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Article: Characteristics of Ancient Shipwreck Wood from Huaguang Jiao No. 1 after Desalination.

Liu, Xinyou / Zhu, Lulu / Tu, Xinwei / Zhang, Changjun / Huang, Houyi / Varodi, Anca Maria

2023 Volume 16, Issue 2

Abstract: Huaguangjiao I refers to the ancient Chinese wooden shipwreck of the South Song Dynasty (1127-1279 AD) discovered in the South China Sea in 1996. From 2008 to 2017, the archaeological waterlogged wood was desalted using deionized water combined with ... ...

Abstract	Huaguangjiao I refers to the ancient Chinese wooden shipwreck of the South Song Dynasty (1127-1279 AD) discovered in the South China Sea in 1996. From 2008 to 2017, the archaeological waterlogged wood was desalted using deionized water combined with ultrasonic treatment, and desalted using EDTA-2Na, EDTAHO, and NaH
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16020510
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Digestive promoting effect and mechanism of Jiao Sanxian in rats.

Liu, Ying / Liao, Wenting / Liu, Xingran / Hu, Yunwei / Zhu, Xiaoxia / Ju, Longtao / Feng, Feng / Qu, Wei / Liu, Wenyuan / Xu, Jian

Journal of ethnopharmacology

2021 Volume 278, Page(s) 114334

Abstract: Ethnopharmacological relevance: Jiao Sanxian, a customary term for the three ... This prescription is called "Jiao Sanxian" in China because people believe that it is a miracle medicine ... for enhancing digestion and improving stagnation of digestive system. Even though Jiao Sanxian is widely used ...

Abstract	Ethnopharmacological relevance: Jiao Sanxian, a customary term for the three Traditional Chinese Medicines of charred hawthorn (Crataegi Fructus), charred malt (Hordei Fructus Germinatus) and Liu Shenqu (Massa Medicata Fermentata), is a classic prescription for the treatment of functional dyspepsia (FD). This prescription is called "Jiao Sanxian" in China because people believe that it is a miracle medicine for enhancing digestion and improving stagnation of digestive system. Even though Jiao Sanxian is widely used in clinical treatment, the underlying mechanism has not been clarified to date. Aim of the study: The present study is aimed to explore the efficacy and mechanism of Jiao Sanxian in improving the symptoms of FD in rats by using multiple pharmacological methods. Materials and methods: The Sprague Dawley (SD) rats were divided into control, model, Jiao Sanxian decoction low-dosage (JSXD LD), Jiao Sanxian decoction medium-dosage (JSXD MD), and Jiao Sanxian decoction high-dosage (JSXD HD) group at random. A FD model was established with reserpine, and animals were given intragastric administration. During this period, weight and food intake of animals were recorded. Samples of rat gastric antrum, spleen, and duodenum were collected for pathological staining and immunohistochemical determination of Ghrelin protein expression after 19 days of treatment. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of related brain gut peptides in serum. Moreover, 16S rRNA sequencing was used to valuate the influence of intestinal flora structure of the cecal contents of experimental rats. And plasma metabolomics by Ultra Performance Liquid Chromatography coupled with Quadrupole-Time-of-Flight mass spectrometry (UPLC-Q/TOF-MS) were performed to further reveal the mechanism of action. Results: Jiao Sanxian decoction (JSXD) group with different dosage could increase body weight and food intake, improve histopathological changes, and alter disordered brain gut peptides in FD rats. 16S rRNA sequencing results described that JSXD improved the disorder of structural composition, biodiversity and function of gut microbiota in FD rats. Metabolomics illustrated 26 metabolites with JSXD treatment underwent continuous changes, which revealed JSXD might exert digestive effect by ameliorating abnormal metabolic pathways. The most relevant metabolic pathways were arachidonic acid metabolism, pyruvate metabolism, glycerophospholipid metabolism, alanine, aspartate and glutamate metabolism. Conclusions: JSXD can improve functional dyspepsia in rats and the mechanism is related to regulate secretion of brain gut peptides, significantly improve the disorder of intestinal flora and ameliorated multi-metabolic pathways.
MeSH term(s)	Animals ; Body Weight/drug effects ; Drugs, Chinese Herbal/pharmacology ; Dyspepsia/drug therapy ; Feeding Behavior/drug effects ; Gastrointestinal Microbiome/drug effects ; Gene Expression Regulation/drug effects ; Male ; Metabolomics ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Stomach/drug effects
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-06-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114334
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Article: [An exploration on the factors of Jiao Xun's compilation and edit of

Liu, Y X / Wang, R H

Zhonghua yi shi za zhi (Beijing, China : 1980)

2019 Volume 48, Issue 6, Page(s) 334–341

Abstract: Wu shi ben ... ...

