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  1. Article: The Impact of Parasitic Infestation on Nutritional Status and Micronutrients among Children.

    Alkholy, Usama M / El Gebaly, Sherief M / Morsi, Walaa E M A / Elawamy, Waleed E / Etewa, Samia E / Yousef, Asmaa M

    Journal of parasitology research

    2024  Volume 2024, Page(s) 6996968

    Abstract: Background: Micronutrient deficiency is a great problem that is augmented by infection and poor nutrition. Iron, zinc, and selenium are trace elements needed for human growth.: Objective: To investigate the impact of parasitic infection on ... ...

    Abstract Background: Micronutrient deficiency is a great problem that is augmented by infection and poor nutrition. Iron, zinc, and selenium are trace elements needed for human growth.
    Objective: To investigate the impact of parasitic infection on nutritional status and serum iron, zinc, and selenium in children attending Pediatrics Outpatient Clinic of Zagazig University Hospitals.
    Results: Parasitic infected children showed a statistically significant low weight for age, height for age, and BMI. Serum iron, zinc, and selenium were significantly lower in parasitic infected children than controls. Serum iron, zinc, and selenium have significant positive correlations with weight, height, and BMI, respectively.
    Conclusion: Studied serum micronutrients especially zinc and iron and anthropometric indices were significantly lower in parasitically infected children.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2563542-6
    ISSN 2090-0031 ; 2090-0023
    ISSN (online) 2090-0031
    ISSN 2090-0023
    DOI 10.1155/2024/6996968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Could Bordetella pertussis vaccine protect against coronavirus COVID-19?

    Alkholy, Usama M / Salama, Mohamed E / Mahmoud, Hagar / Taher, Ahmed / Elsayes, Khaled M

    Journal of global antimicrobial resistance

    2020  Volume 22, Page(s) 803–805

    Abstract: According to the World Health Organization (WHO), as of today, there are 2.165.500 confirmed cases of the novel coronavirus disease (COVID-19) and 145.705 deaths in over 185 countries. Unfortunately, despite the tremendous efforts to develop a vaccine ... ...

    Abstract According to the World Health Organization (WHO), as of today, there are 2.165.500 confirmed cases of the novel coronavirus disease (COVID-19) and 145.705 deaths in over 185 countries. Unfortunately, despite the tremendous efforts to develop a vaccine initiated by various leading health institutions all over the world, it may be 18 months before a vaccine against the coronavirus is publicly available. We are proposing a theory about testing the use of the Bordetella pertussis vaccine to protect against COVID-19. We deliver this theory to the scientific community, aiming to raise the concern about it, and to provide us with support by realistic and experimental evidence.
    MeSH term(s) Betacoronavirus/immunology ; Bordetella pertussis/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Models, Immunological ; Pandemics/prevention & control ; Pertussis Vaccine/administration & dosage ; Pertussis Vaccine/immunology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
    Chemical Substances Pertussis Vaccine
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2020.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Could Bordetella pertussis vaccine protect against coronavirus COVID-19?

    Alkholy, Usama M. / Salama, Mohamed E. / Mahmoud, Hagar / Taher, Ahmed / Elsayes, Khaled M.

    Journal of Global Antimicrobial Resistance

    2020  Volume 22, Page(s) 803–805

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2020.07.005
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Effectiveness and impact of rotavirus vaccines in Saudi Arabia: A single hospital-based study.

    Zaki, Ahmed / Abousekkien, Mohamed / Alkholy, Usama M / Eid, Abdelrahman

    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

    2017  Volume 18, Issue 3, Page(s) 140–143

    Abstract: Background and study aims: Rotavirus is the most important cause of severe gastroenteritis in children. The primary public health intervention is vaccination. Rota vaccine has been included to the national vaccination schedule in Saudi Arabia since 1 ... ...

