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Article ; Online: Treatment of HIV and HBV coinfection.

Bani-Sadr, Firouzé

The lancet. HIV

2023 Volume 10, Issue 10, Page(s) e624–e625

Language	English
Publishing date	2023-07-23
Publishing country	Netherlands
Document type	Journal Article
ISSN	2352-3018
ISSN (online)	2352-3018
DOI	10.1016/S2352-3018(23)00179-0
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Article ; Online: Significantly reduced duration of antibiotic prescription for erysipelas subsequent to the 2019 French guidelines on skin and soft tissue infection: A before-after study.

Destoop, Justin / Vanhaecke, Clélia / Bani-Sadr, Firouzé / Plenier, Yannick / Viguier, Manuelle-Anne / Hentzien, Maxime

Infectious diseases now

2024 Volume 54, Issue 3, Page(s) 104887

Abstract: Background: New skin and soft tissue infections (SSTI) guidelines were published in 2019 in France, changing the recommended duration for antibiotic treatment. The objective of the present study was to assess the impact of the publication of the 2019 ... ...

Abstract	Background: New skin and soft tissue infections (SSTI) guidelines were published in 2019 in France, changing the recommended duration for antibiotic treatment. The objective of the present study was to assess the impact of the publication of the 2019 French guidelines on SSTIs on the duration of antibiotic prescription for erysipelas. Methods: In a before-after study (a year before and a year after April 1st, 2019), we included all adult patients diagnosed with erysipelas in Reims University Hospital medical wards and the emergency department. We retrospectively retrieved antibiotic prescription duration in the patients' medical files. Results: Among 50 patients in the "before" and 39 in the "after" group, the mean duration of antibiotic prescription was significantly shorter in the "after" group (9.4 ± 2.8 vs. 12.4 ± 3.8 days, p = 0.0001). Conclusions: A 25% decrease in the duration of antibiotic prescription for erysipelas was observed following the implementation of these guidelines, providing useful information for an antibiotic stewardship policy.
MeSH term(s)	Adult ; Humans ; Anti-Bacterial Agents/therapeutic use ; Erysipelas/drug therapy ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/diagnosis ; Retrospective Studies ; Controlled Before-After Studies ; Prescriptions ; Hospitals, University
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-03-15
Publishing country	France
Document type	Journal Article
ISSN	2666-9919
ISSN (online)	2666-9919
DOI	10.1016/j.idnow.2024.104887
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Article ; Online: Epidemiology and characteristics of Paget's disease of bone in a French nationwide HIV cohort.

Blot-Cossard, Amanda / Merad, Yanis / Bachelard, Antoine / Lebreton, Cedric / Palich, Romain / Pugliese, Pascal / Bregigeon, Sophie / Hentzien, Maxime / Bani-Sadr, Firouzé

AIDS (London, England)

2024 Volume 38, Issue 6, Page(s) 929–931

Abstract: Paget's disease of bone (PDB) has rarely been reported in people with HIV (PWH). We describe the prevalence and characteristics of patients with PDB in the French multicenter Dat'AIDS cohort. Among 49 698 PWH actively followed in 2022, 9 had a diagnosis ... ...

Abstract	Paget's disease of bone (PDB) has rarely been reported in people with HIV (PWH). We describe the prevalence and characteristics of patients with PDB in the French multicenter Dat'AIDS cohort. Among 49 698 PWH actively followed in 2022, 9 had a diagnosis of PDB. The overall prevalence of PDB was 0.02% [95% confidence interval (CI) 0.01-0.03]. The prevalence of PDB in PWH is very low and does not appear to differ from the non-HIV population.
MeSH term(s)	Humans ; Osteitis Deformans/epidemiology ; Osteitis Deformans/diagnosis ; HIV Infections/complications ; HIV Infections/epidemiology ; Adenocarcinoma
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003874
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Zs.A 2228: Show issues

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Article ; Online: Persistently elevated alkaline phosphatase could be related to Paget's disease of bone in a patient receiving tenofovir disoproxil fumarate.

