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  1. Article ; Online: Corticoides para el tratamiento de COVID-19.

    Salinas, Mauricio

    Revista medica de Chile

    2021  Volume 148, Issue 7, Page(s) 893–894

    Title translation Corticosteroids treatment for COVID-19.
    MeSH term(s) Adrenal Cortex Hormones ; COVID-19 ; Dexamethasone ; Humans ; Respiratory Distress Syndrome ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones ; Dexamethasone (7S5I7G3JQL)
    Language Spanish
    Publishing date 2021-01-05
    Publishing country Chile
    Document type Editorial ; Comment
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872020000700893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tratamientos experimentales y coronavirus.

    Salinas, Mauricio / Salinas, Rodrigo

    Revista medica de Chile

    2021  Volume 148, Issue 5, Page(s) 571–572

    Title translation Experimental treatments and Coronavirus.
    MeSH term(s) COVID-19/therapy ; Humans ; Therapies, Investigational
    Language Spanish
    Publishing date 2021-01-05
    Publishing country Chile
    Document type Editorial
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872020000500571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: An optimized relational database for querying structural patterns in proteins.

    Angles, Renzo / Arenas-Salinas, Mauricio / García, Roberto / Ingram, Ben

    Database : the journal of biological databases and curation

    2024  Volume 2024

    Abstract: A database is an essential component in almost any software system, and its creation involves more than just data modeling and schema design. It also includes query optimization and tuning. This paper focuses on a web system called GSP4PDB, which is used ...

    Abstract A database is an essential component in almost any software system, and its creation involves more than just data modeling and schema design. It also includes query optimization and tuning. This paper focuses on a web system called GSP4PDB, which is used for searching structural patterns in proteins. The system utilizes a normalized relational database, which has proven to be inefficient even for simple queries. This article discusses the optimization of the GSP4PDB database by implementing two techniques: denormalization and indexing. The empirical evaluation described in the article shows that combining these techniques enhances the efficiency of the database when querying both real and artificial graph-based structural patterns.
    MeSH term(s) Databases, Factual ; Software
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2496706-3
    ISSN 1758-0463 ; 1758-0463
    ISSN (online) 1758-0463
    ISSN 1758-0463
    DOI 10.1093/database/baad093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Double positivity for rheumatoid factor and anti-CCP autoantibodies: improving referral from primary care of patients suspected of having rheumatoid arthritis.

    Salinas, Maria / Blasco, Álvaro / Flores, Emilio / Minguez, Mauricio / Leiva-Salinas, Carlos

    Primary health care research & development

    2024  Volume 25, Page(s) e6

    Abstract: Background: Rheumatoid arthritis (RA) is a chronic progressive autoimmune inflammatory disease with significant morbidity and mortality. The course of the disease can be modified if diagnosis is early and treatment appropriate.: Aim: In this study, ... ...

    Abstract Background: Rheumatoid arthritis (RA) is a chronic progressive autoimmune inflammatory disease with significant morbidity and mortality. The course of the disease can be modified if diagnosis is early and treatment appropriate.
    Aim: In this study, we aimed to evaluate a new strategy for early identification of RA patients in primary care settings (the 'diagnostic bottleneck') based on serological biomarkers and to manage inappropriate rheumatoid factor (RF) laboratory test requests.
    Method: A two-arm study was carried out. The first arm corresponded to a retrospective observational descriptive study of patients referred for RF testing from primary care using the current laboratory workflow. The second arm included the following prospective interventions: cancelation of RF requests corresponding to patients with previous negative results for RF over a one-year period; and automatic reflex testing antibodies against cyclic citrullinated proteins (anti-CCP) for patients displaying RF values >30 IU/ml. Outcomes from both arms were then compared.
    Findings: As double positivity for RF and anti-CCP notably increases the positive likelihood ratio of RA. The intervention enabled a reduction of 2813 tests in 22 months. Moreover, the frequency of unnecessary referrals was reduced from 22% to 8.2%, while that of missed patients decreased slightly (from 21% to 16%), with the number of patients diagnosed per RF request remaining unchanged. In terms of costs, we saved 19.4 RF tests per anti-CCP test added.We developed a simple and cost-effective strategy for reducing the time to diagnosis of RA that can improve patients' quality of life. This approach was supported by primary and specialised care.
    MeSH term(s) Humans ; Anti-Citrullinated Protein Antibodies ; Arthritis, Rheumatoid/diagnosis ; Autoantibodies ; Primary Health Care ; Prospective Studies ; Quality of Life ; Retrospective Studies ; Rheumatoid Factor
    Chemical Substances Anti-Citrullinated Protein Antibodies ; Autoantibodies ; Rheumatoid Factor (9009-79-4)
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2027892-5
    ISSN 1477-1128 ; 1477-1128
    ISSN (online) 1477-1128
    ISSN 1477-1128
    DOI 10.1017/S1463423623000695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nanoparticle‑based antiviral strategies to combat the influenza virus (Review).

