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  1. Article: Protective intraoperative ventilation during thoracic surgery: definitively yes!

    Pasin, Laura

    Journal of thoracic disease

    2019  Volume 11, Issue Suppl 3, Page(s) S341–S342

    Language English
    Publishing date 2019-04-09
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.12.129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immune thrombocytopenia following COVID-19 mRNA vaccine: casuality or causality?

    Pasin, Federico / Calabrese, Alberto / Pelagatti, Laura

    Internal and emergency medicine

    2021  Volume 17, Issue 1, Page(s) 295–297

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Purpura, Thrombocytopenic, Idiopathic/etiology ; Purpura, Thrombotic Thrombocytopenic ; SARS-CoV-2 ; Vaccines, Synthetic ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines
    Language English
    Publishing date 2021-06-07
    Publishing country Italy
    Document type Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02778-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of Lower Tidal Volumes During One-Lung Ventilation: A 2022 Update of the Meta-analysis of Randomized Controlled Trials.

    El Tahan, Mohamed R / Samara, Evangelia / Marczin, Nandor / Landoni, Giovanni / Pasin, Laura

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 37, Issue 10, Page(s) 1983–1992

    Abstract: Objectives: To clarify the influence of lower tidal volume (4-7 mL/kg) compared with higher tidal volume (8-15 mL/kg) during one-lung ventilation (OLV) on gas exchange and postoperative clinical outcome.: Design: Meta-analysis of randomized trials.!## ...

    Abstract Objectives: To clarify the influence of lower tidal volume (4-7 mL/kg) compared with higher tidal volume (8-15 mL/kg) during one-lung ventilation (OLV) on gas exchange and postoperative clinical outcome.
    Design: Meta-analysis of randomized trials.
    Setting: Thoracic surgery.
    Participants: Patients receiving OLV.
    Interventions: Lower tidal volume during OLV.
    Measurements and main results: Primary outcome was PaO
    Conclusions: The use of lower tidal volume, a component of protective OLV, increases the PaO
    MeSH term(s) Humans ; One-Lung Ventilation ; Tidal Volume ; Randomized Controlled Trials as Topic ; Respiration, Artificial ; Lung ; Thoracic Surgical Procedures/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Meta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen.

    Covello, Remo Daniel / Pasin, Laura / Fresilli, Stefano / Tóth, Krisztina / Damiani, Caterina / Hajjar, Ludhmila Abrahão / Zangrillo, Alberto / Landoni, Giovanni

    NEJM evidence

    2023  Volume 2, Issue 5, Page(s) EVIDoa2200283

    Abstract: Glucocorticoids for Covid-19 Patients Not on OxygenGlucocorticoids reduce mortality in hospitalized patients with severe and critical Covid-19. Covello et al. performed a meta-analysis to test the hypothesis that glucocorticoids could be detrimental in ... ...

    Abstract Glucocorticoids for Covid-19 Patients Not on OxygenGlucocorticoids reduce mortality in hospitalized patients with severe and critical Covid-19. Covello et al. performed a meta-analysis to test the hypothesis that glucocorticoids could be detrimental in patients not on oxygen therapy.
    MeSH term(s) Humans ; Glucocorticoids ; COVID-19 ; Oxygen ; SARS-CoV-2
    Chemical Substances Glucocorticoids ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDoa2200283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Angiotensin II - A Brief Review and Role in Severe SARS-COV-2 Sepsis.

    Carà, Gianmarco A / Pasin, Laura / Alborino, Ettore / Zarbock, Alexander / Bellomo, Rinaldo / Landoni, Giovanni

    Journal of cardiothoracic and vascular anesthesia

    2022  Volume 36, Issue 12, Page(s) 4496–4500

    Abstract: The renin-angiotensin-aldosterone system (RAAS), whose major vasopressor effector is angiotensin II (ATII), has multiple activities and regulates sodium-water homeostasis and fluid and blood pressure homeostasis. RAAS plays a crucial role in ... ...

    Abstract The renin-angiotensin-aldosterone system (RAAS), whose major vasopressor effector is angiotensin II (ATII), has multiple activities and regulates sodium-water homeostasis and fluid and blood pressure homeostasis. RAAS plays a crucial role in cardiocirculatory shock because it counteracts hypotension and hypovolemia by activating different physiologic responses. Based on the encouraging results of the ATHOS-3 trial, the US Food and Drug Administration and the European Medicines Agency approved the use of ATII for catecholamine-resistant vasodilatory shock. More recently, ATII was used for the compassionate treatment of critically ill patients with COVID-19. Beyond its vasopressor properties, ATII was hypothesized to have antiviral activity because it induces internalization and degradation of angiotensin-converting enzyme 2 receptors used by SARS-Cov-2 to infect cells. Overall, the use of ATII in patients with COVID-19 showed promising results because its administration was associated with the achievement and maintenance of target mean arterial pressure, increased P
    MeSH term(s) Humans ; SARS-CoV-2 ; Angiotensin II/therapeutic use ; COVID-19 ; Renin-Angiotensin System/physiology ; Vasoconstrictor Agents/therapeutic use ; Vasoconstrictor Agents/pharmacology ; Sepsis/drug therapy
    Chemical Substances Angiotensin II (11128-99-7) ; Vasoconstrictor Agents
    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2022.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Using a Social Robot to Engage Older Adults Living in Residential Care Homes in Cognitive Training: Preliminary Results from the SHAPES Project.

