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  1. Article ; Online: Hijacking the epigenetic mechanisms of

    Smiline Girija, S A

    Molecular biology research communications

    2023  Volume 13, Issue 2, Page(s) 51–53

    Abstract: Epigenetic mechanisms attribute to the resistance and virulence ... ...

    Abstract Epigenetic mechanisms attribute to the resistance and virulence of
    Language English
    Publishing date 2023-04-25
    Publishing country Iran
    Document type Journal Article ; Review
    ISSN 2345-2005
    ISSN (online) 2345-2005
    DOI 10.22099/MBRC.2024.48801.1899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Moonlighting proteins [ML proteins]: The pandora's box of insidious oro-dental diseases.

    Smiline Girija, A S

    Biochimica et biophysica acta. Molecular cell research

    2023  Volume 1870, Issue 4, Page(s) 119435

    Abstract: Oral pathogens survive in the harsh niche of the oral microbiome on account of a plethora of moonlighting [ML] proteins that can multitask in the oro-mucosal layers. ML proteins are considered as the complex protein hyperspace expressed in many oral ... ...

    Abstract Oral pathogens survive in the harsh niche of the oral microbiome on account of a plethora of moonlighting [ML] proteins that can multitask in the oro-mucosal layers. ML proteins are considered as the complex protein hyperspace expressed in many oral bacterial pathogens and encompass many hypothetical and experimentally evidenced proteins that can efficiently assist in the initiation and progression of various oro-dental infections. With the propensity of multi-drug resistance and biofilm formation, unravelling the mysterious functions associated with the oral ML proteins could be essential in targeting the vital oral bacteria and their associated infections. This commentary thus throws insights onto the key clues on various ML proteins that can be considered for the development of therapeutic versatility to curtail the complications caused by various oral bacterial species.
    MeSH term(s) Humans ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bacteria/metabolism ; Stomatognathic Diseases
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2023-02-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2023.119435
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  3. Article ; Online: Natural "epidrugs" and the need of basket trials in the treatment of oral cancer in India.

    Smiline Girija, A S

    Oral oncology

    2022  Volume 130, Page(s) 105931

    MeSH term(s) Humans ; India/epidemiology ; Mouth Neoplasms/drug therapy ; Neoplasms
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.105931
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    Zs.A 4869: Show issues Location:
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  4. Article ; Online: Exploring the ROS reduction strategies in chronic lupus management.

    Kannan, Kannika Parameshwari / Girija A S, Smiline

    Frontiers in immunology

    2024  Volume 15, Page(s) 1346656

    MeSH term(s) Reactive Oxygen Species ; Lupus Erythematosus, Systemic/therapy ; Humans
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1346656
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  5. Article: Prediction of Antigenic Vaccine Peptide Candidates From BfmRS Associated With Biofilm Formation in Acinetobacter baumannii.

    Girija, A S Smiline

    Cureus

    2023  Volume 15, Issue 10, Page(s) e47804

    Abstract: Introduction:  : Materials and methods: 11 different FASTA sequences of bfmR and bfmS from : Results: Four peptide sequences (E1-E4) were predicted for B-cell dominance, with E1, E2, and E4 as probable antigens. All were soluble and non-toxigenic. ...

    Abstract Introduction:  
    Materials and methods: 11 different FASTA sequences of bfmR and bfmS from 
    Results: Four peptide sequences (E1-E4) were predicted for B-cell dominance, with E1, E2, and E4 as probable antigens. All were soluble and non-toxigenic. E1 and E3 were considered non-allergens. GRAVY values were negative for all the peptides, indicating the protein to be hydrophilic in nature. Analysis of the T-cell epitopes was promising, with 100% conservancy for class-I HLA alleles, high interaction scores for similarity with TLR2, and more hydrogen bonds for E2, followed by other epitope peptides.
    Conclusion: The promising four epitopes, as predicted for bfmR and bfmS in the present study, suggest their potent role as possible candidates for the design of vaccines targeting the TCS of
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.47804
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  6. Article ; Online: Protean role of epigenetic mechanisms and their impact in regulating the Tregs in TME.

    Smiline Girija, A S

    Cancer gene therapy

    2021  Volume 29, Issue 6, Page(s) 661–664

    Abstract: Constitutive expression of Foxp3+ Tregs in the tumor microenvironment (TME) specifically renders immune suppression in the tumor tissues. Being highly stable and self-tolerant, Tregs may be influenced by various epigenetic-associated mechanisms while ... ...