Abstract	Wu shi ben cao
MeSH term(s)	China ; History, Ancient ; Materia Medica
Chemical Substances	Materia Medica
Language	Chinese
Publishing date	2019-01-21
Publishing country	China
Document type	Historical Article ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.issn.0255-7053.2018.06.003
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Article: [Application of Tri-Jiao Theory in the treatment of male immune infertility].

Liu, Cheng-Yong / Xu, Fu-Song

Zhonghua nan ke xue = National journal of andrology

2020 Volume 24, Issue 12, Page(s) 1122–1125

Abstract: ... pathogenesis of the disease are based on limited and isolated understandings. With the Tri-Jiao Theory ... differentiation. The Tri-Jiao Theory reflects the holistic thought of TCM and offers a comprehensive insight ... on the mucosal immune system have provided some new ideas for applying the Tri-Jiao Theory to TCM researches ...

Abstract	Male immune infertility is a common disease with an incidence rate of about 10%. This article aimed to find some breakthrough clues to the etiology and pathogenesis of male immune infertility from years of relevant studies in traditional Chinese medicine (TCM). Some consensuses on the diagnosis, etiology and pathogenesis of the disease are based on limited and isolated understandings. With the Tri-Jiao Theory as the breakthrough point, we analyzed the three studies by the Xu Fu-song Group and discussed the causes, development and outcome of male immune infertility from the aspects of its positioning, transmission and syndrome differentiation. The Tri-Jiao Theory reflects the holistic thought of TCM and offers a comprehensive insight into the dynamic changes of the disease. As the basis for TCM understanding of male immune infertility, studies on the mucosal immune system have provided some new ideas for applying the Tri-Jiao Theory to TCM researches into the disease.
MeSH term(s)	Drugs, Chinese Herbal ; Humans ; Infertility, Male/therapy ; Male ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2020-03-25
Publishing country	China
Document type	Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Conference proceedings ; Online: Flood forecasting via blending nowcasts with NWP over the Jiao River, East China

Xu, Y. / Liu, L. / Gu, H.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: ... by Typhoon Lekima in Jiao River, East China, was forecasted. First, the Xinanjiang (XAJ) model was developed ...

Abstract	Multi-source precipitation products can play an important role in monitoring and forecasting short-duration heavy rainfall and the resulted intense flood. In this study, the record-breaking flood induced by Typhoon Lekima in Jiao River, East China, was forecasted. First, the Xinanjiang (XAJ) model was developed and calibrated based on parameter regionalization derived from SOM and k-Means clustering. Then, the performance of currently prevailing atmosphere reanalysis (CLDASv2 and CMA-CMORP), quantitative precipitation estimation (QPEs) (IMERG-ER and PERSIANN-CCS) and quantitative precipitation forecasts (QPFs) (GRAPES_MESO, ECMWF and GFS) in monitoring and forecasting the Lekima heavy rainfall and flood was evaluated. Finally, in order to obtain good-accuracy rainfall, a three-component blended ensemble was proposed through blending QPE nowcasts with the weighted ensemble of QPFs through a transition of the regional GRAPES_MESO product. The results showed that parameter regionalization in the hydrological model enabled an explicit consideration of the spatial heterogeneity of basin attributes as well as meteorology with a minimum NSE value of 0.81. The two products namely CLDASv2 and CMA-CMORPH provided superior spatial-temporal accuracy with Structural Similarity Index up to 0.75 and NSE > 0.9 for flood simulation. The real-time application of QPFs during the Lekima flood provided encouraging results with a lead time of 40 hours. The proposed ensemble method generated more stable and accurate flood forecasts. The findings in this study can present good reference for real-time flood preparation and mitigation with practical significances.
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
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Article: Digestive promoting effect and mechanism of Jiao Sanxian in rats

