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  1. Article ; Online: Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss.

    Rosen, Clifford J / Horowitz, Mark C

    Nature reviews. Endocrinology

    2023  Volume 19, Issue 11, Page(s) 626–638

    Abstract: Adipose tissue is a dynamic component of the bone marrow, regulating skeletal remodelling and secreting paracrine and endocrine factors that can affect haematopoiesis, as well as potentially nourishing the bone marrow during periods of stress. Bone ... ...

    Abstract Adipose tissue is a dynamic component of the bone marrow, regulating skeletal remodelling and secreting paracrine and endocrine factors that can affect haematopoiesis, as well as potentially nourishing the bone marrow during periods of stress. Bone marrow adipose tissue is regulated by multiple factors, but particularly nutrient status. In this Review, we examine how bone marrow adipocytes originate, their function in normal and pathological states and how bone marrow adipose tissue modulates whole-body homoeostasis through actions on bone cells, haematopoietic stem cells and extra-medullary adipocytes during nutritional challenges. We focus on both rodent models and human studies to help understand the unique marrow adipocyte, its response to the external nutrient environment and its effects on the skeleton. We finish by addressing some critical questions that to date remain unanswered.
    MeSH term(s) Humans ; Adipocytes/physiology ; Adipose Tissue ; Bone Marrow/pathology ; Bone Marrow/physiology ; Bone Marrow Cells/physiology ; Obesity/pathology ; Weight Loss
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-023-00879-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Human immunodeficiency virus and the lung

    Rosen, Mark J.

    (Lung biology in health and disease ; 119)

    1998  

    Author's details ed. by Mark J. Rosen
    Series title Lung biology in health and disease ; 119
    Collection
    Keywords HIV Infections / complications ; Lung Diseases / complications ; HIV-Infektion ; Sekundärkrankheit ; Lungenkrankheit
    Subject Lungenerkrankung ; Folgekrankheit ; Erworbener Defekt ; Sekundärerkrankung ; Folgeerkrankung ; Zweiterkrankung ; Begleitkrankheit ; Komorbidität ; Begleiterkrankung ; Conduct disorder ; Comorbid disorder ; HIV
    Language English
    Size XIX, 548 S. : Ill., graph. Darst.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT009002700
    ISBN 0-8247-9883-X ; 978-0-8247-9883-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1998 A 6185 order for loan Magazin

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  3. Article ; Online: Impact of Arterial Input Function and Pharmacokinetic Models on DCE-MRI Biomarkers for Detection of Vascular Effect Induced by Stroma-Directed Drug in an Orthotopic Mouse Model of Pancreatic Cancer.

    Cao, Jianbo / Pickup, Stephen / Rosen, Mark / Zhou, Rong

    Molecular imaging and biology

    2023  Volume 25, Issue 4, Page(s) 638–647

    Abstract: ... Results: Individual AIF exhibit a marked difference in peak gadolinium concentration. However, across ...

    Abstract Purpose: We demonstrated earlier in mouse models of pancreatic ductal adenocarcinoma (PDA) that K
    Procedures: Retrospective analyses of the DCE-MRI of the orthotopic PDA model are performed to examine the impact of individual versus group AIF combined with Tofts model (TM), extended-Tofts model (ETM), or shutter-speed model (SSM) on the ability to detect the microvascular changes induced by PEGPH20 treatment.
    Results: Individual AIF exhibit a marked difference in peak gadolinium concentration. However, across all three PK models, k
    Conclusion: Our results suggest that k
    MeSH term(s) Animals ; Mice ; Contrast Media/pharmacokinetics ; Retrospective Studies ; Image Enhancement/methods ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/drug therapy ; Disease Models, Animal ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/drug therapy ; Magnetic Resonance Imaging/methods ; Reproducibility of Results ; Pancreatic Neoplasms
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-023-01824-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antibody Titers against Mpox Virus after Vaccination.

    Kottkamp, Angelica C / Samanovic, Marie I / Duerr, Ralf / Oom, Aaron L / Belli, Hayley M / Zucker, Jane R / Rosen, Jennifer B / Mulligan, Mark J

    The New England journal of medicine

    2023  Volume 389, Issue 24, Page(s) 2299–2301

    MeSH term(s) Humans ; Antibodies, Viral/analysis ; Antibodies, Viral/immunology ; Monkeypox virus/immunology ; Vaccination ; Mpox (monkeypox)/immunology ; Mpox (monkeypox)/prevention & control
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2306239
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  5. Article ; Online: Myofibroblastoma in the Liver: A Case Report and Review of Literature.

    Narasimhamurthy, Mohan / Savant, Deepika / Shreve, Lauren / Rosen, Mark A / Lee, Major Kenneth / Cooper, Kumarasen / Furth, Emma E / Zhang, Paul J / Yang, Zhaohai

    International journal of surgical pathology

    2023  Volume 31, Issue 8, Page(s) 1559–1564

    Abstract: Myofibroblastoma is a rare benign mesenchymal tumor first described in the breast. It is also known as mammary-type myofibroblastoma outside of the breast, more frequently located along the embryonic milk line. Exceptionally, myofibroblastoma can occur ... ...

