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Article: [The effect of Ba Duan Jin on the balance of community-dwelling older adults: a cluster randomized control trial].

Duan, L L / Zhao, Y B / Er, Y L / Ye, P P / Wang, W / Gao, X / Deng, X / Jin, Y / Wang, Y / Ji, C R / Ma, X Y / Gao, C / Zhao, Y H / Zhu, S Q / Su, S Z / Guo, X E / Peng, J J / Yu, Y / Yang, C /

Su, Y Y / Zhao, M / Guo, L H / Wu, Y P / Luo, Y N / Meng, R L / Xu, H F / Liu, H Z / Ruan, H H / Xie, B / Zhang, H M / Liao, Y H / Chen, Y / Wang, L H

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2024 Volume 45, Issue 2, Page(s) 250–256

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Male ; Humans ; Female ; Aged ; Independent Living ; Exercise ; Health Education ; China
Language	Chinese
Publishing date	2024-02-26
Publishing country	China
Document type	Randomized Controlled Trial ; English Abstract ; Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20230506-00283
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Zs.B 3276: Show issues

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Article ; Online: The Role of Zuo Jin Wan in Modulating the Tumor Microenvironment of Colorectal Cancer.

Wang, Jiajia / Hua, Dongming / Li, Mengyao / Liu, Ningning / Zhang, Yingru / Zhao, Yiyang / Jiang, Shasha / Hu, Xueqing / Wang, Yan / Zhu, Huirong

Combinatorial chemistry & high throughput screening

2024

Abstract: ... 4 compounds, respectively. Huang Lian targets 146 proteins, and Wu Zhu Yu targets 28 proteins based ...

Abstract	Introduction: Traditional Chinese medicine (TCM) can modulate the immune function of tumor patients in various ways. Zuojin Wan (ZJW, a 6:1 ratio of Huanglian and Wuzhuyu) can modulate the microenvironment of ulcerative colitis, but its role in regulating the CRC microenvironment remains unclear. Exploring the role of ZJW in CRC immunomodulation may improve the antitumor effect of existing immunotherapeutic strategies. Material and methods: The active compounds of each herb in ZJW were obtained from the HIT2.0 database with literature evidence. Single-cell RNA sequencing data of CRC were obtained from published studies (PMID: 32451460, 32103181, and 32561858). Pathway enrichment was analyzed using the reactome database, and intergenic correlation analysis was performed using the corrplot R software package. ZJW-regulated gene expression was verified by RT-qPCR. Results: Huanglian and Wuzhu contain 19 and 4 compounds, respectively. Huang Lian targets 146 proteins, and Wu Zhu Yu targets 28 proteins based on evidence from the literature. ZJW regulates a range of biological processes associated with immune function, including cytokine signaling and Toll-Like Receptor 4 (TLR4) cascade. ZJW regulates malignant CRC cells, immune cells (including T-cells, B-cells, mast cells, NK/NKT cells, and myeloid cells), and other non-immune cells (including endothelial cells, enteric glial cells, and pericytes). We confirmed that ZJW significantly downregulated the expression of TIMP1 and MTDH. Conclusions: ZJW regulates a range of cells in the CRC microenvironment, including malignant CRC, immune cells, and stromal cells. In CRC cell lines, downregulation of TIMP1 and MTDH by ZJW may play an important role in the immunomodulation in CRC.
Language	English
Publishing date	2024-01-25
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073281374231228041841
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Zs.A 5577: Show issues

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Article ; Online: Jin Tiange capsule combined with rehabilitation training for the treatment of skeletal muscle atrophy after orthopedic surgery.

Xu, Jie / Wang, Sheng-Gen / Xu, Jia-Cheng / Zhu, Jian-Wei

Asian journal of surgery

2024

Language	English
Publishing date	2024-04-23
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.04.048
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Article: [Carbon Dioxide Mitigation Co-effect Analysis of Structural Adjustment Measures in the "2+26" Cities in the Jing-Jin-Ji Region and Its Surroundings].

Yang, Tian-Qi / Wang, Hong-Chang / Zhang, Chen / Zhu, Jin-Wei / Cui, Yu-Tao / Tan, Yu-Ling / Shu, Yun

Huan jing ke xue= Huanjing kexue

2022 Volume 43, Issue 11, Page(s) 5315–5325

Abstract: The Three-Year Action Plan for Winning the Blue Sky Defense Battle states that structural adjustments of industrial, energy, transportation, and land use are important to significantly reduce ... ...