    Abstract Background and study aims: Rotavirus is the most important cause of severe gastroenteritis in children. The primary public health intervention is vaccination. Rota vaccine has been included to the national vaccination schedule in Saudi Arabia since 1 January 2013. Here we aim to evaluate the effectiveness and impact of rotavirus vaccines in Saudi Arabia following the addition of rotavirus vaccine to the national vaccination schedule.
    Patients and methods: Retrospective analysis of electronic data of children admitted to al Jeddani Hospital, Jeddah, Saudi Arabia, with gastroenteritis between 1 September 2011 and 31 August 2012 (1year before the implementation of Rota vaccine; group 1) compared to those admitted between 1 September 2015 and 31 August 2016 (3years after the implementation of the vaccine; group 2).
    Results: A total of 730 patients with gastroenteritis had documented rotavirus stool analysis. Their median age was 32 (16-56) months, 54% male and 46% female. The prevalence of rotavirus-positive gastroenteritis significantly decreased from 38.5% in group 1 to 13.2% in group 2, P=0.0001. The median age of rotavirus infection significantly increased to 44 (21-56) months after the implementation of rotavirus vaccine compared to 16 (12-36) months before routine vaccination, P=0.003.
    Conclusion: Rotavirus gastroenteritis has significantly decreased among Saudi children, especially infants below 24months of age, after the implementation of rotavirus vaccine in the national vaccination programme.
    MeSH term(s) Age Distribution ; Child, Preschool ; Female ; Gastroenteritis/prevention & control ; Gastroenteritis/virology ; Hospitals ; Humans ; Infant ; Interrupted Time Series Analysis ; Male ; Retrospective Studies ; Rotavirus Infections/prevention & control ; Rotavirus Vaccines ; Saudi Arabia
    Chemical Substances Rotavirus Vaccines
    Language English
    Publishing date 2017-09-27
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2502114-X
    ISSN 2090-2387 ; 1687-1979
    ISSN (online) 2090-2387
    ISSN 1687-1979
    DOI 10.1016/j.ajg.2017.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Could Bordetella pertussis vaccine protect against coronavirus COVID-19?

    Alkholy, Usama M / Salama, Mohamed E / Mahmoud, Hagar / Taher, Ahmed / Elsayes, Khaled M

    J Glob Antimicrob Resist

    Abstract: According to the World Health Organization (WHO), as of today, there are 2.165.500 confirmed cases of the novel coronavirus disease (COVID-19) and 145.705 deaths in over 185 countries. Unfortunately, despite the tremendous efforts to develop a vaccine ... ...

    Abstract According to the World Health Organization (WHO), as of today, there are 2.165.500 confirmed cases of the novel coronavirus disease (COVID-19) and 145.705 deaths in over 185 countries. Unfortunately, despite the tremendous efforts to develop a vaccine initiated by various leading health institutions all over the world, it may be 18 months before a vaccine against the coronavirus is publicly available. We are proposing a theory about testing the use of the Bordetella pertussis vaccine to protect against COVID-19. We deliver this theory to the scientific community, aiming to raise the concern about it, and to provide us with support by realistic and experimental evidence.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #651155
    Database COVID19

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  6. Article ; Online: Vascular endothelial growth factor and pulmonary hypertension in children with beta thalassemia major.

    Alkholy, Usama M / Mohamed, Soma Abdalla / Elhady, Marwa / Attar, Shahinaz El / Abdalmonem, Nermin / Zaki, Ahmed

    Jornal de pediatria

    2018  Volume 95, Issue 5, Page(s) 593–599

    Abstract: Objective: The purpose of this study was to illustrate the association between vascular endothelial growth factor level and pulmonary artery hypertension in children with β-thalassemia major.: Method: This case-control study was conducted on 116 ... ...

