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Article ; Online: A Comparison of Host Responses to Infection with Wild-Type Avian Influenza Viruses in Chickens and Tufted Ducks.

Naguib, Mahmoud M / Eriksson, Per / Jax, Elinor / Wille, Michelle / Lindskog, Cecilia / Bröjer, Caroline / Krambrich, Janina / Waldenström, Jonas / Kraus, Robert H S / Larson, Göran / Lundkvist, Åke / Olsen, Björn / Järhult, Josef D / Ellström, Patrik

Microbiology spectrum

2023 Volume 11, Issue 4, Page(s) e0258622

Abstract: Cross-species transmission of influenza A virus (IAV) from wild waterfowl to poultry is the first step in a chain of events that can ultimately lead to exposure and infection of humans. Herein, we study the outcome of infection with eight different ... ...

Abstract	Cross-species transmission of influenza A virus (IAV) from wild waterfowl to poultry is the first step in a chain of events that can ultimately lead to exposure and infection of humans. Herein, we study the outcome of infection with eight different mallard-origin IAV subtypes in two different avian hosts: tufted ducks and chickens. We found that infection and shedding patterns as well as innate immune responses were highly dependent on viral subtypes, host species, and inoculation routes. For example, intraoesophageal inoculation, commonly used in mallard infection experiments, resulted in no infections in contrast to oculonasal inoculation, suggesting a difference in transmission routes. Despite H9N2 being endemic in chickens, inoculation of mallard-origin H9N2 failed to cause viable infection beyond 1 day postinfection in our study design. The innate immune responses were markedly different in chickens and tufted ducks, and despite the presence of retinoic acid-inducible gene-I (RIG-I) in tufted duck transcriptomes, it was neither up nor downregulated in response to infection. Overall, we have revealed the heterogeneity of infection patterns and responses in two markedly different avian hosts following a challenge with mallard-origin IAV. These virus-host interactions provide new insights into important aspects of interspecies transmission of IAV.
MeSH term(s)	Humans ; Animals ; Ducks ; Chickens ; Influenza A Virus, H9N2 Subtype ; Influenza in Birds ; Immunity, Innate
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02586-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Expression of influenza A virus glycan receptor candidates in mallard, chicken, and tufted duck.

Nilsson, Jonas / Eriksson, Per / Naguib, Mahmoud M / Jax, Elinor / Sihlbom, Carina / Olsson, Britt-Marie / Lundkvist, Åke / Olsen, Björn / Järhult, Josef D / Larson, Göran / Ellström, Patrik

Glycobiology

2023 Volume 34, Issue 3

Abstract: Influenza A virus (IAV) pandemics result from interspecies transmission events within the avian reservoir and further into mammals including humans. Receptor incompatibility due to differently expressed glycan structures between species has been ... ...

Abstract	Influenza A virus (IAV) pandemics result from interspecies transmission events within the avian reservoir and further into mammals including humans. Receptor incompatibility due to differently expressed glycan structures between species has been suggested to limit zoonotic IAV transmission from the wild bird reservoir as well as between different bird species. Using glycoproteomics, we have studied the repertoires of expressed glycan structures with focus on putative sialic acid-containing glycan receptors for IAV in mallard, chicken and tufted duck; three bird species with different roles in the zoonotic ecology of IAV. The methodology used pinpoints specific glycan structures to specific glycosylation sites of identified glycoproteins and was also used to successfully discriminate α2-3- from α2-6-linked terminal sialic acids by careful analysis of oxonium ions released from glycopeptides in tandem MS/MS (MS2), and MS/MS/MS (MS3). Our analysis clearly demonstrated that all three bird species can produce complex N-glycans including α2-3-linked sialyl Lewis structures, as well as both N- and O- glycans terminated with both α2-3- and α2-6-linked Neu5Ac. We also found the recently identified putative IAV receptor structures, Man-6P N-glycopeptides, in all tissues of the three bird species. Furthermore, we found many similarities in the repertoires of expressed receptors both between the bird species investigated and to previously published data from pigs and humans. Our findings of sialylated glycan structures, previously anticipated to be mammalian specific, in all three bird species may have major implications for our understanding of the role of receptor incompatibility in interspecies transmission of IAV.
MeSH term(s)	Humans ; Animals ; Swine ; Influenza A virus/metabolism ; Ducks/metabolism ; Chickens/metabolism ; Tandem Mass Spectrometry ; Glycopeptides/metabolism ; Polysaccharides/metabolism ; Mammals/metabolism
Chemical Substances	Glycopeptides ; Polysaccharides
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1067689-2
ISSN	1460-2423 ; 0959-6658
ISSN (online)	1460-2423
ISSN	0959-6658
DOI	10.1093/glycob/cwad098
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Article: Ekonomiska utvärderingar allt viktigare för beslut i vården. Men även vid hälsoekonomiska studier måste kostnad balanseras mot nytta.

