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  1. Article ; Online: A new frontier in HIV care: the predictive power of renal biomarkers on heart health.

    Mascolo, Silvia / Romanelli, Antonio

    AIDS (London, England)

    2024  Volume 38, Issue 4, Page(s) 595–596

    MeSH term(s) Humans ; HIV Infections/drug therapy ; Kidney ; Biomarkers ; Heart Disease Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Editorial
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003819
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    Zs.A 2228: Show issues Location:
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  2. Article ; Online: Immunosuppression drug-related and clinical manifestation of Coronavirus disease 2019: A therapeutical hypothesis.

    Romanelli, Antonio / Mascolo, Silvia

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2020  Volume 20, Issue 7, Page(s) 1947–1948

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Kidney Transplantation ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.15905
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  3. Article ; Online: Sirolimus to treat SARS-CoV-2 infection

    Antonio Romanelli / Silvia Mascolo

    Journal of Research in Clinical Medicine, Vol 8, Iss 1, Pp 44-

    an old drug for a new disease

    2020  Volume 44

    Keywords sirolimus ; sars-cov-2 ; covid-19 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Tabriz University of Medical Sciences Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Liposomal-encapsulated doxorubicin supercharge-containing front-line treatment improves response rates in primary mediastinal large B-cell lymphoma and mediastinal gray zone lymphoma.

    Picardi, Marco / Giordano, Claudia / Pugliese, Novella / Mascolo, Massimo / Varricchio, Silvia / Troncone, Giancarlo / Vigliar, Elena / Bellavicine, Claudio / Lamagna, Martina / Lisi, Dario / Vincenzi, Annamaria / Pane, Fabrizio

    Hematological oncology

    2024  Volume 42, Issue 1, Page(s) e3247

    MeSH term(s) Humans ; Lymphoma, B-Cell/pathology ; Doxorubicin/therapeutic use ; Polyethylene Glycols/therapeutic use ; Mediastinal Neoplasms/pathology ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances liposomal doxorubicin ; Doxorubicin (80168379AG) ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Letter
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3247
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  6. Article ; Online: Prognostic value of Bcl2 and p53 in Hodgkin lymphoma: A systematic review and meta-analysis.

    Travaglino, Antonio / Russo, Daniela / Varricchio, Silvia / Picardi, Marco / Mascolo, Massimo

    Pathology, research and practice

    2021  Volume 219, Page(s) 153370

    Abstract: Aims: Several studies suggested that high expression of Bcl2 and/or p53 in Hodgkin/Reed-Sternberg cells is an unfavorable prognostic factor in Hodgkin lymphoma (HL). However, results in this field appear contrasting. We aimed to assess the prognostic ... ...

    Abstract Aims: Several studies suggested that high expression of Bcl2 and/or p53 in Hodgkin/Reed-Sternberg cells is an unfavorable prognostic factor in Hodgkin lymphoma (HL). However, results in this field appear contrasting. We aimed to assess the prognostic value of p53 and Bcl2 in HL through a systematic review and meta-analysis.
    Methods: Electronic databases were searched from January 2000 to December 2020 for all studies assessing the prognostic value of p53 and Bcl2 in HL. The association of high p53 or Bcl2 expression with overall survival (OS), progression-free survival (PFS) and response to treatment was assessed by using hazard ratio (HR) and odds ratio (OR).
    Results: Eighteen studies were included. Bcl2 overexpression was significantly associated with decreased PFS (HR = 2.202; p < 0.0001), while the associations with decreased OS (HR = 1.565; p = 0.257) and refractoriness to treatment (OR = 0.482; p = 0.068) were non-significant. p53 overexpression was not significantly associated with refractoriness to treatment (OR = 0.904; p = 0.155); the analysis of OS and PFS was not feasible, but published data suggested the absence of a significant association.
    Conclusions: In HL, Bcl2 overexpression is associated with decreased PFS, while a significant prognostic value could not be demonstrated for p53. Defining optimal criteria for interpreting Bcl2 and p53 immunostaining is necessary to draw definitive conclusions.
    MeSH term(s) Chemoradiotherapy/methods ; Disease-Free Survival ; Hodgkin Disease/diagnosis ; Hodgkin Disease/metabolism ; Hodgkin Disease/pathology ; Humans ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Lymphoma, Large B-Cell, Diffuse/pathology ; Prognosis ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances BCL2 protein, human ; Proto-Oncogene Proteins c-bcl-2 ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2021-02-08
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2021.153370
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    Ud III Zs.20: Show issues Location:
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  7. Article ; Online: Impact of COVID-19 Pandemic and Lockdown Measures on the Nutrition Plan Service Cohort

    Mariana Di Lorenzo / Silvia Mascolo / Antonio Romanelli

    Iranian Journal of Diabetes and Obesity, Vol 13, Iss 3, Pp 117-

    2021  Volume 124

    Abstract: Objective: This study analyses the patientschr('39') factors can influence the attitude to follow or not the therapeutic weight-loss plan after national lockdown measures adopted from March 2020 to May 2020. Materials and Methods: Patients that visited a ...

