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  1. Book: Verhaltensmedizin

    Leupoldt, Andreas von

    Psychobiologie, Psychopathologie und klinische Anwendung

    2008  

    Author's details Andreas von Leupoldt ... (Hrsg.)
    Keywords Verhaltensmedizin
    Subject Behavioral medicine
    Language German
    Size 437 S. : graph. Darst.
    Edition 1. Aufl.
    Publisher Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT015214174
    ISBN 978-3-17-019294-2 ; 3-17-019294-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 1989 order for loan Magazin

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  2. Article ; Online: Introduction to the 2022 special issue on neuroscience and psychobiology of respiration in Biological Psychology.

    Ritz, Thomas / von Leupoldt, Andreas

    Biological psychology

    2022  Volume 176, Page(s) 108478

    Language English
    Publishing date 2022-12-12
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2022.108478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The effect of unpredictability on the perception of breathlessness: a narrative review.

    Pavy, Fabien / Torta, Diana M / von Leupoldt, Andreas

    Frontiers in rehabilitation sciences

    2024  Volume 4, Page(s) 1339072

    Abstract: Breathlessness is an aversive bodily sensation impacting millions of people worldwide. It is often highly detrimental for patients and can lead to profound distress and suffering. Notably, unpredictable breathlessness episodes are often reported as being ...

    Abstract Breathlessness is an aversive bodily sensation impacting millions of people worldwide. It is often highly detrimental for patients and can lead to profound distress and suffering. Notably, unpredictable breathlessness episodes are often reported as being more severe and unpleasant than predictable episodes, but the underlying reasons have not yet been firmly established in experimental studies. This review aimed to summarize the available empirical evidence about the perception of unpredictable breathlessness in the adult population. Specifically, we examined: (1) effects of unpredictable relative to predictable episodes of breathlessness on their perceived intensity and unpleasantness, (2) potentially associated neural and psychophysiological correlates, (3) potentially related factors such as state and trait negative affectivity. Nine studies were identified and integrated in this review, all of them conducted in healthy adult participants. The main finding across studies suggested that unpredictable compared to predictable, breathlessness elicits more frequently states of high fear and distress, which may contribute to amplify the perception of unpredictable breathlessness, especially its unpleasantness. Trait negative affectivity did not seem to directly affect the perception of unpredictable breathlessness. However, it seemed to reinforce state fear and anxiety, hence possible indirect modulatory pathways through these affective states. Studies investigating neural correlates of breathlessness perception and psychophysiological measures did not show clear associations with unpredictability. We discuss the implication of these results for future research and clinical applications, which necessitate further investigations, especially in clinical samples suffering from breathlessness.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-6861
    ISSN (online) 2673-6861
    DOI 10.3389/fresc.2023.1339072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The effect of unpredictability on the perception of breathlessness

    Fabien Pavy / Diana M. Torta / Andreas von Leupoldt

    Frontiers in Rehabilitation Sciences, Vol

    a narrative review

    2024  Volume 4

    Abstract: Breathlessness is an aversive bodily sensation impacting millions of people worldwide. It is often highly detrimental for patients and can lead to profound distress and suffering. Notably, unpredictable breathlessness episodes are often reported as being ...

    Abstract Breathlessness is an aversive bodily sensation impacting millions of people worldwide. It is often highly detrimental for patients and can lead to profound distress and suffering. Notably, unpredictable breathlessness episodes are often reported as being more severe and unpleasant than predictable episodes, but the underlying reasons have not yet been firmly established in experimental studies. This review aimed to summarize the available empirical evidence about the perception of unpredictable breathlessness in the adult population. Specifically, we examined: (1) effects of unpredictable relative to predictable episodes of breathlessness on their perceived intensity and unpleasantness, (2) potentially associated neural and psychophysiological correlates, (3) potentially related factors such as state and trait negative affectivity. Nine studies were identified and integrated in this review, all of them conducted in healthy adult participants. The main finding across studies suggested that unpredictable compared to predictable, breathlessness elicits more frequently states of high fear and distress, which may contribute to amplify the perception of unpredictable breathlessness, especially its unpleasantness. Trait negative affectivity did not seem to directly affect the perception of unpredictable breathlessness. However, it seemed to reinforce state fear and anxiety, hence possible indirect modulatory pathways through these affective states. Studies investigating neural correlates of breathlessness perception and psychophysiological measures did not show clear associations with unpredictability. We discuss the implication of these results for future research and clinical applications, which necessitate further investigations, especially in clinical samples suffering from breathlessness.
    Keywords breathlessness ; dyspnea ; respiration ; unpredictability ; uncertainty ; fear ; Other systems of medicine ; RZ201-999 ; Medical technology ; R855-855.5
    Subject code 150
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: To breathe or not to breathe: Interoceptive predictions in an anxious brain.

