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Article ; Online: Consent, Cryopreserved Sperm, and Posthumous Conception: Navigating the Ethical Maze.

Gowda, Vrushab / Abou Ghayda, Ramy

2021 Volume 156, Page(s) e93–e95

MeSH term(s)	Bioethical Issues ; Cryopreservation ; Humans ; Informed Consent ; Male ; Posthumous Conception/ethics ; Spermatozoa
Language	English
Publishing date	2021-07-05
Publishing country	United States
Document type	Editorial
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2021.06.024
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Zs.MO 275: Show issues

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Article ; Online: There is not enough evidence to support the claim that Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count.

Rhodes, Stephen / Badreddine, Jad / Abou Ghayda, Ramy

Andrology

2022 Volume 11, Issue 1, Page(s) 6–7

MeSH term(s)	Humans ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Semen ; Vaccination/adverse effects
Chemical Substances	BNT162 Vaccine ; COVID-19 Vaccines
Language	English
Publishing date	2022-11-21
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13316
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Article ; Online: The association of socioeconomic status with semen parameters in a cohort of men in the United States.

Badreddine, Jad / Sellke, Nicholas / Rhodes, Stephen / Thirumavalavan, Nannan / Abou Ghayda, Ramy

Andrology

2024

Abstract: Background: Socioeconomic differences are present within the population of men who experience infertility and seek treatment.: Objective: To study the association of socioeconomic status with semen parameters in a group of men using mail-in semen ... ...

Abstract	Background: Socioeconomic differences are present within the population of men who experience infertility and seek treatment. Objective: To study the association of socioeconomic status with semen parameters in a group of men using mail-in semen analyses. Materials and methods: The records of 11,134 men that used mail-in semen analyses from a fertility company were identified. Their demographic information, semen parameters, and ZIP codes were collected. Area deprivation index (ADI) was used as a proxy for socioeconomic status and was calculated for each individual using their ZIP codes in order to measure their level of socioeconomic deprivation. A higher ADI signifies a more deprived area. The association between ADI and the semen parameters of this group was measured using linear regression analysis adjusted for age. Results: 11,134 men were included in the study with a median age of 35 years (interquartile range (IQR): 32-40) and a median ADI of 83 (IQR: 68-97). The cohort had a median sperm concentration of 31 million/mL (IQR: 14-59), median total sperm count of 123 million (IQR: 57-224), median total motile sperm of 35 million (IQR: 9-95), median total motility of 32% (IQR: 15-52), progressive motility of 22% (IQR: 9-38), and morphology percent normal of 4% (IQR: 2-7). Higher ADI, indicating lower socioeconomic status, was negatively associated with various semen parameters, including sperm concentration, total sperm count, total motile sperm, and total and progressive motility. Discussion and conclusion: Men who live in more deprived areas are more likely to have worse semen parameters. Further research is needed to thoroughly examine the impact of socioeconomic status on male fertility. A comprehensive approach that targets upstream social, economic, and healthcare factors can possibly alleviate the negative association of socioeconomic status with fertility and semen parameters.
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13614
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Article ; Online: Malpractice litigation related to management of varicocele: a legal database review.

Zhou, Eric / Sellke, Nicholas / Sun, Helen / Tay, Kimberly / Mortach, Sherry / Ghayda, Ramy Abou / Loeb, Aram / Thirumavalavan, Nannan

International journal of impotence research

2024

Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-024-00881-y
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Article ; Online: Uncovering the interhospital price variations for vasectomies in the United States.

Mortach, Sherry / Sellke, Nicholas / Rhodes, Stephen / Sun, Helen H / Tay, Kimberly / Abou Ghayda, Ramy / Loeb, Aram / Thirumavalavan, Nannan

International journal of impotence research

2024

Abstract: Due to the historic lack of transparency in healthcare pricing in the United States, the degree of price variation for vasectomy is largely unknown. Our study aims to assess characteristics of hospitals reporting prices for vasectomy as well as price ... ...

