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  1. Book: Neural stem cells in health and diseases

    Shetty, Ashok K.

    2016  

    Author's details ed. Ashok K. Shetty
    Language English
    Size XXIII, 548 S. : Ill., graph. Darst.
    Publisher World Scientific
    Publishing place New Jersey u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018519979
    ISBN 978-981-4623-17-9 ; 981-4623-17-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 3951 available for loan (reading room) Lesesaal EG

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  2. Book ; Online: New Directions in the Management of Status Epilepticus

    Kirmani, Batool F. / Shetty, Ashok K. / Shapiro, Lee A.

    2019  

    Keywords Medicine ; Neurology & clinical neurophysiology ; Status Epilepticus ; Epilepsy ; Seizures ; Anticonvulsants ; Autoimmune epilepsy ; Temporal Lobe Epilepsy ; Epileptogenesis
    Size 1 electronic resource (106 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231205
    ISBN 9782889457274 ; 2889457273
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses.

    Nguyen, Faith / Shetty, Ashok K

    Military Medical Research

    2024  Volume 11, Issue 1, Page(s) 5

    MeSH term(s) Humans ; Male ; Stress Disorders, Post-Traumatic ; Cytokines ; Persian Gulf Syndrome/complications ; Veterans ; Immunity
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2768940-2
    ISSN 2054-9369 ; 2054-9369
    ISSN (online) 2054-9369
    ISSN 2054-9369
    DOI 10.1186/s40779-023-00508-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Can rapamycin slow down memory decline in Alzheimer's disease with seizures?

    Shetty, Ashok K

    Brain : a journal of neurology

    2022  Volume 145, Issue 1, Page(s) 14–16

    MeSH term(s) Alzheimer Disease/complications ; Alzheimer Disease/drug therapy ; Cognitive Dysfunction ; Humans ; Memory Disorders/drug therapy ; Memory Disorders/etiology ; Seizures/drug therapy ; Sirolimus
    Chemical Substances Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awab474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Editorial: Advances in adult neurogenesis.

    Hitoshi, Seiji / Mandyam, Chitra D / Shetty, Ashok K

    Frontiers in neuroscience

    2024  Volume 17, Page(s) 1307844

    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1307844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Gulf War illness with or without post-traumatic stress disorder

    Faith Nguyen / Ashok K. Shetty

    Military Medical Research, Vol 11, Iss 1, Pp 1-

    differential symptoms and immune responses

    2024  Volume 3

    Keywords Gulf War Illness ; Immune response ; Interleukin-15 ; Natural killer cells ; Post-traumatic stress disorder ; T lymphocytes ; Medicine (General) ; R5-920 ; Military Science ; U
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  7. Article ; Online: Extracellular Vesicles Derived From Neural Stem Cells, Astrocytes, and Microglia as Therapeutics for Easing TBI-Induced Brain Dysfunction.

    Hering, Catherine / Shetty, Ashok K

    Stem cells translational medicine

    2023  Volume 12, Issue 3, Page(s) 140–153

    Abstract: Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs), and microglia (MDEVs) have neuroregenerative properties. This review discusses the therapeutic efficacy of NSC-EVs, ADEVs, and MDEVs in traumatic brain injury (TBI) ...

