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Article ; Online: Integrated Geophysical Prediction of Goaf and Water Accumulation in Pingshuo Dong Open-Cut Mine with Ultrashallow and High Drops

Sheng Zhang / Wenyuan Guan / Suoliang Chang / Qinggang Meng / Yinping Dong / Qiang Chen

Processes, Vol 11, Iss 1653, p

2023 Volume 1653

Abstract: To address safety problems caused by goaf and water accumulation in open-pit mines, the shallow three-dimensional seismic method and transient electromagnetic method were integrated and applied to detect the mining goaf distribution scope and the water ... ...

Abstract	To address safety problems caused by goaf and water accumulation in open-pit mines, the shallow three-dimensional seismic method and transient electromagnetic method were integrated and applied to detect the mining goaf distribution scope and the water accumulation conditions. In view of the special topographic conditions of an ultrashallow layer and high drop in an open-pit mine, we proposed utilizing bin homogenization and multidomain joint denoising to improve the reliability of seismic data. By using seismic-sensitive attributes to predict the goaf, the transient electromagnetic method was employed to further predict the water accumulation in the goaf. The results show that the shallow seismic method could clearly reflect the reflected-wave variation features of the goaf. The features of a junction between a normal seam and goaf vary obviously, and the prediction effect of the goaf boundary with high resolution is in line with the actual situation. Furthermore, taking the goaf scope prediction with the shallow three-dimensional seismic method as a base, targeted transient electromagnetic detection was deployed, with a detailed analysis of the survey-line repeated areas of the shallow seismic and transient electromagnetic methods. Making full use of the advantages of the shallow seismic and transient electromagnetic methods, we propose a reasonable data interpretation method in combination with the special topographic conditions of open-pit mines, which greatly improves the prediction effect of goaf and water accumulation conditions.
Keywords	integrated geophysical prospecting ; goaf prediction ; water accumulation ; open-cut mine ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	550
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Study of the Antimicrobial Activity of the Chinese Dong Ethnic Minority Medicine, Madeng'ai.

Tang, Zhenrong / Zhao, Yannan / Zhang, Zaiqi / Yue, Huan / Wang, Dan / Liu, Shengchun / Tang, Hua

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 3678240

Abstract: ... multidrug-resistant infections are needed. The traditional Dong ethnic minority medicines have emerged ...

Abstract	The overuse of antibiotics has contributed to the emergence of multidrug-resistant bacteria, which poses a challenging task for clinical therapy. Thus, new agents with antibiotic efficacy against multidrug-resistant infections are needed. The traditional Dong ethnic minority medicines have emerged as a new source for prodrug selection. Among them, Madeng'ai (
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/3678240
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Article: RNA-Seq and 16S rRNA Reveals That Tian-Dong-Tang-Gan Powder Alleviates Environmental Stress-Induced Decline in Immune and Antioxidant Function and Gut Microbiota Dysbiosis in

Xie, Xiao-Dong / Zhou, Ying / Sun, Yu-Bo / Yi, Shou-Li / Zhao, Yi / Chen, Qi / Xie, Ying-Hong / Cao, Mi-Xia / Yu, Mei-Ling / Wei, Ying-Yi / Zhang, Ling / Hu, Ting-Jun

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Ammonia stress and nitrite stress can induce immune depression and oxidative stress ... ...

Abstract	Ammonia stress and nitrite stress can induce immune depression and oxidative stress in
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061262
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Article ; Online: Comprehensive analyses of genetic diversities and population structure of the Guizhou Dong group based on 44 Y-markers.

Zhang, Hongling / Huang, Xiaolan / Jin, Xiaoye / Ren, Zheng / Wang, Qiyan / Yang, Meiqing / Xu, Ronglan / Yuan, Xiang / Yang, Daiquan / Liu, Hongyan / Shen, Wanyi / Zhang, Huiying / Que, Yangjie / Huang, Jiang

PeerJ

2023 Volume 11, Page(s) e16183

Abstract: ... the genetic distribution of Y-STRs in the Guizhou Dong population, provide reference data for forensic ... application, and explore the phylogenetic relationships between the Guizhou Dong population and ... other comparison populations.: Methods: Based on the allele profile of 44 Y-markers in the Guizhou Dong group ...