    Cesario, Lisa / Gherardini, Arianna / Pasin, Marco / Bugo, Laura / Malavasi, Massimiliano / Hoogerwerf, Evert-Jan / Fiordelmondo, Valentina / Pascual, Esperança Lladó / Desideri, Lorenzo

    Studies in health technology and informatics

    2023  Volume 306, Page(s) 3–8

    Abstract: The employment of socially assistive robotics (SAR) is increasingly being considered a credible solution to support healthcare systems in dealing with an aging society. In this contribution, we explore the experience of older adults (n = 11) living in a ... ...

    Abstract The employment of socially assistive robotics (SAR) is increasingly being considered a credible solution to support healthcare systems in dealing with an aging society. In this contribution, we explore the experience of older adults (n = 11) living in a residential facility with a cognitive training intervention conducted with the support of a SAR. Within the HORIZON2020 Project SHAPES, a mixed-method study has been conducted to collect preliminary evidence on users' engagement and acceptance of the proposed SAR-based intervention. The results suggest that the SAR-based cognitive training intervention conducted was accepted by all stakeholders. Data on enjoyment of participants indicate that users did not experience a "novelty effect" of the proposed innovation, but longer sessions are needed to confirm this result.
    MeSH term(s) Robotics ; Cognitive Training/instrumentation ; Humans ; Male ; Female ; Aged ; Cognition Disorders/therapy ; Follow-Up Studies ; Social Cognition ; Social Interaction ; Homes for the Aged
    Language English
    Publishing date 2023-08-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Propofol and survival: an updated meta-analysis of randomized clinical trials.

    Kotani, Yuki / Pruna, Alessandro / Turi, Stefano / Borghi, Giovanni / Lee, Todd C / Zangrillo, Alberto / Landoni, Giovanni / Pasin, Laura

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 139

    Abstract: Background: Propofol is one of the most widely used hypnotic agents in the world. Nonetheless, propofol might have detrimental effects on clinically relevant outcomes, possibly due to inhibition of other interventions' organ protective properties. We ... ...

    Abstract Background: Propofol is one of the most widely used hypnotic agents in the world. Nonetheless, propofol might have detrimental effects on clinically relevant outcomes, possibly due to inhibition of other interventions' organ protective properties. We performed a systematic review and meta-analysis of randomized controlled trials to evaluate if propofol reduced survival compared to any other hypnotic agent in any clinical setting.
    Methods: We searched eligible studies in PubMed, Google Scholar, and the Cochrane Register of Clinical Trials. The following inclusion criteria were used: random treatment allocation and comparison between propofol and any comparator in any clinical setting. The primary outcome was mortality at the longest follow-up available. We conducted a fixed-effects meta-analysis for the risk ratio (RR). Using this RR and 95% confidence interval, we estimated the probability of any harm (RR > 1) through Bayesian statistics. We registered this systematic review and meta-analysis in PROSPERO International Prospective Register of Systematic Reviews (CRD42022323143).
    Results: We identified 252 randomized trials comprising 30,757 patients. Mortality was higher in the propofol group than in the comparator group (760/14,754 [5.2%] vs. 682/16,003 [4.3%]; RR = 1.10; 95% confidence interval, 1.01-1.20; p = 0.03; I
    Conclusions: Propofol may reduce survival in perioperative and critically ill patients. This needs careful assessment of the risk versus benefit of propofol compared to other agents while planning for large, pragmatic multicentric randomized controlled trials to provide a definitive answer.
    MeSH term(s) Adult ; Humans ; Propofol/adverse effects ; Bayes Theorem ; Randomized Controlled Trials as Topic ; Systematic Reviews as Topic ; Hypnotics and Sedatives/adverse effects
    Chemical Substances Propofol (YI7VU623SF) ; Hypnotics and Sedatives
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04431-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Early initiation of renal replacement therapy in critically ill patients: a meta-analysis of randomized clinical trials.

    Pasin, Laura / Boraso, Sabrina / Tiberio, Ivo

    BMC anesthesiology

    2019  Volume 19, Issue 1, Page(s) 62

    Abstract: Background: Acute kidney injury (AKI) is strongly associated with high morbidity and mortality of critically ill patients. In the last years several different biological markers with higher sensitivity and specificity for the occurrence of renal ... ...

