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Article: Xue Ping Tablets treat abnormal uterine bleeding via VEGF-ERK1/2 pathway.

Zhong, Suqin / Qian, Lichao / Tan, Yong

2024 Volume 10, Issue 9, Page(s) e30079

Abstract: ... possible mechanisms of Xue Ping tablets (XPT) using a rat model.: Methods: A total of 58 unmated female ...

Abstract	Objective: To investigate the protective effects against abnormal uterine bleeding (AUB) and possible mechanisms of Xue Ping tablets (XPT) using a rat model. Methods: A total of 58 unmated female and 25 male SPF SD rats aged 8-9 weeks were selected. Eight unmated female rats were selected as the blank control group according to the complete random method. The other 50 rats were mated in a female/male ratio of 2:1. In the morning after mating, vaginal smears were collected. Presence of vaginal plug or sperm was regarded as the first day of pregnancy. All pregnant rats were given 8.3 mg/kg of mifepristone by gavage at 8:00 a.m. and 100 μg/kg misoprostol by gavage at 6:00 p.m. on the seventh day of pregnancy to induce incomplete abortion, thereby establishing a rat model of AUB. Forty rats were randomly divided into model, low- (220 mg/kg), medium- (441 mg/kg), high-dose (882 mg/kg) XPT, and positive control groups. The positive group was given 130 mg/kg Gong Xue Ning (GXN). The model group and the blank group were given an equal amount of distilled water. Results: Compared with the model group, the volume of bleeding in the positive and middle- and high-dose XPT groups decreased ( Conclusions: XPT could reduce AUB by inhibiting the inflammatory factors involved in the VEGF-ERK1/2 pathway.
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e30079
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Anti-inflammatory effect of Yu-Ping-Feng-San

Yang, Zhong-Shan / Yan, Jin-Yuan / Han, Ni-Ping / Zhou, Wei / Cheng, Yu / Zhang, Xiao-Mei / Li, Ning / Yuan, Jia-Li

Iranian journal of basic medical sciences

2016 Volume 19, Issue 9, Page(s) 993–1002

Abstract: Objectives: Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely ...

Abstract	Objectives: Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (COPD) recognized as chronic inflammatory disease. However, the molecular mechanism remains unclear. Here we detected the factors involved in transforming growth factor beta 1 (TGF-β1)/Smad2 signaling pathway and inflammatory cytokines, to clarify whether YPFS could attenuate inflammatory response dependent on TGF-β1/Smad2 signaling in COPD rats or cigarette smoke extract (CSE)-treated human bronchial epithelial (Beas-2B) cells. Materials and methods: The COPD rat model was established by exposure to cigarette smoke and intratracheal instillation of lipopolysaccharide, YPFS was administered to the animals. The efficacy of YPFS was evaluated by comparing the severity of pulmonary pathological damage, pro-inflammation cytokines, collagen related genes and the activation of TGF-β1/Smad2 signaling pathway. Furthermore, CSE-treated cells were employed to confirm whether the effect of YPFS was dependent on the TGF-β1/Smad2 signaling via knockdown Smad2 (Si-RNA), or pretreatment with the inhibitor of TGF-β1. Results: Administration of YPFS effectively alleviated injury of lung, suppressed releasing of pro-inflammatory cytokines and collagen deposition in COPD animals ( Conclusion: YPFS accomplished anti-inflammatory effects mainly by suppressing phosphorylation of Smad2, TGF-β1/Smad2 signaling pathway was required for YPFS-mediated anti-inflammation in COPD rats or CSE-treated Beas-2B cells.
Language	English
Publishing date	2016-10-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
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Article: Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model.

Yin, Wen / Zhang, Si-Qi / Pang, Wen-Lin / Chen, Xiao-Jiao / Wen, Jing / Hou, Jiong / Wang, Cui / Song, Li-Yun / Qiu, Zhen-Ming / Liang, Peng-Tao / Yuan, Jia-Li / Yang, Zhong-Shan / Bian, Yao

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 2563–2581

Abstract: ... metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM ...

Abstract	Purpose: Type 2 diabetes mellitus (T2DM) is a complex genetic disease associated with genetic and environmental factors. Previous studies have shown that changes in the gut microbiota may affect the development of host metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM. However, its specific mechanisms must be evaluated. Patients and methods: In the present study, we established an animal model of T2DM using a high‑fat diet (HFD) with intraperitoneal injection streptozotocin injection. Results: The therapeutic effect of TPS decoction on T2DM in mice was initially evaluated. TPS decoction was found to improve hyperglycemia, hyperlipidemia, insulin resistance, and pathological liver, pancreatic, and colon changes. Moreover, it reduced the pro-inflammatory cytokine levels. Based on 16SrRNA sequencing, TPS decoction reduced the Conclusion: TPS decoction improves T2DM and liver function and reduces the risk of hyperglycemia, hyperlipidemia, insulin resistance, pathological organ changes, and inflammatory reactions. The mechanism of TPS decoction in T2DM can be correlated with the reversal of gut microbiota dysfunction and repair of the intestinal mucosal barrier.
Language	English
Publishing date	2022-08-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S375572
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Article ; Online: Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology.

