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  1. Article ; Online: The Smallpox Epidemics in America in the 1700s and the Role of the Surgeons: Lessons to be Learned During the Global Outbreak of COVID-19.

    Hasselgren, Per-Olof

    World journal of surgery

    2020  Volume 44, Issue 9, Page(s) 2837–2841

    Abstract: Today's COVID-19 pandemic offers many similarities with previous pandemics hitting our country. In particular, the smallpox epidemics during the 1700s threatened the lives of multitudes and created panic and fear in the society, similar to the situation ... ...

    Abstract Today's COVID-19 pandemic offers many similarities with previous pandemics hitting our country. In particular, the smallpox epidemics during the 1700s threatened the lives of multitudes and created panic and fear in the society, similar to the situation caused by the coronavirus. Remedies that were instituted, especially inoculations, were met with opposition and even violence when first introduced. The newspapers were filled with headlines reflecting the disputes. There was a "six feet rule" during the smallpox epidemics, although it had a different meaning than today. Politicians and other leaders of the society were engaged in the war against the infection. Boston became involved in the fight against the smallpox by Dr. Zabdiel Boylston's and Rev. Cotton Mather's introduction of inoculations. When George Washington realized the benefits of the procedure and ordered mass inoculations of the Continental Army, it became an important factor in winning not only the fight against smallpox but the Revolutionary War as well. Looking back at history, realizing that we have survived previous outbreaks of devastating diseases, can provide hope during the current pandemic.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Outbreaks/history ; History, 18th Century ; Humans ; Immunization/history ; Mass Vaccination/history ; Pandemics ; Physician's Role ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Smallpox/epidemiology ; Smallpox/history ; Surgeons ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05670-4
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  2. Article: The Smallpox Epidemics in America in the 1700s and the Role of the Surgeons: Lessons to be Learned During the Global Outbreak of COVID-19

    Hasselgren, Per-Olof

    World J Surg

    Abstract: Today's COVID-19 pandemic offers many similarities with previous pandemics hitting our country. In particular, the smallpox epidemics during the 1700s threatened the lives of multitudes and created panic and fear in the society, similar to the situation ... ...

    Abstract Today's COVID-19 pandemic offers many similarities with previous pandemics hitting our country. In particular, the smallpox epidemics during the 1700s threatened the lives of multitudes and created panic and fear in the society, similar to the situation caused by the coronavirus. Remedies that were instituted, especially inoculations, were met with opposition and even violence when first introduced. The newspapers were filled with headlines reflecting the disputes. There was a "six feet rule" during the smallpox epidemics, although it had a different meaning than today. Politicians and other leaders of the society were engaged in the war against the infection. Boston became involved in the fight against the smallpox by Dr. Zabdiel Boylston's and Rev. Cotton Mather's introduction of inoculations. When George Washington realized the benefits of the procedure and ordered mass inoculations of the Continental Army, it became an important factor in winning not only the fight against smallpox but the Revolutionary War as well. Looking back at history, realizing that we have survived previous outbreaks of devastating diseases, can provide hope during the current pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #632243
    Database COVID19

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  3. Article ; Online: The Smallpox Epidemics in America in the 1700s and the Role of the Surgeons

    Hasselgren, Per-Olof

    World Journal of Surgery

    Lessons to be Learned During the Global Outbreak of COVID-19

    2020  Volume 44, Issue 9, Page(s) 2837–2841

    Keywords Surgery ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05670-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Posttranslational Modifications in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, Classification, and Treatment.

    Broekhuis, Jordan M / James, Benjamin C / Cummings, Richard D / Hasselgren, Per-Olof

    Cancers

    2022  Volume 14, Issue 7

    Abstract: There is evidence that posttranslational modifications, including phosphorylation, acetylation, methylation, ubiquitination, sumoylation, glycosylation, and succinylation, may be involved in thyroid cancer. We review recent reports supporting a role of ... ...