Lundkvist, Jonas

Lakartidningen

2006 Volume 103, Issue 46, Page(s) 3624–3627

Title translation	Economic evaluations more and more important in healthcare decision making. Costs must be balanced against benefits also in studies on health economics.
MeSH term(s)	Cost-Benefit Analysis ; Decision Making ; Economics, Medical ; Health Policy/economics ; Humans ; Resource Allocation/economics
Language	Swedish
Publishing date	2006-11
Publishing country	Sweden
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article ; Online: Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes

Henrik Hill / Andris Elksnis / Per Lundkvist / Kumari Ubhayasekera / Jonas Bergquist / Bryndis Birnir / Per-Ola Carlsson / Daniel Espes

Biomedicines, Vol 10, Iss 91, p

2022 Volume 91

Abstract: Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the central nervous system (CNS) and outside of the CNS, found in the highest concentrations in immune cells and pancreatic beta-cells. GABA is gaining increasing interest in ... ...

Abstract	Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the central nervous system (CNS) and outside of the CNS, found in the highest concentrations in immune cells and pancreatic beta-cells. GABA is gaining increasing interest in diabetes research due to its immune-modulatory and beta-cell stimulatory effects and is a highly interesting drug candidate for the treatment of type 1 diabetes (T1D). GABA is synthesized from glutamate by glutamic acid decarboxylase (GAD), one of the targets for autoantibodies linked to T1D. Using mass spectrometry, we have quantified the endogenous circulating levels of GABA in patients with new-onset and long-standing T1D and found that the levels are unaltered when compared to healthy controls, i.e., T1D patients do not have a deficit of systemic GABA levels. In T1D, GABA levels were negatively correlated with IL-1 beta, IL-12, and IL-15 15 and positively correlated to levels of IL-36 beta and IL-37. Interestingly, GABA levels were also correlated to the levels of GAD-autoantibodies. The unaltered levels of GABA in T1D patients suggest that the GABA secretion from beta-cells only has a minor impact on the circulating systemic levels. However, the local levels of GABA could be altered within pancreatic islets in the presence of GAD-autoantibodies.
Keywords	type 1 diabetes ; GABA ; islets of Langerhans GAD-autoantibodies ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes.

Hill, Henrik / Elksnis, Andris / Lundkvist, Per / Ubhayasekera, Kumari / Bergquist, Jonas / Birnir, Bryndis / Carlsson, Per-Ola / Espes, Daniel

