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Article ; Online: [Knowledge Structure of Chronic Obstructive Pulmonary Disease Health Information on Health-Related Websites and Patients' Needs in the Literature Using Text Network Analysis].

Choi, Ja Yun / Lim, Su Yeon / Yun, So Young

2022 Volume 51, Issue 6, Page(s) 720–731

Abstract: Purpose: The purpose of this study was to identify the knowledge structure of health information (HI) for chronic obstructive pulmonary disease (COPD).: Methods: Keywords or meaningful morphemes from HI presented on five health-related websites (HRWs) ...

Abstract	Purpose: The purpose of this study was to identify the knowledge structure of health information (HI) for chronic obstructive pulmonary disease (COPD). Methods: Keywords or meaningful morphemes from HI presented on five health-related websites (HRWs) of one national HI institute and four hospitals, as well as HI needs among patients presented in nine literature, were reviewed, refined, and analyzed using text network analysis and their co-occurrence matrix was generated. Two networks of 61 and 35 keywords, respectively, were analyzed for degree, closeness, and betweenness centrality, as well as betweenness community analysis. Results: The most common keywords pertaining to HI on HRWs were lung, inhaler, smoking, dyspnea, and infection, focusing COPD treatment. In contrast, HI needs among patients were lung, medication, support, symptom, and smoking cessation, expanding to disease management. Two common sub-topic groups in HI on HRWs were COPD overview and medication administration, whereas three common sub-topic groups in HI needs among patients in the literature were COPD overview, self-management, and emotional management. Conclusion: The knowledge structure of HI on HRWs is medically oriented, while patients need supportive information. Thus, the support system for self-management and emotional management on HRWs must be informed according to the structure of patients' needs for HI. Healthcare providers should consider presenting COPD patient-centered information on HRWs.
MeSH term(s)	Humans ; Lung ; Pulmonary Disease, Chronic Obstructive ; Self-Management ; Smoking ; Smoking Cessation
Language	Korean
Publishing date	2022-01-13
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2619665-7
ISSN	2093-758X ; 2093-758X
ISSN (online)	2093-758X
ISSN	2093-758X
DOI	10.4040/jkan.21086
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preparedness for further boosting coronavirus disease 2019 vaccines.

Lim, So Yun / Jung, Jiwon / Kim, Sung-Han

Clinical and translational discovery

2022 Volume 2, Issue 2, Page(s) e55

Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article
ISSN	2768-0622
ISSN (online)	2768-0622
DOI	10.1002/ctd2.55
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Article ; Online: Waning of humoral immunity depending on the types of COVID-19 vaccine.

Lim, So Yun / Kim, Ji Yeun / Jung, Jiwon / Yun, Sung-Cheol / Kim, Sung-Han

Infectious diseases (London, England)

2023 Volume 55, Issue 3, Page(s) 216–220

Abstract: Background: There are limited data on the rates of the waning of antibody levels after two-dose and booster vaccination according to the different platforms of COVID-19 vaccines.: Methods: We enrolled healthcare workers (HCWs) in a tertiary care ... ...

Abstract	Background: There are limited data on the rates of the waning of antibody levels after two-dose and booster vaccination according to the different platforms of COVID-19 vaccines. Methods: We enrolled healthcare workers (HCWs) in a tertiary care hospital who received homologous two-dose vaccination, followed by a homologous or heterologous booster mRNA vaccine. SARS-CoV-2 S1-specific IgG was measured using ELISA. A linear mixed regression model was used to compare the slope from the peak antibody titre to the lowest antibody titres 3 months after vaccination. Results: A total of 113 HCWs (BNT162b2 ( Conclusions: Two-dose homologous ChAdOx1 vaccination or homologous mRNA-1273 booster appears to induce more-durable antibody responses than 2-dose homologous mRNA vaccination, homologous BNT162b2 booster, or 2-dose ChAdOx1 followed by BNT62b2 booster, although our findings are based on the relatively short term (3-month) follow-up after the vaccinations and the evaluation of the slopes from different antibody peak levels. Further studies on long-term durability depending on the types of vaccines are needed.
MeSH term(s)	Humans ; COVID-19 Vaccines ; Immunity, Humoral ; BNT162 Vaccine ; ChAdOx1 nCoV-19 ; 2019-nCoV Vaccine mRNA-1273 ; Prospective Studies ; COVID-19/prevention & control ; SARS-CoV-2 ; Antibodies, Viral ; Immunoglobulin G ; Vaccination
Chemical Substances	COVID-19 Vaccines ; BNT162 Vaccine ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2839775-7
ISSN	2374-4243 ; 2374-4235
ISSN (online)	2374-4243
ISSN	2374-4235
DOI	10.1080/23744235.2023.2165707
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Article: Double Primary Cancers of Earlobe Merkel Cell Carcinoma and Lung Adenocarcinoma.