Liu, Ying / Liao, Wenting / Liu, Xingran / Hu, Yunwei / Zhu, Xiaoxia / Ju, Longtao / Feng, Feng / Qu, Wei / Liu, Wenyuan / Xu, Jian

Journal of ethnopharmacology. 2021 Oct. 05, v. 278

2021

Abstract: Jiao Sanxian, a customary term for the three Traditional Chinese Medicines of charred hawthorn ... a classic prescription for the treatment of functional dyspepsia (FD). This prescription is called “Jiao ... improving stagnation of digestive system. Even though Jiao Sanxian is widely used in clinical treatment ...

Abstract	Jiao Sanxian, a customary term for the three Traditional Chinese Medicines of charred hawthorn (Crataegi Fructus), charred malt (Hordei Fructus Germinatus) and Liu Shenqu (Massa Medicata Fermentata), is a classic prescription for the treatment of functional dyspepsia (FD). This prescription is called “Jiao Sanxian” in China because people believe that it is a miracle medicine for enhancing digestion and improving stagnation of digestive system. Even though Jiao Sanxian is widely used in clinical treatment, the underlying mechanism has not been clarified to date.The present study is aimed to explore the efficacy and mechanism of Jiao Sanxian in improving the symptoms of FD in rats by using multiple pharmacological methods.The Sprague Dawley (SD) rats were divided into control, model, Jiao Sanxian decoction low-dosage (JSXD LD), Jiao Sanxian decoction medium-dosage (JSXD MD), and Jiao Sanxian decoction high-dosage (JSXD HD) group at random. A FD model was established with reserpine, and animals were given intragastric administration. During this period, weight and food intake of animals were recorded. Samples of rat gastric antrum, spleen, and duodenum were collected for pathological staining and immunohistochemical determination of Ghrelin protein expression after 19 days of treatment. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of related brain gut peptides in serum. Moreover, 16S rRNA sequencing was used to valuate the influence of intestinal flora structure of the cecal contents of experimental rats. And plasma metabolomics by Ultra Performance Liquid Chromatography coupled with Quadrupole-Time-of-Flight mass spectrometry (UPLC-Q/TOF-MS) were performed to further reveal the mechanism of action.Jiao Sanxian decoction (JSXD) group with different dosage could increase body weight and food intake, improve histopathological changes, and alter disordered brain gut peptides in FD rats. 16S rRNA sequencing results described that JSXD improved the disorder of structural composition, biodiversity and function of gut microbiota in FD rats. Metabolomics illustrated 26 metabolites with JSXD treatment underwent continuous changes, which revealed JSXD might exert digestive effect by ameliorating abnormal metabolic pathways. The most relevant metabolic pathways were arachidonic acid metabolism, pyruvate metabolism, glycerophospholipid metabolism, alanine, aspartate and glutamate metabolism.JSXD can improve functional dyspepsia in rats and the mechanism is related to regulate secretion of brain gut peptides, significantly improve the disorder of intestinal flora and ameliorated multi-metabolic pathways.
Keywords	Crataegus ; alanine ; arachidonic acid ; aspartic acid ; biodiversity ; blood serum ; body weight ; brain ; digestion ; duodenum ; enzyme-linked immunosorbent assay ; food intake ; ghrelin ; glutamic acid ; glycerophospholipids ; histopathology ; immunohistochemistry ; indigestion ; intestinal microorganisms ; intragastric administration ; malt ; mass spectrometry ; metabolites ; metabolomics ; models ; people ; protein synthesis ; pyruvic acid ; rats ; reserpine ; secretion ; spleen ; ultra-performance liquid chromatography ; China
Language	English
Dates of publication	2021-1005
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114334
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Study on the Accumulation of Heavy Metals in Different Soil-Crop Systems and Ecological Risk Assessment: A Case Study of Jiao River Basin

Dong, Hongzhi / Gao, Zongjun / Liu, Jiutan / Jiang, Bing

Agronomy. 2023 Aug. 26, v. 13, no. 9

2023

Abstract: ... To achieve this aim, four typical crops, wheat, corn, potatoes, and leeks grown in the Jiao River Basin (JRB ...