Yang, Shasha / Fu, Qinwei / Deng, Hua / Liu, Zhiqing / Zhong, Juan / Zhu, Xiaoyu / Wang, Qian / Sun, Chuanhui / Wu, Jing

Medicine

2021 Volume 100, Issue 35, Page(s) e26929

Abstract: Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat ...

Abstract	Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat allergic rhinitis (AR) for centuries. However, the mechanisms underlying its effects or its molecular targets in AR treatment are yet to be elucidated. Therefore, the active compounds of YPFP and their targets were collected and identified from the Traditional Chinese Medicine Systems Pharmacology database. Moreover, AR-associated targets were acquired from the GeneCards and Online Mendelian Inheritance in Man database. Proteins interactions network of YPFP presumed targets and AR-associated targets were examined and merged to reveal the candidate YPFP targets against AR.Cytoscape software and BisoGenet Database were employed to perform the Visualization and Integrated Discovery (Cluster Profiler R package, version: 3.8.1). Kyoto Encyclopedia of Genes and Genomes and genome pathway analyses. To identify the key target genes, a gene-pathway network has been constructed.We identified 44 effective active compounds and 622 YPFP targets. Also 1324 target genes related to AR were identified. Twenty pathways, including those of AGE-RAGE signaling, fluid shear stress, atherosclerosis, PI3K-Akt signaling, and tumor necrosis factor signaling was enriched significantly. MAPK1 was identified as the core gene, while others including RELA, AKT1, NFKBIA, IL6, and JUN, were also important in the gene-pathway network. Clearly, network pharmacology can be applied in revealing the molecular targets and mechanisms of action of complex herbal preparations.These findings suggested that YPFP could treat AR by regulating immunological functions, diminishing inflammation, and improving immunity through different pathways.
MeSH term(s)	Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Pharmacology/methods ; Protein Interaction Maps/drug effects ; Rhinitis, Allergic/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026929
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Article ; Online: Yu ping feng san for pediatric allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials.

Liao, Yong / Zhong, Juan / Liu, Shuqin / Dai, Menglin / Liu, Yang / Li, Xinrong / Yang, Yepeng / Zhang, Dazheng / Lai, Dan / Lu, Tao / Zhang, Qinxiu / Zhao, Yu

Medicine

2021 Volume 100, Issue 13, Page(s) e24534

Abstract: Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric ...

Abstract	Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric allergic rhinitis (PAR) patients have yet to be studied systematically. Objectives: To assess the effects and safety of YPFS for treat pediatric patients, allergic rhinitis. Methods: We systematically searched PubMed, EMBASE (Excerpta Medical Database), Cochrane library, Chinese Cochrane Centre's Controlled Trials Register platform, Wanfang Chinese Digital Periodical and Conference Database, China National Knowledge Infrastructure Database, and VIP Chinese Science, from inception dates to November 1, 2019. Randomized controlled trials (RCTs) were included. The risk of bias in the trials was assessed in accordance with the Cochrane Handbook, version 5.1.0. RevMan 5.3 software was used to perform a meta-analysis. Grading of Recommendations Assessment, Development and Evaluation methodology was applied to evaluate the evidence quality for each outcome. The quality of evidence for each outcome measurement was low for 4 outcomes and very low for 5 outcomes. Results: A total of 10 RCTs involving 1069 participants (3-15 years old) fulfilled the inclusion criteria. After exclusion, 8 RCTs were pooled for efficacy assessment. The overall efficacy evaluation result did not show benefit for the experimental group (relative risk 0.32, CI 95% 0.24-0.45; P = .98;) Investigation of variation of serum IgA, immunoglobulin E, IgG in three studies in 2 groups returned no statistical significance. YPFS gave relatively better safety (relative risk 0.29, CI 95% 0.14-0.58; P = .0005; Fig. S8, http://links.lww.com/MD/F751) and lower recurrence rates than did Western medical therapy. Conclusions: Current evidence cannot support the routine use of YPFS for treatment of PAR. This may be due to poor-quality study-design limitations of the included YPFS studies. Our data showed that the use of YPFS for PAR is relatively safe compared to Western medical therapy, but a conclusion could not be drawn because only 5 studies were analyzed. Every study suffered from some methodological limitation. Therefore, further large, rigorously-designed studies are necessary to determine conclusively the utility of YPFS in PAR.
MeSH term(s)	Adolescent ; Child ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Randomized Controlled Trials as Topic ; Rhinitis, Allergic/drug therapy ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024534
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Characteristics and weathering mechanisms of the traditional Chinese blue brick from the ancient city of Ping Yao.