Abstract	The Three-Year Action Plan for Winning the Blue Sky Defense Battle states that structural adjustments of industrial, energy, transportation, and land use are important to significantly reduce CO
MeSH term(s)	Cities ; Carbon Dioxide/analysis ; Air Pollution/prevention & control ; Air Pollution/analysis ; Air Pollutants/analysis ; Greenhouse Gases/analysis
Chemical Substances	Carbon Dioxide (142M471B3J) ; Air Pollutants ; Greenhouse Gases
Language	Chinese
Publishing date	2022-09-23
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202111234
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Article ; Online: Successful complementary therapy with traditional Chinese medicine in a patient with Qi and Jin deficiency symptoms from adult-onset Still's disease: A case report.

Yu, Xiali / Zhu, Yuqing / Xu, Junmiao / Song, Xinwei

Explore (New York, N.Y.)

2023 Volume 20, Issue 2, Page(s) 256–260

Abstract: ... deficiency syndrome who received combined treatment with formulated Zhu Ye Shi Gao Decoction (ZYSGD).: Case ...

Abstract	Background: Adult-onset Still's disease (AOSD) is a rare yet well-documented polygenic and systemic autoinflammatory disease characterized by recurrent spiking fever, transient skin rash, arthralgia, and sore throat. Traditional Chinese medicine (TCM) holds a significant role in complementary and alternative medicine. This study presents a unique case of a female AOSD patient with concurrent Qi and fluid deficiency syndrome who received combined treatment with formulated Zhu Ye Shi Gao Decoction (ZYSGD). Case presentation: In this case, a 28-year-old female patient presented with a 15-day history of fever and skin rash accompanied by sore throat, fatigue, myalgia, and arthralgia. Additionally, leucocytosis, aminotransferase abnormalities, and elevated inflammatory factor levels were observed. Infectious diseases, solid tumors, and hematological disorders were all ruled out. Anti-infective treatments proved ineffective, leading to the final diagnosis of AOSD. Glucocorticoid therapy provided only partial relief. Consequently, formulated ZYSGD and hepatoprotective drugs were added to the glucocorticoid treatment. Subsequently, the patient's symptoms and inflammatory biomarkers showed improvement. After discharge, the patient's condition remained stable while continuing the formulated ZYSGD in combination with 4 mg of Medrolol (qd) during a 10-month follow-up period. Conclusion: This case report suggests that formulated ZYSGD could be a viable option for complementary and alternative therapy for late-stage AOSD, especially in cases involving both Qi and body fluid imbalances.
MeSH term(s)	Adult ; Humans ; Female ; Medicine, Chinese Traditional ; Still's Disease, Adult-Onset/drug therapy ; Still's Disease, Adult-Onset/complications ; Glucocorticoids/therapeutic use ; Qi ; Exanthema/complications ; Pharyngitis/complications ; Arthralgia/complications
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2183945-1
ISSN	1878-7541 ; 1550-8307
ISSN (online)	1878-7541
ISSN	1550-8307
DOI	10.1016/j.explore.2023.08.006
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Article ; Online: Complete Genome Sequence of Glutamicibacter mysorens NBNZ-009, Isolated from Jin Lake Sediment.

Wang, Yueying / Su, Xin / Liu, Jie / Fang, Wei / Zhu, Lei

Microbiology resource announcements

2022 Volume 11, Issue 10, Page(s) e0076222

Abstract: Members of the ... ...

Abstract	Members of the genus
Language	English
Publishing date	2022-09-07
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.00762-22
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Article: Exploring the impact of mass migration in Jin Dynasty by psycholinguistic analysis on Classical Chinese legacy text.

Xiong, Huan / Wu, Gengxuan / Li, Sijia / Xue, Shujie / Li, Hua / Zhu, Tingshao

Frontiers in psychology

2022 Volume 13, Page(s) 993141

Abstract: The first mass migration in China took place at the end of the Western Jin, which resulted ... exerted significant impacts on the gentry of the Jin Dynasty. This paper used a huge volume of Classical ... Chinese legacy text of Jin gentry members. We used CC-LIWC to calculate frequencies of different word ...

