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  1. Article ; Online: Targeting Epithelium Dysfunction and Impaired Nasal Biofilms to Treat Immunological, Functional, and Structural Abnormalities of Chronic Rhinosinusitis.

    Petalas, Konstantinos / Goudakos, John / Konstantinou, George N

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Chronic rhinosinusitis (CRS) with (CRSwNP) or without (CRSsNP) nasal polyps is a prevalent and heterogeneous disorder existing as a spectrum of clinical conditions with complex underlying pathomechanisms. CRS comprises a broad syndrome characterized by ... ...

    Abstract Chronic rhinosinusitis (CRS) with (CRSwNP) or without (CRSsNP) nasal polyps is a prevalent and heterogeneous disorder existing as a spectrum of clinical conditions with complex underlying pathomechanisms. CRS comprises a broad syndrome characterized by multiple immunological features involving complex interactions between the genes, the microbiome, host- and microbiota-derived exosomes, the epithelial barrier, and environmental and micromilieu exposures. The main pathophysiological feature is an epithelial barrier disruption, accompanied by microbiome alterations and unpredictable and multifactorial immunologic overreactions. Extrinsic pathogens and irritants interact with multiple epithelial receptors, which show distinct expression patterns, activate numerous signaling pathways, and lead to diverse antipathogen responses. CRSsNP is mainly characterized by fibrosis and mild inflammation and is often associated with Th1 or Th17 immunological profiles. CRSwNP appears to be associated with moderate or severe type 2 (T2) or Th2 eosinophilic inflammation. The diagnosis is based on clinical, endoscopic, and imaging findings. Possible CRS biomarkers from the peripheral blood, nasal secretions, tissue biopsies, and nasally exhaled air are studied to subgroup different CRS endotypes. The primary goal of CRS management is to maintain clinical control by nasal douching with isotonic or hypertonic saline solutions, administration of nasal and systemic steroids, antibiotics, biologic agents, or, in persistent and more severe cases, appropriate surgical procedures.
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Revision Rhinoplasty: Retrospective Chart Review Analysis of Deformities and Surgical Maneuvers in Patients with Nasal Airway Obstruction-Five Years of Experience.

    Goudakos, John K / Daskalakis, Dimitrios / Patel, Kalpesh

    Facial plastic surgery : FPS

    2017  Volume 33, Issue 3, Page(s) 334–338

    Abstract: Nasal airway obstruction is one of the most frequent causes of revision rhinoplasty in patients after previous rhinoplasty procedure. Purpose of this study is to present the deformities and the surgical maneuvers conducted in revision rhinoplasty ... ...

    Abstract Nasal airway obstruction is one of the most frequent causes of revision rhinoplasty in patients after previous rhinoplasty procedure. Purpose of this study is to present the deformities and the surgical maneuvers conducted in revision rhinoplasty patients with functional complaint, anatomical sites at risk, and potential prophylactic maneuvers. This study is a retrospective chart review analysis of 46 consecutive revision rhinoplasty procedures in patients with nasal airway obstruction. Inclusion criteria were at least one previous rhinoplasty and nasal airway obstruction as the epicenter of patients' complaint. Thorough clinical examination to certify the obstruction was performed. Deformities noted were separated in three categories according to functional, cosmetic, and combination of functional and cosmetic implications. Surgical maneuvers conducted were reviewed. Deformities found were checked for statistically significant coexistences. The average patient age was 34.9 years. The mean number of previous septorhinoplasties was 1.33. Nasal ventilation obstruction mainly caused either by septum deviation or nasal valve dysfunction was identified in 91.3% of our patients. Surgical maneuvers conducted included placement of grafts in 89.1% of all cases, septoplasty in 76.1%, lateral wall support in 47.8%, and placement of spreader grafts in 39.1% of patients. The average preoperative Nasal Obstruction Symptom Evaluation (NOSE) score was 61 ± 15 and it improved substantially, even from month 1, postoperatively. Owing to high prevalence of nasal airway obstruction after primary or secondary rhinoplasty, we conducted the first retrospective chart review study to identify the most common deformities in revision rhinoplasty patients with nasal airway obstruction and the appropriate surgical maneuvers to address them. Septum deviation and nasal valve dysfunction were the two pillars of nasal airway obstruction in those patients.
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/s-0037-1598041
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  3. Article ; Online: Intracapsular coblation tonsillectomy versus extracapsular coblation tonsillectomy: a systematic review and a meta-analysis.