Abstract	The purpose of this study is to evaluate the bio-accumulation of different soil-crop systems (SCSs) for heavy metals (HMs) and the geo-accumulation of different agricultural growing regions. The ecological risk (ER) assessment was conducted to understand the impact of intensive agricultural production on the environment. To achieve this aim, four typical crops, wheat, corn, potatoes, and leeks grown in the Jiao River Basin (JRB), were selected as the research objects. The concentrations of eight HMs, including copper (Cu), lead (Pb), zinc (Zn), nickel (Ni), chromium (Cr), cadmium (Cd), arsenic (As), and mercury (Hg) in crop tissue and soil were detected. The statistical analysis, including the geo-accumulation index (Igeo), geostatistical analysis, correlation and cluster analysis were then used to evaluate soil contamination and determine the source types of HMs. The results show that the average concentrations of eight HMs in the soil follow the order: Zn > Cr > Ni > Pb > Cu > As > Cd > Hg and the calculated concentration coefficients (K) vary from 0.41–1.12, indicating relative scarcity in sources of HMs. All the Igeo values of HMs are less than 0 except the Igeo of Cr within potato-farmland is from 0 to 1, illustrating that the soil in JRB is uncontaminated. The correlation and cluster analysis reveal that Cu, Zn, and Cd have a strong relationship with each other and the relationship between Pb, Ni, and Cr is general. The content of eight HMs in different crops varies greatly and most of them are within the scope of National Food Safety Standards—Limit of Pollutants in food of China. The bioconcentration factors (BCF) indicate that wheat, corn, potato, and leek have strong bio-accumulation ability of Cu, Zn, and Cd. The ecological risk factor (Er) shows that JRB is in low risk of Cu, Pb, Zn, Ni, Cr, and As; however, the risk of Cr and Hg are mostly low, characterized by partially dotted moderate risk. The risk index (RI) is mainly moderate with partially low risk distributed in planar and high risk distributed in point.
Keywords	agronomy ; arsenic ; bioaccumulation ; cadmium ; case studies ; chromium ; cluster analysis ; corn ; environmental assessment ; food safety ; geostatistics ; lead ; leeks ; mercury ; nickel ; potatoes ; risk factors ; soil ; soil pollution ; watersheds ; wheat ; zinc ; China
Language	English
Dates of publication	2023-0826
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2607043-1
ISSN	2073-4395
ISSN	2073-4395
DOI	10.3390/agronomy13092238
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Article ; Online: Evaluation of nine active components of Lu-Jiao Fang in normal and hypertrophic rat myocardia via LC-MS/MS.

Ma, Jing-Ya / Shi, Xiao-Li / Liu, Li / Xu, Guang-Lin / Zhang, Jian-Wei

Biomedical chromatography : BMC

2020 Volume 34, Issue 5, Page(s) e4814

Abstract: Lu-Jiao Fang (LJF), a traditional Chinese medicine prescription, can improve the cardiac function ...

Abstract	Lu-Jiao Fang (LJF), a traditional Chinese medicine prescription, can improve the cardiac function of chronic heart failure (CHF) patients; however, knowledge about the cardiac distribution of LJF, especially in CHF animal models, is rather limited. This work aimed to explore the cardiac distribution of LJF in pressure overload-induced CHF rats at the last gavage administration of LJF after 30 weeks of treatment. LC-MS/MS methods for analyzing nine active components (i.e. loganin, hesperidin, epimedin C, icariin, psoralen, isopsoralen, baohuoside I, morroniside and specnuezhenide) of LJF in cardiac tissue samples were established, and the components were then analyzed in left ventricular wall (LVW) and right ventricular wall (RVW) in parallel at same time point postdose for three dose groups. The results showed that most analytical component levels in LVW (hypertrophic myocardium) were only 39-74% of those in RVW (normal myocardium); however, psoralen and isopsoralen levels in LVW were equal to or even greater than the levels in RVW, suggesting that the hypertrophic myocardium tissue affinity of psoralen and isopsoralen might overcome the negative effect of decreased blood flow on distribution. This study indicated that the pathological state may influence drug distribution, and the efficacy of psoralen and isopsoralen for improving CHF deserves further investigation.
MeSH term(s)	Animals ; Cardiomyopathy, Hypertrophic/drug therapy ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Heart/drug effects ; Heart Failure/drug therapy ; Humans ; Male ; Rats ; Rats, Wistar ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2020-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.4814
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Article ; Online: Jiao-tai-wan for insomnia symptoms caused by the disharmony of the heart and kidney

