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Article ; Online: Assessing the immediate impact of Twin-block appliance insertion on adolescents' sleep using a wearable device.

Saifeldin, Hatem / Negm, Ibrahim M

2024

Abstract: Objective: This prospective clinical study aimed to evaluate the immediate impact of Twin-block appliance insertion on the sleep of adolescents using a wearable device.: Materials and methods: A total of 24 girls, aged 11-13 years, with Class II ... ...

Abstract	Objective: This prospective clinical study aimed to evaluate the immediate impact of Twin-block appliance insertion on the sleep of adolescents using a wearable device. Materials and methods: A total of 24 girls, aged 11-13 years, with Class II division 1 molar relationship, skeletal class 2 malocclusion (ANB ≥5) and overjet measuring ≥5 mm were selected. Exclusion criteria included a history of previous orthodontic treatment, systemic disease, irregular sleep pattern, obstructive sleep apnea, medical history of breathing disorders, or concurrent use of medications. Participants wore a wearable device to measure sleep parameters, including deep sleep, light sleep, minutes awake during sleep, wake-up times, bedtimes and total sleep times. The participants wore the device for 10 days prior to Twin-block insertion and sleep data were collected for another 10 days after insertion. Results: Following the insertion of the Twin-block appliance, there was a highly statistically significant shift in bedtime and wake-up time to later hours (P < .001). All participants experienced a highly significant delay in bedtime compared to the recommended 10 pm time (P < .001). Additionally, there was a significant increase in the duration of light sleep (P < .05). However, the effect on deep sleep, minutes awake during sleep and sleep duration was not statistically significant. None of the sleep parameters tested showed statistically significant changes between the first 5 days after Twin-block insertion with the subsequent 5 days. Conclusion: The immediate insertion of the Twin-block appliance disrupts sleep onset, wake-up time and light sleep during the specified period of 10 days.
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2076514-9
ISSN	1601-6343 ; 1601-6335
ISSN (online)	1601-6343
ISSN	1601-6335
DOI	10.1111/ocr.12773
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Could COVID-19 improve psychiatric awareness at the heart of the Middle East? - A personal reflection on Bahrain's response.

Negm, H M

Irish journal of psychological medicine

2020 Volume 39, Issue 4, Page(s) 406–408

Abstract: This perspective offers a personal insight into COVID-19 in Bahrain along with the response to this unprecented pandemic. In a country where a robust health care system and economic prosperity have allowed it to cope with the medical sequelae, the mental ...

Abstract	This perspective offers a personal insight into COVID-19 in Bahrain along with the response to this unprecented pandemic. In a country where a robust health care system and economic prosperity have allowed it to cope with the medical sequelae, the mental health consequences may have been less anticipated but more problematic. An unforeseen positive emerging from the pandemic might be the nation's recognition of the importance of mental health well-being and a new openness to discussing it.
MeSH term(s)	Humans ; Bahrain ; COVID-19 ; Middle East ; Delivery of Health Care ; Mental Health
Keywords	covid19
Language	English
Publishing date	2020-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	227751-7
ISSN	2051-6967 ; 0790-9667
ISSN (online)	2051-6967
ISSN	0790-9667
DOI	10.1017/ipm.2020.74
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Article: Could COVID-19 improve psychiatric awareness at the heart of the Middle East? - A personal reflection on Bahrain's response

Negm, H M

Ir J Psychol Med

Abstract	This perspective offers a personal insight into COVID-19 in Bahrain along with the response to this unprecented pandemic. In a country where a robust health care system and economic prosperity have allowed it to cope with the medical sequelae, the mental health consequences may have been less anticipated but more problematic. An unforeseen positive emerging from the pandemic might be the nation's recognition of the importance of mental health well-being and a new openness to discussing it.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #459295
Database	COVID19

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Article ; Online: Could COVID-19 improve psychiatric awareness at the heart of the Middle East? – A personal reflection on Bahrain’s response

Negm, H. M.

Irish Journal of Psychological Medicine

2020 , Page(s) 1–3

Abstract	This perspective offers a personal insight into COVID-19 in Bahrain along with the response to this unprecented pandemic. In a country where a robust health care system and economic prosperity have allowed it to cope with the medical sequelae, the mental health consequences may have been less anticipated but more problematic. An unforeseen positive emerging from the pandemic might be the nation’s recognition of the importance of mental health well-being and a new openness to discussing it.
Keywords	Applied Psychology ; History and Philosophy of Science ; Psychiatry and Mental health ; covid19
Language	English
Publisher	Cambridge University Press (CUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	227751-7
ISSN	0790-9667
ISSN	0790-9667
DOI	10.1017/ipm.2020.74
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Deep Learning-Based Metasurface Design for Smart Cooling of Spacecraft.