Biomedicines

2021 Volume 10, Issue 1

Abstract	Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the central nervous system (CNS) and outside of the CNS, found in the highest concentrations in immune cells and pancreatic beta-cells. GABA is gaining increasing interest in diabetes research due to its immune-modulatory and beta-cell stimulatory effects and is a highly interesting drug candidate for the treatment of type 1 diabetes (T1D). GABA is synthesized from glutamate by glutamic acid decarboxylase (GAD), one of the targets for autoantibodies linked to T1D. Using mass spectrometry, we have quantified the endogenous circulating levels of GABA in patients with new-onset and long-standing T1D and found that the levels are unaltered when compared to healthy controls, i.e., T1D patients do not have a deficit of systemic GABA levels. In T1D, GABA levels were negatively correlated with IL-1 beta, IL-12, and IL-15 15 and positively correlated to levels of IL-36 beta and IL-37. Interestingly, GABA levels were also correlated to the levels of GAD-autoantibodies. The unaltered levels of GABA in T1D patients suggest that the GABA secretion from beta-cells only has a minor impact on the circulating systemic levels. However, the local levels of GABA could be altered within pancreatic islets in the presence of GAD-autoantibodies.
Language	English
Publishing date	2021-12-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10010091
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Article: Serogrouping and seroepidemiology of North European hantaviruses using a novel broadly targeted synthetic nucleoprotein antigen array.

Rönnberg, Bengt / Vapalahti, Olli / Goeijenbier, Marco / Reusken, Chantal / Gustafsson, Åke / Blomberg, Jonas / Lundkvist, Åke

Infection ecology & epidemiology

2017 Volume 7, Issue 1, Page(s) 1350086

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2017-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627673-2
ISSN	2000-8686
ISSN	2000-8686
DOI	10.1080/20008686.2017.1350086
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Article ; Online: Sensitivity of Andes hantavirus to antiviral effect of human saliva.

Hardestam, Jonas / Lundkvist, Ake / Klingström, Jonas

Emerging infectious diseases

2009 Volume 15, Issue 7, Page(s) 1140–1142

MeSH term(s)	Antibodies, Viral/immunology ; Hantavirus/genetics ; Hantavirus/immunology ; Hantavirus Infections/immunology ; Hantavirus Infections/transmission ; Hantavirus Pulmonary Syndrome/transmission ; Hemorrhagic Fever with Renal Syndrome/transmission ; Humans ; RNA, Viral ; Saliva/immunology ; Saliva/virology
Chemical Substances	Antibodies, Viral ; RNA, Viral
Language	English
Publishing date	2009-07-23
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid1507.090097
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Zs.A 4778: Show issues

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Article ; Online: Distinction between serological responses following tick-borne encephalitis virus (TBEV) infection vs vaccination, Sweden 2017.

Albinsson, Bo / Vene, Sirkka / Rombo, Lars / Blomberg, Jonas / Lundkvist, Åke / Rönnberg, Bengt

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2017 Volume 23, Issue 3

Abstract: Tick-borne encephalitis virus (TBEV) is an important European vaccine-preventable pathogen. Discrimination of vaccine-induced antibodies from those elicited by infection is important. We studied anti-TBEV IgM/IgG responses, including avidity and ... ...

Abstract	Tick-borne encephalitis virus (TBEV) is an important European vaccine-preventable pathogen. Discrimination of vaccine-induced antibodies from those elicited by infection is important. We studied anti-TBEV IgM/IgG responses, including avidity and neutralisation, by multiplex serology in 50 TBEV patients and 50 TBEV vaccinees. Infection induced antibodies reactive to both whole virus (WV) and non-structural protein 1 (NS1) in 48 clinical cases, whereas 47 TBEV vaccinees had WV, but not NS1 antibodies, enabling efficient discrimination of infection/vaccination.
MeSH term(s)	Antibodies, Viral/blood ; Encephalitis Viruses, Tick-Borne/genetics ; Encephalitis Viruses, Tick-Borne/immunology ; Encephalitis Viruses, Tick-Borne/isolation & purification ; Encephalitis, Tick-Borne/blood ; Encephalitis, Tick-Borne/epidemiology ; Encephalitis, Tick-Borne/prevention & control ; Encephalitis, Tick-Borne/virology ; Female ; Humans ; Immunoglobulin G/blood ; Male ; Sweden/epidemiology ; Vaccination/statistics & numerical data
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2017-11-22
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2018.23.3.17-00838
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Zs.A 5066: Show issues

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Article: Strukturerad introduktion av nya läkemedelsbehandlingar: Värdefullt initiativ--transparens krävs.

