecting against memory and synapse deficits in kidney deficiency dementia.
    MeSH term(s) Rats ; Animals ; Amyloid beta-Peptides/toxicity ; Yang Deficiency ; Alzheimer Disease/metabolism ; Disks Large Homolog 4 Protein ; Kidney/metabolism ; Kidney/pathology ; Synapses/metabolism ; Disease Models, Animal ; Peptide Fragments/toxicity
    Chemical Substances Amyloid beta-Peptides ; ginsenoside Re (46F3R0BL3I) ; Disks Large Homolog 4 Protein ; Peptide Fragments
    Language English
    Publishing date 2023-05-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205170-3
    ISSN 1875-5828 ; 1567-2050
    ISSN (online) 1875-5828
    ISSN 1567-2050
    DOI 10.2174/1567205020666230512094230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6235: Show issues Location:
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  5. Article ; Online: The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification.

    Peng, Xiaohuan / Zhu, Xiaofeng / Di, Tianning / Tang, Futian / Guo, Xiaojia / Liu, Yang / Bai, Jun / Li, Yanhong / Li, Lijuan / Zhang, Liansheng

    Frontiers in immunology

    2022  Volume 13, Page(s) 994053

    Abstract: ... Yin-Yang theory" in ancient China, meaning that the opposing forces may actually be interdependent and ...

    Abstract Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid clonal diseases with diverse clinical courses, and immune dysregulation plays an important role in the pathogenesis of MDS. However, immune dysregulation is complex and heterogeneous in the development of MDS. Lower-risk MDS (LR-MDS) is mainly characterized by immune hyperfunction and increased apoptosis, and the immunosuppressive therapy shows a good response. Instead, higher-risk MDS (HR-MDS) is characterized by immune suppression and immune escape, and the immune activation therapy may improve the survival of HR-MDS. Furthermore, the immune dysregulation of some MDS changes dynamically which is characterized by the coexistence and mutual transformation of immune hyperfunction and immune suppression. Taken together, the authors think that the immune dysregulation in MDS with different risk stratification can be summarized by an advanced philosophical thought "Yin-Yang theory" in ancient China, meaning that the opposing forces may actually be interdependent and interconvertible. Clarifying the mechanism of immune dysregulation in MDS with different risk stratification can provide the new basis for diagnosis and clinical treatment. This review focuses on the manifestations and roles of immune dysregulation in the different risk MDS, and summarizes the latest progress of immunotherapy in MDS.
    MeSH term(s) Humans ; Immunosuppression Therapy ; Immunotherapy/adverse effects ; Myelodysplastic Syndromes/therapy ; Risk Assessment ; Yin-Yang
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.994053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

    Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9110704

    Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

    Abstract Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW.
    Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms.
    Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our
    Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9110704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  7. Article ; Online: Understanding Yin-Yang Philosophic Concept Behind Tai Chi Practice.

    Liu, Hao Howe / Nichols, Charles / Zhang, Hong

    Holistic nursing practice

    2023  Volume 37, Issue 5, Page(s) E75–E82

    Abstract: Yin-yang theorizes that everything in the world is interoppositionally unified with 2 dynamic ... opposites (yin and yang), interrooted, interchangeable, and interconvertible. Tai chi (TC) movements and ... postures are essentially yin-yang concept-based. However, there is still a lack of understanding ...

