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  1. Article ; Online: Early Percutaneous Tracheostomy During the Pandemic "As Good as It Gets".

    Auzinger, Georg

    Critical care medicine

    2020  Volume 49, Issue 2, Page(s) 361–364

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Respiration, Artificial ; Tracheostomy
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute liver failure on the transplant waiting list: lessons learned?

    Bernal, William / Auzinger, Georg

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2023  Volume 29, Issue 3, Page(s) 244–245

    MeSH term(s) Humans ; Liver Transplantation ; Waiting Lists ; Liver Failure, Acute ; Risk Factors
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Long-term outcome after VV ECMO: like the iceberg beneath the Titanic.

    Auzinger, Georg

    Minerva anestesiologica

    2019  Volume 85, Issue 9, Page(s) 934–936

    MeSH term(s) Caregivers ; Extracorporeal Membrane Oxygenation ; Humans ; Respiratory Distress Syndrome, Adult ; Retrospective Studies
    Language English
    Publishing date 2019-05-03
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.19.13688-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hemodynamic profile of cirrhotic patients with sepsis and septic shock: A propensity score matched case-control study.

    You, Jee Young / Sato, Ryota / Chawla, Sanchit / Kapoor, Aanchal / Wang, Xiaofeng / Collier, Patrick / Auzinger, Georg / Duggal, Abhijit / Dugar, Siddharth

    Journal of critical care

    2024  Volume 81, Page(s) 154532

    Abstract: Purpose: Our understanding of hemodynamics in cirrhotic patients with sepsis remains limited. Our study aims to investigate differences in hemodynamic profiles using echocardiography between septic patients with and without cirrhosis.: Materials and ... ...

    Abstract Purpose: Our understanding of hemodynamics in cirrhotic patients with sepsis remains limited. Our study aims to investigate differences in hemodynamic profiles using echocardiography between septic patients with and without cirrhosis.
    Materials and methods: This is a single-center, retrospective study of septic patients with echocardiogram within 3 days of ICU admission. We compared baseline characteristics, echocardiographic markers of LV systolic function arterial load between patients with and without cirrhosis. A propensity score-matched case-control model was developed to describe the differences in those echocardiography derived parameters between the groups.
    Results: 3151 patients with sepsis were included of which 422 (13%) had cirrhosis. In the propensity score matched group with 828 patients, cirrhotic patients had significantly higher left ventricular ejection fraction (64 vs.56%, p < 0.001) and stroke volume (72 vs.48 ml, p < 0.001) along with lower arterial elastance (Ea) (1.35 1vs.20.3, p < 0.001) and systemic vascular resistance (SVR) (851 vs.1209 dynes/s/m
    Conclusions: Septic patients with cirrhosis had higher LVEF with lower Ea and SVR with higher Ees and significantly lower Ea/Ees suggesting vasodilation as the principal driver of the hyperdynamic profile in cirrhosis.
    MeSH term(s) Humans ; Shock, Septic/complications ; Stroke Volume ; Case-Control Studies ; Retrospective Studies ; Propensity Score ; Ventricular Function, Left ; Sepsis/complications ; Hemodynamics ; Liver Cirrhosis/complications
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2024.154532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeted temperature management in acute liver failure: A systematic review.

    Ribaud, Juliette / McLernon, Siobhan / Auzinger, Georg

    Nursing in critical care

    2020  Volume 27, Issue 6, Page(s) 784–795

    Abstract: Background: Targeted temperature management is the modern term for therapeutic hypothermia, where cooling is induced by intensive care clinicians to achieve body temperatures below 36°C. Its use in acute liver failure to improve refractory intracranial ... ...

    Abstract Background: Targeted temperature management is the modern term for therapeutic hypothermia, where cooling is induced by intensive care clinicians to achieve body temperatures below 36°C. Its use in acute liver failure to improve refractory intracranial hypertension and patient outcomes is not supported by strong quality evidence.
    Aim: This systematic review aims to determine if targeted temperature management improves patient outcome as opposed to normothermia in acute liver failure.
    Methods: A computerized and systematic search of six academic and medical databases was conducted using the following keywords: "acute liver failure", "fulminant hepatic injury", "targeted temperature management", "therapeutic hypothermia", and "cooling". Broad criteria were applied to include all types of primary observational studies, from case reports to randomized controlled trials. Standardized tools were used throughout to critically appraise and extract data.
    Findings: Nine studies published between 1999 and 2016 were included. Early observational studies suggest a benefit of targeted temperature management in the treatment of refractory intracranial hypertension and in survival. More recent controlled studies do not show such a benefit in the prevention of intracranial hypertension. All studies revealed that the incidence of coagulopathy is not higher in patients treated with targeted temperature management. There remains some uncertainty regarding the increased risk of infection and dysrhythmias. Heterogeneity was found between study types, design, sample sizes, and quality.
    Conclusion: Although it does not significantly improve survival, targeted temperature management is efficient in treating episodes of intracranial hypertension and stabilizing an unstable critical care patient without increasing the risk of bleeding. It does not, however, prevent intracranial hypertension. Data heterogeneity may explain the contradictory findings.
    Relevance to clinical practice: Controlled studies are needed to elucidate the true clinical benefit of targeted temperature management in improving patient outcome.
    MeSH term(s) Humans ; Hypothermia/complications ; Hypothermia/therapy ; Temperature ; Hypothermia, Induced ; Intracranial Hypertension/therapy ; Intracranial Hypertension/etiology ; Liver Failure/complications ; Liver Failure/therapy
    Language English
    Publishing date 2020-06-29
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2011956-2
    ISSN 1478-5153 ; 1362-1017
    ISSN (online) 1478-5153
    ISSN 1362-1017
    DOI 10.1111/nicc.12524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Invasive candidiasis following liver transplantation and surgical complications.