Lundkvist, Jonas / Henriksson, Freddie

Lakartidningen

2009 Volume 106, Issue 1-2, Page(s) 51

Title translation	Structured introduction of new drug therapies: valuable initiative--transparency required.
MeSH term(s)	Biomedical Research ; Diffusion of Innovation ; Drug Costs ; Drug Design ; Drug Evaluation/methods ; Drug Industry ; Drugs, Investigational/economics ; Drugs, Investigational/therapeutic use ; Humans ; Product Surveillance, Postmarketing
Chemical Substances	Drugs, Investigational
Language	Swedish
Publishing date	2009-01
Publishing country	Sweden
Document type	Comment ; Journal Article
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article ; Online: Compensating for cross-reactions using avidity and computation in a suspension multiplex immunoassay for serotyping of Zika versus other flavivirus infections.

Rönnberg, Bengt / Gustafsson, Åke / Vapalahti, Olli / Emmerich, Petra / Lundkvist, Åke / Schmidt-Chanasit, Jonas / Blomberg, Jonas

Medical microbiology and immunology

2017 Volume 206, Issue 5, Page(s) 383–401

Abstract: The recent spread of Zika virus (ZIKV) in the Americas and Asia necessitates an increased preparedness for improved maternal and perinatal health and blood safety. However, serological cross-reactions, especially to Dengue virus (DENV), complicate ZIKV ... ...

Abstract	The recent spread of Zika virus (ZIKV) in the Americas and Asia necessitates an increased preparedness for improved maternal and perinatal health and blood safety. However, serological cross-reactions, especially to Dengue virus (DENV), complicate ZIKV antibody serodiagnosis. A novel "pan-Flavi" suspension multiplex immunoassay (PFSMIA) using 25 antigens, whole virus (WV), non-structural protein 1 (NS1), and envelope (E) proteins, from 7 zoonotic flaviviruses for specific detection of ZIKV and DENV IgM and IgG was developed. Patterns of antibody cross-reactivity, avidity, and kinetics were established in 104 sera from returning travelers with known ZIKV and DENV infections. PFSMIA gave IgM- and IgG-sensitivities for both viruses of 96-100%, compared to an immunofluorescence assay. Main IgM cross-reactions were to NS1, for IgG to the E and WV antigens. Infecting virus yielded reactivity to several antigens of the homologous virus, while cross-reactions tended to occur only to a single antigen from heterologous virus(es). A specificity-enhancing computer procedure took into account antibody isotype, number of antibody-reactive antigens per virus, avidity, average degree of cross-reactivity to heterologous flavivirus antigens, and reactivity changes in serial sera. It classified all 50 cases correctly. Applied to sera from 200 pregnant women and 173 blood donors from Sweden, one blood donor was found ZIKV NS1 IgM positive, and another as ZIKV NS1 IgG positive. These samples did not react with other ZIKV antigens and were thereby judged as false-positives. PFSMIA provided sensitive and specific ZIKV and DENV serology, warranting high-throughput serological surveillance and a minimized need for laborious and expensive virus neutralization assays.
MeSH term(s)	Antibodies, Viral/blood ; Antibody Affinity ; Cross Reactions ; Diagnostic Tests, Routine/methods ; Female ; Humans ; Immunoassay/methods ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Pregnancy ; Sensitivity and Specificity ; Serologic Tests/methods ; Software ; Zika Virus Infection/diagnosis
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2017-10
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article
ZDB-ID	120933-4
ISSN	1432-1831 ; 0300-8584
ISSN (online)	1432-1831
ISSN	0300-8584
DOI	10.1007/s00430-017-0517-y
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