    Abstract Constitutive expression of Foxp3+ Tregs in the tumor microenvironment (TME) specifically renders immune suppression in the tumor tissues. Being highly stable and self-tolerant, Tregs may be influenced by various epigenetic-associated mechanisms while exhibiting their functions. DNA methylation, histone acetylation, epigenetic silencing, alteration in chromatin networks, etc., are some of the main factors underlying the epigenetic-based Treg cell functional modulations in the TME. The possible reasons on why these epigenetic modulations should be specifically targeted are thus discussed, so that enhanced anti-tumor immunity in TME can be achieved.
    MeSH term(s) DNA Methylation ; Epigenesis, Genetic ; Forkhead Transcription Factors/genetics ; Humans ; Immune Tolerance ; T-Lymphocytes, Regulatory ; Tumor Microenvironment/genetics
    Chemical Substances Forkhead Transcription Factors
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Letter
    ZDB-ID 1212513-1
    ISSN 1476-5500 ; 0929-1903
    ISSN (online) 1476-5500
    ISSN 0929-1903
    DOI 10.1038/s41417-021-00371-z
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  7. Article: Molecular Characterization of the glyA Gene From the Clinical Isolates of Tannerella forsythia.

    A, Sujitha / Girija, A S Smiline / Priyadharsini, Vijayashree J

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54909

    Abstract: Background: The : Objectives: The study is thus aimed to determine the frequency of the : Materials and methods: Forty-five patients with varying degrees of periodontitis were included in the study, and the plaque samples collected from them were ... ...

    Abstract Background: The 
    Objectives: The study is thus aimed to determine the frequency of the
    Materials and methods: Forty-five patients with varying degrees of periodontitis were included in the study, and the plaque samples collected from them were anaerobically processed by inoculating onto sterile anaerobic blood agar plates using a gaspak system, with incubation at 37°C for 5-7 days. The DNA was extracted from the obtained isolated colony, and PCR was performed to confirm the presence of the
    Results: In total, 46.6% (
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54909
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  8. Article: Detection of the early putative biofilm marker

    Khanna, Navya / Girija A S, Smiline / Priyadharsini J, Vijayashree

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e27020

    Abstract: Background: pgaB: Methodology: MDR strains of : Results: The biofilm assay showed high, low and negative biofilm formers in 58.9%, 31.5% and 0.9% of the strains respectively. The : Conclusion: The study findings showed the occurrence of ... ...

    Abstract Background: pgaB
    Methodology: MDR strains of
    Results: The biofilm assay showed high, low and negative biofilm formers in 58.9%, 31.5% and 0.9% of the strains respectively. The
    Conclusion: The study findings showed the occurrence of biofilms associated with
    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27020
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  9. Article: Delineating the Immuno-Dominant Antigenic Vaccine Peptides Against gacS

    Smiline Girija, A S

    Frontiers in microbiology

    2020  Volume 11, Page(s) 2078

    Abstract: Objectives: To predict the novel vaccine peptide candidates against gacS protein involved with the citrate utilization in the two-component system of : Methods: The study is designed as an observational : Results: Nine peptides (20aa) with the ... ...

    Abstract Objectives: To predict the novel vaccine peptide candidates against gacS protein involved with the citrate utilization in the two-component system of
    Methods: The study is designed as an observational
    Results: Nine peptides (20aa) with the highest score of 1 were selected from the 137 epitopes, and five were predicted as antigenic epitopes (E1-E5). E3 was selected as the potent antigen (score: 0.939537) and E1 as the best vaccine candidate (score: 0.9803) under AntigenPro and Vaxijen server, respectively. SolPro predicted all epitopes as soluble peptides. ProtParam predictions showed E3 and E5 as stable proteins with a shelf life of 3.5 and 1.9 h and possessed negative GRAVY values. PsortB server predicted a final localization score of 7.88 for the gacS protein sequence as a cytoplasmic membrane protein. IEDB conservancy analysis showed 100% conserved sequences within the gacS sequence, and class I conservancy yielded positive values for all epitopes. Cluster analysis showed strong interactions, and the protein-peptide interactions with TLR-2 finally detected E5 as the best interacting peptide (H bonds = 14) followed by E3 (H bonds = 12).
    Conclusion: The study suggests five antigenic peptides as promiscuous vaccine candidates to target the gacS of
    Language English
    Publishing date 2020-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.02078
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  10. Article ; Online: Bispecific antibodies targeting tumor-associated metalloprotease and recruit NK cells - Multifunctional therapeutic approach against oral cancer.

    Kumaresan, Venkatesh / Sivaperumal, Pitchiah / Smiline Girija, A S

    Oral oncology

    2022  Volume 132, Page(s) 106013

    MeSH term(s) Antibodies, Bispecific/therapeutic use ; Humans ; Killer Cells, Natural ; Metalloproteases ; Mouth Neoplasms/therapy ; Neoplasms
    Chemical Substances Antibodies, Bispecific ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2022-07-06
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.106013
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