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Article ; Online: Microbiota signatures associated with invasive

Yan, Jia-Ying / Lin, Tsung-Han / Jong, Yu-Tang / Hsueh, Jun-Wei / Wu, Sze-Hsien / Lo, Hsiu-Jung / Chen, Yee-Chun / Pan, Chien-Hsiung

Frontiers in cellular and infection microbiology

2024 Volume 13, Page(s) 1278600

Abstract: ... Candida ... ...

Abstract	Candida albicans
MeSH term(s)	Humans ; Animals ; Mice ; Candida albicans ; Microbiota ; Candidiasis, Invasive ; Gastrointestinal Tract/microbiology ; Candidiasis
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1278600
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Article: Safety and efficacy of early varenicline prescription in hospitalized patients with acute myocardial infarction: East Asian population.

Lo, Chien-Hsien / Li, Li-Ching / Chang, Kai-Wei / Tsai, Chin-Feng / Su, Chun-Hung / Lo, Tse-Hsien / Yen, Chi-Hua / Chan, Kuei-Chuan

Journal of the Formosan Medical Association = Taiwan yi zhi

2023 Volume 122, Issue 10, Page(s) 1035–1041

Abstract: Background: Smoking is a strong risk factor for patients with acute myocardial infarction (AMI). Varenicline is commonly used as a smoking cessation medication, but little is known about its usage in patients with AMI, particularly in hospitalized ... ...

Abstract	Background: Smoking is a strong risk factor for patients with acute myocardial infarction (AMI). Varenicline is commonly used as a smoking cessation medication, but little is known about its usage in patients with AMI, particularly in hospitalized patients. Methods: This is a prospective observational, single-center study collected from May 2018 to July 2021. Study patients underwent percutaneous coronary intervention for AMI. The primary end point was set as safety of varenicline, focusing on any serious adverse cardiac events within 24 weeks after treatment. Efficacy of smoking abstinence was also assessed through self-reports of complete abstinence over a week before the 24- week clinic visit. Results: A total of 162 patients hospitalized with AMI were enrolled in our study. Mean age was 56.7 ± 9.95 years and 97% of the patients were male. Most patients (93.2%) received their first dose of varenicline during hospitalization. Time from admission to first dose of study medication was 2.31 ± 2.73 days and duration of drug intake was 7.41 ± 5.18 weeks. At week 24, only one patient had recurrent myocardial infarction, five patients had undergone revascularization for target lesion failure, and no additional patients developed stroke or died. In terms of efficacy, the rate of smoking abstinence was 79%. Light smokers found it easier to quit smoking than heavy smokers. Conclusion: This study may represent the first report on the safety and efficacy of early initiation of varenicline treatment in East Asian population hospitalized due to AMI who recently underwent percutaneous coronary intervention.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Middle Aged ; East Asian People ; Myocardial Infarction/drug therapy ; Nicotinic Agonists/therapeutic use ; Smoking Cessation ; Treatment Outcome ; Varenicline/therapeutic use
Chemical Substances	Nicotinic Agonists ; Varenicline (W6HS99O8ZO)
Language	English
Publishing date	2023-03-29
Publishing country	Singapore
Document type	Observational Study ; Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2023.03.016
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Article ; Online: Tongue feature dataset construction and real-time detection.

Chang, Wen-Hsien / Chen, Chih-Chieh / Wu, Han-Kuei / Hsu, Po-Chi / Lo, Lun-Chien / Chu, Hsueh-Ting / Chang, Hen-Hong

PloS one

2024 Volume 19, Issue 3, Page(s) e0296070

Abstract: Background: Tongue diagnosis in traditional Chinese medicine (TCM) provides clinically important, objective evidence from direct observation of specific features that assist with diagnosis. However, the current interpretation of tongue features requires ...