    Abstract Background: Acute kidney injury (AKI) is strongly associated with high morbidity and mortality of critically ill patients. In the last years several different biological markers with higher sensitivity and specificity for the occurrence of renal impairment have been developed in order to promptly recognize and treat AKI. Nonetheless, their potential role in improving patients' outcome remains unclear since the effectiveness of an "earlier" initiation of renal replacement therapy (RRT) is still debated. Since one large, high-quality randomized clinical trial has been recently pubblished, we decided to perform a meta-analysis of all the RCTs ever performed on "earlier" initiation of RRT versus standard RRT in critically ill patients with AKI to evaluate its effect on major outcomes.
    Methods: Pertinent studies were independently searched in BioMedCentral, PubMed, Embase, and Cochrane Central Register of clinical trials. The following inclusion criteria were used: random allocation to treatment ("earlier" initiation of RRT versus later/standard initiation); critically ill patients.
    Results: Ten trials randomizing 2214 patients, 1073 to earlier initiation of RRT and 1141 to later initiation were included. No difference in mortality (43.3% (465 of 1073) for those receiving early RRT and 40.8% (466 of 1141) for controls, p = 0.97) and survival without dependence on RRT (3.6% (34 of 931) for those receiving early RRT and 4.2% (40 of 939) for controls, p = 0.51) were observed in the overall population. On the contrary, early initiation of RRT was associated with a significant reduction in hospital length of stay. No differences in occurrence of adverse events were observed.
    Conclusions: Our study suggests that early initiation of RRT in critically ill patients with AKI does not provide a clinically relevant advantage when compared with standard/late initiation.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/therapy ; Critical Illness/epidemiology ; Critical Illness/therapy ; Humans ; Randomized Controlled Trials as Topic/methods ; Renal Replacement Therapy/methods ; Time-to-Treatment
    Language English
    Publishing date 2019-05-01
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ISSN 1471-2253
    ISSN (online) 1471-2253
    DOI 10.1186/s12871-019-0733-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Trial sequential analysis: plain and simple.

    De Cassai, Alessandro / Pasin, Laura / Boscolo, Annalisa / Salvagno, Michele / Navalesi, Paolo

    Korean journal of anesthesiology

    2020  Volume 74, Issue 4, Page(s) 363–365

    MeSH term(s) Analgesia/methods ; Humans
    Language English
    Publishing date 2020-12-18
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2557340-8
    ISSN 2005-7563 ; 2005-7563
    ISSN (online) 2005-7563
    ISSN 2005-7563
    DOI 10.4097/kja.20637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The use of extracorporeal blood purification therapies and sequential extracorporeal support in patients with septic shock (EROICASS): a study protocol for a national, non-interventional, observational multicenter, prospective study.

    De Rosa, Silvia / Ferrari, Fiorenza / Greco, Massimiliano / Pota, Vincenzo / Umbrello, Michele / Cotoia, Antonella / Pasin, Laura / Nalesso, Federico / Paternoster, Gianluca / Villa, Gianluca / Lassola, Sergio / Miori, Sara / Sanna, Andrea / Cantaluppi, Vicenzo / Marengo, Marita / Valente, Fabrizio / Fiorentino, Marco / Brunori, Giuliano / Bellani, Giacomo /
    Giarratano, Antonino

    Journal of anesthesia, analgesia and critical care

    2024  Volume 4, Issue 1, Page(s) 16

    Abstract: Background: Septic shock, a critical condition characterized by organ failure, presents a substantial mortality risk in intensive care units (ICUs), with the 28-day mortality rate possibly reaching 40%. Conventional management of septic shock typically ... ...

    Abstract Background: Septic shock, a critical condition characterized by organ failure, presents a substantial mortality risk in intensive care units (ICUs), with the 28-day mortality rate possibly reaching 40%. Conventional management of septic shock typically involves the administration of antibiotics, supportive care for organ dysfunction, and, if necessary, surgical intervention to address the source of infection. In recent decades, extracorporeal blood purification therapies (EBPT) have emerged as potential interventions aimed at modulating the inflammatory response and restoring homeostasis in patients with sepsis. Likewise, sequential extracorporeal therapy in sepsis (SETS) interventions offer comprehensive organ support in the setting of multiple organ dysfunction syndrome (MODS). The EROICASS study will assess and describe the utilization of EBPT in patients with septic shock. Additionally, we will evaluate the potential association between EBPT treatment utilization and 90-day mortality in septic shock cases in Italy.
    Methods: The EROICASS study is a national, non-interventional, multicenter observational prospective cohort study. All consecutive patients with septic shock at participating centers will be prospectively enrolled, with data collection extending from intensive care unit (ICU) admission to hospital discharge. Variables including patient demographics, clinical parameters, EBPT/SETS utilization, and outcomes will be recorded using a web-based data capture system. Statistical analyses will encompass descriptive statistics, hypothesis testing, multivariable regression models, and survival analysis to elucidate the associations between EBPT/SETS utilization and patient outcomes.
    Conclusions: The EROICASS study provides valuable insights into the utilization and outcomes of EBPT and SETS in septic shock management. Through analysis of usage patterns and clinical data, this study aims to guide treatment decisions and enhance patient care. The implications of these findings may impact clinical guidelines, potentially improving survival rates and patient outcomes in septic shock cases.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ISSN 2731-3786
    ISSN (online) 2731-3786
    DOI 10.1186/s44158-024-00153-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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