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  1. Article ; Online: Cardiopulmonary exercise testing in younger patients with persistent dyspnea following acute, outpatient COVID-19 infection.

    Holley, Aaron B / Fabyan, Kimberly D / Haynes, Zachary A / Holtzclaw, Arthur W / Huprikar, Nikhil A / Shumar, John N / Sheth, Phorum S / Hightower, Stephanie L

    Physiological reports

    2024  Volume 12, Issue 3, Page(s) e15934

    Abstract: Studies using cardiopulmonary exercise testing (CPET) to evaluate persistent dyspnea following infection with COVID-19 have focused on older patients with co-morbid diseases who are post-hospitalization. Less attention has been given to younger patients ... ...

    Abstract Studies using cardiopulmonary exercise testing (CPET) to evaluate persistent dyspnea following infection with COVID-19 have focused on older patients with co-morbid diseases who are post-hospitalization. Less attention has been given to younger patients with post-COVID-19 dyspnea treated as outpatients for their acute infection. We sought to determine causes of persistent dyspnea in younger patients recovering from acute COVID-19 infection that did not require hospitalization. We collected data on all post-COVID-19 patients who underwent CPET in our clinic in the calendar year 2021. Data on cardiac function and respiratory response were abstracted, and diagnoses were assigned using established criteria. CPET data on 45 patients (238.3 ± 124 days post-test positivity) with a median age of 27.0 (22.0-40.0) were available for analysis. All but two (95.6%) were active-duty service members. The group showed substantial loss of aerobic capacity-average VO
    MeSH term(s) Humans ; Exercise Test/methods ; Outpatients ; COVID-19/complications ; Dyspnea/diagnosis ; Dyspnea/etiology ; Respiration ; Exercise Tolerance/physiology
    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A visit guide for adolescent hidradenitis suppurativa: Bridging the divide between pediatric and adult care.

    Toledo, Isabella / Lee, Stephanie S / Park, Helen H / Vuong, Carrie / Conic, Rosalynn R Z / Hightower, George K

    JAAD international

    2022  Volume 6, Page(s) 84–85

    Language English
    Publishing date 2022-01-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2021.11.007
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  3. Article ; Online: Case of a tracheal diverticulum causing airway obstruction.

    Ellis, John / Hightower, Stephanie / Hostler, David

    Postgraduate medical journal

    2018  Volume 95, Issue 1120, Page(s) 104–105

    MeSH term(s) Adult ; Airway Obstruction/diagnostic imaging ; Airway Obstruction/etiology ; Airway Obstruction/surgery ; Bronchoscopy ; Diagnosis, Differential ; Diverticulum/complications ; Diverticulum/diagnostic imaging ; Diverticulum/surgery ; Humans ; Male ; Tomography, X-Ray Computed ; Tracheal Diseases/complications ; Tracheal Diseases/diagnostic imaging ; Tracheal Diseases/surgery
    Language English
    Publishing date 2018-11-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2018-136121
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  4. Article: Post-COVID-19 Pulmonary Fibrosis: Novel Sequelae of the Current Pandemic.

    Ambardar, Shiva Rattan / Hightower, Stephanie L / Huprikar, Nikhil A / Chung, Kevin K / Singhal, Anju / Collen, Jacob F

    Journal of clinical medicine

    2021  Volume 10, Issue 11

    Abstract: Since the initial identification of the novel coronavirus SARS-CoV-2 in December 2019, the COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As effective vaccines and treatments begin to emerge, it will become ... ...

