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  1. Article ; Online: "It was a reflection of myself, that i was weak": The impact of depression on the sense of self - An interpretive phenomenological analysis.

    O'Mahony, James / Happell, Brenda / O'Connell, Rhona

    International journal of mental health nursing

    2024  

    Abstract: The World Health Organisation states that more than 350 million people experience depression globally. The phenomenological changes in individuals experiencing depression are profound Phenomenological research can further researchers' and clinicians' ... ...

    Abstract The World Health Organisation states that more than 350 million people experience depression globally. The phenomenological changes in individuals experiencing depression are profound Phenomenological research can further researchers' and clinicians' understanding of this experience. This study aimed to gain a phenomenological understanding of how individuals with depression understood and made sense of their experiences. A methodology of interpretative phenomenological analysis was adopted. In-depth semi-structured interviews explored the lived experience of depression for eight individuals. Data were analysed into the superordinate theme Broken Self - Transforming the Self. The superordinate theme developed from the subordinate themes of 'unknown self, loss of self and one's identity', 'desperate for a way out', and thirdly, 'conflict with self and what's known', which related directly to how individuals made sense of their experience of depression. These research findings highlight the human implications of the experience of depression and the limitations of viewing depression from a biological or medical model lens. Understanding the human impact is essential for the effective, holistic practice of mental health nursing.
    Language English
    Publishing date 2024-01-18
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2076760-2
    ISSN 1447-0349 ; 1445-8330
    ISSN (online) 1447-0349
    ISSN 1445-8330
    DOI 10.1111/inm.13281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5240: Show issues Location:
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  2. Article ; Online: Mental Health Nurses' Self-Care at Work,

    O'Malley, Maria / Happell, Brenda / O'Mahony, James

    Issues in mental health nursing

    2023  Volume 44, Issue 5, Page(s) 425–436

    Abstract: The nursing workforce plays a central role in quality health care delivery. Nursing work is associated with high levels of stress due to often unmanageable workloads. The associated attrition poses a serious challenge for recruitment and retention ... ...

    Abstract The nursing workforce plays a central role in quality health care delivery. Nursing work is associated with high levels of stress due to often unmanageable workloads. The associated attrition poses a serious challenge for recruitment and retention strategies. Self-care is recognised as a tactic for addressing workplace stressors, shaping a sense of cohesion where the world is viewed as comprehensible, meaningful, and manageable, thereby mitigating the risk of burnout. Yet research suggests it is not widely utilised by nurses. The aim of this study was to understand mental health nurses' lived experience of self-care at work. The research was undertaken using an Interpretative Phenomenological Analysis methodology. In-depth individual interviews explored nurses' attitudes to self-care and how they did or did not adopt self-care practices in the workplace. Data were analysed thematically.
    MeSH term(s) Humans ; Mental Health ; Self Care ; Occupational Stress ; Delivery of Health Care ; Workplace/psychology ; Qualitative Research ; Nurses
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 603180-8
    ISSN 1096-4673 ; 0161-2840
    ISSN (online) 1096-4673
    ISSN 0161-2840
    DOI 10.1080/01612840.2023.2205509
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2562: Show issues Location:
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  3. Article ; Online: Enumeration of Viable Chlamydia from Infected Animals Using Immunofluorescent Microscopy.

    Liang, Steven / Mahony, James B

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2042, Page(s) 237–244

    Abstract: An appropriate means of quantitating infectious Chlamydia from infected animals is essential for the evaluation of vaccines. However, unlike methods involving culture, nonculture methods, including detection of antigen or DNA, are not able to ... ...

    Abstract An appropriate means of quantitating infectious Chlamydia from infected animals is essential for the evaluation of vaccines. However, unlike methods involving culture, nonculture methods, including detection of antigen or DNA, are not able to differentiate between viable and nonviable organisms. As an obligate intracellular bacterium, Chlamydia replicates inside host cells by forming unique organelles called inclusions. Here, we describe the enumeration of viable C. trachomatis from infected mice by culturing vaginal swabs on McCoy cells and counting inclusions via immunofluorescent microscopy.
    MeSH term(s) Animals ; Bacterial Load/methods ; Chlamydia Infections/microbiology ; Chlamydia trachomatis/isolation & purification ; Female ; Humans ; Mice ; Microbial Viability ; Microscopy, Fluorescence/methods ; Vagina/microbiology
    Language English
    Publishing date 2019-08-05
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9694-0_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The nurse bombarded, consumed and vulnerable: An interpretative phenomenological analysis of mental health nurses' self-care at work.

