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  1. Article ; Online: MAV(S)erick mitochondria: an unconventional role for mitochondrial antiviral signalling protein in pulmonary fibrosis.

    Naikawadi, Ram P / Wolters, Paul J

    The European respiratory journal

    2021  Volume 57, Issue 4

    MeSH term(s) Antiviral Agents/therapeutic use ; Humans ; Mitochondria ; Pulmonary Fibrosis
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-04-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.04500-2020
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    Zs.A 2322: Show issues Location:
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  2. Article ; Online: Cut from the Same Cloth: Similarities between Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis.

    Yang, Monica M / Wolters, Paul J

    American journal of respiratory and critical care medicine

    2021  Volume 205, Issue 1, Page(s) 4–6

    MeSH term(s) Alveolitis, Extrinsic Allergic/diagnosis ; Humans ; Idiopathic Pulmonary Fibrosis
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202109-2211ED
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  3. Article ; Online: Reply: Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease.

    Zhang, David / Adegunsoye, Ayodeji / Oldham, Justin M / Wolters, Paul J / Garcia, Christine Kim / Newton, Chad A

    The European respiratory journal

    2024  Volume 63, Issue 1

    MeSH term(s) Humans ; Pulmonary Fibrosis/genetics ; Lung Diseases, Interstitial ; Immunosuppression Therapy ; Telomere
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02146-2023
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  4. Article ; Online: Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease.

    Yang, Monica M / Lee, Seoyeon / Neely, Jessica / Hinchcliff, Monique / Wolters, Paul J / Sirota, Marina

    Frontiers in immunology

    2024  Volume 15, Page(s) 1326922

    Abstract: Aging and cellular senescence are increasingly recognized as key contributors to pulmonary fibrosis. However, our understanding in the context of scleroderma-associated interstitial lung disease (SSc-ILD) is limited. To investigate, we leveraged ... ...

    Abstract Aging and cellular senescence are increasingly recognized as key contributors to pulmonary fibrosis. However, our understanding in the context of scleroderma-associated interstitial lung disease (SSc-ILD) is limited. To investigate, we leveraged previously established lung aging- and cell-specific senescence signatures to determine their presence and potential relevance to SSc-ILD. We performed a gene expression meta-analysis of lung tissues from 38 SSc-ILD and 18 healthy controls and found that markers (GDF15, COMP, and CDKN2A) and pathways (p53) of senescence were significantly increased in SSc-ILD. When probing the established aging and cellular senescence signatures, we found that epithelial and fibroblast senescence signatures had a 3.6- and 3.7-fold enrichment, respectively, in the lung tissue of SSc-ILD and that lung aging genes (
    MeSH term(s) Humans ; Lung Diseases, Interstitial/genetics ; Lung Diseases, Interstitial/complications ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/complications ; Aging/genetics ; Cellular Senescence/genetics ; Gene Expression ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/genetics
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1326922
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  5. Article ; Online: A recurring theme in pulmonary fibrosis genetics.

    Wolters, Paul J

    The European respiratory journal

    2017  Volume 49, Issue 5

    MeSH term(s) Humans ; Pulmonary Fibrosis
    Language English
    Publishing date 2017
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00545-2017
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  6. Article ; Online: Molecular endpoints for establishing target engagement by novel idiopathic pulmonary fibrosis therapies.

    Wolters, Paul J / Cottin, Vincent

    The European respiratory journal

    2019  Volume 53, Issue 3

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis
    Language English
    Publishing date 2019-03-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00283-2019
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  7. Article: Gene Expression Meta-Analysis Reveals Aging and Cellular Senescence Signatures in Scleroderma-associated Interstitial Lung Disease.

    Yang, Monica M / Lee, Seoyeon / Neely, Jessica / Hinchcliff, Monique / Wolters, Paul J / Sirota, Marina

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Aging and cellular senescence are increasingly recognized as key contributors to pulmonary fibrosis. However, our understanding in the context of scleroderma associated interstitial lung disease (SSc-ILD) is limited. To investigate, we leveraged ... ...

    Abstract Aging and cellular senescence are increasingly recognized as key contributors to pulmonary fibrosis. However, our understanding in the context of scleroderma associated interstitial lung disease (SSc-ILD) is limited. To investigate, we leveraged previously established lung aging and cell-specific senescence signatures to determine their presence and potential relevance to SSc-ILD. We performed a gene expression meta-analysis of lung tissue from 38 SSc-ILD and 18 healthy controls and found markers (GDF15, COMP, CDKN2A) and pathways (p53) of senescence were significantly increased in SSc-ILD. When probing the established aging and cellular senescence signatures, we found epithelial and fibroblast senescence signatures had a 3.6-fold and 3.7-fold enrichment respectively in the lung tissue of SSc-ILD and that lung aging genes (
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.06.565810
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  8. Article ; Online: Diffuse lung involvement in rheumatoid arthritis: a respiratory physician's perspective.

    Huang, Hui / Chen, Ruxuan / Shao, Chi / Xu, Zuojun / Wolters, Paul J

    Chinese medical journal

    2023  Volume 136, Issue 3, Page(s) 280–286

    Abstract: Abstract: The lungs are one of the most common extra-articular organs involved in rheumatoid arthritis (RA), which is reported to occur in up to 60% to 80% of RA patients. Respiratory complications are the second leading cause of death due to RA. ... ...

    Abstract Abstract: The lungs are one of the most common extra-articular organs involved in rheumatoid arthritis (RA), which is reported to occur in up to 60% to 80% of RA patients. Respiratory complications are the second leading cause of death due to RA. Although there is a wide spectrum of RA-associated respiratory diseases, interstitial lung disease is the most common manifestation and it impacts the prognosis of RA. There has been progress in understanding the management and progression of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and RA-associated respiratory diseases recently, for example, opportunistic pulmonary infectious diseases and toxicity from RA therapies. From a chest physicians' perspective, we will update the diagnosis and treatment of RA-associated ILD, methotrexate-associated lung disease, and the complication of Pneumocystis jiroveci pneumonia in RA in this review.
    MeSH term(s) Humans ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/complications ; Methotrexate/therapeutic use ; Lung Diseases, Interstitial/complications ; Prognosis ; Lung
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2023-02-05
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002577
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  9. Article ; Online: Pirfenidone in the kaleidoscope: reflecting mechanisms through different angles.

    Tzouvelekis, Argyris / Wolters, Paul J

    The European respiratory journal

    2018  Volume 52, Issue 5

    MeSH term(s) Fibroblasts ; Gene Expression Profiling ; Humans ; Idiopathic Pulmonary Fibrosis ; Pyridones
    Chemical Substances Pyridones ; pirfenidone (D7NLD2JX7U)
    Language English
    Publishing date 2018-11-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02046-2018
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  10. Article ; Online: Treatment of fibrotic interstitial lung disease: current approaches and future directions.

    Johannson, Kerri A / Chaudhuri, Nazia / Adegunsoye, Ayodeji / Wolters, Paul J

    Lancet (London, England)

    2021  Volume 398, Issue 10309, Page(s) 1450–1460

    Abstract: Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Important advancements in the past 10 years have enabled a better understanding, ... ...

    Abstract Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Important advancements in the past 10 years have enabled a better understanding, characterisation, and treatment of these diseases. This Series paper summarises the current approach to treatment of fibrotic ILDs, both pharmacological and non-pharmacological, including recent discoveries and practice-changing clinical trials. We further outline controversies and challenges, with discussion of evolving concepts and future research directions.
    MeSH term(s) Humans ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/therapy ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/therapy
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01826-2
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