    Daskalakis, Dimitrios / Tsetsos, Nikolaos / Karagergou, Stella / Goudakos, John / Markou, Konstantinos / Karkos, Peter

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2020  Volume 278, Issue 3, Page(s) 637–644

    Abstract: Purpose: To assess all available data regarding the comparative benefit of intracapsular coblation tonsillectomy (ICT) versus extracapsular coblation tonsillectomy (ECT) in children.: Methods: MEDLINE, the Cochrane Library and Springerlink databases ... ...

    Abstract Purpose: To assess all available data regarding the comparative benefit of intracapsular coblation tonsillectomy (ICT) versus extracapsular coblation tonsillectomy (ECT) in children.
    Methods: MEDLINE, the Cochrane Library and Springerlink databases as well as other sources were searched by two independent reviewers. Controlled studies comparing ICT versus ECT in paediatric patients with obstructive sleep apnea (OSA) or recurrent tonsillitis were included. Overall postoperative pain was the primary outcome. Secondary outcomes were postoperative hemorrhage, diet and activity, duration of operation and tonsillar regrowth. In case of homogenous, processable data (I
    Results: Six studies met the inclusion criteria. The analysis showed significant difference between the two methods in terms of late postoperative pain with the ICT being less painful (SMD - 0.78, 95% CI [- 1.03, - 0.53]). However, there was no significant difference in early postoperative pain (≤ 48 h) between the two techniques (SMD - 0.18, 95% CI [- 0.47, 0.12]). All the rest of the secondary outcomes are presented in a qualitative synthesis due to published data limitations of the included studies.
    Conclusion: Intracapsular coblation tonsillectomy appears to be a less painful operation in comparison to extracapsular coblation tonsillectomy. This seems to occur due to prevention of late pain flare up that normally happens several days after the procedure (described as postoperative dip) and not due to reduced pain at the immediate postoperative period. However, as all studies published are small sized, high-quality, large-sample studies need to be performed in the future for more concrete conclusions.
    MeSH term(s) Humans ; Pain, Postoperative/etiology ; Palatine Tonsil ; Postoperative Hemorrhage/epidemiology ; Postoperative Hemorrhage/etiology ; Tonsillectomy ; Tonsillitis/surgery
    Language English
    Publishing date 2020-07-04
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06178-2
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  4. Article ; Online: Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis.

    Goudakos, John K / Blioskas, Sarantis / Nikolaou, Angelos / Vlachtsis, Konstantinos / Karkos, Peter / Markou, Konstantinos D

    American journal of rhinology & allergy

    2018  Volume 32, Issue 3, Page(s) 167–174

    Abstract: Background Pure endoscopic surgery (functional endoscopic sinus surgery) has been increasingly replacing external approaches in the management of sinonasal inverted papillomas. Objective To analyze and compare the effectiveness of pure endoscopic ... ...

    Abstract Background Pure endoscopic surgery (functional endoscopic sinus surgery) has been increasingly replacing external approaches in the management of sinonasal inverted papillomas. Objective To analyze and compare the effectiveness of pure endoscopic procedure with external or combined procedures to paranasal inverted papillomas, including the experience from two institutions in North Greece, over a 20-year period. Methods Systematic literature searches of MEDLINE (1952-2016), EMBASE (1974-2016), and the Cochrane Central Register of Controlled Trials. Review of all English-language studies comparing endoscopic and open techniques. Odds ratios (ORs), risk ratio, 95% confidence intervals (CIs), and tests for heterogeneity were reported. Recurrence rates according to initial tumor stage. Results In total, 2451 patients had been enrolled in the 23 studies, published between 1992 and 2014. All the included articles are graded as level IV evidence. Among the 1526 patients of the endoscopic group, 212 (13.8%) had recurrence, with the mean time of recurrence to range from 14 to 46.6 months. In the external approach group, 111 (18.7%) of the 592 patients had recurrence, with the time of recurrence to range from 7 to 92 months. The recurrence rate in the combined approach group was 12.9%. The occurrence rate of recurrence attributable to the surgical choice was significantly different between endoscopic and external group (OR: 0.61; 95% CI: 0.40-0.92; P = 0.02; 14.9% vs. 18.8% in endoscopic and external group, respectively). Conclusions The present systematic review and meta-analysis indicates that endoscopic approach seems a favorable treatment option of sinonasal inverted papillomas and confirms the global recommendation that is the gold standard in the treatment of such nose lesions, revealing a lower recurrence rate compared to external approaches.
    MeSH term(s) Endoscopy ; Humans ; Neoplasm Recurrence, Local/prevention & control ; Odds Ratio ; Papilloma, Inverted/surgery ; Paranasal Sinus Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2018-04-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2482804-X
    ISSN 1945-8932 ; 1945-8924
    ISSN (online) 1945-8932
    ISSN 1945-8924
    DOI 10.1177/1945892418765004
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    Zs.A 2542: Show issues Location:
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  5. Article: Revision Rhinoplasty: Retrospective Chart Review Analysis of Deformities and Surgical Maneuvers in Patients with Nasal Airway Obstruction—Five Years of Experience