    O'Malley, Maria / O'Mahony, James / Happell, Brenda / Mulcahy, Helen

    Journal of psychiatric and mental health nursing

    2023  Volume 31, Issue 1, Page(s) 66–76

    Abstract: Introduction: Self-care is essential for nurses' wellbeing, with stress posing a major barrier. Research into self-care is often absorbed into studies of burnout or resilience. Understanding lived experiences of influences on nurses' self-care practices ...

    Abstract Introduction: Self-care is essential for nurses' wellbeing, with stress posing a major barrier. Research into self-care is often absorbed into studies of burnout or resilience. Understanding lived experiences of influences on nurses' self-care practices is essential. There is currently a paucity of literature on this topic.
    Aim: To explore mental health nurses' views about what influences their ability to self-care in relation to workplace stress and the impact on their practice and work environment.
    Methods: An Interpretative Phenomenological Analysis approach was utilized. In-depth interviews explored how nurses perceived the influence of environment and relationships on self-care practices in the workplace.
    Results: Participants' perceptions and experiences are embodied by the theme: the nurse bombarded, comprising two subordinate themes-the nurse consumed by the intensity of work and therapeutic relationships; and feeling vulnerable from colleague relationships and feeling undervalued. Participants described conflict between workload demands and expectations and the desire to provide optimal care.
    Conclusions: Stressful working environments pose major barriers to effective self-care. Feeling bombarded and vulnerable, impacts nurses' lives personally and professionally.
    Implications for practice: Mental health nurses' self-care is crucial for quality practice. Strategies to address relational, personal and environmental barriers to self-care are therefore necessary.
    MeSH term(s) Humans ; Mental Health ; Self Care ; Occupational Stress ; Burnout, Professional/psychology ; Nurses
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328479-4
    ISSN 1365-2850 ; 1351-0126
    ISSN (online) 1365-2850
    ISSN 1351-0126
    DOI 10.1111/jpm.12956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4466: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: A Phenomenological Understanding of Mental Health Nurses' Experiences of Self-Care: A Review of the Empirical Literature.

    O'Malley, Maria / Happell, Brenda / O'Mahony, James

    Issues in mental health nursing

    2022  , Page(s) 1–9

    Abstract: Nurses are central to health care as the largest professional workforce and the providers of constant, ongoing care. Difficulties retaining enough qualified and motivated nurses presents an ongoing problem that threatens the quality of healthcare ... ...

    Abstract Nurses are central to health care as the largest professional workforce and the providers of constant, ongoing care. Difficulties retaining enough qualified and motivated nurses presents an ongoing problem that threatens the quality of healthcare delivery. Demands of nursing practice, often resulting in stress and burnout, is a major barrier to retaining nurses. Self-care approaches and techniques have proven effective in reducing stress and burnout, increasing job satisfaction and the likelihood of nurses remaining in the profession. Despite knowing the benefits, nurses frequently do not engage in self-care resulting in negative consequences both personally and professionally. To advance our knowledge in this important area, a review of the literature was conducted to explore nurses' experience of self-care and how they made sense of their experiences. The literature was analysed critically and synthesised through a phenomenological lens. The identified themes were structured according to phenomenological concerns:
    Language English
    Publishing date 2022-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 603180-8
    ISSN 1096-4673 ; 0161-2840
    ISSN (online) 1096-4673
    ISSN 0161-2840
    DOI 10.1080/01612840.2022.2108528
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    Zs.B 2562: Show issues Location:
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  6. Article ; Online: Measuring pH of skim milk and milk permeate at ultra-high temperatures at laboratory and pilot scale

    Aydogdu, Tugce / O'Mahony, James A. / Huppertz, Thom / Magan, Jonathan B. / McCarthy, Noel A.