Abstract	Due to the historic lack of transparency in healthcare pricing in the United States, the degree of price variation for vasectomy is largely unknown. Our study aims to assess characteristics of hospitals reporting prices for vasectomy as well as price variation associated with hospital factors and insurance status. A cross-sectional analysis was performed in October, 2022 using the Turquoise Database which compiles publicly available hospital pricing data. The database was queried for vasectomy prices to identify the cash (paid by patients not using insurance), commercial (negotiated by private insurers) and Medicare and Medicaid prices for vasectomies. Hospital characteristics of those that reported a price for vasectomy and those that did not were compared and pricing differences based on hospital ownership and reimbursement source were determined using multivariable linear regression analysis. Overall, only 24.7% (1657/6700) of hospitals reported a price for vasectomy. Those that reported a price had more beds (median 117 vs 80, p < 0.001), more physicians (median 1745 vs 1275, p < 0.001). They were also more likely to be nonprofit hospitals (77% vs 14%, p < 0.001) and to be in well-resourced areas (ADI 91.7 vs 94.4, p < 0.001). Both commercial prices and cash prices for vasectomy were lower at nonprofit hospitals than at for-profit hospitals (commercial: $1959.47 vs $2861.56, p < 0.001; cash: $1429.74 vs $3185.37, p < 0.001). Our study highlights the current state of pricing transparency for vasectomy in the United States. Patients may be counseled to consider seeking vasectomy at a nonprofit hospital to reduce their costs, especially when paying with cash. These findings also suggest a need for new policies to target areas with decreased price transparency to reduce price disparities.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-024-00833-6
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Article ; Online: The Racial and Socioeconomic Characteristics of Men Using Mail-in Semen Testing Kits in the United States.

Sellke, Nicholas / Badreddine, Jad / Rhodes, Stephen / Thirumavalavan, Nannan / Abou Ghayda, Ramy

Urology

2023 Volume 180, Page(s) 135–139

Abstract: Objective: To describe the racial and socioeconomic characteristics of men using mail-in semen testing kits for their fertility care in the United States over 3 years.: Methods: A cross-sectional analysis was conducted of men who used mail-in semen ... ...

Abstract	Objective: To describe the racial and socioeconomic characteristics of men using mail-in semen testing kits for their fertility care in the United States over 3 years. Methods: A cross-sectional analysis was conducted of men who used mail-in semen analyses from a single direct-to-consumer (DTC) fertility platform between 2020 and 2022. Age, race/ethnicity, place of residence, and education level of men using mail-in semen analysis kits was collected from user questionnaires. Zip code level socioeconomic status was estimated using the Area Deprivation Index (ADI). These characteristics were compared to the overall population of the United States. Results: 4342 men used mail-in semen analyses from a single DTC fertility company between 2020 and 2022 and completed the questionnaire. The median age of this cohort was 36 (IQR: 32,40) years. The group consisted of predominantly white men (72%), with 7.9% Asian and only 5.1% Black, 3.2% Hispanic, 0.4% Indian American, 0.1% pacific islander, 5.8% mixed race, and 2.8% other groups. 45.8% of the group had completed college, 22% had a master's degree, and 9% had a doctoral degree. The mean ADI was 83.47 (SD 21.44) compared to the average ADI of 100 for the general US population (P < .005). Conclusion: DTC mail-in semen analyses have the potential to improve access to affordable fertility care. Racial and ethnic minorities and lower socioeconomic classes are underrepresented for men seeking DTC fertility testing as they are for men presenting for in-office fertility care. Additional studies are needed to determine the factors responsible for these discrepancies.
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2023.07.023
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Article ; Online: The Variability of Semen Parameters With Sexual Abstinence Using Mail-in Sperm Testing Is Similar to That Seen With Traditional In-Office Semen Analysis.

Badreddine, Jad / Rhodes, Stephen / Sellke, Nicholas / Navarrete, Felipe / Keller, Stephanie / Gowda, Vrushab / Simon, Paul H G / Abou Ghayda, Ramy

American journal of men's health

2023 Volume 17, Issue 5, Page(s) 15579883231197910

Abstract: The impact of ejaculatory abstinence on semen parameters using in-office semen analyses has been well-established; however, their variability has not been evaluated in men using mail-in semen analysis kits. Our study aims to describe how the sperm ... ...

Abstract	The impact of ejaculatory abstinence on semen parameters using in-office semen analyses has been well-established; however, their variability has not been evaluated in men using mail-in semen analysis kits. Our study aims to describe how the sperm parameters using mail-in semen analysis tests change with abstinence and validate their equivalence to those seen with in-office semen analysis tests. We retrospectively reviewed the semen analysis results of men using mail-in semen analysis tests provided by Give Legacy, Inc (Legacy) facilities from 2019 to 2021. We collected their demographic information, abstinence duration, and semen parameters (conventional and kinematic) from their records. Semen samples were categorized as normozoospermic and oligozoospermic based on concentration. The shape of the relationship between abstinence duration and semen parameters was assessed via generalized additive models. We have collected 3,469 unique samples provided by 2,609 (75%) normozoospermic men and 860 (25%) oligozoospermic from all over the United States. In normozoospermic men, longer periods of sexual abstinence were linked to higher levels of sperm concentration, total sperm count, and total motile sperm. However, there was a decline in both total and progressive motility. Conversely, in oligozoospermic men, extended periods of abstinence led to a rapid decline in total motile sperm, as well as total and progressive motility. There was no significant correlation observed between sexual abstinence and variations in sperm morphology. Our study shows that variability of sperm parameters with abstinence, as measured through mail-in semen analysis tests, is comparable to the patterns observed with conventional in-office sperm testing.
MeSH term(s)	Male ; Humans ; Semen ; Sexual Abstinence ; Retrospective Studies ; Postal Service ; Sperm Motility ; Semen Analysis ; Spermatozoa
Language	English
Publishing date	2023-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/15579883231197910
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Article ; Online: Driving Time and Compliance With Postvasectomy Semen Analysis Drop-Off.