    Abstract Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs), and microglia (MDEVs) have neuroregenerative properties. This review discusses the therapeutic efficacy of NSC-EVs, ADEVs, and MDEVs in traumatic brain injury (TBI) models. The translational value and future directions for such EV therapy are also deliberated. Studies have demonstrated that NSC-EV or ADEV therapy can mediate neuroprotective effects and improve motor and cognitive function after TBI. Furthermore, NSC-EVs or ADEVs generated after priming parental cells with growth factors or brain-injury extracts can mediate improved therapeutic benefits. However, the therapeutic effects of naïve MDEVs are yet to be tested rigorously in TBI models. Studies using activated MDEVs have reported both adverse and beneficial effects. NSC-EV, ADEV, or MDEV therapy for TBI is not ready for clinical translation. Rigorous testing of their efficacy for preventing chronic neuroinflammatory cascades and enduring motor and cognitive impairments after treatment in the acute phase of TBI, an exhaustive evaluation of their miRNA or protein cargo, and the effects of delayed EV administration post-TBI for reversing chronic neuroinflammation and enduring brain impairments, are needed. Moreover, the most beneficial route of administration for targeting EVs into different neural cells in the brain after TBI and the efficacy of well-characterized EVs from NSCs, astrocytes, or microglia derived from human pluripotent stem cells need to be evaluated. EV isolation methods for generating clinical-grade EVs must also be developed. Overall, NSC-EVs and ADEVs promise to mitigate TBI-induced brain dysfunction, but additional preclinical studies are needed before their clinical translation.
    MeSH term(s) Animals ; Humans ; Microglia ; Astrocytes/metabolism ; Disease Models, Animal ; Neural Stem Cells/metabolism ; Brain ; Extracellular Vesicles/metabolism
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2642270-0
    ISSN 2157-6580 ; 2157-6580
    ISSN (online) 2157-6580
    ISSN 2157-6580
    DOI 10.1093/stcltm/szad004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia.

    Shetty, Ashok K

    Aging and disease

    2020  Volume 11, Issue 2, Page(s) 462–464

    Abstract: A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes ( ...

    Abstract A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes (
    Keywords covid19
    Language English
    Publishing date 2020-03-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2020.0301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neural stem cells persist to generate new neurons in the hippocampus of adult and aged human brain - Fiction or accurate?

    Zanirati, Gabriele / Shetty, Padmashri A / Shetty, Ashok K

    Ageing research reviews

    2023  Volume 92, Page(s) 102133

    Abstract: Adult neurogenesis, comprising the generation, differentiation and integration of new neurons in the mature brain, has emerged as a dynamic area of research over decades. The discovery of adult neurogenesis was a paradigm shift to comprehend mechanisms ... ...

    Abstract Adult neurogenesis, comprising the generation, differentiation and integration of new neurons in the mature brain, has emerged as a dynamic area of research over decades. The discovery of adult neurogenesis was a paradigm shift to comprehend mechanisms underlying brain plasticity, cognitive function, and neurological disorders. This review deliberates significant findings from articles published over four decades on adult neurogenesis, highlighting key milestones, methodological advances, and controversies that have shaped our comprehension of the phenomenon of adult neurogenesis. Early skepticism gave way to a rich body of evidence via various reliable approaches. Studies on neurogenic niches, microenvironmental factors, molecular regulators, and functional implications have uncovered the involvement of adult neurogenesis in learning, memory, mood, and even neurological and neurodegenerative conditions. Despite significant progress, several questions still need to be answered, including the exact contributions of new neurons to brain function, their integration into existing circuits, and the impact of enhancing adult neurogenesis in the human hippocampus. While the existence of robust neurogenesis in the adult and aged human hippocampus is yet to be confirmed, this review highlights evidence from a significant number of studies supporting the persistence of hippocampal neurogenesis during adulthood and aging in humans, including in some neurological conditions, such as epilepsy and Alzheimer's disease. Nonetheless, additional large-scale studies using single cell-RNA-seq, single nucleus-RNA-seq, and spatial transcriptomics are critical to validate the presence and contribution of hippocampal neurogenesis in the pathophysiology of various neurological and neurodegenerative conditions at different stages of the disease. There is also a need to develop standardized protocols for analyzing postmortem hippocampal tissues for cellular and molecular analyses.
    MeSH term(s) Humans ; Adult ; Aged ; Neurons ; Neural Stem Cells ; Hippocampus ; Brain/physiology ; Neurogenesis/physiology ; Neurodegenerative Diseases
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.102133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Extracellular Vesicles in Health and Disease.

    Shetty, Ashok K / Upadhya, Raghavendra

    Aging and disease

    2021  Volume 12, Issue 6, Page(s) 1358–1362

    Abstract: The journal, ...

    Abstract The journal,
    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2021.0827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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