    International Dairy Journal

    2023  Volume 139

    Abstract: Changes in the pH of skim milk and skim milk ultrafiltration permeate on heating from 25 to 140 °C were examined. Results showed that the decrease in pH with increase in temperature up to 140 °C was not linear. Hydrogen ion release due to changes in the ... ...

    Abstract Changes in the pH of skim milk and skim milk ultrafiltration permeate on heating from 25 to 140 °C were examined. Results showed that the decrease in pH with increase in temperature up to 140 °C was not linear. Hydrogen ion release due to changes in the milk mineral balance were responsible for the reduction in pH with increase in temperature. The presence of milk proteins offered little buffering against the drop in pH. The precipitation of calcium phosphate resulted in sediment in milk permeate heated above ∼70 °C, but this did not occur in skim milk, with the pH remaining lower in milk permeate after heat treatment when measured at 25 °C. This study has shown that in-line pH measurements of milk at ultra-high temperatures is feasible, and could prove useful at laboratory and pilot-scale for studying interactions within, and stability of, more complex formulations with added minerals.
    Keywords Life Science
    Subject code 660
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 1076400-8
    ISSN 0958-6946
    ISSN 0958-6946
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Bonn / Germany

    Z 5292: Show issues

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  7. Article ; Online: Boosting inpatient exercise after hip fracture using an alternative workforce: a mixed methods implementation evaluation.

    March, Marie K / Dennis, Sarah M / Caruana, Sarah / Mahony, Christopher / Elliott, James M / Polley, Stephanie / Thomas, Bijoy / Lin, Charlie / Harmer, Alison R

    BMC geriatrics

    2024  Volume 24, Issue 1, Page(s) 149

    Abstract: Background: Hip fracture has a devastating impact on individuals and is an increasing burden for health systems and society. Compared to usual care, increased physiotherapy provision has demonstrated efficacy in improving patient and health service ... ...

    Abstract Background: Hip fracture has a devastating impact on individuals and is an increasing burden for health systems and society. Compared to usual care, increased physiotherapy provision has demonstrated efficacy in improving patient and health service outcomes in this population. However, physiotherapy workforce challenges prevent sustained implementation.
    Methods: Our aim was to evaluate the safety, feasibility, acceptability, effectiveness and implementation cost of thrice daily physiotherapy for patients in the acute care setting after hip fracture at two public hospitals. We added twice-daily exercise implemented by an alternative workforce, to usual care consisting of daily mobility practice by a physiotherapist. Sites identified their preferred alternative workforce, with pre-registration physiotherapy students and allied health assistants chosen. We used a mixed methods approach, using the Consolidated Framework for Implementation Research (CFIR) as a determinant framework to guide implementation planning and data collection. We compared hospital length of stay data to a reference cohort.
    Results: We recruited 25 patients during the study period. Acute care hospital length of stay decreased from 11 days in the reference cohort to 8 days in the BOOST cohort (mean difference - 3.3 days, 95%CI -5.4 to -1.2 days, p = 0.003). Intervention fidelity was 72% indicating feasibility, no safety concerns were attributed to the intervention, and uptake was 96% of all eligible patients. The intervention was acceptable to patients, carers and healthcare providers. This intervention was cost-effective from the acute orthopaedic service perspective.
    Conclusion: Higher daily frequency of physiotherapy can be safely, feasibly and effectively implemented by an alternative workforce for patients in the acute care setting following hip fracture surgery.
    MeSH term(s) Humans ; Exercise ; Hip Fractures/rehabilitation ; Hip Fractures/surgery ; Inpatients ; Physical Therapy Modalities ; Workforce ; Implementation Science
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-024-04730-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Joint sequence & chromatin neural networks characterize the differential abilities of Forkhead transcription factors to engage inaccessible chromatin.

    Arora, Sonny / Yang, Jianyu / Akiyama, Tomohiko / James, Daniela Q / Morrissey, Alexis / Blanda, Thomas R / Badjatia, Nitika / Lai, William K M / Ko, Minoru S H / Pugh, B Franklin / Mahony, Shaun

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The DNA-binding activities of transcription factors (TFs) are influenced by both intrinsic sequence preferences and extrinsic interactions with cell-specific chromatin landscapes and other regulatory proteins. Disentangling the roles of these binding ... ...