    Jelinčić, Valentina / von Leupoldt, Andreas

    Neuron

    2021  Volume 109, Issue 24, Page(s) 3904–3907

    Abstract: Respiration is gaining traction as an important and consciously accessible interoceptive domain with strong relationships to anxiety. In this issue of Neuron, Harrison et al. (2021) report a tour de force investigation into this relationship at multiple ... ...

    Abstract Respiration is gaining traction as an important and consciously accessible interoceptive domain with strong relationships to anxiety. In this issue of Neuron, Harrison et al. (2021) report a tour de force investigation into this relationship at multiple levels of interoception, featuring a novel respiratory learning task.
    MeSH term(s) Anxiety ; Anxiety Disorders ; Brain ; Humans ; Interoception/physiology ; Respiration
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2021.11.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The load of dyspnoea on brain and legs.

    von Leupoldt, Andreas / Farre, Núria

    The European respiratory journal

    2020  Volume 56, Issue 2

    MeSH term(s) Brain/diagnostic imaging ; Cognition ; Dyspnea ; Humans ; Leg ; Locomotion
    Language English
    Publishing date 2020-08-06
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01096-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 292: Show issues

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  7. Article ; Online: Expectations underlie the effects of unpredictable pain: a behavioral and electroencephalogram study.

    Pavy, Fabien / Zaman, Jonas / Von Leupoldt, Andreas / Torta, Diana M

    Pain

    2023  Volume 165, Issue 3, Page(s) 596–607

    Abstract: Abstract: Previous studies on the potential effects of unpredictability on pain perception and its neural correlates yielded divergent results. This study examined whether this may be explained by differences in acquired expectations. We presented 41 ... ...

    Abstract Abstract: Previous studies on the potential effects of unpredictability on pain perception and its neural correlates yielded divergent results. This study examined whether this may be explained by differences in acquired expectations. We presented 41 healthy volunteers with laser heat stimuli of different intensities. The stimuli were preceded either by predictable low, medium, or high cues or by unpredictable low-medium, medium-high, or low-high cues. We recorded self-reports of pain intensity and unpleasantness and laser-evoked potentials (LEPs). Furthermore, we investigated whether dynamic expectations that evolved throughout the experiment based on past trials were better predictors of pain ratings than fixed (nonevolving) expectations. Our results replicate previous findings that unpredictable pain is higher than predictable pain for low-intensity stimuli but lower for high-intensity stimuli. Moreover, we observed higher ratings for the medium-high unpredictable condition than the medium-low unpredictable condition, in line with an effect of expectation. We found significant interactions (N1, N2) for the LEP components between intensity and unpredictability. However, the few significant differences in LEP peak amplitudes between cue conditions did not survive correction for multiple testing. In line with predictive coding perspectives, pain ratings were best predicted by dynamic expectations. Surprisingly, expectations of reduced precision (increased variance) were associated with lower pain ratings. Our findings provide strong evidence that (dynamic) expectations contribute to the opposing effects of unpredictability on pain perception; therefore, we highlight the importance of controlling for them in pain unpredictability manipulations. We also suggest to conceptualize pain expectations more often as dynamic constructs incorporating previous experiences.
    MeSH term(s) Humans ; Motivation ; Pain ; Electroencephalography/methods ; Pain Perception/physiology ; Pain Measurement/methods
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000003046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Treating anxious expectations can improve dyspnoea in patients with COPD.

    von Leupoldt, Andreas

    The European respiratory journal

    2017  Volume 50, Issue 3

    MeSH term(s) Anxiety ; Dyspnea ; Humans ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2017-09-12
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01352-2017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of transcutaneous auricular vagus nerve stimulation on P300 magnitudes and salivary alpha-amylase during an auditory oddball task.