Abstract	Background: Tongue diagnosis in traditional Chinese medicine (TCM) provides clinically important, objective evidence from direct observation of specific features that assist with diagnosis. However, the current interpretation of tongue features requires a significant amount of manpower and time. TCM physicians may have different interpretations of features displayed by the same tongue. An automated interpretation system that interprets tongue features would expedite the interpretation process and yield more consistent results. Materials and methods: This study applied deep learning visualization to tongue diagnosis. After collecting tongue images and corresponding interpretation reports by TCM physicians in a single teaching hospital, various tongue features such as fissures, tooth marks, and different types of coatings were annotated manually with rectangles. These annotated data and images were used to train a deep learning object detection model. Upon completion of training, the position of each tongue feature was dynamically marked. Results: A large high-quality manually annotated tongue feature dataset was constructed and analyzed. A detection model was trained with average precision (AP) 47.67%, 58.94%, 71.25% and 59.78% for fissures, tooth marks, thick and yellow coatings, respectively. At over 40 frames per second on a NVIDIA GeForce GTX 1060, the model was capable of detecting tongue features from any viewpoint in real time. Conclusions/significance: This study constructed a tongue feature dataset and trained a deep learning object detection model to locate tongue features in real time. The model provided interpretability and intuitiveness that are often lacking in general neural network models and implies good feasibility for clinical application.
MeSH term(s)	Tongue ; Neural Networks, Computer ; Medicine, Chinese Traditional/methods
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296070
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Article ; Online: Navigation-Assisted One-Staged Posterior Spinal Fusion Using Pedicle Screw Instrumentation in Adolescent Idiopathic Scoliosis-A Case Series.

Chang, Pao-Lung / Chen, Michael Jian-Wen / Hsiao, Pang-Hsuan / Lin, Chia-Yu / Lo, Yuan-Shun / Tseng, Chun / Li, Ling-Yi / Lai, Chien-Ying / Chen, Hsien-Te

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 2

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Female ; Humans ; Adolescent ; Male ; Scoliosis/surgery ; Scoliosis/complications ; Pedicle Screws/adverse effects ; Retrospective Studies ; Blood Loss, Surgical ; Spinal Fusion/methods ; Imaging, Three-Dimensional ; Tomography, X-Ray Computed/methods ; Surgery, Computer-Assisted ; Kyphosis/surgery ; Postoperative Complications/etiology ; Treatment Outcome ; Thoracic Vertebrae
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60020300
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Article: Ruptured Sinus of Valsalva Aneurysm Presenting as Acute Coronary Syndrome with Cardiogenic Shock and aVR ST-Elevation - A Case Report.

Huang, Sheng-Wei / Lo, Chien-Hsien / Tsai, Chin-Feng / Su, Chun-Hung

Acta Cardiologica Sinica

2019 Volume 36, Issue 1, Page(s) 76–80

Language	English
Publishing date	2019-10-11
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	1051394-2
ISSN	1011-6842
ISSN	1011-6842
DOI	10.6515/ACS.202001_36(1).20190731A
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Article ; Online: Transparent tissue in solid state for solvent-free and antifade 3D imaging.

Hsiao, Fu-Ting / Chien, Hung-Jen / Chou, Ya-Hsien / Peng, Shih-Jung / Chung, Mei-Hsin / Huang, Tzu-Hui / Lo, Li-Wen / Shen, Chia-Ning / Chang, Hsiu-Pi / Lee, Chih-Yuan / Chen, Chien-Chia / Jeng, Yung-Ming / Tien, Yu-Wen / Tang, Shiue-Cheng

Nature communications

2023 Volume 14, Issue 1, Page(s) 3395

Abstract: Optical clearing with high-refractive-index (high-n) reagents is essential for 3D tissue imaging. However, the current liquid-based clearing condition and dye environment suffer from solvent evaporation and photobleaching, causing difficulties in ... ...

