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  1. Article ; Online: Taxes on Sugar-Sweetened Beverages Reach a Turning Point.

    Wang, Y Claire

    Clinical chemistry

    2017  Volume 64, Issue 1, Page(s) 42–43

    MeSH term(s) Beverages ; Commerce/economics ; Dietary Sucrose/administration & dosage ; Dietary Sucrose/economics ; Food Industry ; Taxes
    Chemical Substances Dietary Sucrose
    Language English
    Publishing date 2017-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2017.272310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Valuing the cross-sector benefits from improving youth health to drive investment in place-based preventive interventions in the US: A simulation modeling study.

    Counts, Nathaniel Z / Kuklinski, Margaret R / Kelleher, Kelly J / Wang, Y Claire

    Preventive medicine

    2022  Volume 156, Page(s) 106981

    Abstract: Healthcare payment reform has not produced incentives for investing in place-based, or population-level, upstream preventive interventions. This article uses economic modeling to estimate the long-term benefits to different sectors associated with ... ...

    Abstract Healthcare payment reform has not produced incentives for investing in place-based, or population-level, upstream preventive interventions. This article uses economic modeling to estimate the long-term benefits to different sectors associated with improvements in population health indicators in childhood. This information can motivate policymakers to invest in prevention and provide guidance for cross-sector contracting to align incentives for implementing place-based preventive interventions. A benefit-cost model developed by the Washington State Institute for Public Policy was used to estimate total and sector-specific benefits expected from improvements to nine different population health indicators at ages 17 and 18. The magnitudes of improvement used in the model were comparable to those that could be achieved by high-quality implementation of evidence-based population-level preventive interventions. Benefits accruing throughout the lifecycle and over a ten-year time horizon were modelled. Intervention effect sizes of 0.10 and 0.20 demonstrated substantial long-term benefits for eight of the nine outcomes measured. At an effect size of 0.10, the median lifecycle benefit per participant across the ten indicators was $3080 (ranged: $93 to $14,220). The median over a 10-year time horizon was $242 (range: $14 to $1357). Benefits at effect sizes of 0.20 were approximately double. Policymakers may be able to build will for additional investment based on these cross-sector returns and communities may be able to capture these cross-sector benefits through contracting to better align incentives for implementing and sustaining place-based preventive interventions.
    MeSH term(s) Adolescent ; Cost-Benefit Analysis ; Humans ; Washington
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184600-0
    ISSN 1096-0260 ; 0091-7435
    ISSN (online) 1096-0260
    ISSN 0091-7435
    DOI 10.1016/j.ypmed.2022.106981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.

    Wang, Lan / Toutkoushian, Hannah / Belyy, Vladislav / Kokontis, Claire Y / Walter, Peter

    eLife

    2022  Volume 11

    Abstract: The mitochondrial AAA ( ...

    Abstract The mitochondrial AAA (
    MeSH term(s) AAA Proteins/metabolism ; Adenosine Triphosphatases/metabolism ; Amino Acids ; Amino Acids, Aromatic ; Humans ; Membrane Proteins/metabolism ; Merozoite Surface Protein 1 ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Amino Acids ; Amino Acids, Aromatic ; Membrane Proteins ; Merozoite Surface Protein 1 ; Saccharomyces cerevisiae Proteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; MSP1 protein, S cerevisiae (EC 3.6.1.-) ; AAA Proteins (EC 3.6.4.-)
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.73941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Concurrent presentation of IgG4-related tubulointerstitial nephritis and ANCA MPO crescentic glomerulonephritis.

    Wu, Henry H L / Wang, Claire C Y / Woywodt, Alexander / Ponnusamy, Arvind

    Clinical nephrology. Case studies

    2022  Volume 10, Page(s) 47–53

    Abstract: Concurrent IgG4-related tubulointerstitial nephritis and anti-neutrophil cytoplasmic antibodies (ANCA) myeloperoxidase (MPO) crescentic glomerulonephritis is an uncommon scenario, and the link between the two conditions, if any, is incompletely ... ...