Abstract	The first mass migration in China took place at the end of the Western Jin, which resulted in the southward transfer of the Central Plains Culture and brought about huge social changes. Such social changes exerted significant impacts on the gentry of the Jin Dynasty. This paper used a huge volume of Classical Chinese legacy text of Jin gentry members. We used CC-LIWC to calculate frequencies of different word categories used in these text contents and conducted an analysis of variance to measure significant differences between the three groups. We found 16 categories of words with significant differences and calculated their effect sizes, such as tense markers (tensem),
Language	English
Publishing date	2022-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.993141
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Article: Zuo Jin Wan Reverses the Resistance of Colorectal Cancer to Oxaliplatin by Regulating the MALAT1/miR-200s/JNK Signaling Pathway.

Wei, Zhenzhen / Zhou, Jing / Yu, Hao / Pu, Yunzhou / Cheng, Yuelei / Zhang, Yi / Ji, Qing / Zhu, Huirong

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 3032407

Abstract: ... of colorectal cancer (CRC). Our previous work showed that Zuo Jin Wan (ZJW), a traditional Chinese medicine ...

Abstract	Background: Oxaliplatin (L-OHP) is a common chemotherapy drug used in the treatment of colorectal cancer (CRC). Our previous work showed that Zuo Jin Wan (ZJW), a traditional Chinese medicine prescription, could improve sensitivity to L-OHP in the treatment of CRC, but the detailed mechanism is not clear. In previous mechanistic studies, we found that the miR-200s expression in CRC is associated with L-OHP sensitivity through regulation of MDR1/p-gp and the downstream c-JunN-terminal kinase (JNK) signaling pathway. Moreover, lncRNA-MALAT1 offers great potential in the regulation of drug resistance by interacting with miR-200s. Therefore, in this work, we explored whether ZJW could reverse L-OHP resistance in CRC by regulating MALAT1, miR-200s, and the downstream signaling pathway. Methods: Cell Counting Kit-8 and flow cytometry were used to detect the effects of ZJW combined with L-OHP on chemotherapy tolerance and cell apoptosis of HCT116/L-OHP cells. Western blotting and quantitative real-time PCR (qRT-PCR) were used to detect the activation of the JNK signaling pathway and the protein and mRNA expression levels of the drug resistance-related MDR1/ABCB1 gene in HCT116/L-OHP cells treated with ZJW. The binding sites of MALAT1 and miR-200s were predicted by bioinformatics tools and confirmed by qRT-PCR. qRT-PCR was used to detect the expression of miR-200s and MALAT1 in HCT116/L-OHP cells treated with ZJW. A xenograft model of CRC in nude mice was established to observe the effect of ZJW combined with L-OHP on the growth of subcutaneously transplanted tumors. Apoptosis in tumor cells was detected by TUNEL staining. The activation of the JNK signaling pathway and the expression of drug resistance-related proteins were detected by immunohistochemistry and immunofluorescence. qRT-PCR was used to detect the expression of miR-200s and the MALAT1 gene in the tumors. Results: Our study showed that ZJW could significantly decrease the proliferation and promote apoptosis of HCT116/L-OHP cells treated with L-OHP. We further proved that ZJW could reverse the drug resistance of HCT116/L-OHP cells by reducing MALAT1, indirectly upregulating miR-200s, alleviating the activation of the JNK signaling axis, and downregulating the expression of resistance proteins such as MDR1/ABCB1 and ABCG2. ZJW combined with L-OHP inhibited the growth of subcutaneously transplanted tumors and induced apoptosis in nude mice. ZJW reduced the expression of MALAT1 and upregulated the expression of miR-200s in transplanted tumors. In addition, ZJW also alleviated the activation of the JNK signaling pathway while reducing the expression of MDR1/ABCB1 and ABCG2. Conclusions: Our study identified that MALAT1 promotes colorectal cancer resistance to oxaliplatin by reducing the miR-200s expression. ZJW may reverse chemoresistance by inhibiting the expression of MALAT1 and regulating the miR-200s/JNK pathway, providing an experimental basis for the clinical application of ZJW in relieving chemotherapy resistance.
Language	English
Publishing date	2022-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/3032407
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Zs.A 5995: Show issues

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Article: Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Wen-Yu-Jin against Pulmonary Fibrosis in a Mouse Model.

