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Article ; Online: Emerging roles for estrogen in regulating skeletal muscle physiology.

Coyle-Asbil, Bridget / Ogilvie, Leslie M / Simpson, Jeremy A

2023 Volume 55, Issue 2, Page(s) 75–78

MeSH term(s)	Mice ; Animals ; Estrogens ; Muscle, Skeletal/physiology
Chemical Substances	Estrogens
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2038823-8
ISSN	1531-2267 ; 1094-8341
ISSN (online)	1531-2267
ISSN	1094-8341
DOI	10.1152/physiolgenomics.00158.2022
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Zs.A 5697: Show issues

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Article ; Online: Therapy-naïve malignancy causes cardiovascular disease: A state-of-the-art cardio-oncology perspective

Ogilvie, Leslie M / Coyle-Asbil, Bridget / Brunt, Keith R / Petrik, Jim / Simpson, Jeremy A

American journal of physiology. Heart and circulatory physiology

2024

Abstract: Cardiovascular disease (CVD) and cancer are the leading causes of mortality worldwide. Although generally thought of as distinct diseases, the intersectional overlap between CVD and cancer is increasingly evident in both causal and mechanistic ... ...

Abstract	Cardiovascular disease (CVD) and cancer are the leading causes of mortality worldwide. Although generally thought of as distinct diseases, the intersectional overlap between CVD and cancer is increasingly evident in both causal and mechanistic relationships. The field of cardio-oncology is largely focused on cardiotoxic effects of cancer therapies (e.g., chemotherapy, radiation). Further, the cumulative effects of cardiotoxic therapy exposure and the prevalence of CVD risk factors in cancer patients leads to long-term morbidity and poor quality of life in this patient population-even when patients are cancer-free. Evidence from cancer patients and animal models demonstrates that the presence of malignancy itself, independent of cardiotoxic therapy exposure or CVD risk factors, negatively impacts cardiac structure and function. As such, the primary focus of this review is the cardiac pathophysiologic and molecular features of therapy-naïve cancer. We also summarize the strengths and limitations of preclinical cancer models for cardio-oncology research and discuss therapeutic strategies that have been tested experimentally for the treatment of cancer-induced cardiac atrophy and dysfunction. Finally, we explore an adjacent area of interest, called 'reverse cardio-oncology', where the sequelae of heart failure augment cancer progression. Here, we emphasize the cross-disease communication between malignancy and the injured heart, and discuss the importance of chronic low-grade inflammation and endocrine factors in the progression of both diseases.
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00795.2023
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Article ; Online: Monoclonal antibodies targeting sites in respiratory syncytial virus attachment G protein provide protection against RSV-A and RSV-B in mice.

Lee, Youri / Klenow, Laura / Coyle, Elizabeth M / Grubbs, Gabrielle / Golding, Hana / Khurana, Surender

Nature communications

2024 Volume 15, Issue 1, Page(s) 2900

Abstract: Currently, only Palivizumab and Nirsevimab that target the respiratory syncytical virus (RSV) fusion protein are licensed for pre-treatment of infants. Glycoprotein-targeting antibodies may also provide protection against RSV. In this study, we generate ... ...

Abstract	Currently, only Palivizumab and Nirsevimab that target the respiratory syncytical virus (RSV) fusion protein are licensed for pre-treatment of infants. Glycoprotein-targeting antibodies may also provide protection against RSV. In this study, we generate monoclonal antibodies from mice immunized with G proteins from RSV-A2 and RSV-B1 strains. These monoclonal antibodies recognize six unique antigenic classes (G0-G5). None of the anti-G monoclonal antibodies neutralize RSV-A2 or RSV-B1 in vitro. In mice challenged with either RSV-A2 line 19 F or RSV-B1, one day after treatment with anti-G monoclonal antibodies, all monoclonal antibodies reduce lung pathology and significantly reduce lung infectious viral titers by more than 2 logs on day 5 post-RSV challenge. RSV dissemination in the lungs was variable and correlated with lung pathology. We demonstrate new cross-protective anti-G monoclonal antibodies targeting multiple sites including conformation-dependent class G0 MAb 77D2, CCD-specific class G1 MAb 40D8, and carboxy terminus of CCD class G5 MAb 7H11, to support development of G-targeting monoclonal antibodies against RSV.
MeSH term(s)	Humans ; Mice ; Animals ; Antibodies, Monoclonal ; Respiratory Syncytial Virus Infections/prevention & control ; Antibodies, Viral ; Respiratory Syncytial Virus, Human ; Viral Fusion Proteins ; GTP-Binding Proteins ; Respiratory Syncytial Virus Vaccines ; Antibodies, Neutralizing
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Viral ; Viral Fusion Proteins ; GTP-Binding Proteins (EC 3.6.1.-) ; Respiratory Syncytial Virus Vaccines ; Antibodies, Neutralizing
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47146-2
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Article ; Online: The Potential of Electrospinning to Enable the Realization of Energy-Autonomous Wearable Sensing Systems.