Negm, Ayman / Bakr, Mohamed H / Howlader, Matiar M R / Ali, Shirook M

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 23

Abstract: A reconfigurable metasurface constitutes an important block of future adaptive and smart nanophotonic applications, such as adaptive cooling in spacecraft. In this paper, we introduce a new modeling approach for the fast design of tunable and ... ...

Abstract	A reconfigurable metasurface constitutes an important block of future adaptive and smart nanophotonic applications, such as adaptive cooling in spacecraft. In this paper, we introduce a new modeling approach for the fast design of tunable and reconfigurable metasurface structures using a convolutional deep learning network. The metasurface structure is modeled as a multilayer image tensor to model material properties as image maps. We avoid the dimensionality mismatch problem using the operating wavelength as an input to the network. As a case study, we model the response of a reconfigurable absorber that employs the phase transition of vanadium dioxide in the mid-infrared spectrum. The feed-forward model is used as a surrogate model and is subsequently employed within a pattern search optimization process to design a passive adaptive cooling surface leveraging the phase transition of vanadium dioxide. The results indicate that our model delivers an accurate prediction of the metasurface response using a relatively small training dataset. The proposed patterned vanadium dioxide metasurface achieved a 28% saving in coating thickness compared to the literature while maintaining reasonable emissivity contrast at 0.43. Moreover, our design approach was able to overcome the non-uniqueness problem by generating multiple patterns that satisfy the design objectives. The proposed adaptive metasurface can potentially serve as a core block for passive spacecraft cooling applications. We also believe that our design approach can be extended to cover a wider range of applications.
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13233073
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nematocidal activity of chitosan nanoparticles conjugated with albendazole against the enteral and parenteral phases of trichinosis in experimentally infected mice.

Mahgoub, Abeer A / Shoieb, Ragaa M / Negm, Mohamed Sherif / Ibrahim, Hassan M / El-Sayed, Shaimaa H / Khater, Mona M

Journal of parasitic diseases : official organ of the Indian Society for Parasitology

2024 Volume 48, Issue 1, Page(s) 141–149

Abstract: Trichinosis is a serious parasitic zoonotic disease caused mainly ... ...

Abstract	Trichinosis is a serious parasitic zoonotic disease caused mainly by
Language	English
Publishing date	2024-02-19
Publishing country	India
Document type	Journal Article
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-024-01648-4
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Article ; Online: Synthesis of novel azo pyrazole disperse dyes for dyeing and antibacterial finishing of PET fabric under supercritical carbon dioxide.

Sofan, Mamdouh / El-Taweel, Fathy / Abdel-Rahman, Adel / Salman, Hagar / Negm, Elham

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1121

Abstract: Supercritical carbon dioxide ( ... ...

Abstract	Supercritical carbon dioxide (scCO
MeSH term(s)	Amines ; Anti-Bacterial Agents/chemistry ; Azo Compounds/chemistry ; Carbon Dioxide ; Coloring Agents/chemistry ; Pyrazoles/chemistry ; Staining and Labeling
Chemical Substances	Amines ; Anti-Bacterial Agents ; Azo Compounds ; Carbon Dioxide (142M471B3J) ; Coloring Agents ; Pyrazoles
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48740-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Investigating genomic, proteomic, and post-transcriptional regulation profiles in colorectal cancer: a comparative study between primary tumors and associated metastases.

Ham-Karim, Hersh / Negm, Ola / Ahmad, Narmeen / Ilyas, Mohammad

Cancer cell international

2023 Volume 23, Issue 1, Page(s) 192

Abstract: Introduction: Approximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the possible molecular discrepancies between primary colorectal cancer (pCRC) and their respective metastases.: Methods: A ...

Abstract	Introduction: Approximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the possible molecular discrepancies between primary colorectal cancer (pCRC) and their respective metastases. Methods: A total of 22 pairs of pCRC and metastases were tested. Mutation profiling of 26 cancer-associated genes was undertaken in 22/22primary-metastasis tumour pairs using next-generation sequencing, whilst the expression of a panel of six microRNAs (miRNAs) was investigated using qPCRin 21/22 pairs and 22 protein biomarkers was tested using Reverse Phase Protein Array (RPPA)in 20/22 patients' tumour pairs. Results: Among the primary and metastatic tumours the mutation rates for the individual genes are as follows:TP53 (86%), APC (44%), KRAS (36%), PIK3CA (9%), SMAD4 (9%), NRAS (9%) and 4% for FBXW7, BRAF, GNAS and CDH1. The primary-metastasis tumour mutation status was identical in 54/60 (90%) loci. However, there was discordance in heterogeneity status in 40/58 genetic loci (z-score = 6.246, difference = 0.3793, P < 0.0001). Furthermore, there was loss of concordance in miRNA expression status between primary and metastatic tumours, and 57.14-80.95% of the primary-metastases tumour pairs showed altered primary-metastasis relative expression in all the miRNAs tested. Moreover, 16 of 20 (80%) tumour pairs showed alteration in at least 3 of 6 (50%) of the protein biomarker pathways analysed. Conclusion: The molecular alterations of primary colorectal tumours differ significantly from those of their matched metastases. These differences have profound implications for patients' prognoses and response to therapy.
Language	English
Publishing date	2023-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-023-03020-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of prosthetic management of congenital cleft lip and palate on the middle ear function of infants: A clinical trial.