Aubert, Arthur / Berger, Jean-Luc / Hittinger Roux, Ambre / N'Guyen, Yohan / Bani-Sadr, Firouzé

International journal of STD & AIDS

2022 Volume 34, Issue 2, Page(s) 137–138

Abstract: The prevalence of Paget's disease of bone (PDB) reaches 1-2% of all adults aged ≥55 years old. However, reports describing PDB among HIV positive patients are extremely rare. We report here the case of a HIV positive person receiving tenofovir disoproxil ...

Abstract	The prevalence of Paget's disease of bone (PDB) reaches 1-2% of all adults aged ≥55 years old. However, reports describing PDB among HIV positive patients are extremely rare. We report here the case of a HIV positive person receiving tenofovir disoproxil fumarate (DF)-based antiretroviral therapy and who had persistently elevated alkaline phosphatase (AP) revealing PDB. It is well established that tenofovir-DF use is associated with reversible increases in serum AP levels. Clinicians should bear in mind that persistently elevated AP in a person receiving tenofovir DF-based cART could be related to PDB, in particular in person older than 50 years with no other notable biological abnormalities related to kidney tubular dysfunction.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Adenine/adverse effects ; Alkaline Phosphatase/therapeutic use ; Anti-HIV Agents/adverse effects ; HIV Infections/drug therapy ; HIV Seropositivity/drug therapy ; Osteitis Deformans/drug therapy ; Tenofovir/adverse effects
Chemical Substances	Adenine (JAC85A2161) ; Alkaline Phosphatase (EC 3.1.3.1) ; Anti-HIV Agents ; Tenofovir (99YXE507IL)
Language	English
Publishing date	2022-11-14
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624221136643
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Article ; Online: Mycobacterium genavense mesenteritis responsible for refractory chylous ascites despite multiple immunomodulatory therapies in a patient with AIDS.

Laurent, Clémence / Hentzien, Maxime / Pavel, Simona / Didier, Kévin / Bermejo, Messaline / N'Guyen, Yohan / Bani-Sadr, Firouzé

AIDS (London, England)

2023 Volume 37, Issue 5, Page(s) 856–858

MeSH term(s)	Humans ; Chylous Ascites ; HIV Infections/complications ; Acquired Immunodeficiency Syndrome ; Mycobacterium ; Ascites
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Letter
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003510
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Article ; Online: Disappearance of anti-thyroglobulin antibodies from the cerebrospinal fluid in parallel with neurological improvement during treatment for Hashimoto's encephalopathy

Petithomme-Nanrocki, Maïwen / Brunet, Aurélie / Didier, Kévin / Hentzien, Maxime / Tabary, Thierry / Doe de Maindreville, Anne / Bani-Sadr, Firouzé

Annales de biologie clinique

2022 Volume 80, Issue 5, Page(s) 464–465

Abstract: Abnormal elevation of thyroid antibodies in the CSF is observed in 62-75% of Hashimoto's encephalopathy cases. However, the relationship between CSF thyroid antibody levels and response to therapy has been poorly evaluated. We report the case of a 68- ... ...

Title translation	Disparition des anticorps anti-thyroglobuline dans le liquide céphalo-rachidien après traitement de l’encéphalopathie de Hashimoto
Abstract	Abnormal elevation of thyroid antibodies in the CSF is observed in 62-75% of Hashimoto's encephalopathy cases. However, the relationship between CSF thyroid antibody levels and response to therapy has been poorly evaluated. We report the case of a 68-year-old man with Hashimoto's encephalopathy, in whom there was a relation between the favorable clinical outcome and the disappearance of antithyroid antibodies from the CSF and a decrease in serum thyroid antibodies.
MeSH term(s)	Male ; Humans ; Aged ; Hashimoto Disease/diagnosis ; Encephalitis/diagnosis ; Autoantibodies
Chemical Substances	anti-thyroglobulin ; Autoantibodies
Language	French
Publishing date	2022-08-12
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	418098-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2022.1759
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Ud II Zs.203: Show issues

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Article ; Online: Idiopathic intracranial hypertension secondary to fluoroquinolone therapy: French pharmacovigilance data review.