    Abstract There is evidence that posttranslational modifications, including phosphorylation, acetylation, methylation, ubiquitination, sumoylation, glycosylation, and succinylation, may be involved in thyroid cancer. We review recent reports supporting a role of posttranslational modifications in the tumorigenesis of thyroid cancer, sensitivity to radioiodine and other types of treatment, the identification of molecular treatment targets, and the development of molecular markers that may become useful as diagnostic tools. An increased understanding of posttranslational modifications may be an important supplement to the determination of alterations in gene expression that has gained increasing prominence in recent years.
    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14071610
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  5. Article ; Online: β-Hydroxy-β-methylbutyrate (HMB) and prevention of muscle wasting.

    Hasselgren, Per-Olof

    Metabolism: clinical and experimental

    2014  Volume 63, Issue 1, Page(s) 5–8

    MeSH term(s) Animals ; Caloric Restriction ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Male ; Muscle, Skeletal/physiology ; Physical Conditioning, Animal/physiology ; Physical Endurance/physiology ; Valerates/pharmacology
    Chemical Substances Valerates
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2013.09.015
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  6. Book: Protein metabolism in sepsis

    Hasselgren, Per-Olof

    (Medical intelligence unit)

    1993  

    Author's details Per-Olof Hasselgren
    Series title Medical intelligence unit
    Keywords Infection / physiopathology ; Infection / metabolism ; Proteins / metabolism ; Sepsis ; Proteinstoffwechsel
    Subject Eiweissstoffwechsel ; Proteine ; Blutvergiftung ; Septikämie
    Language English
    Size 130 S. : Ill., graph. Darst.
    Publisher Landes
    Publishing place Austin
    Publishing country United States
    Document type Book
    HBZ-ID HT006316806
    ISBN 1-879702-77-0 ; 978-1-879702-77-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1994 A 2673 order for loan Magazin

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  7. Article ; Online: Can Cytologic and Sonographic Features Help Prevent Overtreatment of Bethesda V Thyroid Nodules?

    Higgins, Sara / James, Benjamin C / Sacks, Barry / Mowschenson, Peter / Nishino, Michiya / Hasselgren, Per-Olof

    The Journal of surgical research

    2021  Volume 268, Page(s) 112–118

    Abstract: Background: Although nearly half of thyroid nodules with Bethesda V cytology (suspicious for malignancy) may be benign or harbor low-grade neoplasms that can be sufficiently treated with lobectomy, many patients with Bethesda V cytology continue to be ... ...

    Abstract Background: Although nearly half of thyroid nodules with Bethesda V cytology (suspicious for malignancy) may be benign or harbor low-grade neoplasms that can be sufficiently treated with lobectomy, many patients with Bethesda V cytology continue to be treated with total thyroidectomy. The objectives of this study were to establish whether cytomorphologic and ultrasonographic features can determine appropriate surgery for thyroid nodules with Bethesda V cytology and how often patients are overtreated with total instead of partial thyroidectomy.
    Methods: Utilizing a 10-y prospective database starting January 1, 2004, cytomorphologic and ultrasonographic features of thyroid nodules with Bethesda V cytology were reviewed. Overtreatment was defined as total thyroidectomy when histopathology revealed benign nodule, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) or a unilateral < 4 cm low risk cancer.
    Results: Sixty-three patients were included in the study. Seventeen (27%) had benign, 14 (22%) NIFTP, and 32 (51%) malignant nodules. On cytology, nuclear pseudoinclusions, and on ultrasound, taller-than-wide configuration, were more common in malignant than benign or NIFTP nodules. Among 56 patients who underwent total thyroidectomy, 14 and 11 had a benign or NIFTP nodule, respectively, and 13 had a unilateral < 4 cm low risk cancer, suggesting that 68% (38/56) were overtreated.
    Conclusions: Total thyroidectomy for Bethesda V thyroid nodules may result in overtreatment in more than half of the patients. Although certain cytomorphologic and ultarsonographic features may be helpful in determining appropriate surgery for Bethesda V thyroid nodules, additional characteristics are needed to reduce overtreatment of these nodules.
    MeSH term(s) Adenocarcinoma, Follicular/diagnostic imaging ; Adenocarcinoma, Follicular/pathology ; Adenocarcinoma, Follicular/surgery ; Biopsy, Fine-Needle ; Humans ; Overtreatment ; Retrospective Studies ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology ; Thyroid Nodule/surgery
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2021.05.050
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    Zs.A 178: Show issues Location:
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  8. Article ; Online: Ubiquitination, phosphorylation, and acetylation--triple threat in muscle wasting.

