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  1. Article ; Online: Long-Term Outcome of Horizontal Root Fractures in Permanent Teeth: A Retrospective Cohort Study.

    Sheikhnezami, Mahshid / Shahmohammadi, Reza / Jafarzadeh, Hamid / Azarpazhooh, Amir

    Journal of endodontics

    2024  Volume 50, Issue 5, Page(s) 579–589

    Abstract: Introduction: Horizontal root fracture (HRF) is a complex traumatic dental injury that affects the pulp, dentin, cementum, and periodontal ligament. This retrospective cohort study evaluated treatment outcomes in permanent teeth with HRF.: Methods: ... ...

    Abstract Introduction: Horizontal root fracture (HRF) is a complex traumatic dental injury that affects the pulp, dentin, cementum, and periodontal ligament. This retrospective cohort study evaluated treatment outcomes in permanent teeth with HRF.
    Methods: We analyzed clinical and radiographic data from a dental trauma center (2006-2022). Permanent teeth with HRF with a follow up of ≥12 weeks were considered for outcome assessment (defined as clinical normalcy and radiographic healing at the fracture line). Prognostic factors were identified through multivariable logistic regression analyses (P value ≤ .05).
    Results: 125 teeth from 103 patients were included. After a median follow-up of 79 weeks, the overall favorable outcome was 92%. This includes teeth that received emergency splinting/repositioning at baseline (62.2%) and those that received subsequent endodontic intervention for the coronal fragment (baseline: 85%; subsequent follow-ups: 91.8%). Being male and incomplete root development were both significantly associated with a better outcome of splinting/repositioning (OR = 2.58; 95% CI, 1.06-6.24 and OR = 4.37; 95% CI, 1.16-16.41, respectively) and a reduced likelihood of requiring endodontic treatment (OR = 0.44; 95% CI, 0.20-0.96 and OR = 0.24; 95% CI, 0.08-0.76, respectively). Treatment delays surpassing one week were significantly associated with an increased likelihood of requiring endodontic treatment compared to timely presentations within 24 hours (OR = 3.06; 95% CI, 1.07-8.77; P value < .05).
    Conclusion: With timely diagnosis and treatment, and close monitoring, HRF cases can achieve a 92% favorable outcome. Male sex and incomplete root development correlate with improved baseline outcomes and a reduced need for endodontic treatment. Conversely, delayed presentation increases the likelihood of requiring endodontic intervention.
    MeSH term(s) Humans ; Tooth Fractures/therapy ; Retrospective Studies ; Male ; Female ; Tooth Root/injuries ; Adult ; Treatment Outcome ; Dentition, Permanent ; Middle Aged ; Root Canal Therapy ; Young Adult ; Adolescent ; Follow-Up Studies
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752412-2
    ISSN 1878-3554 ; 0099-2399
    ISSN (online) 1878-3554
    ISSN 0099-2399
    DOI 10.1016/j.joen.2024.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Shouldn't Patients With Paradoxical Emboli and Thrombophilia Be Given Anticoagulant Agents?

    Azarpazhooh, M Reza / Bogiatzi, Chrysi / Spence, J David

    JACC. Cardiovascular interventions

    2021  Volume 14, Issue 5, Page(s) 583

    MeSH term(s) Anticoagulants/adverse effects ; Embolism, Paradoxical/etiology ; Humans ; Thrombophilia/diagnosis ; Thrombophilia/drug therapy ; Treatment Outcome
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.12.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Stroke Prevention: Little-Known and Neglected Aspects.

    Azarpazhooh, M Reza / Bogiatzi, Chrysi / Spence, J David

    Cerebrovascular diseases (Basel, Switzerland)

    2021  Volume 50, Issue 6, Page(s) 622–635

    Abstract: Combining available therapies has the potential to reduce the risk of stroke by 80% or more. A comprehensive review of all aspects of stroke prevention would be very lengthy; in this narrative review, we focus on some aspects of stroke prevention that ... ...