Jang, Kyung Il / Lim, So Yun / Lee, Jeon Mi / Jeon, Eun-Ju / Lee, Hyun Jin

Journal of audiology & otology

2024

Abstract: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma with a high rate of metastasis. MCC is rarely suspected during clinical examination, thus requiring biopsy to establish a pathologic diagnosis. In addition, MCC sometimes occurs in ... ...

Abstract	Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma with a high rate of metastasis. MCC is rarely suspected during clinical examination, thus requiring biopsy to establish a pathologic diagnosis. In addition, MCC sometimes occurs in double primary cancers. Although there have been reviews on double primary cancers, only a few cases involving MCC have been described. Herein, we report a case of a 54-year-old female patient who presented to our clinic with a diagnosis of earlobe MCC following an excisional biopsy performed by another clinic. Further evaluation, including chest imaging, revealed a mass in the lung. The patient underwent a wide excision of the right earlobe, and video-assisted thoracic surgery on the lung. Pathology confirmed MCC in the right earlobe and adenocarcinoma in the lung. The patient underwent postoperative adjuvant chemotherapy followed by radiotherapy. Up to this point, 3 years after the surgery, there has been no evidence of recurrence.
Language	English
Publishing date	2024-02-22
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3018961-5
ISSN	2384-1710 ; 2384-1621
ISSN (online)	2384-1710
ISSN	2384-1621
DOI	10.7874/jao.2023.00479
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Article ; Online: Characterization of a unique pH-dependent amylosucrase from Deinococcus cellulosilyticus.

Lee, Chang-Young / So, Yun-Sang / Lim, Min-Cheol / Jeong, Soyoung / Yoo, Sang-Ho / Park, Choen-Seok / Jung, Jong-Hyun / Seo, Dong-Ho

International journal of biological macromolecules

2024 , Page(s) 131834

Abstract: The amylosucrase (ASase, EC 2.4.1.4) utilizes sucrose as the sole substrate to catalyze multifunctional reactions. It can naturally synthesize α-1,4-linked glucans such as amylose as well as sucrose isomers with more favorable properties than sucrose ... ...

Abstract	The amylosucrase (ASase, EC 2.4.1.4) utilizes sucrose as the sole substrate to catalyze multifunctional reactions. It can naturally synthesize α-1,4-linked glucans such as amylose as well as sucrose isomers with more favorable properties than sucrose with a lower intestinal digestibility and non-cariogenic properties. The amino acid sequence of the asase gene from Deinococcus cellulosilyticus (DceAS) exhibits low homology with those of other ASases from other Deinococcus species. In this study, we cloned and expressed DceAS and demonstrated its high activity at pH 6 and pH 8 and maintained stability. It showed higher polymerization activity at pH 6 than at pH 8, but similar isomerization activity and produced more turanose and trehalulose at pH 6 than at pH 8 and produced more isomaltulose at pH 8. Furthermore, the molecular weight of DceAS was 226.6 kDa at pH 6 and 145.5 kDa at pH 8, indicating that it existed as a trimer and dimer, respectively under those conditions. Additionally, circular dichroism spectra showed that the DceAS secondary structure was different at pH 6 and pH 8. These differences in reaction products at different pHs can be harnessed to naturally produce sucrose alternatives that are more beneficial to human health.
Language	English
Publishing date	2024-04-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131834
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Article ; Online: Characterization of Natural Compounds as Inhibitors of NS1 Endonuclease from Canine Parvovirus Type 2.

Kwak, So-Hyung / Kim, Hayeong / Yun, Hyeli / Lim, Juho / Kang, Dong-Hyun / Kim, Doman

Journal of microbiology and biotechnology

2023 Volume 33, Issue 6, Page(s) 788–796

Abstract: Canine parvovirus type 2 (CPV-2) has high morbidity and mortality rates in canines. Nonstructural protein 1 (NS1) of CPV-2 has endonuclease activity, initiates viral DNA replication, and is highly conserved. Thus, it is a promising target for antiviral ... ...

Abstract	Canine parvovirus type 2 (CPV-2) has high morbidity and mortality rates in canines. Nonstructural protein 1 (NS1) of CPV-2 has endonuclease activity, initiates viral DNA replication, and is highly conserved. Thus, it is a promising target for antiviral inhibitor development. We overexpressed a 41.9 kDa active recombinant endonuclease in
MeSH term(s)	Animals ; Dogs ; Parvovirus, Canine ; DNA Replication ; Virus Replication ; Endonucleases/genetics ; Molecular Docking Simulation ; Curcumin/pharmacology ; Linoleic Acid ; alpha-Tocopherol ; Viral Nonstructural Proteins/genetics ; DNA, Viral/genetics ; Parvoviridae Infections ; Dog Diseases
Chemical Substances	Endonucleases (EC 3.1.-) ; Curcumin (IT942ZTH98) ; Linoleic Acid (9KJL21T0QJ) ; alpha-Tocopherol (H4N855PNZ1) ; Viral Nonstructural Proteins ; DNA, Viral
Language	English
Publishing date	2023-02-13
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2412195-2
ISSN	1738-8872 ; 1738-8872
ISSN (online)	1738-8872
ISSN	1738-8872
DOI	10.4014/jmb.2211.11040
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Article ; Online: Adverse Reactions After Intradermal Vaccination With JYNNEOS for Mpox in Korea.