Abstract	Optical clearing with high-refractive-index (high-n) reagents is essential for 3D tissue imaging. However, the current liquid-based clearing condition and dye environment suffer from solvent evaporation and photobleaching, causing difficulties in maintaining the tissue optical and fluorescent features. Here, using the Gladstone-Dale equation [(n-1)/density=constant] as a design concept, we develop a solid (solvent-free) high-n acrylamide-based copolymer to embed mouse and human tissues for clearing and imaging. In the solid state, the fluorescent dye-labeled tissue matrices are filled and packed with the high-n copolymer, minimizing scattering in in-depth imaging and dye fading. This transparent, liquid-free condition provides a friendly tissue and cellular environment to facilitate high/super-resolution 3D imaging, preservation, transfer, and sharing among laboratories to investigate the morphologies of interest in experimental and clinical conditions.
MeSH term(s)	Mice ; Humans ; Animals ; Imaging, Three-Dimensional/methods ; Solvents ; Fluorescent Dyes ; Acrylamide ; Optical Imaging
Chemical Substances	Solvents ; Fluorescent Dyes ; Acrylamide (20R035KLCI)
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39082-4
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Article ; Online: Correspondence on '

Lo, Chien Hsien / Wang, Yu-Hsun / Tsai, Chin Feng / Chan, Kuei Chuan / Li, Li Ching / Lo, Tse Hsien / Su, Chun Hung / Wei, James Cheng-Chung

Annals of the rheumatic diseases

2020

Keywords	covid19
Language	English
Publishing date	2020-08-07
Publishing country	England
Document type	Letter
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2020-218589
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Article ; Online: Role of the ROS-JNK Signaling Pathway in Hypoxia-Induced Atrial Fibrotic Responses in HL-1 Cardiomyocytes.

Tsai, Chin-Feng / Yang, Shun-Fa / Lo, Chien-Hsien / Chu, Hsiao-Ju / Ueng, Kwo-Chang

International journal of molecular sciences

2021 Volume 22, Issue 6

Abstract: By promoting atrial structural remodeling, atrial hypoxia contributes to the development of the atrial fibrillation substrate. Our study aimed to investigate the modulatory effect of hypoxia on profibrotic activity in cultured HL-1 cardiomyocytes and ... ...

Abstract	By promoting atrial structural remodeling, atrial hypoxia contributes to the development of the atrial fibrillation substrate. Our study aimed to investigate the modulatory effect of hypoxia on profibrotic activity in cultured HL-1 cardiomyocytes and explore the possible signaling transduction mechanisms of profibrotic activity in vitro. Hypoxia (1% O
MeSH term(s)	Animals ; Biomarkers ; Cell Line ; Fibrosis ; Gene Expression ; Heart Atria/metabolism ; Heart Atria/pathology ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; MAP Kinase Signaling System ; Models, Biological ; Myocytes, Cardiac/metabolism ; Reactive Oxygen Species/metabolism
Chemical Substances	Biomarkers ; Hypoxia-Inducible Factor 1, alpha Subunit ; Reactive Oxygen Species
Language	English
Publishing date	2021-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22063249
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Article: Cardiovascular Disease Burden Attributable to High Body Mass Index in Taiwan.

Yeh, Tzu-Lin / Chen, Yi-Hsuan Roger / Hsu, Hsin-Yin / Tsai, Ming-Chieh / Wu, Yun-Chun / Lo, Wei-Cheng / Huang, Tzu-Hsuan / Liu, Bo-Chen / Lin, Hsien-Ho / Chien, Kuo-Liong

Acta Cardiologica Sinica

2023 Volume 39, Issue 4, Page(s) 628–642

Abstract: Background: Studies on disease burden in Taiwan are lacking. We aimed to quantify the burden of cardiovascular disease (CVD) attributable to high body mass index (BMI) in Taiwan.: Methods: Using a comparative risk assessment approach from the Global ... ...