Ward, Brandon / Sellke, Nicholas / Rhodes, Stephen / Sun, Helen / Tay, Kimberly / Abou Ghayda, Ramy / Thirumavalavan, Nannan / Loeb, Aram

Urology

2023 Volume 184, Page(s) 1–5

Abstract: Objective: Current literature demonstrates low rates of compliance with postvasectomy semen analysis (PVSA). This study sought to determine factors that correlate with noncompliance with PVSA.: Methods: A retrospective chart review was conducted for ... ...

Abstract	Objective: Current literature demonstrates low rates of compliance with postvasectomy semen analysis (PVSA). This study sought to determine factors that correlate with noncompliance with PVSA. Methods: A retrospective chart review was conducted for patients who underwent vasectomy within our institution. ArcGIS was used to securely calculate the shortest driving time from each patient's home to the single PVSA drop-off site. Kruskal-Wallis and chi-square tests analyzed characteristics of patients who did and did not submit PVSA samples, and odds ratios were calculated via multivariable logistic regression. Results: Overall, 515 of 850 patients met inclusion criteria and 219 (42.5%) of these had no recorded PVSA. Of those with a PVSA, 59% were completed within 16 weeks. Compliance with PVSA was associated with a shorter median driving time (30.6 minutes vs 34.2 minutes), more vasectomy in the operating room (19% vs 10%), and attending a follow-up appointment (40% vs 17%) (P < .005 for all). Age at vasectomy, race, ethnicity, BMI, paternity, and location of preoperative consultation did not significantly differ between the groups. Each 30 minutes of driving time was associated with a 48% reduction in the odds of a patient submitting PVSA at any time (OR 0.52 [0.37, 0.73]). Conclusion: As driving time to a drop-off center appears to be a significant barrier to PVSA compliance, providers should consider alternative collection methods such as at-home or in-office semen analysis.
MeSH term(s)	Humans ; Retrospective Studies ; Semen Analysis ; Body Fluids ; Semen ; Ethnicity
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2023.11.027
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Article ; Online: Readability assessment of online men's health education materials from the Sexual Medicine Society of North America, American Urologic Association, and European Association of Urology.

Callegari, Michael / Pominville, Raymond / Zhou, Christopher / Piyevsky, Brandon / Jesse, Erin / Prunty, Megan / Loeb, Aram / Thirumavalavan, Nannan / Abou-Ghayda, Ramy

International journal of impotence research

2022 Volume 35, Issue 8, Page(s) 758–760

Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Letter
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-022-00609-w
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Article: Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application.

Megerian, Mark F / Kim, Jae Seok / Badreddine, Jad / Hong, Sung Hwi / Ponsky, Lee E / Shin, Jae Il / Ghayda, Ramy Abou

Aging and disease

2023 Volume 14, Issue 3, Page(s) 840–857

Abstract: Melatonin is an endogenous indoleamine that has been shown to inhibit tumor growth in laboratory models of prostate cancer. Prostate cancer risk has additionally been associated with exogenous factors that interfere with normal pineal secretory activity, ...

Abstract	Melatonin is an endogenous indoleamine that has been shown to inhibit tumor growth in laboratory models of prostate cancer. Prostate cancer risk has additionally been associated with exogenous factors that interfere with normal pineal secretory activity, including aging, poor sleep, and artificial light at night. Therefore, we aim to expand on the important epidemiological evidence, and to review how melatonin can impede prostate cancer. More specifically, we describe the currently known mechanisms of melatonin-mediated oncostasis in prostate cancer, including those that relate to the indolamine's ability to modulate metabolic activity, cell cycle progression and proliferation, androgen signaling, angiogenesis, metastasis, immunity and oxidative cell status, apoptosis, genomic stability, neuroendocrine differentiation, and the circadian rhythm. The outlined evidence underscores the need for clinical trials to determine the efficacy of supplemental, adjunct, and adjuvant melatonin therapy for the prevention and treatment of prostate cancer.
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2625789-0
ISSN	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2022.1010
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