    Abstract Yin-yang theorizes that everything in the world is interoppositionally unified with 2 dynamic opposites (yin and yang), interrooted, interchangeable, and interconvertible. Tai chi (TC) movements and postures are essentially yin-yang concept-based. However, there is still a lack of understanding of yin-yang concepts and applications among people practicing TC. So, in this concept review, we aimed to provide basic understanding of the yin-yang concept and characteristics behind TC practice. Terms derived from the yin-yang concept in TC practice may include blood/qi (energy), stability/mobility, closing/opening moves, expiration/inspiration, solid/empty stance, and defensive/offensive hand movements and postures. These yin-yang attributes are interrestricted and dependent on maintaining a dynamic mind-body harmony. With the yin-yang application, TC can be considered a self-controlled balance perturbation exercise to challenge the stability-mobility (yin-yang) to a new level of harmony. As a health promotion holistic intervention, TC can facilitate the flow in blood/qi pathways or meridians to improve medical conditions. As an integrative mind-body exercise, TC can activate different body parts and brain regions to participate in and coordinate the combined physical and mental activities.
    MeSH term(s) Humans ; Yin-Yang ; Tai Ji ; Meridians ; Exercise Therapy ; Health Promotion
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639032-8
    ISSN 1550-5138 ; 0887-9311
    ISSN (online) 1550-5138
    ISSN 0887-9311
    DOI 10.1097/HNP.0000000000000598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2212: Show issues Location:
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  8. Article ; Online: Lee-Yang zeros and quantum Fisher information matrix in a nonlinear system.

    Tao, Hong / Su, Yuguo / Zhang, Xingyu / Liu, Jing / Wang, Xiaoguang

    Physical review. E

    2023  Volume 108, Issue 2-1, Page(s) 24104

    Abstract: The distribution of Lee-Yang zeros not only matters in thermodynamics and quantum mechanics ... of corresponding Lee-Yang zeros. Utilizing the coupling between a probe qubit and the nonlinear system, all Lee ... Yang zeros can be detected in the dynamics of the probe qubit by tuning the coupling strength and ...

    Abstract The distribution of Lee-Yang zeros not only matters in thermodynamics and quantum mechanics, but also in mathematics. Hereby we propose a nonlinear quantum toy model and discuss the distribution of corresponding Lee-Yang zeros. Utilizing the coupling between a probe qubit and the nonlinear system, all Lee-Yang zeros can be detected in the dynamics of the probe qubit by tuning the coupling strength and linear coefficient of the nonlinear system. Moreover, the analytical expression of the quantum Fisher information matrix at the Lee-Yang zeros is provided and an interesting phenomenon is discovered. Both the coupling strength and temperature can simultaneously attain their precision limits at the Lee-Yang zeros. However, the probe qubit cannot work as a thermometer at a Lee-Yang zero if it sits on the unit circle.
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.108.024104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Effects of Ying Yang Bao on Nutritional Status of Children Aged 6-60 Months in Underdeveloped Rural Areas of China.

    Feng, Jing / Wang, Yongjun / Liu, Tingting / Huo, Junsheng / Zhuo, Qin / Gong, Zhaolong

    Nutrients

    2024  Volume 16, Issue 2

    Abstract: The Ying Yang Bao (YYB) intervention, a national policy in China, has been implemented for over two ...

    Abstract The Ying Yang Bao (YYB) intervention, a national policy in China, has been implemented for over two decades. Most previous studies have focused only on the short-term effects of YYB, while the long-term effects remain unexplored. This study was designed to evaluate the long-term effects of YYB in children aged 6-60 months. A sample of 4666 children was divided into intervention and control groups. Information on basic characteristics, physical examination, YYB consumption, etc., was obtained annually from 2018 to 2021. T-tests or chi-square tests were used to compare differences between the groups for continuous or categorical variables. Children in the intervention group showed greater incremental improvements in hemoglobin levels and physical development (
    MeSH term(s) Humans ; Anemia/epidemiology ; Cachexia ; China/epidemiology ; Growth Disorders ; Nutritional Status ; Infant ; Child, Preschool
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16020202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Yin-Yang sign.

    Liu, S-Z / Song, A / Zhou, X / Wang, Y-P / Liu, Y

    QJM : monthly journal of the Association of Physicians

    2019  Volume 113, Issue 4, Page(s) 288

    MeSH term(s) Back Pain/etiology ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lung Neoplasms/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/secondary ; Yin-Yang
    Language English
    Publishing date 2019-08-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcz204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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