Aboelsayed, Kamel M S / Abdel Razek, Mahmoud K H / Assal, Samir / Habib, Ahmed M A / Negm, Rana A

The Journal of prosthetic dentistry

2024

Abstract: Statement of problem: Infants with a cleft palate often experience middle ear disease, a condition of great significance, and early prosthetic management of these infants is essential. However, any correlation between prosthetic palatal obturation and ... ...

Abstract	Statement of problem: Infants with a cleft palate often experience middle ear disease, a condition of great significance, and early prosthetic management of these infants is essential. However, any correlation between prosthetic palatal obturation and middle ear function is unclear. Purpose: The purpose of this clinical trial was to assess whether prosthetic palatal obturation with a feeding appliance prevented or improved middle ear problems in infants with a cleft lip and palate. Material and methods: Ten infants with congenital cleft lip and palate (20 ears) were referred to the Prosthodontics department immediately after birth. Assessment of the middle ear function by tympanometry as well as hearing quality by auditory brainstem response (ABR) was conducted before the prosthetic treatment (control readings). The middle ear function and hearing quality was followed up after the prosthetic treatment every month until surgical palatal closure (tenth month). The Friedman test was applied to compare data from the various study periods. When the results were significant, the Dunn post hoc test was conducted to compare the control first week readings with those of the later periods (α=.05 for all tests). Results: The preprosthetic readings of tympanometry in the first week were 90% Type A and 10% Type B for both right and left ears. Readings starting from the first to the fifth month revealed no statistically significant differences compared with the first week readings (P>.05). However, tympanometry readings starting from the sixth month (20% Type A and 80% Type B) until the tenth month (90% Type B and 10% Type C) for both ears represented a statistically significant difference compared with the first week readings (P≤.05). The preprosthetic readings of ABR in the first week showed that 90% of ears had normal hearing status and 10% had mild hearing loss. Readings starting from the first until the fifth month revealed no statistically significant differences compared with the first week readings (P>.05). However, ABR readings starting from the sixth month (20% normal hearing, 70% mild hearing loss, and 10% moderate hearing loss) until the tenth month (0% normal hearing, 80% mild hearing loss, and 20% moderate hearing loss) for both ears revealed a statistically significant difference compared with the first week readings (P≤.05). Conclusions: Prosthetic palatal obturation with a feeding appliance plays a role in delaying rather than preventing the occurrence of otitis media with effusion in infants with a cleft lip and palate and could reduce the need for ventilation tubes.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2024.02.032
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effects of cholesterol and statins on Parkinson's neuropathology: a narrative review.

Al-Kuraishy, Hayder M / Fahad, Esraa H / Al-Windy, Salah / El-Sherbeni, Suzy A / Negm, Walaa A / Batiha, Gaber El-Saber

Inflammopharmacology

2024 Volume 32, Issue 2, Page(s) 917–925

Abstract: Parkinson disease (PD) is chronic and progressive neurodegenerative disease of the brain characterized by motor symptoms including tremors, rigidity, postural instability, and bradykinesia. PD neuropathology is due to the progressive degeneration of ... ...

Abstract	Parkinson disease (PD) is chronic and progressive neurodegenerative disease of the brain characterized by motor symptoms including tremors, rigidity, postural instability, and bradykinesia. PD neuropathology is due to the progressive degeneration of dopaminergic neurons in the substantia nigra and accumulation of Lewy bodies in the survival neurons. The brain contains a largest amount of cholesterol which is mainly synthesized from astrocytes and glial cells. Cholesterol is intricate in the pathogenesis of PD and may be beneficial or deleterious. Therefore, there are controversial points concerning the role of cholesterol in PD neuropathology. In addition, cholesterol-lowering agents' statins can affect brain cholesterol. Different studies highlighted that statins, via inhibition of brain HMG-CoA, can affect neuronal integrity through suppression of neuronal cholesterol, which regulates synaptic plasticity and neurotransmitter release. Furthermore, statins affect the development and progression of different neurodegenerative diseases in bidirectional ways that could be beneficial or detrimental. Therefore, the objective of the present review was to clarify the double-sward effects of cholesterol and statins on PD neuropathology.
MeSH term(s)	Humans ; Parkinson Disease/drug therapy ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Neurodegenerative Diseases/drug therapy ; Dopaminergic Neurons ; Cholesterol
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-023-01400-z
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