    Abstract Since the initial identification of the novel coronavirus SARS-CoV-2 in December 2019, the COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As effective vaccines and treatments begin to emerge, it will become increasingly important to identify and proactively manage the long-term respiratory complications of severe disease. The patterns of imaging abnormalities coupled with data from prior coronavirus outbreaks suggest that patients with severe COVID-19 pneumonia are likely at an increased risk of progression to interstitial lung disease (ILD) and chronic pulmonary vascular disease. In this paper, we briefly review the definition, classification, and underlying pathophysiology of interstitial lung disease (ILD). We then review the current literature on the proposed mechanisms of lung injury in severe COVID-19 infection, and outline potential viral- and immune-mediated processes implicated in the development of post-COVID-19 pulmonary fibrosis (PCPF). Finally, we address patient-specific and iatrogenic risk factors that could lead to PCPF and discuss strategies for reducing risk of pulmonary complications/sequelae.
    Language English
    Publishing date 2021-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10112452
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  5. Article ; Online: Post-COVID-19 Pulmonary Fibrosis

    Shiva Rattan Ambardar / Stephanie L. Hightower / Nikhil A. Huprikar / Kevin K. Chung / Anju Singhal / Jacob F. Collen

    Journal of Clinical Medicine, Vol 10, Iss 2452, p

    Novel Sequelae of the Current Pandemic

    2021  Volume 2452

    Abstract: Since the initial identification of the novel coronavirus SARS-CoV-2 in December 2019, the COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As effective vaccines and treatments begin to emerge, it will become ... ...

    Abstract Since the initial identification of the novel coronavirus SARS-CoV-2 in December 2019, the COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As effective vaccines and treatments begin to emerge, it will become increasingly important to identify and proactively manage the long-term respiratory complications of severe disease. The patterns of imaging abnormalities coupled with data from prior coronavirus outbreaks suggest that patients with severe COVID-19 pneumonia are likely at an increased risk of progression to interstitial lung disease (ILD) and chronic pulmonary vascular disease. In this paper, we briefly review the definition, classification, and underlying pathophysiology of interstitial lung disease (ILD). We then review the current literature on the proposed mechanisms of lung injury in severe COVID-19 infection, and outline potential viral- and immune-mediated processes implicated in the development of post-COVID-19 pulmonary fibrosis (PCPF). Finally, we address patient-specific and iatrogenic risk factors that could lead to PCPF and discuss strategies for reducing risk of pulmonary complications/sequelae.
    Keywords SARS-CoV-2 ; coronavirus ; pulmonary fibrosis ; interstitial lung disease ; COVID-19 ; ARDS ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Recurrent Inactive Hydatid Cyst of the Liver Causing Restrictive Pulmonary Physiology.

    Boyce, Dacia S K / Ellis, John S / Hightower, Stephanie L / Lew, Jeffery L / Price, Michael W / Lin-Hurtubise, Kevin M / Hostler, Jordanna M

    Hawai'i journal of health & social welfare

    2019  Volume 78, Issue 7, Page(s) 230–235

    Abstract: Hydatid and alveolar cysts are formed by the ... ...

    Abstract Hydatid and alveolar cysts are formed by the helminths
    MeSH term(s) Aged ; Animals ; Echinococcosis/complications ; Echinococcosis/diagnosis ; Echinococcus granulosus/pathogenicity ; Egypt ; Humans ; Liver/abnormalities ; Liver/physiopathology ; Lung Diseases, Obstructive/etiology ; Lung Diseases, Obstructive/physiopathology ; Male ; Radiography/methods ; Recurrence ; Tomography, X-Ray Computed/methods ; Ultrasonography/methods
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2983566-5
    ISSN 2641-5224 ; 2641-5216
    ISSN (online) 2641-5224
    ISSN 2641-5216
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 305: Show issues Location:
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  7. Article ; Online: Correlation of indirect markers of hypercoagulability with thromboelastography in severe coronavirus 2019.

    Hightower, Stephanie / Ellis, Harvey / Collen, Jacob / Ellis, John / Grasso, Ian / Roswarski, Joseph / Cap, Andrew P / Chung, Kevin / Prescher, Lindsey / Kavanaugh, Michael / Brown, Tara / Nau, Mark / Clark, Paul

    Thrombosis research

    2020  Volume 195, Page(s) 69–71

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/isolation & purification ; Biomarkers/blood ; Blood Coagulation ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Critical Illness/epidemiology ; Cross-Sectional Studies ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Thrombelastography ; Thrombophilia/blood ; Thrombophilia/etiology ; Venous Thromboembolism/blood ; Venous Thromboembolism/etiology ; Young Adult
    Chemical Substances Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.07.013
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  8. Article: Detection of increased intracranial pressure by ultrasound.