    Goudakos, John K. / Daskalakis, Dimitrios / Patel, Kalpesh

    Facial Plastic Surgery

    (Beyond the Facelift: Procedures to Enhance Rhytidectomy)

    2017  Volume 33, Issue 03, Page(s) 334–338

    Abstract: Nasal airway obstruction is one of the most frequent causes of revision rhinoplasty in patients after previous rhinoplasty procedure. Purpose of this study is to present the deformities and the surgical maneuvers conducted in revision rhinoplasty ... ...

    Series title Beyond the Facelift: Procedures to Enhance Rhytidectomy
    Abstract Nasal airway obstruction is one of the most frequent causes of revision rhinoplasty in patients after previous rhinoplasty procedure. Purpose of this study is to present the deformities and the surgical maneuvers conducted in revision rhinoplasty patients with functional complaint, anatomical sites at risk, and potential prophylactic maneuvers. This study is a retrospective chart review analysis of 46 consecutive revision rhinoplasty procedures in patients with nasal airway obstruction. Inclusion criteria were at least one previous rhinoplasty and nasal airway obstruction as the epicenter of patients' complaint. Thorough clinical examination to certify the obstruction was performed. Deformities noted were separated in three categories according to functional, cosmetic, and combination of functional and cosmetic implications. Surgical maneuvers conducted were reviewed. Deformities found were checked for statistically significant coexistences. The average patient age was 34.9 years. The mean number of previous septorhinoplasties was 1.33. Nasal ventilation obstruction mainly caused either by septum deviation or nasal valve dysfunction was identified in 91.3% of our patients. Surgical maneuvers conducted included placement of grafts in 89.1% of all cases, septoplasty in 76.1%, lateral wall support in 47.8%, and placement of spreader grafts in 39.1% of patients. The average preoperative Nasal Obstruction Symptom Evaluation (NOSE) score was 61 ± 15 and it improved substantially, even from month 1, postoperatively. Owing to high prevalence of nasal airway obstruction after primary or secondary rhinoplasty, we conducted the first retrospective chart review study to identify the most common deformities in revision rhinoplasty patients with nasal airway obstruction and the appropriate surgical maneuvers to address them. Septum deviation and nasal valve dysfunction were the two pillars of nasal airway obstruction in those patients.
    Keywords nasal airway obstruction ; revision rhinoplasty ; functional complaint
    Language English
    Publishing date 2017-06-01
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/s-0037-1598041
    Database Thieme publisher's database

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  6. Article ; Online: Corticosteroids vs corticosteroids plus antiviral agents in the treatment of Bell palsy: a systematic review and meta-analysis.

    Goudakos, John K / Markou, Konstantinos D

    Archives of otolaryngology--head & neck surgery

    2009  Volume 135, Issue 6, Page(s) 558–564

    Abstract: Objective: To review systematically and meta-analyze the results of all randomized controlled trials (RCTs) for the treatment of patients with Bell palsy with corticosteroids vs corticosteroids plus antiviral agents.: Data sources: A MEDLINE, EMBASE, ...

    Abstract Objective: To review systematically and meta-analyze the results of all randomized controlled trials (RCTs) for the treatment of patients with Bell palsy with corticosteroids vs corticosteroids plus antiviral agents.
    Data sources: A MEDLINE, EMBASE, Cochrane Library, and CENTRAL database search, followed by extensive hand-searching for the identification of relevant studies. No time and language limitations were applied.
    Study selection: Prospective RCTs on the treatment of patients with Bell palsy.
    Data extraction: Odds ratios (ORs), 95% confidence intervals (CIs), and tests for heterogeneity were reported.
    Data synthesis: Five studies were eventually identified and systematically reviewed. Meta-analysis was performed for 4 studies. Regarding the complete recovery rate of facial nerve paralysis 3 months after initiation of therapy, the current systematic review and meta-analysis suggests that the addition of an antiviral agent does not provide any benefit (OR, 1.03 [95% CI, 0.74-1.42]; P = .88). The same conclusion emerged at posterior (fourth, sixth, and ninth) months of assessment. Subgroup analysis, conducted on the basis of time point of therapy initiation, type of antiviral agent, and blindness of assessments did not change the results obtained. The occurrence rate of adverse effects attributable to therapy choice was not significantly different between patients receiving corticosteroids and those following combined treatment.
    Conclusion: The present systematic review and meta-analysis, based on the currently available evidence, suggests that the addition of an antiviral agent to corticosteroids for the treatment of Bell palsy is not associated with an increase in the complete recovery rate of the facial motor function.
    MeSH term(s) Antiviral Agents/therapeutic use ; Bell Palsy/drug therapy ; Drug Therapy, Combination ; Glucocorticoids/therapeutic use ; Humans ; Odds Ratio ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Glucocorticoids
    Language English
    Publishing date 2009-06
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 632721-7
    ISSN 1538-361X ; 0886-4470 ; 2168-6181
    ISSN (online) 1538-361X
    ISSN 0886-4470 ; 2168-6181
    DOI 10.1001/archoto.2009.44
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  7. Article ; Online: An overview of the etiology of otosclerosis.