    Abstract Combining available therapies has the potential to reduce the risk of stroke by 80% or more. A comprehensive review of all aspects of stroke prevention would be very lengthy; in this narrative review, we focus on some aspects of stroke prevention that are little-known and/or neglected. These include the following: (1) implementation of a Mediterranean diet; (2) B vitamins to lower homocysteine; (3) coordinated approaches to smoking cessation; (4) intensive lipid-lowering therapy; (5) lipid lowering in the elderly; (6) physiologically individualized therapy for hypertension based on renin/aldosterone phenotyping; (7) avoiding excessive blood pressure reduction in patients with stiff arteries; (8) treatment of insulin resistance with pioglitazone in stroke patients with prediabetes and diabetes; (9) impaired activation of clopidogrel in patients with variants of CYP2C19; (10) aspirin pseudoresistance due to enteric coating; (11) rationale for anticoagulation in patients with embolic stroke of unknown source; (12) pharmacologic properties of direct-acting oral anticoagulants that should be considered when choosing among them; (13) the identification of which patients with asymptomatic carotid stenosis are at a high enough risk to benefit from carotid endarterectomy or stenting; and (14) the importance of age in choosing between endarterectomy and stenting. Stroke prevention could be improved by better recognition of these issues and by implementation of the principles derived from them.
    MeSH term(s) Humans ; Stroke/prevention & control
    Language English
    Publishing date 2021-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1069462-6
    ISSN 1421-9786 ; 1015-9770
    ISSN (online) 1421-9786
    ISSN 1015-9770
    DOI 10.1159/000515829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Choosing the right therapy for a patient with asymptomatic carotid stenosis.

    Bogiatzi, Chrysi / Azarpazhooh, M Reza / Spence, J David

    Expert review of cardiovascular therapy

    2020  Volume 18, Issue 2, Page(s) 53–63

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Carotid Stenosis/diagnosis ; Carotid Stenosis/surgery ; Carotid Stenosis/therapy ; Disease Management ; Endarterectomy, Carotid ; Humans ; Stents
    Language English
    Publishing date 2020-02-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2020.1729127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Carotid Vessel-Wall-Volume Ultrasound Measurement via a UNet++ Ensemble Algorithm Trained on Small Data Sets.

    Zhou, Ran / Guo, Fumin / Azarpazhooh, M Reza / Spence, J David / Gan, Haitao / Ding, Mingyue / Fenster, Aaron

    Ultrasound in medicine & biology

    2023  Volume 49, Issue 4, Page(s) 1031–1036

    Abstract: Vessel wall volume (VWV) is a 3-D ultrasound measurement for the assessment of therapy in patients with carotid atherosclerosis. Deep learning can be used to segment the media-adventitia boundary (MAB) and lumen-intima boundary (LIB) and to quantify VWV ... ...

    Abstract Vessel wall volume (VWV) is a 3-D ultrasound measurement for the assessment of therapy in patients with carotid atherosclerosis. Deep learning can be used to segment the media-adventitia boundary (MAB) and lumen-intima boundary (LIB) and to quantify VWV automatically; however, it typically requires large training data sets with expert manual segmentation, which are difficult to obtain. In this study, a UNet++ ensemble approach was developed for automated VWV measurement, trained on five small data sets (n = 30 participants) and tested on 100 participants with clinically diagnosed coronary artery disease enrolled in a multicenter CAIN trial. The Dice similarity coefficient (DSC), average symmetric surface distance (ASSD), Pearson correlation coefficient (r), Bland-Altman plots and coefficient of variation (CoV) were used to evaluate algorithm segmentation accuracy, agreement and reproducibility. The UNet++ ensemble yielded DSCs of 91.07%-91.56% and 87.53%-89.44% and ASSDs of 0.10-0.11 mm and 0.33-0.39 mm for the MAB and LIB, respectively; the algorithm VWV measurements were correlated (r = 0.763-0.795, p < 0.001) with manual segmentations, and the CoV for VWV was 8.89%. In addition, the UNet++ ensemble trained on 30 participants achieved a performance similar to that of U-Net and Voxel-FCN trained on 150 participants. These results suggest that our approach could provide accurate and reproducible carotid VWV measurements using relatively small training data sets, supporting deep learning applications for monitoring atherosclerosis progression in research and clinical trials.
    MeSH term(s) Humans ; Reproducibility of Results ; Imaging, Three-Dimensional/methods ; Carotid Arteries/diagnostic imaging ; Ultrasonography/methods ; Algorithms
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2022.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The impact of socioeconomic status on the burden of atherosclerosis, and the effect of intensive preventive therapy on its progression: A retrospective cohort study.

    Woolsey, Amadene B / Arsang-Jang, Shahram / Spence, J David / Hackam, Daniel G / Azarpazhooh, M Reza

    Atherosclerosis

    2022  Volume 358, Page(s) 29–33

    Abstract: Background and aims: Socioeconomic status (SES) is associated with cardiovascular disease. However, the relationship between SES and atherosclerosis is not well documented. This study aims to explore this relationship.: Methods: This is a ... ...