    Rios-Ibarra, Clara Patricia / Salinas-Santander, Mauricio / Orozco-Nunnelly, Danielle Annette / Bravo-Madrigal, Jorge

    Biomedical reports

    2024  Volume 20, Issue 4, Page(s) 65

    Abstract: The rapid availability of effective antiviral treatments would be beneficial during the early phases of a pandemic, as they could reduce viral loads and control serious infections until antigenic vaccines become widely available. One promising ... ...

    Abstract The rapid availability of effective antiviral treatments would be beneficial during the early phases of a pandemic, as they could reduce viral loads and control serious infections until antigenic vaccines become widely available. One promising alternative therapy to combat pandemics is nanotechnology, which has the potential to inhibit a wide variety of viruses, including the influenza virus. This review summarizes the recent progress using gold, copper, silver, silicone, zinc and selenium nanoparticles, since these materials have shown remarkable antiviral capacity against influenza A virus.
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2024.1753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Modelling quarantine effects on SARS-CoV-2 epidemiological dynamics in Chilean communes and their relationship with the Social Priority Index.

    Salinas, Dino G / Bustamante, M Leonor / Gallardo, Mauricio O

    PeerJ

    2023  Volume 11, Page(s) e14892

    Abstract: Background: An epidemiological model (susceptible, un-quarantined infected, quarantined infected, confirmed infected (SUQC)) was previously developed and applied to incorporate quarantine measures and calculate COVID-19 contagion dynamics and pandemic ... ...

    Abstract Background: An epidemiological model (susceptible, un-quarantined infected, quarantined infected, confirmed infected (SUQC)) was previously developed and applied to incorporate quarantine measures and calculate COVID-19 contagion dynamics and pandemic control in some Chinese regions. Here, we generalized this model to incorporate the disease recovery rate and applied our model to records of the total number of confirmed cases of people infected with the SARS-CoV-2 virus in some Chilean communes.
    Methods: In each commune, two consecutive stages were considered: a stage without quarantine and an immediately subsequent quarantine stage imposed by the Ministry of Health. To adjust the model, typical epidemiological parameters were determined, such as the confirmation rate and the quarantine rate. The latter allowed us to calculate the reproduction number.
    Results: The mathematical model adequately reproduced the data, indicating a higher quarantine rate when quarantine was imposed by the health authority, with a corresponding decrease in the reproduction number of the virus down to values that prevent or decrease its exponential spread. In general, during this second stage, the communes with the lowest social priority indices had the highest quarantine rates, and therefore, the lowest effective viral reproduction numbers. This study provides useful evidence to address the health inequity of pandemics. The mathematical model applied here can be used in other regions or easily modified for other cases of infectious disease control by quarantine.
    MeSH term(s) Humans ; SARS-CoV-2 ; Quarantine ; COVID-19/epidemiology ; Chile/epidemiology ; Communicable Disease Control
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.14892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modelling quarantine effects on SARS-CoV-2 epidemiological dynamics in Chilean communes and their relationship with the Social Priority Index

    Dino G. Salinas / M. Leonor Bustamante / Mauricio O. Gallardo

    PeerJ, Vol 11, p e

    2023  Volume 14892

    Abstract: Background An epidemiological model (susceptible, un-quarantined infected, quarantined infected, confirmed infected (SUQC)) was previously developed and applied to incorporate quarantine measures and calculate COVID-19 contagion dynamics and pandemic ... ...

    Abstract Background An epidemiological model (susceptible, un-quarantined infected, quarantined infected, confirmed infected (SUQC)) was previously developed and applied to incorporate quarantine measures and calculate COVID-19 contagion dynamics and pandemic control in some Chinese regions. Here, we generalized this model to incorporate the disease recovery rate and applied our model to records of the total number of confirmed cases of people infected with the SARS-CoV-2 virus in some Chilean communes. Methods In each commune, two consecutive stages were considered: a stage without quarantine and an immediately subsequent quarantine stage imposed by the Ministry of Health. To adjust the model, typical epidemiological parameters were determined, such as the confirmation rate and the quarantine rate. The latter allowed us to calculate the reproduction number. Results The mathematical model adequately reproduced the data, indicating a higher quarantine rate when quarantine was imposed by the health authority, with a corresponding decrease in the reproduction number of the virus down to values that prevent or decrease its exponential spread. In general, during this second stage, the communes with the lowest social priority indices had the highest quarantine rates, and therefore, the lowest effective viral reproduction numbers. This study provides useful evidence to address the health inequity of pandemics. The mathematical model applied here can be used in other regions or easily modified for other cases of infectious disease control by quarantine.
    Keywords Reproduction number ; COVID-19 ; Differential equations ; Social inequality ; Quarantine ; Lockdown ; Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The monarch butterfly in Mexico: a conservation model.