    Markou, Konstantinos / Goudakos, John

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2008  Volume 266, Issue 1, Page(s) 25–35

    Abstract: Otosclerosis is the primary disease affecting the homeostasis of otic capsule and is among the most common causes of acquired hearing loss. Otosclerosis is considered as a multifactor disease, caused by both genetic and environmental factors. The aim of ... ...

    Abstract Otosclerosis is the primary disease affecting the homeostasis of otic capsule and is among the most common causes of acquired hearing loss. Otosclerosis is considered as a multifactor disease, caused by both genetic and environmental factors. The aim of the present review is to summarize and analyze the bibliographic data, associated with the etiology of the disease. In some cases, the otosclerosis has an autosomal dominant mode of inheritance with incomplete penetrance. Genetic studies reveal the occurrence of at least nine chromosomal loci as candidate genes of the disease. The localized measles virus infection of the otic capsule has been postulated as a possible etiological theory. The role of hormonal factors, immune and bone-remodeling system in the etiopathogenesis of otosclerosis and the association of the disease with the disorders of the connective tissue are the issues of the present study. Despite the extensive research, many etiological factors and theories have been suggested and the process of development of the otosclerosis remains unclear.
    MeSH term(s) Bone Remodeling/genetics ; Bone Remodeling/immunology ; Chromosome Mapping ; Collagen Diseases/complications ; Endocrine System Diseases/complications ; Endocrine System Diseases/diagnosis ; Female ; Genetic Predisposition to Disease ; HLA-A Antigens/genetics ; HLA-A Antigens/immunology ; Humans ; Male ; Measles/complications ; Otosclerosis/etiology ; Otosclerosis/genetics ; Otosclerosis/virology ; Pregnancy ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Factors
    Chemical Substances HLA-A Antigens
    Language English
    Publishing date 2008-08-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-008-0790-x
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  8. Article ; Online: Corticosteroids and vestibular exercises in vestibular neuritis. Single-blind randomized clinical trial.

    Goudakos, John K / Markou, Konstantinos D / Psillas, George / Vital, Victor / Tsaligopoulos, Miltiadis

    JAMA otolaryngology-- head & neck surgery

    2014  Volume 140, Issue 5, Page(s) 434–440

    Abstract: IMPORTANCE The management of patients with unilateral acute vestibular neuritis (VN) has not been established to date. OBJECTIVE To compare the use of vestibular exercises vs corticosteroid therapy in the recovery of patients with acute VN. DESIGN, ... ...

    Abstract IMPORTANCE The management of patients with unilateral acute vestibular neuritis (VN) has not been established to date. OBJECTIVE To compare the use of vestibular exercises vs corticosteroid therapy in the recovery of patients with acute VN. DESIGN, SETTING, AND PARTICIPANTS Prospective, single-blind, randomized clinical trial at a primary referral center. Among all patients with acute vertigo, those having VN were eligible for inclusion in the study. INTERVENTIONS Forty patients with acute VN were randomly assigned to perform vestibular exercises or to receive corticosteroid therapy. After a baseline examination, follow-up evaluations were performed at 1, 6, and 12 months. MAIN OUTCOMES AND MEASURES Efficacy outcomes included clinical, canal, and otolith recovery. Scores on the European Evaluation of Vertigo Scale and the Dizziness Handicap Inventory were used for the evaluation of clinical recovery. Findings of caloric irrigation and vestibular evoked myogenic potentials indicated canal and otolith improvement, respectively. RESULTS Comparing the 2 treatment groups, no statistically significant differences were found in clinical, canal, or otolith recovery. At the 6-month examination, the number of patients with complete disease resolution in the corticosteroids group was significantly higher than that in the vestibular exercises group. However, at the end of the follow-up period, 45%(9 of 20) of patients in the vestibular exercises group and 50% (10 of 20) of patients in the corticosteroids group had complete disease resolution (P > .05). CONCLUSIONS AND RELEVANCE Treating patients who have acute VN with vestibular exercises seems equivalently effective as treating them with corticosteroid therapy in clinical, caloric, and otolith recovery. Corticosteroid therapy seems to enhance earlier complete acute VN resolution, with no added benefit in the long-term prognosis.
    MeSH term(s) Adult ; Aged ; Caloric Tests ; Dose-Response Relationship, Drug ; Exercise Therapy/methods ; Female ; Follow-Up Studies ; Glucocorticoids/administration & dosage ; Humans ; Male ; Middle Aged ; Posture/physiology ; Prognosis ; Prospective Studies ; Recovery of Function ; Single-Blind Method ; Time Factors ; Treatment Outcome ; Vestibular Function Tests/methods ; Vestibular Neuronitis/physiopathology ; Vestibular Neuronitis/therapy ; Vestibule, Labyrinth/physiopathology
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2014.48
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  9. Article: Hybrid carcinoma of the larynx: a case report (adenoid cystic and adenocarcinoma) and review of the literature.

