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  1. Article ; Online: Is it a high time to focus on iron-mediated pathology initiated by COVID-induced inflammation?

    Sukhomlin, Tatiana

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 2, Page(s) e2022229

    Abstract: A comment to paper published in the current issue by Duca et al (Acta Biomed 2022; Vol. 93, N. 2: e2022057 - DOI 10.23750/abm.v93i2.12937 - https://mattioli1885journals.com/index.php/actabiomedica/article/view/12937). The paper demonstrated a link ... ...

    Abstract A comment to paper published in the current issue by Duca et al (Acta Biomed 2022; Vol. 93, N. 2: e2022057 - DOI 10.23750/abm.v93i2.12937 - https://mattioli1885journals.com/index.php/actabiomedica/article/view/12937). The paper demonstrated a link between deregulated iron homeostasis and hyperinflammation in nontreated COVID-19 patients. Iron homeostasis links two generally accepted COVID-initiated pathological events: hyperinflammation and abnormal fibrin clotting. Intensive research is needed to look for the ways how to support and recover FeH in COVID infected patients.
    MeSH term(s) COVID-19/complications ; Homeostasis ; Humans ; Inflammation ; Iron
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2022-05-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i2.13165
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  2. Article ; Online: Fibrinolysis Shutdown in COVID-19-Infected Patients Can Result from Iron-Induced Stabilization of Fibril Clots.

    Sukhomlin, Tatiana

    Journal of the American College of Surgeons

    2020  Volume 231, Issue 5, Page(s) 607–608

    MeSH term(s) COVID-19 ; Fibrin Clot Lysis Time ; Fibrinolysis ; Humans ; Iron ; SARS-CoV-2
    Chemical Substances Iron (E1UOL152H7)
    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/j.jamcollsurg.2020.08.170
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  3. Article ; Online: Could an acute respiratory distress syndrome in COVID-19 infected patients be calmed down simply by iron withdrawal from lung tissues?

    Sukhomlin, Tatiana

    Journal of medical virology

    2020  Volume 93, Issue 2, Page(s) 577–578

    MeSH term(s) COVID-19/complications ; COVID-19/prevention & control ; Erythropoietin/genetics ; Erythropoietin/therapeutic use ; Humans ; Iron/isolation & purification ; Lung/pathology ; Lung/virology ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology
    Chemical Substances EPO protein, human ; Erythropoietin (11096-26-7) ; Iron (E1UOL152H7)
    Keywords covid19
    Language English
    Publishing date 2020-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26372
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  4. Article ; Online: Hepcidin is a friend rather than a foe in COVID19-induced complications.

    Sukhomlin, Tatiana

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 4, Page(s) e2020138

    Abstract: Clinical observations in concert with literary data demonstrate that detrimental complications of COVID19-induced pathology (acute respiratory distress syndrome, multi-organ failure, Kawasaki-like disease etc.), could result from a disturbance of local ... ...

    Abstract Clinical observations in concert with literary data demonstrate that detrimental complications of COVID19-induced pathology (acute respiratory distress syndrome, multi-organ failure, Kawasaki-like disease etc.), could result from a disturbance of local iron homeostasis (FeH) in damaged tissues followed by abnormal coagulation in small vessels. To resolve these complications the local FeH needs to be recovered. Hepcidin, as a master regulator of FeH is both a major player in the recovery and a marker of an efficacy of the restoration. Therefore, both local and systemic hepcidin levels could serve as a dynamic marker of disease progression (the more hepcidin the worse is disease) and treatment efficacy (after iron homeostasis is recovered hepcidin disappears). On the contrast, artificial attempts to suppress hepcidin expression directly or application of hepcidin antagonists could be detrimental. Overall, more comprehensive research of hepcidin role in COVID-19 pathology is needed.
    MeSH term(s) Aged ; COVID-19 ; Diabetes Mellitus ; Friends ; Hepcidins ; Humans ; Iron Overload ; Obesity ; SARS-CoV-2
    Chemical Substances Hepcidins
    Language English
    Publishing date 2020-11-05
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i4.10768
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  7. Article ; Online: Fibrinolysis Shutdown in COVID-19-Infected Patients Can Result from Iron-Induced Stabilization of Fibril Clots

    Sukhomlin, Tatiana

    Journal of the American College of Surgeons

    2020  Volume 231, Issue 5, Page(s) 607–608

    Keywords Surgery ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/j.jamcollsurg.2020.08.170
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  8. Article ; Online: Could an acute respiratory distress syndrome in COVID‐19 infected patients be calmed down simply by iron withdrawal from lung tissues?