    Auzinger, Georg

    Mycoses

    2011  Volume 54 Suppl 4, Page(s) 4–7

    Abstract: The following case report describes a patient with acute liver failure who presented in multiple organ failure and required emergency liver transplantation. A complicated postoperative course lead to sepsis which did not respond to conventional anti ... ...

    Abstract The following case report describes a patient with acute liver failure who presented in multiple organ failure and required emergency liver transplantation. A complicated postoperative course lead to sepsis which did not respond to conventional anti bacterial therapy. Despite antifungal prophylaxis with an azole invasive candidiasis was diagnosed and the patient was successfully treated with anidulafungin. The difficulties in diagnosis and treatment of invasive fungal infections in this population are highlighted.
    MeSH term(s) Adult ; Antifungal Agents/administration & dosage ; Candidiasis, Invasive/diagnosis ; Candidiasis, Invasive/drug therapy ; Candidiasis, Invasive/microbiology ; Echinocandins/administration & dosage ; Humans ; Immunocompromised Host ; Liver Failure/surgery ; Liver Transplantation/adverse effects ; Male ; Postoperative Complications/diagnosis ; Postoperative Complications/drug therapy ; Postoperative Complications/microbiology ; Treatment Outcome
    Chemical Substances Antifungal Agents ; Echinocandins ; anidulafungin (9HLM53094I)
    Language English
    Publishing date 2011-12
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 392487-7
    ISSN 1439-0507 ; 0933-7407
    ISSN (online) 1439-0507
    ISSN 0933-7407
    DOI 10.1111/j.1439-0507.2011.02135.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A case series of non-valvular cardiac aspergillosis in critically ill solid organ transplant and non-transplant patients and systematic review.

    Navaratnam, Annalan Md / Al-Freah, Mohammad / Cavazza, Anna / Auzinger, Georg

    Journal of the Intensive Care Society

    2020  Volume 22, Issue 3, Page(s) 241–247

    Abstract: Introduction: Non-valvular cardiac aspergillosis is a rare infection of the pericardium, myocardium or endocardium and is associated with a high mortality. There is a paucity of reports of non-valvular cardiac aspergillosis in critically ill and solid ... ...

    Abstract Introduction: Non-valvular cardiac aspergillosis is a rare infection of the pericardium, myocardium or endocardium and is associated with a high mortality. There is a paucity of reports of non-valvular cardiac aspergillosis in critically ill and solid organ transplant (SOT) patients. The majority of cases have been reported in haemato-oncology patients, some of whom have undergone a bone marrow transplant.
    Objectives: We describe four cases affected by non-valvular cardiac aspergillosis in the intensive care setting including a systematic review of this extremely rare infection which is associated with high mortality.
    Results: All four-patients died but presented with varying clinical, radiological and microbiological evidence of the disease. Three patients presented following complications after solid organ transplantation, two in the context of acute liver failure and emergency liver transplant and one several years after a double lung transplant. The last patient presented with necrotising gall stone pancreatitis, multi-organ failure and subsequently a prolonged intensive care unit (ICU) stay. On review of the literature, January 1955 to July 2019, 45 cases were identified, with different risk factors, clinical and radiological manifestations, treatment regimen and outcome.
    Conclusion: Antemortem diagnosis of cardiac aspergillosis is difficult and rare, with no cases reporting positive blood culture results. Galactomannan serology has poor sensitivity in solid organ transplant patients, further reduced by prophylactic antimicrobial treatment, which is common in the ICU setting especially post-transplant patients. Due to the scarcity of cases, treatment is extrapolated from invasive aspergillosis management, with emphasis on early treatment with combination therapy.
    Language English
    Publishing date 2020-07-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2701626-2
    ISSN 1751-1437 ; 1751-1437
    ISSN (online) 1751-1437
    ISSN 1751-1437
    DOI 10.1177/1751143720936821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Variation in the Care of Acute Liver Failure: A Survey of Intensive Care Professionals.