    Rendón-Salinas, Eduardo / Alonso, Alfonso / García-Serrano, Eligio / Valera-Bermejo, Adriana / Quesada, Mauricio

    Current opinion in insect science

    2023  Volume 60, Page(s) 101112

    Abstract: Each fall, millions of monarch butterflies (Danaus plexippus L.) travel from Canada and the United States to overwinter in Mexico and California. In 2022, the IUCN listed migratory monarchs as endangered because of their population decline. The main ... ...

    Abstract Each fall, millions of monarch butterflies (Danaus plexippus L.) travel from Canada and the United States to overwinter in Mexico and California. In 2022, the IUCN listed migratory monarchs as endangered because of their population decline. The main accepted drivers are widespread use of herbicides, effects of climate, and land use change that causes habitat loss. We analyzed the main actions taken to officially protect the overwintering sites and the migration phenomenon with the establishment of the Monarch Butterfly Biosphere Reserve in 2000. The conservation of the monarch overwintering sites in Mexico is an example of continuous work from their discovery to the present. We highlight the importance of monitoring the areas covered by overwintering monarchs in Mexico. These colonies represent the largest concentrations of monarch populations in the world. In the last 10 years, the average area covered by monarchs was 2.72 ( ± 0.47 SE) hectares.
    MeSH term(s) Animals ; United States ; Butterflies ; Mexico ; Ecosystem ; Climate ; Animal Migration
    Language English
    Publishing date 2023-09-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2772833-X
    ISSN 2214-5753 ; 2214-5745
    ISSN (online) 2214-5753
    ISSN 2214-5745
    DOI 10.1016/j.cois.2023.101112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Connective Tissue Disease-Interstitial Lung Disease-Associated Mortality Rates and Years of Potential Life Lost in the United States.

    Salinas, Mauricio / Solomon, Joshua J / Fernández Pérez, Evans R

    Chest

    2021  Volume 160, Issue 4, Page(s) 1368–1371

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/mortality ; Connective Tissue Diseases/complications ; Connective Tissue Diseases/epidemiology ; Connective Tissue Diseases/mortality ; Dermatomyositis/complications ; Dermatomyositis/epidemiology ; Dermatomyositis/mortality ; Female ; Humans ; Life Expectancy ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/mortality ; Male ; Middle Aged ; Polymyositis/complications ; Polymyositis/epidemiology ; Polymyositis/mortality ; Prevalence ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/epidemiology ; Scleroderma, Systemic/mortality ; United States ; Young Adult
    Language English
    Publishing date 2021-08-07
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.03.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Foramen oval persistente como causa de hipoxemia persistente en un paciente con neumonía grave COVID-19. Reporte de un caso.

    Kramer, Tomas / Ramírez, Andrés / Salinas, Mauricio

    Revista medica de Chile

    2021  Volume 149, Issue 7, Page(s) 1090–1092

    Abstract: In patients with severe COVID-19, it has been proposed as mechanism of respiratory failure, intra and extrapulmonary shunt. However, there are no reported or documented cases of this mechanism. Also, there are studies showing this mechanism is not ... ...

    Title translation Persistent foramen ovale as a cause of persistent hypoxemia after a pneumonia caused with COVID-19. Report of one case.
    Abstract In patients with severe COVID-19, it has been proposed as mechanism of respiratory failure, intra and extrapulmonary shunt. However, there are no reported or documented cases of this mechanism. Also, there are studies showing this mechanism is not relevant. In this report, we present the case of a patient with severe COVID-19 pneumonia, who after two months, during his rehabilitation period, presented persistent hypoxemia with orthodeoxia. Persistent oval foramen with shunt from right to left was diagnosed. The patient underwent a percutaneous closure of the defect and at 48 hours oxygen therapy could be discontinued and the patient discharged.
    MeSH term(s) COVID-19 ; Dyspnea ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnostic imaging ; Humans ; Hypoxia/etiology ; Pneumonia ; SARS-CoV-2
    Language Spanish
    Publishing date 2021-11-04
    Publishing country Chile
    Document type Case Reports ; Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/s0034-98872021000701090
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