Abstract	Background: The non-recombining region of the human Y chromosome (NRY) is a strictly paternally inherited genetic marker and the best material to trace the paternal lineages of populations. Y chromosomal short tandem repeat (Y-STR) is characterized by high polymorphism and paternal inheritance pattern, so it has been widely used in forensic medicine and population genetic research. This study aims to understand the genetic distribution of Y-STRs in the Guizhou Dong population, provide reference data for forensic application, and explore the phylogenetic relationships between the Guizhou Dong population and other comparison populations. Methods: Based on the allele profile of 44 Y-markers in the Guizhou Dong group, we estimate their allele frequencies and haplotype frequencies. In addition, we also compare the forensic application efficiency of different Y-STR sets in the Guizhou Dong group. Finally, genetic relationships among Guizhou Dong and other reference populations are dissected by the multi-dimensional scaling and the phylogenetic tree. Results: A total of 393 alleles are observed in 312 Guizhou Dong individuals for these Y-markers, with allele frequencies ranging from 0.0032 to 0.9679. The haplotype diversity and discriminatory capacity for these Y-markers in the Guizhou Dong population are 0.99984 and 0.97440, respectively. The population genetic analyses of the Guizhou Dong group and other reference populations show that the Guizhou Dong group has the closest genetic relationship with the Hunan Dong population, and followed by the Guizhou Tujia population. Conclusions: In conclusion, these 44 Y-markers can be used as an effective tool for male differentiation in the Guizhou Dong group. The haplotype data in this study not only enrich the Y-STR data of different ethnic groups in China, but also have important significance for population genetics and forensic research.
MeSH term(s)	Humans ; Phylogeny ; Gene Frequency ; Genetics, Population ; Polymorphism, Genetic/genetics ; Ethnicity/genetics
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16183
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Article: Qi-Dong-Huo-Xue-Yin balances the immune microenvironment to protect against LPS induced acute lung injury.

Zhao, Tian / Wang, Le / Zhang, Yongjun / Ye, Wu / Liu, Juan / Wu, Haiyan / Wang, Fei / Tang, Tingyu / Li, Zhijun

Frontiers in pharmacology

2023 Volume 14, Page(s) 1200058

Abstract: ... of a traditional Chinese medicine, Qi-Dong-Huo-Xue-Yin (QD), in protecting against LPS induced acute lung injury in mouse models ...

Abstract	COVID-19 induces acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and leads to severe immunological changes that threatens the lives of COVID-19 victims. Studies have shown that both the regulatory T cells and macrophages were deranged in COVID-19-induced ALI. Herbal drugs have long been utilized to adjust the immune microenvironment in ALI. However, the underlying mechanisms of herbal drug mediated ALI protection are largely unknown. This study aims to understand the cellular mechanism of a traditional Chinese medicine, Qi-Dong-Huo-Xue-Yin (QD), in protecting against LPS induced acute lung injury in mouse models. Our data showed that QD intrinsically promotes Foxp3 transcription via promoting acetylation of the Foxp3 promoter in CD4
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1200058
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Article ; Online: The Tian-Men-Dong decoction suppresses the tumour-infiltrating G-MDSCs via IL-1β-mediated signalling in lung cancer.

Su, Lin / Zhang, Fei / Liu, Ming-Xi / Li, Hong / Li, Qiang / Zhu, Yang-Zhuangzhuang / Hou, Yi-Fei / Chen, Xiao / Wang, Xiao-Yu / Qian, Chun-Mei / Yao, Chao / Wang, Li-Xin / Jiao, Xiao-Ning / Zhu, Xian-Dan / Xu, Zi-Hang / Zou, Chun-Pu

Journal of ethnopharmacology

2023 Volume 313, Page(s) 116491

Abstract: Ethnopharmacological relevance: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD ...