    Abstract Background and aims: Socioeconomic status (SES) is associated with cardiovascular disease. However, the relationship between SES and atherosclerosis is not well documented. This study aims to explore this relationship.
    Methods: This is a retrospective cohort study in London, Ontario Canada. It includes 6,907 subjects from a vascular prevention centre at baseline, with long term follow up from 1989 to 2021 (total ultrasound examinations 27,103). Using carotid ultrasound, the burden of atherosclerosis was measured as total plaque area (TPA). The Ontario Marginalization Index (OMI) was used to identify SES of participants' neighborhoods. We used a Bayesian hierarchical regression and mixed effects model to identify associations between SES, baseline TPA and plaque progression. In 2003, we implemented more intensive therapy of vascular risk factors after 2003 (called "Treating arteries instead of risk treating factors"); therefore, we compared our findings before and after 2003.
    Results: SES was found to have a significant association with TPA, with lower SES associated with higher TPA (adjusted odds ratio [OR] = 2.22, 95% Credible interval [CrI]: 1.37, 3.66). While we observed a higher rate of plaque progression with lower SES in those treated before 2003 (OR = 1.46, 95% CrI:1.04, 2.06), there was no significant association between plaque progression and SES after implementation more intensive therapy (OR = 0.99, 95% CrI: 0.78, 1.27).
    Conclusions: SES has a strong association with atherosclerosis and should be considered an important risk factor in clinical practice and vascular disease research. Intensive preventive therapy can prevent plaque progression irrespective of baseline SES.
    MeSH term(s) Atherosclerosis/epidemiology ; Atherosclerosis/prevention & control ; Bayes Theorem ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/epidemiology ; Carotid Artery Diseases/prevention & control ; Disease Progression ; Humans ; Plaque, Atherosclerotic ; Retrospective Studies ; Risk Factors ; Social Class
    Language English
    Publishing date 2022-08-15
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2022.08.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Triglyceride/High‐Density Lipoprotein Cholesterol Ratio: A Clue to Metabolic Syndrome, Insulin Resistance, and Severe Atherosclerosis

    Azarpazhooh, M. Reza / Najafi, Farid / Darbandi, Mitra / Kiarasi, Soushyant / Oduyemi, Temilola / Spence, J. David

    Lipids. 2021 July, v. 56, no. 4

    2021  

    Abstract: High serum levels of triglycerides (Tg) and low levels of high‐density lipoprotein cholesterol (HDL‐C) are characteristic of the Metabolic Syndrome (MetS). We assessed the ratio of Tg to HDL‐C as a way to identify MetS and insulin resistance. We also ... ...

    Abstract High serum levels of triglycerides (Tg) and low levels of high‐density lipoprotein cholesterol (HDL‐C) are characteristic of the Metabolic Syndrome (MetS). We assessed the ratio of Tg to HDL‐C as a way to identify MetS and insulin resistance. We also evaluated its association with severity of carotid atherosclerosis. Data were analyzed from three cohorts totaling 13,908 participants. MetS was defined according to the International Diabetes Federation criteria. Optimal cut‐off for Tg/HDL‐C ratio was obtained using Youden's index in receiver‐operating characteristic (ROC) curve analyses. The risk of MetS and IR in those with a Tg/HDL‐C ratio above the optimum cutoff was evaluated by logistic regression analysis. A Tg/HDL‐C ratio above the optimal cutoff level significantly increased the odds ratio for MetS in the three cohorts (OR 6.00, 4.04, and 3.50, least in the healthy population), identified insulin resistance defined by the homeostatic model of insulin resistance (HOMA‐IR) (p < 0.0001), and was strongly associated with atherosclerosis severity (p = 0.0001). Tg/HDL‐C ratio identifies persons with MetS, insulin resistance, and severe atherosclerosis. It should be used more widely to identify patients at high risk. This is clinically important because insulin resistance is treatable.
    Keywords atherosclerosis ; blood serum ; diabetes ; high density lipoprotein cholesterol ; insulin resistance ; metabolic syndrome ; models ; odds ratio ; regression analysis ; risk
    Language English
    Dates of publication 2021-07
    Size p. 405-412.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12302
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Reliability, Reproducibility, and Advantages of Measuring Carotid Total Plaque Area.