Dinuwan Gunawardhana, K R Sanjaya / Simorangkir, Roy B V B / McGuinness, Garrett Brian / Rasel, M Salauddin / Magre Colorado, Luz A / Baberwal, Sonal S / Ward, Tomás E / O'Flynn, Brendan / Coyle, Shirley M

ACS nano

2024 Volume 18, Issue 4, Page(s) 2649–2684

Abstract: The market for wearable electronic devices is experiencing significant growth and increasing potential for the future. Researchers worldwide are actively working to improve these devices, particularly in developing wearable electronics with balanced ... ...

Abstract	The market for wearable electronic devices is experiencing significant growth and increasing potential for the future. Researchers worldwide are actively working to improve these devices, particularly in developing wearable electronics with balanced functionality and wearability for commercialization. Electrospinning, a technology that creates nano/microfiber-based membranes with high surface area, porosity, and favorable mechanical properties for human
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c09077
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Article ; Online: Staphylococcus aureus Descending Necrotizing Mediastinitis in a Healthy Adult.

Williams, Robert J / Coyle, Meredith M / Johnson, Leonard B

The Annals of thoracic surgery

2020 Volume 111, Issue 6, Page(s) e397–e398

Abstract: Descending necrotizing mediastinitis (DNM) is a severe form of mediastinitis with high mortality rates due to the rapid progression of infection into the mediastinum through tissue planes, often from a dental or pharyngeal source. We present a case of ... ...

Abstract	Descending necrotizing mediastinitis (DNM) is a severe form of mediastinitis with high mortality rates due to the rapid progression of infection into the mediastinum through tissue planes, often from a dental or pharyngeal source. We present a case of monomicrobial methicillin-resistant Staphylococcus aureus DNM in a healthy young man who was initially misdiagnosed with strep throat. This is well described in the pediatric literature; however, DNM in adults is typically polymicrobial and occurs in those with comorbidities such as diabetes mellitus and older age. Survival is excellent with early identification of mediastinitis, prompt surgical intervention, and appropriate antibiotics.
MeSH term(s)	Humans ; Male ; Mediastinitis/microbiology ; Mediastinitis/pathology ; Mediastinum/pathology ; Methicillin-Resistant Staphylococcus aureus ; Necrosis/microbiology ; Severity of Illness Index ; Staphylococcal Infections/pathology ; Young Adult
Language	English
Publishing date	2020-12-05
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2020.09.058
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Zs.A 252: Show issues

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Article ; Online: Construct validity of movement-evoked pain operational definitions in older adults with chronic low back pain.

Knox, Patrick J / Simon, Corey B / Pohlig, Ryan T / Pugliese, Jenifer M / Coyle, Peter C / Sions, Jaclyn M / Hicks, Gregory E

Pain medicine (Malden, Mass.)

2023 Volume 24, Issue 8, Page(s) 985–992

Abstract: ... Greater aggregated posttest MeP was independently associated with worse disability (b = 0.593, t = 2.913 ... P = .004), self-efficacy (b = -0.870, t = -3.110, P = .002), and physical function (b = -0.017, t ...