Abstract	Ethnopharmacological relevance: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively treat lung cancer in China for thousands of years. TD improves the quality of life in lung cancer patients by promoting nourishment of yin and reducing dryness, clearing the lung and removing toxins. Pharmacological studies show that TD contains active antitumour ingredients, but its underlying mechanism remains unknown. Aim of the study: This study aims at exploring potential mechanisms of TD in the treatment of lung cancer by regulating granulocytic-myeloid-derived suppressor cells (G-MDSCs). Materials and methods: An orthotopic lung cancer mouse model was generated by intrapulmonary injection with LLC-luciferase cells in immunocompetent C57BL/6 mice or immunodeficient nude mice. TD/saline was orally administered once to the model mice daily for 4 weeks. Live imaging was conducted to monitor tumour growth. Immune profiles were detected by flow cytometry. H&E and ELISA were applied to test the cytotoxicity of the TD treatment. RT-qPCR and western blotting were performed to detect apoptosis-related proteins in G-MDSCs. A neutralizing antibody (anti-Ly6G) was utilized to exhaust the G-MDSCs via intraperitoneal injection. G-MDSCs were adoptively transferred from wild-type tumour-bearing mice. Immunofluorescence, TUNEL and Annexin V/PI staining were conducted to analyse apoptosis-related markers. A coculture assay of purified MDSCs and T cells labelled with CFSE was performed to test the immunosuppressive activity of MDSCs. The presence of TD/IL-1β/TD + IL-1β in purified G-MDSCs cocultured with the LLC system was used for ex vivo experiments to detect IL-1β-mediated apoptosis of G-MDSCs. Results: TD prolonged the survival of immune competent C57BL/6 mice in an orthotopic lung cancer model, but did not have the same effect in immunodeficient nude mice, indicating that its antitumour properties of TD are exerted by regulating immunity. TD induced G-MDSC apoptosis via the IL-1β-mediated NF-κB signalling cascade leading to effectively weaken the immunosuppressive activity of G-MDSCs and promote CD8 Conclusion: This study reveals for the first time that TD, a classic TCM prescription, is able to regulate G-MDSC activity and trigger its apoptosis via the IL-1β-mediated NF-κB signalling pathway, reshaping the tumour microenvironment and demonstrating antitumour effects. These findings provide a scientific foundation the clinical treatment of lung cancer with TD.
MeSH term(s)	Mice ; Animals ; Myeloid-Derived Suppressor Cells ; Mice, Nude ; NF-kappa B/metabolism ; Quality of Life ; Mice, Inbred C57BL ; Lung Neoplasms/metabolism ; Immunosuppressive Agents/pharmacology ; Tumor Microenvironment
Chemical Substances	NF-kappa B ; Immunosuppressive Agents
Language	English
Publishing date	2023-04-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116491
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Article: Effect of medical herbs in Tian-Dong-Tang-Gan powder on the oxidative stress induced by ammonia and nitrite in Litopenaeus vannamei

Xie, Xiao-Dong / Cao, Mi-Xia / Chen, Qi / Yu, Mei-Ling / Liu, Qing-Yun / Zhao, Yong-Zhen / Zhang, Ling / Hu, Ting-Jun

Aquaculture. 2022 Feb. 15, v. 548

2022

Abstract: In order to evaluate the effect of different doses of Tian-Dong-Tang-Gan powder (TDTGP ...

Abstract	In order to evaluate the effect of different doses of Tian-Dong-Tang-Gan powder (TDTGP) on the immune function of Litopenaeus vannamei, and the molecular mechanism of anti-ammonia stress and anti-nitrite stress, and screening for the best dose, a 35-day feeding experiment and a 72-h ammonia stress or nitrite stress experiment were carried out. The results showed that when compared with the blank control group, the different doses of TDTGP could increase the body weight (BW), percent weight gain (PWG), body length (BL) and percent body length growth (PBLG), and the activities of acid phosphatase (ACP), phenol oxidase (PO), inducible nitric oxide synthase (i-NOS) and the total antioxidant capacity (T-AOC) in the hemolymph of L. vannamei during the feeding experiment, and the effect of TDTGP-4 treatment group was the best. When exposed ammonia or nitrite stress for 72 h, the PO activity was decreased in the hemolymphs, and the mRNA expression of PPO, MT, GSH-Px, Mn-SOD, HSP70 and HIF-1α in the hepatopancreas of L. vannamei. However, different TDTGP doses were fed to the shrimp followed by the application of ammonia and nitrite stresses. The activities of ACP, PO, i-NOS and T-AOC in the hemolymphs remained stable, and the mRNA expression of PPO, ACP, metallothionein (MT), glutathione peroxidase (GSH-Px), superoxide dismutase (Mn-SOD), heat shock protein 70 (HSP70), Hypoxia inducible factor 1α (HIF-1α) and other factors in the hepatopancreas could be maintained or improved to varying degrees in comparison with the blank control group and positive group. These results indicated that the TDTGP can improve growth performance and non-specific immune response of L. vannamei, and by maintaining the mRNA expression of the antioxidative stress factor, such as MT, GSH-PX, Mn-SOD, HSP70, HIF-1α and PPO and ACP in the hepatopancreas, acting against the damage of hepatopancreas caused by ammonia and nitrite stress in L. vannamei. The changes in BW, WG, activities of PO and ACP, and mRNA expression levels of PO, Mn-SOD and ACP indicated that the optimum supplement of dietary TDTGP should be 4 g per·kg.
Keywords	Litopenaeus vannamei ; acid phosphatase ; ammonia ; antioxidant activity ; aquaculture ; body length ; body weight ; gene expression ; glutathione peroxidase ; growth performance ; heat-shock protein 70 ; hemolymph ; hepatopancreas ; hypoxia ; immune response ; inducible nitric oxide synthase ; metallothionein ; monophenol monooxygenase ; nitrites ; oxidative stress ; shrimp ; superoxide dismutase ; weight gain
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2021.737584
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: X-chromosomal STRs for genetic composition analysis of Guizhou Dong group and its phylogenetic relationships with other reference populations.