    Azarpazhooh, M Reza / Mathiesen, Ellisiv / Rundek, Tatjana / Romanens, Michel / Adams, Ansgar / Armando, Luis / Perez, Hernan / Villafañe, Hugo / Garcia, Nestor H / Ibañez, Borja / Bogiatzi, Chrysi / Tabrizi, Reza / Fuster, Valentín / Spence, J David

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2022  Volume 35, Issue 5, Page(s) 530–532

    MeSH term(s) Carotid Arteries/diagnostic imaging ; Carotid Artery Diseases ; Carotid Stenosis/diagnostic imaging ; Humans ; Plaque, Atherosclerotic/diagnostic imaging ; Reproducibility of Results ; Ultrasonography
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2021.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Measurement of carotid plaque burden: A tool for predicting and preventing dementia?

    Shin, John J / Hachinski, Vladimir / Azarpazhooh, M Reza / Shariatzadeh, Aidin / Spence, J David

    Cerebral circulation - cognition and behavior

    2021  Volume 2, Page(s) 100004

    Abstract: Introduction: Carotid plaque burden is a strong predictor of stroke risk, and preventing stroke reduces the risk of dementia. Treating carotid plaque burden markedly reduces the risk of stroke.: Methods: Among patients age 65-80 years attending a ... ...

    Abstract Introduction: Carotid plaque burden is a strong predictor of stroke risk, and preventing stroke reduces the risk of dementia. Treating carotid plaque burden markedly reduces the risk of stroke.
    Methods: Among patients age 65-80 years attending a stroke prevention clinic, we identified those with a carotid plaque burden in the top 20% of Total Plaque Area (High TPA) and the bottom 20% (Low TPA) and performed cognitive tests: The Montreal Cognitive Assessment test (MoCA), the WAIS-III Digit Symbol-Coding Test (DSST) and Trail-Making Test (TMT) part A and B.
    Results: There were 31 patients recruited; 11 Low TPA (5 men) and 20 High TPA (17 men),
    Discussion: A high carotid plaque burden identifies patients at risk of cognitive impairment. Because carotid plaque burden is treatable, and treating it markedly reduces the risk of stroke, we suggest that measurement of plaque burden is a useful tool for both prediction of cognitive impairment, and prevention of dementia.
    Language English
    Publishing date 2021-01-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2450
    ISSN (online) 2666-2450
    DOI 10.1016/j.cccb.2021.100004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Triglyceride/High-Density Lipoprotein Cholesterol Ratio: A Clue to Metabolic Syndrome, Insulin Resistance, and Severe Atherosclerosis.

    Azarpazhooh, M Reza / Najafi, Farid / Darbandi, Mitra / Kiarasi, Soushyant / Oduyemi, Temilola / Spence, J David

    Lipids

    2021  Volume 56, Issue 4, Page(s) 405–412

    Abstract: High serum levels of triglycerides (Tg) and low levels of high-density lipoprotein cholesterol (HDL-C) are characteristic of the Metabolic Syndrome (MetS). We assessed the ratio of Tg to HDL-C as a way to identify MetS and insulin resistance. We also ... ...

    Abstract High serum levels of triglycerides (Tg) and low levels of high-density lipoprotein cholesterol (HDL-C) are characteristic of the Metabolic Syndrome (MetS). We assessed the ratio of Tg to HDL-C as a way to identify MetS and insulin resistance. We also evaluated its association with severity of carotid atherosclerosis. Data were analyzed from three cohorts totaling 13,908 participants. MetS was defined according to the International Diabetes Federation criteria. Optimal cut-off for Tg/HDL-C ratio was obtained using Youden's index in receiver-operating characteristic (ROC) curve analyses. The risk of MetS and IR in those with a Tg/HDL-C ratio above the optimum cutoff was evaluated by logistic regression analysis. A Tg/HDL-C ratio above the optimal cutoff level significantly increased the odds ratio for MetS in the three cohorts (OR 6.00, 4.04, and 3.50, least in the healthy population), identified insulin resistance defined by the homeostatic model of insulin resistance (HOMA-IR) (p < 0.0001), and was strongly associated with atherosclerosis severity (p = 0.0001). Tg/HDL-C ratio identifies persons with MetS, insulin resistance, and severe atherosclerosis. It should be used more widely to identify patients at high risk. This is clinically important because insulin resistance is treatable.
    MeSH term(s) Atherosclerosis/blood ; Atherosclerosis/etiology ; Carotid Arteries/pathology ; Cholesterol, HDL/blood ; Female ; Humans ; Insulin Resistance/physiology ; Male ; Metabolic Syndrome/blood ; ROC Curve ; Risk Factors ; Sensitivity and Specificity ; Triglycerides/blood
    Chemical Substances Cholesterol, HDL ; Triglycerides
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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