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Article ; Online: "Dar"-ing to target CD38 in T-ALL.

Wynne, Joseph / Stock, Wendy

2018 Volume 131, Issue 9, Page(s) 948–949

MeSH term(s)	ADP-ribosyl Cyclase 1 ; Antibodies, Monoclonal ; Humans ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ; T-Lymphocytes
Chemical Substances	Antibodies, Monoclonal ; daratumumab (4Z63YK6E0E) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
Language	English
Publishing date	2018-03-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2018-01-826446
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Zs.MO 364: Show issues

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Article: Histone Deacetylase Inhibitors Restore Cancer Cell Sensitivity towards T Lymphocytes Mediated Cytotoxicity in Pancreatic Cancer.

Looi, Chin-King / Gan, Li-Lian / Sim, Wynne / Hii, Ling-Wei / Chung, Felicia Fei-Lei / Leong, Chee-Onn / Lim, Wei-Meng / Mai, Chun-Wai

Cancers

2022 Volume 14, Issue 15

Abstract: ... the immunophenotype of PDAC in silico and identified that tumours with high cytotoxic T lymphocytes (CTL) killing ...

Abstract	Despite medical advancements, the prognosis of pancreatic ductal adenocarcinoma (PDAC) has not improved significantly over the past 50 years. By utilising the large-scale genomic datasets available from the Australia Pancreatic Cancer Project (PACA-AU) and The Cancer Genomic Atlas Project (TCGA-PAAD), we studied the immunophenotype of PDAC in silico and identified that tumours with high cytotoxic T lymphocytes (CTL) killing activity were associated with favourable clinical outcomes. Using the STRING protein-protein interaction network analysis, the identified differentially expressed genes with low CTL killing activity were associated with TWIST/IL-6R, HDAC5, and EOMES signalling. Following Connectivity Map analysis, we identified 44 small molecules that could restore CTL sensitivity in the PDAC cells. Further high-throughput chemical library screening identified 133 inhibitors that effectively target both parental and CTL-resistant PDAC cells in vitro. Since CTL-resistant PDAC had a higher expression of histone proteins and its acetylated proteins compared to its parental cells, we further investigated the impact of histone deacetylase inhibitors (HDACi) on CTL-mediated cytotoxicity in PDAC cells in vitro, namely SW1990 and BxPC3. Further analyses revealed that givinostat and dacinostat were the two most potent HDAC inhibitors that restored CTL sensitivity in SW1990 and BxPC3 CTL-resistant cells. Through our in silico and in vitro studies, we demonstrate the novel role of HDAC inhibition in restoring CTL resistance and that combinations of HDACi with CTL may represent a promising therapeutic strategy, warranting its further detailed molecular mechanistic studies and animal studies before embarking on the clinical evaluation of these novel combined PDAC treatments.
Language	English
Publishing date	2022-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14153709
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Article ; Online: The Paired T-Fastener Technique: A Bolster-Free Gastropexy for Laparoscopic Gastrostomy Tube Placement.

Durgin, Jonathan M / Slatnick, Brianna / Yang, Alexander / Crum, Robert / Wynne, Nicole / Neumeyer, Corinne / Kim, Heung Bae / Demehri, Farokh R

Journal of laparoendoscopic & advanced surgical techniques. Part A

2021 Volume 31, Issue 12, Page(s) 1431–1435

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Child ; Gastropexy ; Gastrostomy ; Humans ; Laparoscopy ; Surgical Instruments ; Sutures
Language	English
Publishing date	2021-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2021.0336
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Article ; Online: T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.

Mackay, Laura K / Wynne-Jones, Erica / Freestone, David / Pellicci, Daniel G / Mielke, Lisa A / Newman, Dane M / Braun, Asolina / Masson, Frederick / Kallies, Axel / Belz, Gabrielle T / Carbone, Francis R

Immunity

2015 Volume 43, Issue 6, Page(s) 1101–1111

Abstract: Tissue-resident memory T (Trm) cells contribute to local immune protection in non-lymphoid tissues ... CD103(+) Trm cells, independent of circulating memory T cells, were sufficient for protection against ... We demonstrated that the T-box transcription factors (TFs) Eomes and T-bet combined to control CD8(+)CD103(+) Trm ...