Lim, So Yun / Jung, Yu Mi / Kim, Yeonjae / Kim, Gayeon / Jeon, Jaehyun / Chin, BumSik / Kim, Min-Kyung

Journal of Korean medical science

2024 Volume 39, Issue 8, Page(s) e100

Abstract: In response to the Mpox domestic epidemic, South Korea initiated a nationwide vaccination program in May 2023, administering a 0.1 mL intradermal dose of JYNNEOS (Modified Vaccinia Ankara vaccine, Bavarian Nordic) to a high-risk group. To investigate the ...

Abstract	In response to the Mpox domestic epidemic, South Korea initiated a nationwide vaccination program in May 2023, administering a 0.1 mL intradermal dose of JYNNEOS (Modified Vaccinia Ankara vaccine, Bavarian Nordic) to a high-risk group. To investigate the adverse reactions after intradermal JYNNEOS vaccination, an anonymous online survey was conducted at the National Medical Center from May 22 to July 31, 2023. Overall, 142 individuals responded. Over 80% of the respondents reported local reactions of predominantly mild severity. The predominant local reactions were pruritus, redness, and swelling; their incidence rates after the first dose were 66.2%, 48.1%, and 49.4%, respectively; the corresponding rates after the second dose were 69.2%, 60.6%, and 53.8%. Fewer respondents reported systemic symptoms. The most common systemic symptom was fatigue, the incidence rates of which after the first and second doses were 37.7% and 24.6%, respectively. Overall, the intradermally administered JYNNEOS vaccine appeared well tolerated.
MeSH term(s)	Humans ; Mpox (monkeypox) ; Republic of Korea/epidemiology ; Vaccination/adverse effects ; Vaccines ; Smallpox Vaccine/adverse effects ; Injections, Intradermal
Chemical Substances	Vaccines ; Smallpox Vaccine
Language	English
Publishing date	2024-03-04
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2024.39.e100
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Article ; Online: Bilateral Vocal Fold Paralysis After COVID-19 mRNA Vaccination: A Case Report.

Son, Soo Ah / Kim, Yeon Ji / Lim, So Yun / Kim, Hyun Bum

Journal of Korean medical science

2022 Volume 37, Issue 25, Page(s) e201

Abstract: Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was noted to cause coronavirus disease 2019 (COVID-19) in 2019, there have been many trials to develop vaccines against the virus. Messenger ribonucleic acid (mRNA) vaccine as a type of ... ...

Abstract	Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was noted to cause coronavirus disease 2019 (COVID-19) in 2019, there have been many trials to develop vaccines against the virus. Messenger ribonucleic acid (mRNA) vaccine as a type of the vaccine has been developed and commercialized rapidly, but there was not enough time to verify the long-term safety. An 82-year-old female patient was admitted to the emergency room with dyspnea accompanied by stridor three days after the 3rd COVID-19 mRNA vaccination (Comirnaty, Pfizer-BioNTech, USA). The patient was diagnosed with bilateral vocal fold paralysis (VFP) by laryngoscope. Respiratory distress was improved after the intubation and tracheostomy in sequence. The brain, chest, and neck imaging tests, serological tests, cardiological analysis, and immunological tests were performed to evaluate the cause of bilateral VFP. However, no definite cause was found except for the precedent vaccination. Because bilateral VFP can lead to a fatal condition, a quick evaluation is necessary in consideration of VFP when dyspnea with stridor occurs after vaccination.
MeSH term(s)	Aged, 80 and over ; COVID-19/diagnosis ; Dyspnea/etiology ; Female ; Humans ; RNA, Messenger ; Respiratory Sounds/etiology ; SARS-CoV-2 ; Vaccination/adverse effects ; Vocal Cord Paralysis/diagnosis ; Vocal Cord Paralysis/etiology ; Vocal Cords
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2022-06-27
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2022.37.e201
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Article ; Online: Clinicopathologic significance of mismatch repair protein expression in endometrioid endometrial cancer.

Kim, Mi-Kyung / So, Kyeong A / Chun, Yi-Kyeong / Kim, Yun Hwan / Lim, Kyung Taek / Lee, Ki Heon / Kim, Tae Jin

Taiwanese journal of obstetrics & gynecology

2023 Volume 62, Issue 5, Page(s) 724–728

Abstract: Objective: To evaluate the association between mismatch repair (MMR) protein expression and clinico-pathologic outcomes in patients with endometrioid endometrial cancer (EC).: Materials and methods: A retrospective review of the clinico-pathologic ... ...