Liu, Jian-Bin / Zhang, Zhong-Jian

Royal Society open science

2020 Volume 7, Issue 8, Page(s) 200058

Abstract: ... nineteenth century. The ancient city of Ping Yao ... a United Nations Educational, Scientific and Cultural Organization (UNESCO) heritage site, is an outstanding example of blue brick architecture. The Ping Yao bricks ... efflorescence were collected from the historical buildings of Ping Yao and were studied with regard ...

Abstract	The traditional blue brick was the dominant clay brick used in Chinese architecture before the mid-nineteenth century. The ancient city of Ping Yao, a United Nations Educational, Scientific and Cultural Organization (UNESCO) heritage site, is an outstanding example of blue brick architecture. The Ping Yao bricks within the damp areas (up to 4 m at highest) of the ancient city's walls and private houses are subjected to various weathering, including contour scaling, flaking, powdering and salt crystallization. This study aims to characterize the properties, analyse weathering mechanisms, determine the main weathering factors and discuss the anti-weathering strategies of blue bricks. To do so, samples of brick and salt efflorescence were collected from the historical buildings of Ping Yao and were studied with regard to their mineralogical and physico-mechanical (e.g. density, porosity, pore size distribution, water absorption and uniaxial compressive strength) properties. The resistance to salt crystallization and frost, and the maximum firing temperatures of the brick samples were determined in the laboratory. Weathering mechanisms and anti-weathering strategies were discussed. Salt crystallization and freeze-thaw cycles were found to be two important factors that lead to brick weathering. An anti-weathering strategy of 'damp blocking, desalination and brick replacing' was discussed based on the laboratory experiments, suggestions in literature and site conditions.
Language	English
Publishing date	2020-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.200058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells.

Du, Yingqing / Zheng, Yuzhong / Yu, Ciel Xiaomei / Zhong, Lishan / Li, Yafang / Wu, Baomeng / Hu, Weihui / Zhu, Elsa Wanyi / Xie, Venus Wei / Xu, Qitian / Zhan, Xingri / Huang, Yamiao / Zeng, Liyi / Zhang, Zhenxia / Liu, Xi / Yin, Jiachuan / Zha, Guangcai / Chan, Kelvin / Tsim, Karl Wah Keung

Frontiers in pharmacology

2021 Volume 12, Page(s) 678126

Abstract: ... however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS ...

Abstract	Cisplatin is one of the first line anti-cancer drugs prescribed for treatment of solid tumors; however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS), a well-known ancient Chinese herbal combination formula consisting of Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, is prescribed as a herbal decoction to treat immune disorders in clinic. To understand the fast-onset action of YPFS as an anti-cancer drug to fight against the drug resistance of cisplatin, we provided detailed analyses of intracellular cisplatin accumulation, cell viability, and expressions and activities of ATP-binding cassette transporters and glutathione S-transferases (GSTs) in YPFS-treated lung cancer cell lines. In cultured A549 or its cisplatin-resistance A549/DDP cells, application of YPFS increased accumulation of intracellular cisplatin, resulting in lower cell viability. In parallel, the activities and expressions of ATP-binding cassette transporters and GSTs were down-regulated in the presence of YPFS. The expression of p65 subunit of NF-κB complex was reduced by treating the cultures with YPFS, leading to a high ratio of Bax/Bcl-2, i.e. increasing the rate of cell death. Prim-O-glucosylcimifugin, one of the abundant ingredients in YPFS, modulated the activity of GSTs, and then elevated cisplatin accumulation, resulting in increased cell apoptosis. The present result supports the notion of YPFS in reversing drug resistance of cisplatin in lung cancer cells by elevating of intracellular cisplatin, and the underlying mechanism may be down regulating the activities and expressions of ATP-binding cassette transporters and GSTs.
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.678126
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Article: The WT1/MVP-Mediated Stabilization on mTOR/AKT Axis Enhances the Effects of Cisplatin in Non-small Cell Lung Cancer by a Reformulated Yu Ping Feng San Herbal Preparation.