    Abstract Concurrent IgG4-related tubulointerstitial nephritis and anti-neutrophil cytoplasmic antibodies (ANCA) myeloperoxidase (MPO) crescentic glomerulonephritis is an uncommon scenario, and the link between the two conditions, if any, is incompletely understood. We report the case of a 58-year-old woman who presented with a 2-month history of malaise and joint pain and was found to have acute kidney injury and hemato-proteinuria. Initial immunological tests revealed positive anti-neutrophil cytoplasmic antibodies with a peri-nuclear pattern (pANCA). An enzyme-linked immunoassay (ELISA) for anti-MPO antibodies was also positive, leading to a tentative diagnosis of ANCA-associated small vessel vasculitis with renal involvement. Steroid treatment was commenced, and an urgent kidney biopsy was performed. This showed crescentic glomerulonephritis, but also demonstrated concurrent tubulointerstitial nephritis with a dominance of IgG4-producing plasma cells. Serum IgG4 levels were also elevated. The patient was initially treated with intravenous cyclophosphamide and steroids and then switched to rituximab. When last seen, she was well after 1 dose of rituximab, with kidney function, inflammatory parameters, and serum IgG4 levels returning to normal levels. The concurrent presentation of ANCA-associated vasculitis and IgG4 renal disease is rare with only few cases reported in the literature. More work is needed to understand pathophysiology, outcomes, and management options for this complex scenario.
    Language English
    Publishing date 2022-07-04
    Publishing country Germany
    Document type Case Reports
    ISSN 2196-5293
    ISSN (online) 2196-5293
    DOI 10.5414/CNCS110852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19-Related School Closings and Risk of Weight Gain Among Children.

    Rundle, Andrew G / Park, Yoosun / Herbstman, Julie B / Kinsey, Eliza W / Wang, Y Claire

    Obesity (Silver Spring, Md.)

    2020  Volume 28, Issue 6, Page(s) 1008–1009

    Keywords covid19
    Language English
    Publishing date 2020-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.22813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rapid molecular detection of CMY-2, and CTX-M group 1 and 9 variants via recombinase polymerase amplification.

    Ertl, Nicole G / Irwin, Adam D / Macdonald, Joanne / Bauer, Michelle J / Wang, Claire Y T / Harris, Patrick N A / Heney, Claire / Zowawi, Hosam M / Whiley, David M

    JAC-antimicrobial resistance

    2023  Volume 5, Issue 2, Page(s) dlad023

    Abstract: Background: Due to their prevalence worldwide, the β-lactamases CTX-M and plasmid-mediated CMY-2 are important antimicrobial resistance enzymes in a clinical setting. While culture- and PCR-based detection methods exist for these targets, they are time ... ...

    Abstract Background: Due to their prevalence worldwide, the β-lactamases CTX-M and plasmid-mediated CMY-2 are important antimicrobial resistance enzymes in a clinical setting. While culture- and PCR-based detection methods exist for these targets, they are time consuming and require specialist equipment and trained personnel to carry out.
    Methods: In this study, three rapid diagnostic single-plex and a prototype triplex assay were developed, using recombinase polymerase amplification with lateral flow detection (RPA-LF), and tested for their sensitivity and specificity using two isolate DNA panels (
    Results: The RPA-LF assays were able to detect
    Conclusions: RPA-LF assays developed in this study have the potential to be used at or close to the point of care, as well as in low-resource settings, producing rapid results to support healthcare professionals in their treatment decisions.
    Language English
    Publishing date 2023-03-17
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlad023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Public Health 3.0: Supporting Local Public Health in Addressing Behavioral Health.

    DeSalvo, Karen B / Wang, Y Claire

    American journal of public health

    2018  Volume 108, Issue 10, Page(s) 1279–1280

    MeSH term(s) Accreditation ; Psychiatry ; Public Health ; Public Health Administration
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2018.304626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Disparities in substance use treatment retention: An exploration of reasons for discharge from publicly funded treatment.

    Borton, David / Streisel, Shannon / Stenger, Madeline / Fraser, Kris / Sutton, Mark / Wang, Y Claire

    Journal of ethnicity in substance abuse

    2022  , Page(s) 1–19

    Abstract: Although Delaware is the seventh smallest state in the country (including Washington, D.C.) in terms of population size, it has the second highest drug overdose death rate. The Delaware Division of Substance Abuse and Mental Health has increased ... ...