    Abstract The DNA-binding activities of transcription factors (TFs) are influenced by both intrinsic sequence preferences and extrinsic interactions with cell-specific chromatin landscapes and other regulatory proteins. Disentangling the roles of these binding determinants remains challenging. For example, the FoxA subfamily of Forkhead domain (Fox) TFs are known pioneer factors that can bind to relatively inaccessible sites during development. Yet FoxA TF binding also varies across cell types, pointing to a combination of intrinsic and extrinsic forces guiding their binding. While other Forkhead domain TFs are often assumed to have pioneering abilities, how sequence and chromatin features influence the binding of related Fox TFs has not been systematically characterized. Here, we present a principled approach to compare the relative contributions of intrinsic DNA sequence preference and cell-specific chromatin environments to a TF's DNA-binding activities. We apply our approach to investigate how a selection of Fox TFs (FoxA1, FoxC1, FoxG1, FoxL2, and FoxP3) vary in their binding specificity. We over-express the selected Fox TFs in mouse embryonic stem cells, which offer a platform to contrast each TF's binding activity within the same preexisting chromatin background. By applying a convolutional neural network to interpret the Fox TF binding patterns, we evaluate how sequence and preexisting chromatin features jointly contribute to induced TF binding. We demonstrate that Fox TFs bind different DNA targets, and drive differential gene expression patterns, even when induced in identical chromatin settings. Despite the association between Forkhead domains and pioneering activities, the selected Fox TFs display a wide range of affinities for preexiting chromatin states. Using sequence and chromatin feature attribution techniques to interpret the neural network predictions, we show that differential sequence preferences combined with differential abilities to engage relatively inaccessible chromatin together explain Fox TF binding patterns at individual sites and genome-wide.
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.06.561228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Corrigendum:

    Stone, Chris B / Bulir, David C / Emdin, Connor A / Pirie, Ryan M / Porfilio, Elisa A / Slootstra, Jerry W / Mahony, James B

    Frontiers in microbiology

    2021  Volume 12, Page(s) 726518

    Abstract: This corrects the article DOI: 10.3389/fmicb.2011.00021.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmicb.2011.00021.].
    Language English
    Publishing date 2021-10-12
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.726518
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  10. Article ; Online: Nucleic acid amplification-based diagnosis of respiratory virus infections.

    Mahony, James B

    Expert review of anti-infective therapy

    2010  Volume 8, Issue 11, Page(s) 1273–1292

    Abstract: The appearance of eight new respiratory viruses in the human population in the past 9 years, including two new pandemics (SARS coronavirus in 2003 and swine-origin influenza A/H1N1 in 2009), has tested the ability of virology laboratories to develop ... ...

    Abstract The appearance of eight new respiratory viruses in the human population in the past 9 years, including two new pandemics (SARS coronavirus in 2003 and swine-origin influenza A/H1N1 in 2009), has tested the ability of virology laboratories to develop diagnostic tests to identify these viruses. Nucleic acid amplification tests (NATs) that first appeared two decades ago have been developed for both conventional and emerging viruses and now form the backbone of the clinical laboratory. NATs provide fast, accurate and sensitive detection of respiratory viruses and have significantly increased our understanding of the epidemiology of these viruses. Multiplex PCR assays have been introduced recently and several commercial tests are now available. The final chapter in the evolution of respiratory virus diagnostics will be the addition of allelic discrimination and detection of single nucleotide polymorphisms associated with antiviral resistance to multiplex assays. These resistance assays together with new viral load tests will enable clinical laboratories to provide physicians with important information for optimal treatment of patients.
    MeSH term(s) Drug Resistance, Viral ; Humans ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Nucleic Acid Amplification Techniques ; Pandemics ; Polymerase Chain Reaction ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Viral Load ; Virus Diseases/diagnosis ; Virus Diseases/epidemiology ; Virus Diseases/virology ; Viruses/drug effects ; Viruses/genetics ; Viruses/isolation & purification
    Keywords covid19
    Language English
    Publishing date 2010-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1586/eri.10.121
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