    Cardoso, Filipe S / Mcphail, Mark J / Karvellas, Constantine J / Fuhrmann, Valentin / Germano, Nuno / Auzinger, Georg

    GE Portuguese journal of gastroenterology

    2021  Volume 29, Issue 1, Page(s) 22–30

    Abstract: Introduction: Acute liver failure (ALF) is a rare disease with potentially high mortality. We sought to assess the individual approach to ALF by intensive care unit (ICU) professionals.: Methods: Cross-sectional survey of ICU professionals. Web-based ...

    Abstract Introduction: Acute liver failure (ALF) is a rare disease with potentially high mortality. We sought to assess the individual approach to ALF by intensive care unit (ICU) professionals.
    Methods: Cross-sectional survey of ICU professionals. Web-based survey capturing data on respondents' demographics, characteristics of patients with ALF admitted to ICU, and their management.
    Results: Among 204 participants from 50 countries, 140 (68.6%) worked in Europe, 146 (71.6%) were intensivists, 142 (69.6%) admitted <25 patients with ALF per year, and 166 (81.8%) reported <25% of patients had paracetamol-related ALF. On patients' outcomes, 126 (75.0%) reported an emergency liver transplantation (ELT) rate <25% and 140 (73.3%) a hospital mortality rate <50%. The approach to ALF in the ICU varied with age, region, level of training, type of hospital, and etiology (prescribing N-acetylcysteine for paracetamol toxicity, triggers for endotracheal intubation, measurement of and strategies for lowering serum ammonia, extracorporeal device deployment, and prophylactic antibiotics).
    Conclusions: The management of patients with ALF by ICU professionals differed substantially concerning the relevant clinical measures taken. Further education and high-quality research are warranted.
    Language English
    Publishing date 2021-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2835774-7
    ISSN 2387-1954 ; 2341-4545
    ISSN (online) 2387-1954
    ISSN 2341-4545
    DOI 10.1159/000516672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Persistent left superior vena cava in a patient requiring cannulation for extracorporeal membrane oxygenation.

    Spataru, Ana / Hurst, Thomas P / Loveridge, Robert W / Auzinger, Georg

    Artificial organs

    2019  Volume 43, Issue 10, Page(s) 1042–1043

    MeSH term(s) Adult ; Anatomic Variation ; Arnold-Chiari Malformation/surgery ; Catheterization/methods ; Echocardiography ; Extracorporeal Membrane Oxygenation/methods ; Humans ; Male ; Tomography, X-Ray Computed ; Vena Cava, Superior/abnormalities ; Vena Cava, Superior/diagnostic imaging
    Language English
    Publishing date 2019-05-22
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/aor.13472
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  10. Article ; Online: Too Hot to Handle: A Case Report of Extreme Pyrexia After MDMA Ingestion.

    Jahns, Fritz-Patrick / Pineau Mitchell, Antonine / Auzinger, Georg

    Therapeutic hypothermia and temperature management

    2018  Volume 8, Issue 3, Page(s) 173–175

    Abstract: Hyperpyrexia is a well-documented adverse effect of 3,4-methylenedioxymethamphetamine (MDMA) and is associated with a poor prognosis. There are currently limited published records of patients surviving a pyrexia of or greater than 43°C after MDMA intake. ...

    Abstract Hyperpyrexia is a well-documented adverse effect of 3,4-methylenedioxymethamphetamine (MDMA) and is associated with a poor prognosis. There are currently limited published records of patients surviving a pyrexia of or greater than 43°C after MDMA intake. Rapid cooling and multiorgan support in an intensive care setting may offer patients the best chance of recovery. We present the case of a 16-year-old male who was admitted to our tertiary, adult intensive care unit (ICU) for unrecordable pyrexia (>43°C) after reported ecstasy intake. The patient went on to develop severe multiorgan failure and profound disseminated intravascular coagulopathy. Initial patient management focused on rapid cooling using an endovascular cooling catheter and rigorous monitoring and treatment of autonomic symptoms, followed by subsequent surgical therapy (fasciotomy) and multiorgan support. The patient eventually achieved a good clinical outcome after 4 weeks of management in the ICU, and was discharged well to his local hospital. Despite multiple end-organ dysfunctions and often severely poor prognosis, survival after severe hyperpyrexia induced by MDMA intake is possible with proper management and organ support in an appropriate intensive care environment.
    MeSH term(s) Adolescent ; Fever/chemically induced ; Fever/therapy ; Hallucinogens/adverse effects ; Humans ; Hypothermia, Induced ; Male ; N-Methyl-3,4-methylenedioxyamphetamine/adverse effects
    Chemical Substances Hallucinogens ; N-Methyl-3,4-methylenedioxyamphetamine (KE1SEN21RM)
    Language English
    Publishing date 2018-04-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2609342-X
    ISSN 2153-7933 ; 2153-7658
    ISSN (online) 2153-7933
    ISSN 2153-7658
    DOI 10.1089/ther.2018.0002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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