Abstract	Background: Studies on disease burden in Taiwan are lacking. We aimed to quantify the burden of cardiovascular disease (CVD) attributable to high body mass index (BMI) in Taiwan. Methods: Using a comparative risk assessment approach from the Global Burden of Disease study, we estimated the population attributable fraction (PAF), attributable CVD burden, and disability-adjusted life years (DALYs) according to sex, age, and area of residence in Taiwan. The BMI distribution for the population was obtained from the National Health Interview Survey in 2013. CVD was defined as an ischemic heart disease or stroke. Results: The attributable PAF for CVD from high BMI was 18.0% (19.6% in men and 15.6% in women), and it was highest (42.7%) in those aged 25-30 years. Adults aged 60-65 years had the highest absolute DALYs (11,546). The average relative age-standardized attributable burden was 314 DALYs per 100,000 person-years, and it was highest in those aged 75-80 years (1,407 DALYs per 100,000 person-years). Those living in Taitung County had the highest PAF of 21.9% and the highest age-standardized attributable burden (412 DALYs). Conclusions: In Taiwan, an 18% reduction in CVDs could be achieved if obesity/overweight was prevented. Prevention was most effective in early adulthood. The absolute CVD burden from obesity/overweight was highest in middle-aged men, and the relative burden was highest in older adults. Resource allocation in targeted populations and specific areas to eliminate CVD and health inequities is urgently required.
Language	English
Publishing date	2023-06-30
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	1051394-2
ISSN	1011-6842
ISSN	1011-6842
DOI	10.6515/ACS.202307_39(4).20221219C
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Article ; Online: A newly evolved rice-specific gene JAUP1 regulates jasmonate biosynthesis and signalling to promote root development and multi-stress tolerance.

Muzaffar, Adnan / Chen, Yi-Shih / Lee, Hsiang-Ting / Wu, Cheng-Chieh / Le, Trang Thi / Liang, Jin-Zhang / Lu, Chun-Hsien / Balasubramaniam, Hariharan / Lo, Shuen-Fang / Yu, Lin-Chih / Chan, Chien-Hao / Chen, Ku-Ting / Lee, Miin-Huey / Hsing, Yue-Ie / Ho, Tuan-Hua David / Yu, Su-May

Plant biotechnology journal

2024 Volume 22, Issue 5, Page(s) 1417–1432

Abstract: Root architecture and function are critical for plants to secure water and nutrient supply from the soil, but environmental stresses alter root development. The phytohormone jasmonic acid (JA) regulates plant growth and responses to wounding and other ... ...

Abstract	Root architecture and function are critical for plants to secure water and nutrient supply from the soil, but environmental stresses alter root development. The phytohormone jasmonic acid (JA) regulates plant growth and responses to wounding and other stresses, but its role in root development for adaptation to environmental challenges had not been well investigated. We discovered a novel JA Upregulated Protein 1 gene (JAUP1) that has recently evolved in rice and is specific to modern rice accessions. JAUP1 regulates a self-perpetuating feed-forward loop to activate the expression of genes involved in JA biosynthesis and signalling that confers tolerance to abiotic stresses and regulates auxin-dependent root development. Ectopic expression of JAUP1 alleviates abscisic acid- and salt-mediated suppression of lateral root (LR) growth. JAUP1 is primarily expressed in the root cap and epidermal cells (EPCs) that protect the meristematic stem cells and emerging LRs. Wound-activated JA/JAUP1 signalling promotes crosstalk between the root cap of LR and parental root EPCs, as well as induces cell wall remodelling in EPCs overlaying the emerging LR, thereby facilitating LR emergence even under ABA-suppressive conditions. Elevated expression of JAUP1 in transgenic rice or natural rice accessions enhances abiotic stress tolerance and reduces grain yield loss under a limited water supply. We reveal a hitherto unappreciated role for wound-induced JA in LR development under abiotic stress and suggest that JAUP1 can be used in biotechnology and as a molecular marker for breeding rice adapted to extreme environmental challenges and for the conservation of water resources.
MeSH term(s)	Oryza/genetics ; Oryza/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Breeding ; Plant Growth Regulators/metabolism ; Gene Expression Regulation, Plant/genetics ; Cyclopentanes ; Oxylipins
Chemical Substances	jasmonic acid (6RI5N05OWW) ; Plant Proteins ; Plant Growth Regulators ; Cyclopentanes ; Oxylipins
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7652
ISSN (online)	1467-7652
ISSN	1467-7652
DOI	10.1111/pbi.14276
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