Abstract	Tissue-resident memory T (Trm) cells contribute to local immune protection in non-lymphoid tissues such as skin and mucosa, but little is known about their transcriptional regulation. Here we showed that CD8(+)CD103(+) Trm cells, independent of circulating memory T cells, were sufficient for protection against infection and described molecular elements that were crucial for their development in skin and lung. We demonstrated that the T-box transcription factors (TFs) Eomes and T-bet combined to control CD8(+)CD103(+) Trm cell formation, such that their coordinate downregulation was crucial for TGF-β cytokine signaling. TGF-β signaling, in turn, resulted in reciprocal T-box TF downregulation. However, whereas extinguishment of Eomes was necessary for CD8(+)CD103(+) Trm cell development, residual T-bet expression maintained cell surface interleukin-15 (IL-15) receptor β-chain (CD122) expression and thus IL-15 responsiveness. These findings indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
MeSH term(s)	Adoptive Transfer ; Animals ; CD8-Positive T-Lymphocytes/immunology ; Down-Regulation ; Flow Cytometry ; Gene Expression Regulation/immunology ; Immunologic Memory/immunology ; Interleukin-15/immunology ; Lymphocyte Activation/immunology ; Mice ; Mice, Knockout ; Polymerase Chain Reaction ; T-Box Domain Proteins/immunology ; T-Lymphocyte Subsets/immunology ; Transforming Growth Factor beta/immunology
Chemical Substances	Eomes protein, mouse ; Interleukin-15 ; T-Box Domain Proteins ; T-box transcription factor TBX21 ; Transforming Growth Factor beta
Language	English
Publishing date	2015-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2015.11.008
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: T lymphocyte and monocyte subsets are dysregulated in type 1 diabetes patients with peripheral neuropathic pain.

O'Brien, Jayden A / McGuire, Helen M / Shinko, Diana / Fazekas de St Groth, Barbara / Russo, Marc A / Bailey, Dominic / Santarelli, Danielle M / Wynne, Katie / Austin, Paul J

Brain, behavior, & immunity - health

2021 Volume 15, Page(s) 100283

Abstract: Diabetic neuropathic pain is a common and devastating complication of type 1 diabetes, but the mechanism by which it develops and persists is yet to be fully elucidated. This study utilised high-dimensional suspension mass cytometry in a pilot cohort to ... ...

Abstract	Diabetic neuropathic pain is a common and devastating complication of type 1 diabetes, but the mechanism by which it develops and persists is yet to be fully elucidated. This study utilised high-dimensional suspension mass cytometry in a pilot cohort to investigate differences in peripheral blood immunophenotypes between type 1 diabetes patients with (n = 9) and without (n = 9) peripheral neuropathic pain. The abundance and activation of several leukocyte subsets were investigated with unsupervised clustering approaches FlowSOM and SPADE, as well as by manual gating. Major findings included a proportional increase in CD4
Language	English
Publishing date	2021-06-09
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2021.100283
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Article ; Online: Evaluation of the Cancer Control P.L.A.N.E.T. Web Portal.

Percy-Laurry, Antoinette / Heurtin-Roberts, Suzanne / Norton, Wynne E / McDonnell, Cheryl / Uy, Annabelle / Chambers, David A

Journal of public health management and practice : JPHMP

2019 Volume 27, Issue 1, Page(s) E1–E8

Abstract: Context: The Cancer Control P.L.A.N.E.T. (P.L.A.N.E.T.) Web portal was designed to ease access ... applicability, and opportunities to improve the P.L.A.N.E.T. Web portal after significant changes to the portal ... professionals to assess factors influencing utilization of P.L.A.N.E.T. Data were collected from May 2017 ...

Abstract	Context: The Cancer Control P.L.A.N.E.T. (P.L.A.N.E.T.) Web portal was designed to ease access to data and evidence-based resources for cancer control practitioners and researchers focused on developing, implementing, and evaluating cancer control programs. Objectives: To determine usability, applicability, and opportunities to improve the P.L.A.N.E.T. Web portal after significant changes to the portal over time. Design: The National Cancer Institute surveyed and interviewed cancer control professionals to assess factors influencing utilization of P.L.A.N.E.T. Data were collected from May 2017 to June 2018 via partner agencies, electronic publications, and online links. Outcome measures: Descriptive statistics with χ test were used to analyze the quantitative data and examine the relationship among variables. Qualitative interviews further informed the quantitative analysis. Results: Of the 724 participants surveyed, 51% were users of P.L.A.N.E.T., with the majority accessing P.L.A.N.E.T. within the last 6 months. Most users felt that P.L.A.N.E.T. effectively met their needs for accessing specific cancer data, identifying evidenced-based programs, and ascertaining details on various cancer topics. There were statistically significant differences in demographic characteristics between users and nonusers of P.L.A.N.E.T., where users were more likely to have more experience in the cancer field, were older in age, and located in southern states. Conclusion: Results indicate that P.L.A.N.E.T. is seen as a viable and credible source for cancer control program planning and delivery. A reassessment of P.L.A.N.E.T.'s goals is warranted, which may support reaching out to new audiences, amplifying or removing underutilized resources, and adding additional resources and topics. Consideration for training and tutorials on P.L.A.N.E.T. would benefit partner agencies and build capacity for evidence-based program development.
MeSH term(s)	Delivery of Health Care ; Humans ; Neoplasms/epidemiology ; Neoplasms/prevention & control ; Program Development
Language	English
Publishing date	2019-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2027860-3
ISSN	1550-5022 ; 1078-4659
ISSN (online)	1550-5022
ISSN	1078-4659
DOI	10.1097/PHH.0000000000001043
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Zs.A 5302: Show issues

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Article: Effect of a prophylactic treatment with chloramine-T on gill histology and microbiome of Atlantic salmon (Salmo salar) under commercial conditions

Quezada-Rodriguez, Petra R. / Taylor, Richard S. / Samsing, Francisca / Rigby, Megan / Wood, Andrew T. / Nowak, Barbara F. / Wynne, James W.