    Hasselgren, Per-Olof

    Journal of cellular physiology

    2007  Volume 213, Issue 3, Page(s) 679–689

    Abstract: Loss of muscle mass is commonly seen in patients with critical illness and is associated with increased expression of multiple genes controlling protein breakdown. Transcription factors that are activated during muscle wasting include NF-kB and members ... ...

    Abstract Loss of muscle mass is commonly seen in patients with critical illness and is associated with increased expression of multiple genes controlling protein breakdown. Transcription factors that are activated during muscle wasting include NF-kB and members of the FOXO and C/EBP transcription factor families. The activity of these transcription factors is regulated by multiple posttranslational modifications, including ubiquitination, phosphorylation, and acetylation, providing for a complex and integrated network of regulatory mechanisms in muscle wasting. Targeting posttranslational modifications of transcription factors may prove important in the prevention and treatment of the debilitating consequences of muscle wasting.
    MeSH term(s) Acetylation ; Animals ; Gene Expression Regulation ; Humans ; Models, Biological ; Muscular Atrophy/metabolism ; Phosphorylation ; Protein Processing, Post-Translational ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Ubiquitination
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2007-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.21190
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    Uc I Zs.212: Show issues Location:
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  9. Article: Papillary thyroid cancer with extrathyroidal extension of desmoid-type fibromatosis. A case report of an aggressive presentation of an uncommon pathologic entity.

    Roth, Eve M / Barrows, Courtney E / Nishino, Michiya / Sacks, Barry / Hasselgren, Per-Olof / James, Benjamin C

    International journal of surgery case reports

    2019  Volume 63, Page(s) 5–9

    Abstract: Introduction: Papillary thyroid cancer with desmoid-type fibromatosis (PTC-DTF) is an uncommon tumor characterized by extensive stromal proliferation of fibroblasts and myofibroblasts with a small component of PTC. We report a case of PTC-DTF with ... ...

    Abstract Introduction: Papillary thyroid cancer with desmoid-type fibromatosis (PTC-DTF) is an uncommon tumor characterized by extensive stromal proliferation of fibroblasts and myofibroblasts with a small component of PTC. We report a case of PTC-DTF with infiltration of the mesenchymal component of tumor into perithyroidal muscle and early recurrence of desmoid after thyroidectomy, an outcome previously not reported.
    Presentation of case: A 20-year-old man underwent left hemithyroidectomy for a thyroid nodule. Pathology demonstrated a 4.2 cm tumor with PTC-DTF with the PTC comprising <10% of the tumor. The stromal component extended into adjacent skeletal muscle. After completion thyroidectomy, histopathology of the right thyroid lobe revealed no malignancy or fibromatosis. Neck MRI 16 months after the initial operation revealed a 10.5 cm tumor in the left thyroid bed. Core biopsy and open excisional biopsy showed desmoid-type fibromatosis without PTC. The patient is undergoing chemotherapy of his recurrent desmoid-type fibromatosis.
    Discussion: In patients with PTC-DTF there is a risk of recurrence of the benign component of the tumor. In recent reports, the role of less aggressive surgery, or even non-surgical management, of patients with recurrent DTF has been emphasized, in particular when extensive surgery may be associated with high risk of functional loss. The management of our patient adheres to modern recommendations for the treatment of DTF.
    Conclusion: Patients with PTC-DTF should be carefully monitored after thyroidectomy for both recurrent PTC and local recurrence of the fibrous component of the tumor.
    Language English
    Publishing date 2019-08-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2019.08.001
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  10. Article ; Online: Comment on Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats.

    Alamdari, Nima / Hasselgren, Per-Olof

    Journal of cachexia, sarcopenia and muscle

    2012  Volume 3, Issue 1, Page(s) 71–72

    Language English
    Publishing date 2012-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1007/s13539-012-0057-7
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