Lou, Jian-Shu / Xia, Yi-Teng / Wang, Huai-You / Kong, Xiang-Peng / Yao, Ping / Dong, Tina T X / Zhou, Zhong-Yu / Tsim, Karl W K

Frontiers in pharmacology

2018 Volume 9, Page(s) 853

Abstract: ... herbal medicine has been proposed to resolve this obstacle. Yu Ping Feng San (YPFS), a common Chinese ...

Abstract	Chemo-resistance is an obstacle in therapy of lung cancer. Alternative therapy of using herbal medicine has been proposed to resolve this obstacle. Yu Ping Feng San (YPFS), a common Chinese herbal medicinal mixture, has been reported to show anti-drug resistance on cisplatin (DDP), a common lung cancer drug. To optimize the anti-cancer function of YPFS, different Chinese herbal extracts having known function to overcome lung cancer were screened in combining with YPFS, as to increase the efficacy of DDP in drug resistance lung cancer cell, A549/DDP. Amongst these herbal extracts, Ginkgo Folium exhibited the most promoting sensitized effect. This revised herbal formula, named as YPFS
Language	English
Publishing date	2018-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.00853
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Article ; Online: Characteristics and weathering mechanisms of the traditional Chinese blue brick from the ancient city of Ping Yao

Jian-bin Liu / Zhong-jian Zhang

Royal Society Open Science, Vol 7, Iss

2020 Volume 8

Abstract	The traditional blue brick was the dominant clay brick used in Chinese architecture before the mid-nineteenth century. The ancient city of Ping Yao, a United Nations Educational, Scientific and Cultural Organization (UNESCO) heritage site, is an outstanding example of blue brick architecture. The Ping Yao bricks within the damp areas (up to 4 m at highest) of the ancient city's walls and private houses are subjected to various weathering, including contour scaling, flaking, powdering and salt crystallization. This study aims to characterize the properties, analyse weathering mechanisms, determine the main weathering factors and discuss the anti-weathering strategies of blue bricks. To do so, samples of brick and salt efflorescence were collected from the historical buildings of Ping Yao and were studied with regard to their mineralogical and physico-mechanical (e.g. density, porosity, pore size distribution, water absorption and uniaxial compressive strength) properties. The resistance to salt crystallization and frost, and the maximum firing temperatures of the brick samples were determined in the laboratory. Weathering mechanisms and anti-weathering strategies were discussed. Salt crystallization and freeze–thaw cycles were found to be two important factors that lead to brick weathering. An anti-weathering strategy of ‘damp blocking, desalination and brick replacing’ was discussed based on the laboratory experiments, suggestions in literature and site conditions.
Keywords	blue brick ; ancient city of ping yao ; weathering ; firing temperature ; salt crystallization ; frost resistance ; Science ; Q
Subject code	720
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	The Royal Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anti-inflammatory effect of Yu-Ping-Feng-San via TGF-β1 signaling suppression in rat model of COPD

Zhong-Shan Yang / Jin-Yuan Yan / Ni-Ping Han / Wei Zhou / Yu Cheng / Xiao-Mei Zhang / Ning Li / Jia-Li Yuan

Iranian Journal of Basic Medical Sciences, Vol 19, Iss 9, Pp 993-

2016 Volume 1002

Abstract: Objective(s): Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely ...

Abstract	Objective(s): Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (COPD) recognized as chronic inflammatory disease. However, the molecular mechanism remains unclear. Here we detected the factors involved in transforming growth factor beta 1 (TGF-β1)/Smad2 signaling pathway and inflammatory cytokines, to clarify whether YPFS could attenuate inflammatory response dependent on TGF-β1/Smad2 signaling in COPD rats or cigarette smoke extract (CSE)-treated human bronchial epithelial (Beas-2B) cells. Materials and Methods: The COPD rat model was established by exposure to cigarette smoke and intratracheal instillation of lipopolysaccharide, YPFS was administered to the animals. The efficacy of YPFS was evaluated by comparing the severity of pulmonary pathological damage, pro-inflammation cytokines, collagen related genes and the activation of TGF-β1/Smad2 signaling pathway. Furthermore, CSE-treated cells were employed to confirm whether the effect of YPFS was dependent on the TGF-β1/Smad2 signaling via knockdown Smad2 (Si-RNA), or pretreatment with the inhibitor of TGF-β1. Results: Administration of YPFS effectively alleviated injury of lung, suppressed releasing of pro-inflammatory cytokines and collagen deposition in COPD animals (P
Keywords	COPD ; Pro-inflammatory ; Cytokine ; TGF-β1/Smad2 ; YPFS ; Medicine ; R
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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