    Hightower, Stephanie / Chin, Eric J / Heiner, Jason D

    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals

    2011  Volume 12, Issue 3, Page(s) 19–22

    Abstract: Increases in intracranial pressure (ICP) may damage the brain by compression of its structures or restriction of its blood flow, and medical providers my encounter elevated ICP in conventional and non-conventional medical settings. Early identification ... ...

    Abstract Increases in intracranial pressure (ICP) may damage the brain by compression of its structures or restriction of its blood flow, and medical providers my encounter elevated ICP in conventional and non-conventional medical settings. Early identification of elevated ICP is critical to ensuring timely and appropriate management. However, few diagnostic methods are available for detecting increased ICP in an acutely ill patient, which can be performed quickly and noninvasively at the bedside. The optic nerve sheath is a continuation of the dura mater of the central nervous system and can be viewed by ocular ultrasound. Pressure changes within the intracranial cavity affect the diameter of the optic nerve sheath. Data acquired from multiple clinical settings suggest that millimetric increases in the optic nerve sheath diameter detected via ocular ultrasound correlate with increasing levels of ICP. In this review, we discuss the use of ocular ultrasound to evaluate for the presence of elevated ICP via assessment of optic nerve sheath diameter, and describe critical aspects of this valuable diagnostic procedure. Ultrasound is increasingly becoming a medical fixture in the modern battlefield where other diagnostic modalities can be unavailable or impractical to employ. As Special Forces and other austere medical providers become increasingly familiar with ultrasound, ocular ultrasound for the assessment of increased intracranial pressure may help optimize their ability to provide the most effective medical management for their patients.
    MeSH term(s) High-Energy Shock Waves ; Humans ; Intracranial Hypertension ; Intracranial Pressure ; Optic Nerve ; Ultrasonics
    Language English
    Publishing date 2011-12-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3006517-3
    ISSN 1553-9768
    ISSN 1553-9768
    DOI 10.55460/50CD-9MJD
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    Zs.A 7196: Show issues Location:
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  9. Article: Correlation of indirect markers of hypercoagulability with thromboelastography in severe coronavirus 2019

    Hightower, Stephanie / Ellis, Harvey / Collen, Jacob / Ellis, John / Grasso, Ian / Roswarski, Joseph / Cap, Andrew P / Chung, Kevin / Prescher, Lindsey / Kavanaugh, Michael / Brown, Tara / Nau, Mark / Clark, Paul

    Thromb Res

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #642071
    Database COVID19

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  10. Article ; Online: Author Correction: [

    Pascoal, Tharick A / Chamoun, Mira / Lax, Elad / Wey, Hsiao-Ying / Shin, Monica / Ng, Kok Pin / Kang, Min Su / Mathotaarachchi, Sulantha / Benedet, Andrea L / Therriault, Joseph / Lussier, Firoza Z / Schroeder, Frederick A / DuBois, Jonathan M / Hightower, Baileigh G / Gilbert, Tonya M / Zürcher, Nicole R / Wang, Changning / Hopewell, Robert / Chakravarty, Mallar /
    Savard, Melissa / Thomas, Emilie / Mohaddes, Sara / Farzin, Sarah / Salaciak, Alyssa / Tullo, Stephanie / Cuello, A Claudio / Soucy, Jean-Paul / Massarweh, Gassan / Hwang, Heungsun / Kobayashi, Eliane / Hyman, Bradley T / Dickerson, Bradford C / Guiot, Marie-Christine / Szyf, Moshe / Gauthier, Serge / Hooker, Jacob M / Rosa-Neto, Pedro

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 5833

    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33668-0
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