Hureaux, A / Bermejo, M / Suret, P M / Bonnet, M / N'Guyen, Y / Hentzien, M / Djerada, Z / Azzouz, B / Bani-Sadr, Firouzé

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2023 Volume 43, Issue 2, Page(s) 379–381

Abstract: We investigate spontaneous reports of IIH related to fluoroquinolones recorded in the French national pharmacovigilance database in order to detect a possible pharmacovigilance signal. The association between IIH risk and fluoroquinolone exposure was ... ...

Abstract	We investigate spontaneous reports of IIH related to fluoroquinolones recorded in the French national pharmacovigilance database in order to detect a possible pharmacovigilance signal. The association between IIH risk and fluoroquinolone exposure was assessed using a case/non-case study. Between 1985 and July 2023, 17 reports of IIH after fluoroquinolone exposure were recorded. No specific fluoroquinolone was predominant. IIH led to death in one case and blindness in one case. The Reporting Odds Ratio was 2.58 (95% confidence interval 1.59-4.19). We highlight statistically significant disproportionality, which constitutes a pharmacovigilance signal. IIH risk after fluoroquinolone exposure is a class effect.
MeSH term(s)	Humans ; Pseudotumor Cerebri/diagnosis ; Fluoroquinolones/adverse effects ; Pharmacovigilance ; Databases, Factual
Chemical Substances	Fluoroquinolones
Language	English
Publishing date	2023-11-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-023-04726-2
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Zs.A 1732: Show issues

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Article ; Online: No Association Between HLA-B*57:01 and Prevalence and/or Outcome of Progressive Multifocal Leukoencephalopathy in a French Nationwide Human Immunodeficiency Virus Cohort.

Secher, Solène / Hentzien, Maxime / Cuzin, Lise / Jacomet, Christine / Hocqueloux, Laurent / Rey, David / Menard, Amélie / Arvieux, Cédric / Raffi, François / Bani-Sadr, Firouzé

AIDS research and human retroviruses

2023 Volume 40, Issue 4, Page(s) 253–256

Abstract: Among 34,351 patients living with human immunodeficiency virus with available HLA-B*57:01 included in the Dat'AIDS cohort, 194 patients (0.56%) had a history of progressive multifocal leukoencephalopathy (PML) and 1,746 (5.08%) were carriers of HLA-B*57: ... ...

Abstract	Among 34,351 patients living with human immunodeficiency virus with available HLA-B57:01 included in the Dat'AIDS cohort, 194 patients (0.56%) had a history of progressive multifocal leukoencephalopathy (PML) and 1,746 (5.08%) were carriers of HLA-B57:01. The frequency of HLA-B*57:01 was similar among patients with history of PML compared with patients without a history of PML (6.19% [95% confidence interval, CI 2.8%-9.6%] vs. 5.08% [95% CI 4.8%-5.3%];
MeSH term(s)	Humans ; Leukoencephalopathy, Progressive Multifocal/epidemiology ; HIV ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Prevalence ; HLA-B Antigens
Chemical Substances	HLA-B57 antigen ; HLA-B Antigens
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2023.0050
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Article ; Online: Early switching from intravenous to oral antibiotic therapy in bone and joint infections associated with methicillin-susceptible Staphylococcus aureus bacteremia.

Petithomme-Nanrocki, Maïwenn / Vernet-Garnier, Véronique / Lebrun, Delphine / Bajolet, Odile / Bonnet, Morgane / Hentzien, Maxime / Ohl, Xavier / Diallo, Saidou / Bani-Sadr, Firouzé

Infectious diseases now

2023 Volume 53, Issue 6, Page(s) 104739

Abstract: Objectives: We aimed to evaluate the clinical outcomes of patients with bone and joint infection (BJI) associated with methicillin-susceptible Staphylococcus aureus bacteremia (MSSAB) treated with early oral switch to oral antibiotics (before day 14) ... ...