Abstract	Objective: To evaluate the association between mismatch repair (MMR) protein expression and clinico-pathologic outcomes in patients with endometrioid endometrial cancer (EC). Materials and methods: A retrospective review of the clinico-pathologic outcomes was performed on patients who were diagnosed with EC and had results of MMR protein immunohistochemistry. MMR-deficient (MMR-d) was defined as absence of expression in any of the 4 MMR proteins (MLH1, MSH2, MSH6, and PMS2). Demographics, pathologic variables, and survival outcomes were compared according to the MMR status. Results: A total of 193 EC patients with available MMR expression data were included, of whom 163 patients had endometrioid type EC. Overall, 44 patients (27.0%) were classified as MMR-d. Compared with MMR-proficient (MMR-p) group, MMR-d group was associated with more frequent lymphovascular space invasion (LVSI, p = 0.001). MMR-d was also related with higher risk of lymph node (LN) metastasis in endometrioid type EC (p = 0.008), especially para-aortic LN metastasis. During the median follow-up period of 19.1 months (1-44.5), MMR-d group, especially MLH1/PMS2 subgroup, showed a tendency of reduced PFS (p = 0.036 and p = 0.008, respectively). On Cox regression analysis, however, LN metastasis remained as the only independent risk factor for PFS (p = 0.004) in endometrioid EC, and MLH1/PMS2 loss showed a marginally significant association (p = 0.054). Conclusion: Our findings of the associations between MMR deficiency and poor prognostic factors, such as LVSI and LN metastasis, may suggest the prognostic value of MMR status in EC and need further prospective validation studies.
MeSH term(s)	Humans ; Female ; DNA Mismatch Repair ; Mismatch Repair Endonuclease PMS2 ; Carcinoma, Endometrioid ; Lymph Nodes ; Lymphatic Metastasis
Chemical Substances	Mismatch Repair Endonuclease PMS2 (EC 3.6.1.3)
Language	English
Publishing date	2023-03-16
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2202946-1
ISSN	1875-6263 ; 1875-6263
ISSN (online)	1875-6263
ISSN	1875-6263
DOI	10.1016/j.tjog.2023.07.015
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Article ; Online: Efficient biotransformation of naringenin to naringenin α-glucoside, a novel α-glucosidase inhibitor, by amylosucrase from Deinococcus wulumuquiensis.

Yu, Su-Jeong / So, Yun-Sang / Lim, Changjin / Cho, Chi Heung / Lee, Sang-Gil / Yoo, Sang-Ho / Park, Cheon-Seok / Lee, Byung-Hoo / Min, Kyung Hyun / Seo, Dong-Ho

Food chemistry

2024 Volume 448, Page(s) 139182

Abstract: Amylosucrase (ASase) efficiently biosynthesizes α-glucoside using flavonoids as acceptor molecules and sucrose as a donor molecule. Here, ASase from Deinococcus wulumuqiensis (DwAS) biosynthesized more naringenin α-glucoside (NαG) with sucrose and ... ...

Abstract	Amylosucrase (ASase) efficiently biosynthesizes α-glucoside using flavonoids as acceptor molecules and sucrose as a donor molecule. Here, ASase from Deinococcus wulumuqiensis (DwAS) biosynthesized more naringenin α-glucoside (NαG) with sucrose and naringenin as donor and acceptor molecules, respectively, than other ASases from Deinococcus sp. The biotransformation rate of DwAS to NαG was 21.3% compared to 7.1-16.2% for other ASases. Docking simulations showed that the active site of DwAS was more accessible to naringenin than those of others. The 217th valine in DwAS corresponded to the 221
MeSH term(s)	Flavanones/metabolism ; Flavanones/chemistry ; Deinococcus/enzymology ; Deinococcus/metabolism ; Deinococcus/chemistry ; Deinococcus/genetics ; Glucosyltransferases/metabolism ; Glucosyltransferases/chemistry ; Glucosyltransferases/genetics ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/metabolism ; Glycoside Hydrolase Inhibitors/pharmacology ; Biotransformation ; Bacterial Proteins/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Glucosides/metabolism ; Glucosides/chemistry ; Molecular Docking Simulation ; Kinetics ; alpha-Glucosidases/metabolism ; alpha-Glucosidases/chemistry
Chemical Substances	Flavanones ; naringenin (HN5425SBF2) ; amylosucrase (EC 2.4.1.4) ; Glucosyltransferases (EC 2.4.1.-) ; Glycoside Hydrolase Inhibitors ; Bacterial Proteins ; Glucosides ; alpha-Glucosidases (EC 3.2.1.20)
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.139182
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