Abstract	Objective: Movement-evoked pain (MeP) may predispose the geriatric chronic low back pain (LBP) population to health decline. As there are differing operational definitions for MeP, the question remains as to whether these different definitions have similar associations with health outcomes in older adults with chronic LBP. Design: Cross-sectional analysis of an observational study. Setting: Clinical research laboratory. Subjects: 226 older adults with chronic LBP. Methods: This secondary analysis used baseline data from a prospective cohort study (n = 250). LBP intensity was collected before and after the repeated chair rise test, stair climbing test, and 6-minute walk test; MeP change scores (ie, sum of pretest pain subtracted from posttest pain) and aggregated posttest pain (ie, sum of posttest pain) variables were calculated. LBP-related disability and self-efficacy were measured by the Quebec Back Pain Disability Scale (QBPDS) and Low Back Activity Confidence Scale (LOBACS), respectively. Physical function was measured with the Health ABC Performance Battery. Robust regression with HC3 standard errors was used to evaluate adjusted associations between both MeP variables and disability, self-efficacy, and physical function. Results: Greater aggregated posttest MeP was independently associated with worse disability (b = 0.593, t = 2.913, P = .004), self-efficacy (b = -0.870, t = -3.110, P = .002), and physical function (b = -0.017, t = -2.007, P = .039). MeP change scores were not associated with any outcome (all P > .050). Conclusions: Aggregate posttest MeP was linked to poorer health outcomes in older adults with chronic LBP, but MeP change scores were not. Future studies should consider that the construct validity of MeP paradigms partially depends on the chosen operational definition.
MeSH term(s)	Humans ; Aged ; Low Back Pain/complications ; Prospective Studies ; Cross-Sectional Studies ; Walking ; Pain Measurement ; Disability Evaluation ; Chronic Pain
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2015903-1
ISSN	1526-4637 ; 1526-2375
ISSN (online)	1526-4637
ISSN	1526-2375
DOI	10.1093/pm/pnad034
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Zs.A 6119: Show issues

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Article ; Online: Movement-Evoked Pain Versus Widespread Pain: A Longitudinal Comparison in Older Adults With Chronic Low Back Pain From the Delaware Spine Studies.

Knox, Patrick J / Simon, Corey B / Pohlig, Ryan T / Pugliese, Jenifer M / Coyle, Peter C / Sions, Jaclyn M / Hicks, Gregory E

The journal of pain

2023 Volume 24, Issue 6, Page(s) 980–990

Abstract: ... month LBP-related disability (b = .384, t = 2.013, P = .046) and poorer self-efficacy (b = -.562, t = -2 ...

Abstract	It is currently unknown which pain-related factors contribute to long-term disability and poorer perceived health among older adults with chronic low back pain (LBP). This investigation sought to examine the unique influence of movement-evoked pain (MeP) and widespread pain (WP) on longitudinal health outcomes (ie, gait speed, perceived disability, and self-efficacy) in 250 older adults with chronic LBP. MeP was elicited with 3 standardized functional tests, while presence of WP was derived from the McGill Pain Map. Robust regression with HC3 standard errors was used to examine associations between these baseline pain variables and health outcomes at 12-month follow-up. Covariates for these models included age, sex, body mass index, resting and recall LBP intensity, LBP duration, depression, pain catastrophizing, and baseline outcome (eg, baseline gait speed). Greater MeP was independently associated with worse 12-month LBP-related disability (b = .384, t = 2.013, P = .046) and poorer self-efficacy (b = -.562, t = -2.074, P = .039); but not gait speed (P > .05). In contrast, WP and resting and recall LBP intensity were not associated with any prospective health outcome after adjustment (all P > .05). Compared to WP and resting and recall LBP intensity, MeP is most strongly related to longitudinal health outcomes in older adults with chronic LBP. PERSPECTIVE: This article establishes novel independent associations between MeP and worse perceived disability and self-efficacy at 12-months in older adults with chronic LBP. MeP likely has biopsychosocial underpinnings and consequences and may therefore be an important determinant of health outcomes in LBP and other geriatric chronic pain populations.
MeSH term(s)	Humans ; Aged ; Low Back Pain/psychology ; Delaware ; Chronic Pain/psychology ; Disability Evaluation
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2018789-0
ISSN	1528-8447 ; 1526-5900
ISSN (online)	1528-8447
ISSN	1526-5900
DOI	10.1016/j.jpain.2023.01.012
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Zs.A 5237: Show issues

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Article ; Online: Real-World Effectiveness of Once-Weekly Glucagon-Like Peptide-1 Receptor Agonists (OW GLP-1RAs) in Comparison with Dipeptidyl Peptidase-4 Inhibitors (DPP-4is) for Glycemic Control and Weight Outcomes in Type 2 Diabetes Mellitus (RELATE).