Yang, Meiqing / Jin, Xiaoye / Ren, Zheng / Wang, Qiyan / Zhang, Hongling / Zhang, Han / Chen, Jing / Ji, Jingyan / Liu, Yubo / Huang, Jiang

Annals of human biology

2022 Volume 48, Issue 7-8, Page(s) 621–626

Abstract: ... chromosome play crucial roles in forensic research and human evolution. Dong group, one of 55 minority groups ... short tandem repeats (STRs) and autosomal insertion/deletion polymorphism (InDels) in Dong groups have been reported ... there is little research about X-STRs in the Dong group.: Aim: Purposes of this study are ...

Abstract	Background: X-chromosomes show a specific genetic mode, which makes genetic markers on the X-chromosome play crucial roles in forensic research and human evolution. Dong group, one of 55 minority groups in China, live in Guizhou, Guangxi, and Hunan provinces. Even though some genetic data of Y chromosomal short tandem repeats (STRs) and autosomal insertion/deletion polymorphism (InDels) in Dong groups have been reported, there is little research about X-STRs in the Dong group. Aim: Purposes of this study are to investigate allelic distributions and forensic statistical parameters of 19 X-STRs in the Guizhou Dong group, and explore the genetic composition of the Guizhou Dong group and its phylogenetic relationships with other reference populations. Subjects and methods: Five hundred and seven Dongs (272 males and 235 females) living in Guizhou province were typed using the AGCU X19 STR kit. Allelic frequencies and forensic parameters of 19 X-STRs in the Guizhou Dong group were calculated. Population genetic analyses of Guizhou Dong and another 17 reference populations were conducted using Results: A total of 230 alleles of 19 X-STRs were identified in all Dongs. The frequencies of 19 loci ranged from 0.0013 to 0.6838. The values for cumulative power of discrimination in males (PDM), cumulative power of discrimination in females (PDF), and four different kinds of mean exclusion chance (MEC_Kruger, MEC_Kishida, MEC_Desmarais, and MEC_Desmarais_du) for the 19 X-STRs in all individuals were 0.999999999999761, 0.9999999999999999999993951, 0.999999964841617, 0.999999999997261, 0.999999999997297, and 0.999999993623172, respectively. Besides, genetic polymorphisms of seven linkage clusters ranged from 0.9381 to 0.9963. In addition, these seven groups showed high polymorphism information content (PIC), PDM, PDF, MEC_Kruger, MEC_Kishida, MEC_Desmarais, and MEC_Desmarais_duo. Population genetic analyses of Guizhou Dong and another 17 reference populations showed that the Guizhou Dong group had close genetic relationships with surrounding Tai-Kadai-speaking, Hmong-Mien-speaking, and Han groups. Conclusion: Nineteen X-STRs displayed high genetic diversities and could be employed for forensic personal identification and paternity analysis in the Guizhou Dong group. Close genetic affinities between Guizhou Dong and surrounding populations were observed based on the 19 X-STRs in 17 reference populations.
MeSH term(s)	China ; Ethnicity ; Female ; Gene Frequency ; Genetics, Population ; Humans ; Male ; Microsatellite Repeats ; Phylogeny
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	186656-4
ISSN	1464-5033 ; 0301-4460
ISSN (online)	1464-5033
ISSN	0301-4460
DOI	10.1080/03014460.2021.2008001
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Article ; Online: Genetic analysis of the mitochondrial DNA control region in Tai-Kadai-speaking Dong population in southwest China.