Abstract	Objectives: We aimed to evaluate the clinical outcomes of patients with bone and joint infection (BJI) associated with methicillin-susceptible Staphylococcus aureus bacteremia (MSSAB) treated with early oral switch to oral antibiotics (before day 14) versus later or no switch. Patients and methods: We included all cases reported between January 2016 and December 2021 in the University Hospital of Reims. Results: Among 79 patients with BJI associated with MSSAB, 50.6% had an early switch to oral antibiotics, with median duration of intravenous antibiotics of 9 (IQR 6-11) days. The overall cure rate was 81% with follow-up of 6 months, and was 85.7% after excluding the 9 patients whose death was not related to BJI infection. Failure to control BJI did not differ between the two groups. Conclusion: An early (before day 14) switch to oral antibiotics may be a safe therapeutic option in BJI associated with MSSAB.
MeSH term(s)	Humans ; Staphylococcus aureus ; Methicillin/therapeutic use ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/drug therapy ; Bacteremia/drug therapy
Chemical Substances	Methicillin (Q91FH1328A) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-06-16
Publishing country	France
Document type	Journal Article
ISSN	2666-9919
ISSN (online)	2666-9919
DOI	10.1016/j.idnow.2023.104739
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Article ; Online: External validation of the Dat'AIDS score: A risk score for predicting 5-year overall mortality in people living with HIV aged 60 years or older.

Hentzien, Maxime / Frossard, Jaromil / Kouyos, Roger / Prendki, Virginie / Damas, José / Hofmann, Eveline / Braun, Dominique / Schmid, Patrick / Bernasconi, Enos / Ragozzino, Silvio / Efthimiou, Orestis / Delpierre, Cyrille / Allavena, Clotilde / Bani-Sadr, Firouzé / Calmy, Alexandra

HIV medicine

2023 Volume 25, Issue 1, Page(s) 72–82

Abstract: Objective: To perform an external validation of the Dat'AIDS score for predicting 5-year overall mortality among people with HIV (PWH) aged 60 years or older.: Methods: This was a multi-centre prospective cohort study at all sites participating in ... ...

Abstract	Objective: To perform an external validation of the Dat'AIDS score for predicting 5-year overall mortality among people with HIV (PWH) aged 60 years or older. Methods: This was a multi-centre prospective cohort study at all sites participating in the Swiss HIV Cohort Study (SHCS). We calculated the Dat'AIDS score in PWH aged 60 years or older at their first visit between 1 January 2015 and 1 January 2020. People living with HIV-2 and those whose Dat'AIDS score could not be calculated were excluded. Patients were followed until 1 January 2020. The primary endpoint was all-cause mortality. Vital status was collected throughout the study period. We obtained population and score descriptive statistics and assessed the score's discrimination and calibration. Results: We included 2205 participants (82% male) of median [interquartile range (IQR)] age 62.0 (60.3-67.0) years, mostly with viraemia <50 copies/mL (92.7%). Median follow-up time was 15.9 years and median (IQR) CD4 cell count at enrolment was 586 (420-782) cells/μL. In all, 152 deaths were recorded during a total follow-up period of 7147 patient-years. The median (IQR) observed Dat'AIDS score was 3 (0-8). Discriminative capacities were good as the C-statistic was 0.73 (95% CI: 0.69-0.77) and consistent across all subgroups. Comparison of observed and expected survival probabilities showed good calibration. Conclusions: External validation of the Dat'AIDS score in patients aged 60 years or older showed that it could be a useful tool not only for research purposes, but also to identify older patients at a higher mortality risk and to tailor the most appropriate interventions.
MeSH term(s)	Humans ; Male ; Female ; Cohort Studies ; HIV Infections/epidemiology ; Prospective Studies ; Acquired Immunodeficiency Syndrome ; Risk Factors
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2001932-4
ISSN	1468-1293 ; 1464-2662
ISSN (online)	1468-1293
ISSN	1464-2662
DOI	10.1111/hiv.13534
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