    Abstract Objective: This study analyses the patientschr('39') factors can influence the attitude to follow or not the therapeutic weight-loss plan after national lockdown measures adopted from March 2020 to May 2020. Materials and Methods: Patients that visited a private nutritional center in March 2020 were included in this retrospective observational study. All relevant characteristics were noted. In May 2020, patients who did not attend the follow-up visit were labeled as "abandoned". Variation in Body Mass Index (BMI) was noted in the second visit. Univariate logistic regression was performed to test the influence on dependent variables (lost follow-up). Odds Ratio (OR) was calculated. According to BMI distribution, we performed a Student T-test (α= 0.05) or Wilcoxon test (α= 0.05) to test BMI variation in patients that attended the follow-up visit. A P-value< 0.05 was considered statistically significant. Results: Our population consisted of 77 patients, and 26 patients (33.8%, CI95% 23.4-45.4%) were labelled as "abandoned". Age≥ 54 years old (OR= 8.9048, CI95%:1.888-41.9822, P-value= 0.0057) and suffering from hypertension (OR= 4.8706, CI95%:1.4284-16.6076, P-value= 0.0114) were factors associated with the abandon follow-up visits. Wilcoxon test for BMI variation resulted statistically significant (May BMI 29.5 kg/m2 vs March BMI 29.4 kg/m2, P-value= 0.0094). Conclusion: Age and hypertension are related to the risk of abandoning healthcare services after ending the national lockdown. The losing follow-up phenomenon could worsen clinical conditions and reduce life expectancy. An increase in BMI during lockdown should be interpreted as a personal difficulty in complying with therapeutic prescriptions.
    Keywords covid-19 ; pandemic ; lockdown ; obesity ; diet ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Shahid Sadoughi University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Autoimmune mucocutaneous blistering diseases after SARS-Cov-2 vaccination: A Case report of Pemphigus Vulgaris and a literature review.

    Calabria, Elena / Canfora, Federica / Mascolo, Massimo / Varricchio, Silvia / Mignogna, Michele Davide / Adamo, Daniela

    Pathology, research and practice

    2022  Volume 232, Page(s) 153834

    Abstract: Background: Cases of severe autoimmune blistering diseases (AIBDs) have recently been reported in association with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.: Aims: To describe a report of oropharyngeal Pemphigus ... ...

    Abstract Background: Cases of severe autoimmune blistering diseases (AIBDs) have recently been reported in association with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
    Aims: To describe a report of oropharyngeal Pemphigus Vulgaris (OPV) triggered by the mRNABNT162b2 vaccine (Comirnaty®/ Pfizer/ BioNTech) and to analyze the clinical and immunological characteristics of the AIBDs cases reported following the SARS-CoV-2 vaccination.
    Methods: The clinical and immunological features of our case of OPV were documented. A review of the literature was conducted and only cases of AIBDs arising after the SARS-CoV-2 vaccination were included.
    Case report: A 60-year old female patients developed oropharyngeal and nasal bullous lesions seven days after the administration of a second dose of the mRNABNT162b2 vaccine (Comirnaty®/ Pfizer/BioNtech). According to the histology and direct immunofluorescence findings showing the presence of supra-basal blister and intercellular staining of IgG antibodies and the presence of a high level of anti-Dsg-3 antibodies (80 U/ml; normal < 7 U/ml) in the serum of the patients, a diagnosis of oropharyngeal Pemphigus Vulgaris was made.
    Review: A total of 35 AIBDs cases triggered by the SARS-CoV-2 vaccination were found (including our report). 26 (74.3%) were diagnosed as Bullous Pemphigoid, 2 (5.7%) as Linear IgA Bullous Dermatosis, 6 (17.1%) as Pemphigus Vulgaris and 1 (2.9%) as Pemphigus Foliaceus. The mean age of the sample was 72.8 years and there was a predominance of males over females (F:M=1:1.7). In 22 (62.9%) cases, the disease developed after Pfizer vaccine administration, 6 (17.1%) after Moderna, 3 (8.6%) after AstraZeneca, 3 (8.6%) after CoronaVac (one was not specified). All patients were treated with topical and/or systemic corticosteroids, with or without the addition of immunosuppressive drugs, with a good clinical response in every case.
    Conclusion: Clinicians should be aware of the potential, though rare, occurrence of AIBDs as a possible adverse event after the SARS-CoV-2 vaccination. However, notwithstanding, they should encourage their patients to obtain the vaccination in order to assist the public health systems to overcome the COVID-19 pandemic.
    MeSH term(s) Aged ; Autoimmune Diseases ; Blister/complications ; Blister/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pemphigus/drug therapy ; Pemphigus/epidemiology ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-03-05
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2022.153834
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    Ud III Zs.20: Show issues Location:
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  9. Article ; Online: Could HIV infection alter the clinical course of SARS-CoV-2 infection? When less is better.

    Mascolo, Silvia / Romanelli, Antonio / Carleo, Maria Aurora / Esposito, Vincenzo

    Journal of medical virology

    2020  Volume 92, Issue 10, Page(s) 1777–1778

    MeSH term(s) COVID-19 ; China ; Coinfection ; Coronavirus Infections/epidemiology ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25881
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  10. Article ; Online: A rare evolution of porokeratosis.

    Mascolo, Massimo / Patri, Angela / Pace, Mirella / Costa, Claudia / Varricchio, Silvia / Travaglino, Antonio / Scalvenzi, Massimiliano

    Italian journal of dermatology and venereology

    2020  Volume 157, Issue 1, Page(s) 102–104

    MeSH term(s) Buttocks ; Humans ; Porokeratosis/diagnosis
    Language English
    Publishing date 2020-10-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.20.06630-4
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