    Abstract Objective: The purpose of this study was to illustrate the association between vascular endothelial growth factor level and pulmonary artery hypertension in children with β-thalassemia major.
    Method: This case-control study was conducted on 116 children with β-thalassemia major; 58 of them had pulmonary artery hypertension. They were compared to 58 healthy children who were age and sex-matched (control group). Serum levels of vascular endothelial growth factor and echocardiographic assessment were done for all children.
    Results: Vascular endothelial growth factor serum level was significantly higher in children with β-thalassemia major with pulmonary artery hypertension than in those without pulmonary artery hypertension, as well as in control groups (p<0.001). Vascular endothelial growth factor serum level had a significant positive correlation with pulmonary artery pressure and serum ferritin, as well as a significant negative correlation with the duration of chelation therapy. Logistic regression analysis revealed that elevated vascular endothelial growth factor (Odd Ratio=1.5; 95% Confidence Interval, 1.137-2.065; p=0.005) was an independent risk factor of pulmonary artery hypertension in such children. Vascular endothelial growth factor serum level at a cutoff point of >169pg/mL had 93.1% sensitivity and 93.1% specificity for the presence of pulmonary artery hypertension in children with β-thalassemia major.
    Conclusion: Elevated vascular endothelial growth factor serum level is associated with pulmonary artery hypertension in children with β-thalassemia.
    MeSH term(s) Adolescent ; Age of Onset ; Analysis of Variance ; Case-Control Studies ; Child ; Echocardiography, Doppler ; Female ; Humans ; Hypertension, Pulmonary/blood ; Hypertension, Pulmonary/physiopathology ; Male ; ROC Curve ; Reference Values ; Risk Factors ; Splenectomy ; Statistics, Nonparametric ; Time Factors ; Vascular Endothelial Growth Factor A/blood ; beta-Thalassemia/blood ; beta-Thalassemia/physiopathology
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2018-06-01
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.1016/j.jped.2018.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: B

    Alghobashy, Ashgan Abdallah / Elsharawy, Sahar A / Alkholy, Usama M / Abdalmonem, Nermin / Abdou, Mohamed Ali / Basset, Maha A A / Pasha, Heba Fouad

    Pediatric research

    2018  Volume 83, Issue 3, Page(s) 597–605

    Abstract: BackgroundAlterations of B2 adrenergic receptor ( ... ...

    Abstract BackgroundAlterations of B2 adrenergic receptor (β
    MeSH term(s) Asthma/genetics ; Asthma/physiopathology ; Case-Control Studies ; Child ; Codon ; Female ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Homozygote ; Humans ; Immunoglobulin E/blood ; Male ; Mutation, Missense ; Odds Ratio ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Prospective Studies ; Receptors, Adrenergic, beta-2/genetics ; Respiratory Function Tests ; Severity of Illness Index
    Chemical Substances Codon ; Receptors, Adrenergic, beta-2 ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/pr.2017.304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Trace elements and oxidative stress in children with type 1 diabetes mellitus.

    Alghobashy, Ashgan Abdalla / Alkholy, Usama M / Talat, Mohamed A / Abdalmonem, Nermin / Zaki, Ahmed / Ahmed, Ihab A / Mohamed, Randa H

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2018  Volume 11, Page(s) 85–92

    Abstract: Background: The early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the ... ...

    Abstract Background: The early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the serum level of selenium (Se), zinc (Zn), magnesium (Mg), and copper (Cu), the degree of oxidative stress and evaluate their relations to glycemic control in children with T1D.
    Methods: A case-control study which included 100 diabetic children and 40 healthy children age, sex, and ethnicity-matched as a control group. The diabetic children were divided into poor and good controlled patients according to glycosylated hemoglobin (A1c %). Studied children underwent history taking, clinical examination and laboratory measurement of serum Se, Zn, Mg, and Cu levels, erythrocyte reduced glutathione (GSH) and peroxidase enzyme activity (GPx).
    Results: Serum Se, Zn, Mg, Cu, erythrocyte GSH, and GPx were significantly lower in the diabetic group in comparison to the control group (
    Conclusion: Children with T1D, especially poorly controlled cases, had low serum Se, Zn, Mg, Cu, GSH, and GPx. Low serum Se in diabetic children may affect the erythrocyte GSH-GPx system.
    Language English
    Publishing date 2018-03-26
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S157348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes.