Wang, Lu / Zhu, Wenxiang / Sun, Rui / Liu, Jing / Ma, Qihong / Zhang, Binbin / Shi, Yuanyuan

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7753508

Abstract: ... side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases ...

Abstract	Background: Pulmonary fibrosis (PF) is a devastating lung disease, resulting in gas exchange dysfunction until death. The two drugs approved by the FDA, pirfenidone and nintedanib, have obvious side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases. The potential effects and the underlying mechanism of WYJ against PF are unclear. Purpose: Employing network pharmacology, molecular docking, and in vivo and in vitro experiments to explore the potential effects and underlying mechanisms of WYJ in the treatment of PF. Methods: Ultra-high pressure liquid chromatography combined with linear ion trap-orbital tandem mass spectrometry (UHPLC-LTQ-orbital trap) was used to identify compounds of WYJ. We got PF-related targets and WYJ compounds-related targets from public databases and further completed critical targets exploration, network construction, and pathway analysis by network pharmacology. Molecular docking predicted binding activity of WYJ compounds and critical targets. Based on the above results, in vivo and in vitro experiments validated the potential effects and mechanisms of WYJ against PF. Results: 23 major compositions of WYJ were identified based on UHPLC-LTQ-Orbitrap. According to the results of network pharmacology, STAT3, SRC, IL6, MAPK1, AKT1, EGFR, MAPK8, MAPK14, and IL1B are critical therapeutic targets. Molecular docking results showed that most of the compounds have good binding activities with critical targets. The results of in vivo and in vitro experiments showed that WYJ alleviated the process of fibrosis by targeting MAPK and STAT3 pathways. Conclusion: Network pharmacology, molecular docking, and in vivo and in vitro experiments showed the potential effects and mechanisms of WYJ against PF, which provides a theoretical basis for the treatment of WYJ with PF.
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7753508
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Zs.A 5995: Show issues

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Article ; Online: Integrated microbiome-metabolomics analysis reveals the potential therapeutic mechanism of Zuo-Jin-Wan in ulcerative colitis.

Cai, Ying / Li, Siju / Zhang, Xiaojun / Cao, Xueqin / Liu, Deliang / Zhu, Yanglu / Ye, Simin / Xu, Zengmei / Liao, Qiongfeng / Hong, Yanjun / Xie, Zhiyong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2021 Volume 98, Page(s) 153914

Abstract: ... pathology of ulcerative colitis (UC), while Zuo-Jin-Wan (ZJW), a traditional Chinese medicine has shown ...

Abstract	Background: Dysregulation in gut microbiota and host cometabolome contributes to the complicated pathology of ulcerative colitis (UC), while Zuo-Jin-Wan (ZJW), a traditional Chinese medicine has shown therapeutic effects against UC with its underlying mechanism remains elusive. Purpose: This study utilized an integrated analysis combining gut microbiome and host cometabolism to disclose the potential therapeutic mechanism of ZJW on dextran sulfate sodium (DSS)-induced UC in rats. Methods: We first evaluated the therapeutic effects of ZJW treatment in DSS-induced rat model. 16S rRNA sequencing, Results: Our results showed that UC symptoms in ZJW rats were significantly attenuated. Marked decline in microbial diversity in ZJW group was accompanied by its correspondent function adjustment. Specific enrichment of genus Bacteroides, Sutterella, Akkermansia and Roseburia along with the major varying amino acid metabolism and lipid metabolism were observed meantime. Metabolic data further corroborated that ZJW-related metabolic changes were basically gathered in amino acid metabolism, carbohydrate/energy metabolism and lipid metabolism. Of note, some biochemical parameters were deeply implicated with the discriminative microbial genera and metabolites involved in tricarboxylic acid (TCA) cycle and amino acid metabolism, indicating the microbiome-metabolome association in gut microbiota-metabolite-phenotype axis during UC treatment of ZJW. Conclusion: For the first time, integrated microbiome-metabolome analysis depicted that ZJW could alleviate DSS-induced UC in rats via a crosstalk between gut microbiota and host cometabolites.
Language	English
Publishing date	2021-12-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153914
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