    Abstract Although Delaware is the seventh smallest state in the country (including Washington, D.C.) in terms of population size, it has the second highest drug overdose death rate. The Delaware Division of Substance Abuse and Mental Health has increased attention in identifying disparities in treatment outcomes. We explored reasons for discharge from publicly-funded treatment in Delaware with special attention to populations at risk for health inequities, with a focus on covariates of treatment non-completion. Using secondary data collected from publicly-funded treatment providers, we analyzed data from individuals that were admitted to substance use treatment between 2015 and 2019 and had been discharged in 2019. We did this by using logistic and multinomial regression, focusing on non-completion treatment outcomes such as failure to meet requirements, loss of contact, and treatment refusal. Clients who were Black or African American, compared to white clients, were more likely to be lost contact with, administratively discharged, or marked as failing to meet treatment requirements than having a completed treatment discharge. Women were 30% less likely than men to have "failed to meet treatment requirements" compared to completing treatment. Further investigation is needed into these patterns. While treatment quality cannot be assessed using this data, the results point to a need for closer study of disparities in treatment related to race, ethnicity, gender, employment, criminal justice involvement, and type of drug used. Treatment providers should be made aware of culturally informed care, as well as client-created goals, in order to reduce disparities in exit from treatment.
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2052900-4
    ISSN 1533-2659 ; 1533-2640
    ISSN (online) 1533-2659
    ISSN 1533-2640
    DOI 10.1080/15332640.2022.2143977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Introducing the MAVEN Leadership Training Initiative to diversify the scientific workforce.

    Wang, Y Claire / Brondolo, Elizabeth / Monane, Rachel / Kiernan, Michaela / Davidson, Karina W

    eLife

    2021  Volume 10

    Abstract: Addressing gender and racial-ethnic disparities at all career stages is a priority for the research community. In this article, we focus on efforts to encourage mid-career women, particularly women of color, to move into leadership positions in science ... ...

    Abstract Addressing gender and racial-ethnic disparities at all career stages is a priority for the research community. In this article, we focus on efforts to encourage mid-career women, particularly women of color, to move into leadership positions in science and science policy. We highlight the need to strengthen leadership skills for the critical period immediately following promotion to associate/tenured professor - when formal career development efforts taper off while institutional demands escalate - and describe a program called MAVEN that has been designed to teach leadership skills to mid-career women scientists, particularly those from underrepresented groups.
    MeSH term(s) Career Mobility ; Ethnicity ; Humans ; Leadership ; Minority Groups ; Professional Competence ; Research Personnel ; Workforce
    Language English
    Publishing date 2021-05-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.69063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Abca7

    Butler, Claire A / Mendoza Arvilla, Adrian / Milinkeviciute, Giedre / Da Cunha, Celia / Kawauchi, Shimako / Rezaie, Narges / Liang, Heidi Y / Javonillo, Dominic / Thach, Annie / Wang, Shuling / Collins, Sherilyn / Walker, Amber / Shi, Kai-Xuan / Neumann, Jonathan / Gomez-Arboledas, Angela / Henningfield, Caden M / Hohsfield, Lindsay A / Mapstone, Mark / Tenner, Andrea J /
    LaFerla, Frank M / Mortazavi, Ali / MacGregor, Grant R / Green, Kim N

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  

    Abstract: Background: Variants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer's disease (LOAD).: Methods: CRISPR-Cas9 was used to generate an Abca7: Results: Abca7: ... ...

    Abstract Background: Variants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer's disease (LOAD).
    Methods: CRISPR-Cas9 was used to generate an Abca7
    Results: Abca7
    Discussion: Overall, homozygosity for the Abca7
    Highlights: ABCA7 recognized as a top 10 risk gene for developing Alzheimer's disease. Loss of function mutations result in increased risk for LOAD. V1613M variant reduces amyloid beta plaque burden in 5xFAD mice. V1613M variant modulates APP processing and trafficking in 5xFAD mice. V1613M variant reduces amyloid beta-associated damage in 5xFAD mice.
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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