    Abstract Myofibroblastoma is a rare benign mesenchymal tumor first described in the breast. It is also known as mammary-type myofibroblastoma outside of the breast, more frequently located along the embryonic milk line. Exceptionally, myofibroblastoma can occur at visceral locations. We present a case of myofibroblastoma detected incidentally in the liver. A well-circumscribed mass, grossly measuring 6.2 cm in the liver parenchyma, was found on imaging studies. Histologically, the lesion is characterized by benign spindle cells in a hyalinized collagenous stroma, with positive staining for SMA and ER, focal positivity for CD34, negative for desmin, and loss of RB1. This rare tumor at such an unusual location makes it diagnostically challenging, especially on core biopsy of the lesion. To our knowledge, this is the second case of myofibroblastoma in the liver reported in the English literature and the first such case with a detailed pathology description.
    MeSH term(s) Humans ; Biomarkers, Tumor ; Immunohistochemistry ; Neoplasms, Muscle Tissue/diagnosis ; Neoplasms, Muscle Tissue/surgery ; Neoplasms, Muscle Tissue/pathology ; Breast/pathology ; Liver/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969231160262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sustaining Lifelong Competency of Surgeons: Multimodality Empowerment Personal and Institutional Strategy.

    Rosengart, Todd K / Chen, Jennifer H / Gantt, Nancy L / Angelos, Peter / Warshaw, Andrew L / Rosen, Jennifer E / Perrier, Nancy D / Kaups, Krista L / Doherty, Gerard M / Zoumpou, Theofano / Ashley, Stanley W / Doscher, William / Welsh, David / Savarise, Mark / Sutherland, Michael J / Sidawy, Anton N / Kopelan, Adam M

    Journal of the American College of Surgeons

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1097/XCS.0000000000001066
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  7. Article ; Online: Innovations in Community Care Programs, Policies, and Research.

    Mattocks, Kristin M / Cunningham, Kristin J / Greenstone, Clinton / Atkins, David / Rosen, Amy K / Upton, Mark

    Medical care

    2021  Volume 59, Issue Suppl 3, Page(s) S229–S231

    MeSH term(s) Community Health Services/trends ; Health Policy/trends ; Health Services Research/trends ; Humans ; Veterans Health/trends ; Veterans Health Services/trends
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 411646-x
    ISSN 1537-1948 ; 0025-7079
    ISSN (online) 1537-1948
    ISSN 0025-7079
    DOI 10.1097/MLR.0000000000001550
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  8. Article: Superiorly Based Middle Turbinate Flap for Repair of Cerebrospinal Fluid Rhinorrhea: A Cadaveric Feasibility Study and Case Series.

    Chaskes, Mark B / Barton, Blair / Karsy, Michael / Rabinowitz, Mindy R / Nyquist, Gurston G / Farrell, Christopher / Evans, James J / Rosen, Marc R

    Journal of neurological surgery. Part B, Skull base

    2022  Volume 84, Issue 6, Page(s) 585–590

    Abstract: ... ...

    Abstract Objectives
    Language English
    Publishing date 2022-10-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/a-1934-9095
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  9. Article ; Conference proceedings: Endoscopic Repair of Clival Defects Using Free Flaps

    Rosen, Ross / Bergman, Jenna E. / Mifsud, Mathew J. / Agazzi, Siviero / Van Loveren, Harry / Tabor, Mark H.

    Journal of Neurological Surgery Part B: Skull Base

    2023  Volume 84, Issue S 01

    Event/congress 32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0043-1762220
    Database Thieme publisher's database

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  10. Article ; Online: Conditional Effects of Race on Operative and Nonoperative Outcomes of Emergency General Surgery Conditions.

    Roberts, Sanford E / Rosen, Claire B / Keele, Luke J / Kaufman, Elinore J / Wirtalla, Christopher J / Syvyk, Solomiya / Reilly, Patrick M / Neuman, Mark D / McHugh, Matthew D / Kelz, Rachel R

    Medical care

    2023  Volume 61, Issue 9, Page(s) 587–594

    Abstract: Introduction: Many emergency general surgery (EGS) conditions can be managed both operatively or nonoperatively; however, it is unknown whether the decision to operate affects Black and White patients differentially.: Methods: We identified a ... ...

    Abstract Introduction: Many emergency general surgery (EGS) conditions can be managed both operatively or nonoperatively; however, it is unknown whether the decision to operate affects Black and White patients differentially.
    Methods: We identified a nationwide cohort of Black and White Medicare beneficiaries, hospitalized for common EGS conditions from July 2015 to June 2018. Using near-far matching to adjust for measurable confounding and an instrumental variable analysis to control for selection bias associated with treatment assignment, we compare outcomes of operative and nonoperative management in a stratified population of Black and White patients. Outcomes included in-hospital mortality, 30-day mortality, nonroutine discharge, and 30-day readmissions. An interaction test based on a t test was used to determine the conditional effects of operative versus nonoperative management between Black and White patients.
    Results: A total of 556,087 patients met inclusion criteria, of which 59,519 (10.7%) were Black and 496,568 (89.3%) were White. Overall, 165,932 (29.8%) patients had an operation and 390,155 (70.2%) were managed nonoperatively. Significant outcome differences were seen between operative and nonoperative management for some conditions; however, no significant differences were seen for the conditional effect of race on outcomes.
    Conclusions: The decision to manage an EGS patient operatively versus nonoperatively has varying effects on surgical outcomes. These effects vary by EGS condition. There were no significant conditional effects of race on the outcomes of operative versus nonoperative management among universally insured older adults hospitalized with EGS conditions.
    MeSH term(s) Aged ; Humans ; General Surgery ; Medicare ; Patient Readmission ; Retrospective Studies ; United States ; Black or African American ; White ; Racial Groups ; Emergencies
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 411646-x
    ISSN 1537-1948 ; 0025-7079
    ISSN (online) 1537-1948
    ISSN 0025-7079
    DOI 10.1097/MLR.0000000000001883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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