    D'Agostini, Martina / Burger, Andreas M / Jelinčić, Valentina / von Leupoldt, Andreas / Van Diest, Ilse

    Biological psychology

    2023  Volume 182, Page(s) 108646

    Abstract: Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neurostimulation technique that is thought to modulate noradrenergic activity. Previous studies have demonstrated inconsistent effects of taVNS on noradrenergic activity, which is ...

    Abstract Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neurostimulation technique that is thought to modulate noradrenergic activity. Previous studies have demonstrated inconsistent effects of taVNS on noradrenergic activity, which is possibly due to insufficient statistical power, suboptimal stimulation parameter settings, and data collection procedures. In this preregistered within-subject experiment, 44 healthy participants received taVNS and sham (earlobe) stimulation during two separate experimental sessions. Stimulation intensity was individually calibrated to the maximum level below pain. During each session, participants received the stimulation continuously ten minutes before an auditory novelty oddball task till the end of the experimental session. The P3b component of the event-related potential served as a marker of phasic noradrenergic activity, whereas P3a magnitude was explored as an index of dopaminergic activity. Salivary alpha-amylase (sAA) was measured as an index of tonic noradrenergic activity before and at the end of the stimulation. The taVNS and sham conditions did not differ in P3a or P3b magnitudes, nor sAA secretion. These findings call into question whether taVNS, administered continuously at high, nonpainful stimulation intensities, reliably augments noradrenergic activity via the vagus nerve.
    MeSH term(s) Humans ; Salivary alpha-Amylases ; Vagus Nerve Stimulation ; Caffeine ; Dopamine ; Vagus Nerve
    Chemical Substances Salivary alpha-Amylases (EC 3.2.1.1) ; Caffeine (3G6A5W338E) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-07-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2023.108646
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  10. Article ; Online: Affective traits, states, and breathlessness.

    von Leupoldt, Andreas / Denutte, Ysys

    Current opinion in supportive and palliative care

    2020  Volume 14, Issue 3, Page(s) 182–189

    Abstract: Purpose of review: Breathlessness is a prevalent and aversive symptom in various conditions and closely related to affect. Here, we review recent literature from the previous 18 months examining the interactions between affective traits and states with ... ...

    Abstract Purpose of review: Breathlessness is a prevalent and aversive symptom in various conditions and closely related to affect. Here, we review recent literature from the previous 18 months examining the interactions between affective traits and states with breathlessness.
    Recent findings: Available studies used various qualitative, quantitative, and experimental research designs in diverse samples of patients with breathlessness and in healthy individuals. Most studies clearly demonstrated that nonspecific forms of negative affective personality traits such as anxiety and depression, disease or symptom-specific forms such as fear-of-dyspnea and fear-of-physical activity as well as short-lasting negative affective states such as experimentally induced fear were associated with greater breathlessness. Moreover, breathlessness was shown to evoke negative affect, whereas positive affect reduced breathlessness. Different treatment approaches demonstrated concurrent beneficial effects on both negative affect and breathlessness and several potential mechanisms underlying these interactions were suggested.
    Summary: Negative affect is common in diverse patient groups suffering from breathlessness and is related to increased burden because of breathlessness. Future research is required to improve our understanding of the mechanisms underlying these associations together with increased clinical efforts for improved detection and treatment of negative affect in breathless patients.
    MeSH term(s) Anxiety/epidemiology ; Anxiety/psychology ; Depression/epidemiology ; Depression/psychology ; Dyspnea/epidemiology ; Dyspnea/psychology ; Emotions ; Fear ; Humans ; Personality
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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