    Karasmanis, Ilias / Goudakos, John K / Vital, Iosif / Zarampoukas, Thomas / Vital, Victor / Markou, Konstantinos

    Case reports in otolaryngology

    2013  Volume 2013, Page(s) 385405

    Abstract: Introduction. The nonsquamous carcinomas of the larynx are considered rare with the majority of malignant tumors in this area, reaching the rate of 95%, to be squamous cell neoplasms. Case Report. The case refers to a 53-year-old man that presented with ... ...

    Abstract Introduction. The nonsquamous carcinomas of the larynx are considered rare with the majority of malignant tumors in this area, reaching the rate of 95%, to be squamous cell neoplasms. Case Report. The case refers to a 53-year-old man that presented with symptomatology of motor nerve disease. During the evaluation of the neurologic disease, a subglottic mass of the larynx was revealed accidentally in the imaging examination. Under general anesthesia, we performed direct laryngoscopy and biopsy of the mass. The histopathologic examination revealed a hybrid carcinoma coexistence of two different carcinomas, an adenoid cystic carcinoma and an adenocarcinoma, not otherwise specified with poor differentiation. Regarding the therapeutic plan, the mass was considered inoperable due to its expansion to trachea and the patient received radiotherapy. Conclusions. Both the adenocarcinoma and adenoid cystic carcinoma are extremely rare types of malignant tumors in the larynx. The special interest of the present case is the coexistence of these two rare tumors in the same region of the larynx, being a hybrid tumor of the salivary glands in the larynx, which is the second reported case, based on our systematic literature review.
    Language English
    Publishing date 2013-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2648756-1
    ISSN 2090-6773 ; 2090-6765
    ISSN (online) 2090-6773
    ISSN 2090-6765
    DOI 10.1155/2013/385405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Duplication of the external auditory canal: two cases and a review of the literature.

    Goudakos, John K / Blioskas, Sarantis / Psillas, George / Vital, Victor / Markou, Konstantinos

    Case reports in otolaryngology

    2012  Volume 2012, Page(s) 924571

    Abstract: The objective of the present paper is to describe the clinical presentation, diagnostic process, surgical treatment, and outcome of 2 patients with first branchial cleft anomaly. The first case was an 8-year-old girl presented with an elastic lesion ... ...

    Abstract The objective of the present paper is to describe the clinical presentation, diagnostic process, surgical treatment, and outcome of 2 patients with first branchial cleft anomaly. The first case was an 8-year-old girl presented with an elastic lesion located in the left infra-auricular area, in close relation with the lobule, duplicating the external auditory canal. The magnetic resonance imaging revealed a lesion, appearing as a rather well-circumscribed mass within the left parotid gland and duplicating the ear canal. A superficial parotidectomy was subsequently performed, with total excision of the cyst. The second patient was a 15-year-old girl presented with a congenital fistula of the right lateral neck. At superficial parotidectomy, a total excision of the fistula was performed. During the operation the tract was recorded to lay between the branches of the facial nerve, extending with a blind ending canal parallel to the external acoustic meatus. Conclusively, first branchial cleft anomalies are rare malformations with cervical, parotid, or auricular clinical manifestations. Diagnosis of first branchial cleft lesions is achieved mainly through careful physical examination. Complete surgical excision with wide exposure of the lesion is essential in order to achieve permanent cure and avoid recurrence.
    Language English
    Publishing date 2012-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2648756-1
    ISSN 2090-6773 ; 2090-6765
    ISSN (online) 2090-6773
    ISSN 2090-6765
    DOI 10.1155/2012/924571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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