    Alkholy, Usama M / Abdalmonem, Nermin / Zaki, Ahmed / Elkoumi, Mohamed A / Hashim, Mustafa I Abu / Basset, Maha A A / Salah, Hossam E

    Jornal de pediatria

    2018  Volume 95, Issue 2, Page(s) 224–230

    Abstract: Objective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes.: Method: This case-control study was conducted on 72 children with type 1 ... ...

    Abstract Objective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes.
    Method: This case-control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets.
    Results: Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low-density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high-density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p<0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p<0.05). The platelet redox status showed a negative correlation with the A1c % levels (r=-0.31; p=0.022) and the duration of type 1 diabetes (r=-0.35, p=0.012).
    Conclusion: Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress.
    MeSH term(s) Adolescent ; Biomarkers/blood ; Case-Control Studies ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/blood ; Female ; Humans ; Male ; Oxidation-Reduction ; Oxidative Stress ; Ubiquinone/analogs & derivatives ; Ubiquinone/blood ; Vitamin E/blood
    Chemical Substances Biomarkers ; Ubiquinone (1339-63-5) ; Vitamin E (1406-18-4) ; coenzyme Q10 (EJ27X76M46)
    Language English
    Publishing date 2018-02-07
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.1016/j.jped.2017.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Assessment of left ventricular mass index could predict metabolic syndrome in obese children.

    Alkholy, Usama M / Ahmed, Ihab A / Karam, Nehad A / Ali, Yasser Fathy / Yosry, Ahmed

    Journal of the Saudi Heart Association

    2015  Volume 28, Issue 3, Page(s) 159–166

    Abstract: ... M-mode, Doppler, and tissue Doppler echocardiograpy) and laboratory assessment of serum leptin level ...

    Abstract Background: Childhood obesity is a major risk factor for cardiovascular diseases in children and adults.
    Objectives: The purpose of this study was to evaluate the serum leptin level and the cardiac changes in normotensive obese children and to study the relationship between left ventricular mass index (LVMI) and serum leptin with the parameters of metabolic syndrome (MS) in obese children.
    Methods: This study was conducted in al Jeddani Hospital and Ibn Sina College Hospital in Saudi Arabia in the period from July 2012 to December 2013, and included 82 obese children. Their mean age was 10.2 ± 2.8 years; they were divided into 25 obese children with MS and 57 obese children without MS, and 40 healthy age- and sex-matched children were also included in the study as a control group. All children were subjected to clinical assessment including standing height, body weight, body mass index (BMI), waist circumference (WC), and blood pressure measurements. All children received an echocardiographic examination (2-dimensional, M-mode, Doppler, and tissue Doppler echocardiograpy) and laboratory assessment of serum leptin level, fasting glucose, fasting insulin, the homeostatic model assessment for insulin resistance (HOMA) index, total cholesterol, triglycerides, and high- and low-density lipoprotein profile.
    Results: BMI, BMI standard deviation score, WC, fasting glucose, fasting insulin, HOMA index and the serum leptin level were significantly higher in obese children compared to control group (p < 0.05). The LVMI were increased in the obese compared to the control group (p < 0.001) while left ventricle systolic and diastolic functions did not differ in obese versus control group (p > 0.05). There was a significant positive correlation between both LVMI and serum leptin level in comparison to BMI, WC, fasting glucose, fasting insulin, HOMA, triglycerides, and low-density lipoprotein in all obese children, especially the MS group. However, there was a significant negative correlation between both LVMI and serum leptin level in comparison to high-density lipoprotein.
    Conclusion: Assessment of LVMI as routine echocardiographic examinations and serum leptin level might be a feasible and reliable method for the evaluation of obesity and its related cardiovascular risks during childhood that can predict metabolic syndrome and insulin resistance.
    Language English
    Publishing date 2015-07-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2515647-0
    ISSN 1016-7315
    ISSN 1016-7315
    DOI 10.1016/j.jsha.2015.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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