Aquaculture. 2022 Jan. 15, v. 546

2022

Abstract: Chloramine-T (Cl-T) is a disinfectant and sanitizer widely applied to treat bacterial infections ... While the efficacy of CI-T to reduce specific bacterial pathogens has been demonstrated previously, its effect ... examined the effects of a one-hour Cl-T treatment (nominal 15 mg L⁻¹) on the skin and gill microbiome using ...

Abstract	Chloramine-T (Cl-T) is a disinfectant and sanitizer widely applied to treat bacterial infections on the gill and skin of Atlantic salmon during freshwater culture. It is typically applied as static or flush treatments during periods of disease risk or in response to pathogen detection or gross disease signs. While the efficacy of CI-T to reduce specific bacterial pathogens has been demonstrated previously, its effect on the broader commensal microbial community is largely unknown. To address this knowledge gap, the present study examined the effects of a one-hour Cl-T treatment (nominal 15 mg L⁻¹) on the skin and gill microbiome using a 16S rRNA based amplicon sequencing approach. Furthermore, the total bacterial load and histological changes in the gill were examined following CI-T treatment. Although, bacterial quantification on gills and water confirmed decreased bacterial load at 1 h, these loads returned to pre-treatment levels by 24 h. Microbial richness of bacterial communities on skin and gills varied at 1 h, and 13 d compared to 0 h. Contrary to the gills, microbial diversity on skin decreased after treatment. Gill histology showed subepithelial oedema at 24 h and increased number of lamellar mucous cells at 7 d compared with 0 h. This study reports the effects of commercially deployed Cl-T on two gill health indicators: bacterial microbiome composition and gill morphology in fresh water farmed Atlantic salmon.
Keywords	Salmo salar ; disease prevention ; disinfectants ; edema ; freshwater ; histology ; microbial detection ; microbial load ; microbiome ; risk ; sanitizers
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2021.737319
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Vortioxetine Reduces Marble Burying but Only Transiently Enhances Social Interaction Preference in Adult Male BTBR T

Witt, Nasriya A / Lee, Benita / Ghent, Kaylee / Zhang, Wynne Q / Pehrson, Alan L / Sánchez, Connie / Gould, Georgianna G

ACS chemical neuroscience

2019 Volume 10, Issue 10, Page(s) 4319–4327

Abstract: Vortioxetine is a multimodal antidepressant with agonist activity at serotonin (5-HT) ...

Abstract	Vortioxetine is a multimodal antidepressant with agonist activity at serotonin (5-HT)
MeSH term(s)	Animals ; Autistic Disorder ; Behavior, Animal/drug effects ; Disease Models, Animal ; Male ; Mice ; Mice, Transgenic ; Serotonin Uptake Inhibitors/pharmacology ; Sertraline/pharmacology ; Social Behavior ; Vortioxetine/pharmacology
Chemical Substances	Serotonin Uptake Inhibitors ; Vortioxetine (3O2K1S3WQV) ; Sertraline (QUC7NX6WMB)
Language	English
Publishing date	2019-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.9b00386
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Article ; Online: Endoscopy-assisted technique for removal of a transduodenal T-tube.

Chattopadhyay, D / Garkuwa, D / Wynne, K S / Joypaul, B V

Endoscopy

2011 Volume 43 Suppl 2 UCTN, Page(s) E7–8

MeSH term(s)	Device Removal/methods ; Duodenum/surgery ; Endoscopy ; Humans ; Intubation, Gastrointestinal/instrumentation
Language	English
Publishing date	2011
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0030-1255769
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Kylie M. Quinn / Tabinda Hussain / Felix Kraus / Luke E. Formosa / Wai K. Lam / Michael J. Dagley / Eleanor C. Saunders / Lisa M. Assmus / Erica Wynne-Jones / Liyen Loh / Carolien E. van de Sandt / Lucy Cooper / Kim L. Good-Jacobson / Katherine Kedzierska / Laura K. Mackay / Malcolm J. McConville / Georg Ramm / Michael T. Ryan / Nicole L. La Gruta

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 13

Abstract: ... which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not ... antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL ...

Abstract	Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL-15 signalling and not directly by FAO.
Keywords	Science ; Q
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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