Ren, Zheng / Feng, Yuhang / Zhang, Hongling / Wang, Qiyan / Yang, Meiqing / Liu, Yubo / Le, Cuiyun / Wang, Jie / Huang, Jiang

Annals of human biology

2022 Volume 49, Issue 7-8, Page(s) 354–360

Abstract: Background: Dong people in Southwest China are officially recognised as an ethnic group, but there ... in a typical Dong population, and to provide help for the construction of a forensic mitochondrial DNA analysis ... region were analysed in 200 individuals of Dong in Guizhou. The haplotype frequencies, haplogroup ...

Abstract	Background: Dong people in Southwest China are officially recognised as an ethnic group, but there has been a lack of population genetic research on this group, especially based on mitochondrial DNA data. Aim: To study the sequences and haplogroups of the mitochondrial DNA control region in a typical Dong population, and to provide help for the construction of a forensic mitochondrial DNA analysis reference database in East Asia. Subjects and methods: The sequences of the mitochondrial DNA control region were analysed in 200 individuals of Dong in Guizhou. The haplotype frequencies, haplogroup distribution and paired Fst values of Guizhou Dong and 51 other populations in the world were calculated and explained to explore the genetic polymorphism and population relationships. Results: A total of 180 haplotypes were detected, with frequencies of 0.005-0.02. All haplotypes were assigned to 97 different haplogroups. The haplotype diversity and random matching probability were 0.998643 and 0.00635, respectively. The paired Fst values and correlation Conclusions: Our study was based on the matrilineal genetic structure of Guizhou Dong to study mitochondrial DNA, which was helpful to promote the establishment of the forensic DNA reference database in East Asia and provide reference for anthropological research.
MeSH term(s)	Humans ; DNA, Mitochondrial/genetics ; Polymorphism, Genetic ; Ethnicity/genetics ; Haplotypes ; China
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	186656-4
ISSN	1464-5033 ; 0301-4460
ISSN (online)	1464-5033
ISSN	0301-4460
DOI	10.1080/03014460.2022.2131334
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Article ; Online: Exposure to multiple metals and diabetes mellitus risk in dong ethnicity in China: from the China multi-ethnic cohort study.

Yang, Qianyuan / Liu, Yalan / Liu, Leilei / Zhang, Linyuan / Lei, Juan / Wang, Qiaorong / Hong, Feng

Environmental geochemistry and health

2022 Volume 45, Issue 5, Page(s) 2435–2445

Abstract: ... of metals with diabetes among the Dong ethnicity in China remains poorly understood. The current study aimed ... among 4479 Dong ethnic participants aged 30-79 years from the China Multi-Ethnic Cohort (CMEC) study. Based ...

Abstract	Metals play an important role in the development of diabetes mellitus (DM). The association of metals with diabetes among the Dong ethnicity in China remains poorly understood. The current study aimed to evaluate the association of single metal exposure and multi-metal co-exposure with DM risk. Urinary concentrations of arsenic, cadmium, chromium, copper, iron, lead, manganese, mercury, molybdenum, nickel, strontium, vanadium, and zinc were measured using inductively coupled plasma-mass spectrometry (ICP-MS) among 4479 Dong ethnic participants aged 30-79 years from the China Multi-Ethnic Cohort (CMEC) study. Based on tertiles, the metal exposure can be divided into three groups: low, middle, and high exposure. Multivariate logistic regression models and principal component analysis were performed to determine exposure to single-metal and multi-metal co-exposure in relation to DM. A decrease in risk of DM was associated with iron (OR = 0.78, 95% CI: 0.61-1.00 and 0.68, 0.53-0.88 for the middle and high vs. low) and strontium (OR = 0.87, 95% CI: 0.69-1.12 and 0.67, 0.51-0.86 for the middle and high vs. low), respectively. A principal component 3 (PC3) characterized by iron and strontium showed an inverse association with DM. A principal component 4 (PC4) characterized by manganese and lead positively associated with DM. Exposure to high concentrations of urinary iron and strontium may reduce the risk of diabetes mellitus. This study revealed an increase in the risk of diabetes mellitus by co-exposure to high concentrations of urinary manganese and lead.
MeSH term(s)	Humans ; Cohort Studies ; Manganese/toxicity ; Ethnicity ; Iron ; Strontium ; Diabetes Mellitus/epidemiology ; Arsenic/toxicity ; Vanadium ; China/epidemiology
Chemical Substances	Manganese (42Z2K6ZL8P) ; Iron (E1UOL152H7) ; Strontium (YZS2RPE8LE) ; Arsenic (N712M78A8G) ; Vanadium (00J9J9XKDE)
Language	English
Publishing date	2022-08-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-022-01366-x
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