Congcong Zeng / Xi Liu / Lufeng Hu / Yuan Feng / Nengzhi Xia / Haihuan Zeng / Lin Luo / Ren Ye / Zhengzhong Yuan

Trials, Vol 21, Iss 1, Pp 1-

a study protocol for a randomized, double-blind, placebo-controlled trial

2020 Volume 9

Abstract: ... treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai ...

Abstract	Abstract Background Insomnia seriously affects people’s normal lives and work. However, effective treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai-wan (JTW) for ameliorating insomnia symptoms caused by disharmony of the heart and kidney. Design This is a randomized, double-blind, placebo-controlled pilot clinical trial. A total of 124 participants suffering from insomnia symptoms will be randomly assigned to the JTW or placebo group in an equal ratio. The participants will be asked to take JTW or placebo granules twice a day for 1 week. All data will be gathered at baseline and at the end of the drug intervention. The primary outcome measures will be the mean change in the Pittsburgh Sleep Quality Index (PSQI) from baseline to the end of the drug intervention. Secondary outcome measures will include the altered sleep parameters in polysomnography, 1H-magnetic resonance spectroscopy (1H-MRS) evaluation, the Disharmony of Heart and Kidney Scoring System score, and blood tests, including the levels of serum adenosine and melatonin. A laboratory test will be taken before and after treatment to assess the safety of JTW. Discussion The outcomes of this study will confirm the efficacy of JTW for the treatment of insomnia symptoms and will also be used to monitor the safety of JTW. Trial registration Chinese Clinical Trial Registry, ChiCTR1 800019239 . Registered on 1st November 2018.
Keywords	Jiao-tai-wan ; Insomnia ; Traditional herbal medicine ; Randomized controlled trial ; Study protocol ; Pattern identification ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Jiao-tai-wan for insomnia symptoms caused by the disharmony of the heart and kidney: a study protocol for a randomized, double-blind, placebo-controlled trial.

Zeng, Congcong / Liu, Xi / Hu, Lufeng / Feng, Yuan / Xia, Nengzhi / Zeng, Haihuan / Luo, Lin / Ye, Ren / Yuan, Zhengzhong

Trials

2020 Volume 21, Issue 1, Page(s) 408

Abstract: ... treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai ...

Abstract	Background: Insomnia seriously affects people's normal lives and work. However, effective treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai-wan (JTW) for ameliorating insomnia symptoms caused by disharmony of the heart and kidney. Design: This is a randomized, double-blind, placebo-controlled pilot clinical trial. A total of 124 participants suffering from insomnia symptoms will be randomly assigned to the JTW or placebo group in an equal ratio. The participants will be asked to take JTW or placebo granules twice a day for 1 week. All data will be gathered at baseline and at the end of the drug intervention. The primary outcome measures will be the mean change in the Pittsburgh Sleep Quality Index (PSQI) from baseline to the end of the drug intervention. Secondary outcome measures will include the altered sleep parameters in polysomnography, Discussion: The outcomes of this study will confirm the efficacy of JTW for the treatment of insomnia symptoms and will also be used to monitor the safety of JTW. Trial registration: Chinese Clinical Trial Registry, ChiCTR1800019239. Registered on 1st November 2018.
MeSH term(s)	Adolescent ; Adult ; Double-Blind Method ; Drugs, Chinese Herbal/adverse effects ; Female ; Heart Diseases/complications ; Humans ; Kidney Diseases/complications ; Male ; Middle Aged ; Phytotherapy/methods ; Polysomnography ; Randomized Controlled Trials as Topic ; Sleep/drug effects ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Initiation and Maintenance Disorders/therapy ; Treatment Outcome ; Young Adult
Chemical Substances	Drugs, Chinese Herbal ; jiao tai wan
Language	English
Publishing date	2020-05-15
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1468-6708
ISSN (online)	1745-6215 ; 1468-6694
ISSN	1468-6708
DOI	10.1186/s13063-020-04299-x
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