Tan, Xi / Divino, Victoria / Amamoo, James / Xie, Lin / Coyle, Katharine B / Gamble, Cory L / Guevarra, Mico / Paprocki, Yurek / King, Aaron A

Clinical drug investigation

2024 Volume 44, Issue 4, Page(s) 271–284

Abstract: Background: The efficacy of once-weekly (OW) glucagon-like peptide-1 receptor agonists (GLP-1RAs) has been established in several trials in people with type 2 diabetes mellitus (T2DM); however, real-world evidence on their effectiveness is limited. This ...

Abstract	Background: The efficacy of once-weekly (OW) glucagon-like peptide-1 receptor agonists (GLP-1RAs) has been established in several trials in people with type 2 diabetes mellitus (T2DM); however, real-world evidence on their effectiveness is limited. This study evaluated the effectiveness of OW GLP-1RA regarding glycemic and weight outcomes, and relative to DPP-4i in a comparator analysis. Methods: This observational cohort study evaluated glycated hemoglobin (HbA Results: In the pre-post analysis, a greater numerical reduction in HbA Conclusion: The study reinforces that OW GLP-1RAs are more effective in glycemic control and weight reduction compared with DPP-4is in people with T2DM in the real-world setting. These findings align with the recommendation in the current guidelines for utilizing glucose-lowering treatment regimens that support weight-management goals in people with T2DM.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Glucagon-Like Peptide-1 Receptor Agonists ; Glycemic Control ; Weight Loss ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ; Glucagon-Like Peptide-1 Receptor/agonists
Chemical Substances	Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor Agonists ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-) ; Glucagon-Like Peptide-1 Receptor
Language	English
Publishing date	2024-03-20
Publishing country	New Zealand
Document type	Observational Study ; Journal Article
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-024-01354-2
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Zs.A 2807: Show issues

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Article ; Online: F-Divergences and Cost Function Locality in Generative Modelling with Quantum Circuits.

Leadbeater, Chiara / Sharrock, Louis / Coyle, Brian / Benedetti, Marcello

Entropy (Basel, Switzerland)

2021 Volume 23, Issue 10

Abstract: Generative modelling is an important unsupervised task in machine learning. In this work, we study a hybrid quantum-classical approach to this task, based on the use of a quantum circuit born machine. In particular, we consider training a quantum circuit ...

Abstract	Generative modelling is an important unsupervised task in machine learning. In this work, we study a hybrid quantum-classical approach to this task, based on the use of a quantum circuit born machine. In particular, we consider training a quantum circuit born machine using
Language	English
Publishing date	2021-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e23101281
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Article ; Online: Relationship Between Gestational Weight Gain and Health Service Utilization in Early Childhood: A Retrospective Cohort Study.

Currie, Lisa M / Fell, Deshayne B / Hawken, Steven / Potter, Beth K / Coyle, Doug / Wen, Shi Wu / Walker, Mark / Gaudet, Laura

Maternal and child health journal

2023 Volume 28, Issue 3, Page(s) 426–430

Abstract: Objective: Gestational weight gain (GWG) outside recommended ranges can negatively impact both the woman and child. The long-term effects of below-recommended or above-recommended GWG on the child are unclear.: Methods: This retrospective cohort ... ...

Abstract	Objective: Gestational weight gain (GWG) outside recommended ranges can negatively impact both the woman and child. The long-term effects of below-recommended or above-recommended GWG on the child are unclear. Methods: This retrospective cohort study used a population-based birth registry of 258,005 live births to evaluate the relationship between maternal GWG and paediatric health service use. Results: The results suggest below recommended GWG in underweight women in particular is associated with an increased rate of hospitalizations and specialist visits for the child in the first 24 months. Conclusion: Findings indicate that GWG may impact paediatric outcomes in ways that depend on pre-pregnancy body mass index, as derived from maternal height and weight measures.
MeSH term(s)	Pregnancy ; Child, Preschool ; Female ; Child ; Humans ; Gestational Weight Gain ; Weight Gain ; Pregnancy Outcome ; Retrospective Studies ; Pregnancy Complications ; Body Mass Index ; Overweight/complications ; Birth Weight
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339905-6
ISSN	1573-6628 ; 1092-7875
ISSN (online)	1573-6628
ISSN	1092-7875
DOI	10.1007/s10995-023-03796-0
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