    Tatiana, Sukhomlin

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26372
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  9. Article ; Online: Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain.

    Selivanov, Vitaly A / Votyakova, Tatyana V / Pivtoraiko, Violetta N / Zeak, Jennifer / Sukhomlin, Tatiana / Trucco, Massimo / Roca, Josep / Cascante, Marta

    PLoS computational biology

    2011  Volume 7, Issue 3, Page(s) e1001115

    Abstract: Reactive oxygen species (ROS) produced in the mitochondrial respiratory chain (RC) are primary signals that modulate cellular adaptation to environment, and are also destructive factors that damage cells under the conditions of hypoxia/reoxygenation ... ...

    Abstract Reactive oxygen species (ROS) produced in the mitochondrial respiratory chain (RC) are primary signals that modulate cellular adaptation to environment, and are also destructive factors that damage cells under the conditions of hypoxia/reoxygenation relevant for various systemic diseases or transplantation. The important role of ROS in cell survival requires detailed investigation of mechanism and determinants of ROS production. To perform such an investigation we extended our rule-based model of complex III in order to account for electron transport in the whole RC coupled to proton translocation, transmembrane electrochemical potential generation, TCA cycle reactions, and substrate transport to mitochondria. It fits respiratory electron fluxes measured in rat brain mitochondria fueled by succinate or pyruvate and malate, and the dynamics of NAD(+) reduction by reverse electron transport from succinate through complex I. The fitting of measured characteristics gave an insight into the mechanism of underlying processes governing the formation of free radicals that can transfer an unpaired electron to oxygen-producing superoxide and thus can initiate the generation of ROS. Our analysis revealed an association of ROS production with levels of specific radicals of individual electron transporters and their combinations in species of complexes I and III. It was found that the phenomenon of bistability, revealed previously as a property of complex III, remains valid for the whole RC. The conditions for switching to a state with a high content of free radicals in complex III were predicted based on theoretical analysis and were confirmed experimentally. These findings provide a new insight into the mechanisms of ROS production in RC.
    MeSH term(s) ATP Synthetase Complexes/chemistry ; Algorithms ; Animals ; Brain/metabolism ; Citric Acid Cycle ; Computational Biology/methods ; Computer Simulation ; Electron Transport ; Electrons ; Membrane Potential, Mitochondrial ; Mitochondria/metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species ; Spectrometry, Fluorescence/methods
    Chemical Substances Reactive Oxygen Species ; ATP Synthetase Complexes (EC 2.7.4.-)
    Language English
    Publishing date 2011-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1001115
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  10. Article ; Online: Integration of enzyme kinetic models and isotopomer distribution analysis for studies of in situ cell operation.

    Selivanov, Vitaly A / Sukhomlin, Tatiana / Centelles, Josep J / Lee, Paul W N / Cascante, Marta

    BMC neuroscience

    2006  Volume 7 Suppl 1, Page(s) S7

    Abstract: A current trend in neuroscience research is the use of stable isotope tracers in order to address metabolic processes in vivo. The tracers produce a huge number of metabolite forms that differ according to the number and position of labeled isotopes in ... ...

    Abstract A current trend in neuroscience research is the use of stable isotope tracers in order to address metabolic processes in vivo. The tracers produce a huge number of metabolite forms that differ according to the number and position of labeled isotopes in the carbon skeleton (isotopomers) and such a large variety makes the analysis of isotopomer data highly complex. On the other hand, this multiplicity of forms does provide sufficient information to address cell operation in vivo. By the end of last millennium, a number of tools have been developed for estimation of metabolic flux profile from any possible isotopomer distribution data. However, although well elaborated, these tools were limited to steady state analysis, and the obtained set of fluxes remained disconnected from their biochemical context. In this review we focus on a new numerical analytical approach that integrates kinetic and metabolic flux analysis. The related computational algorithm estimates the dynamic flux based on the time-dependent distribution of all possible isotopomers of metabolic pathway intermediates that are generated from a labeled substrate. The new algorithm connects specific tracer data with enzyme kinetic characteristics, thereby extending the amount of data available for analysis: it uses enzyme kinetic data to estimate the flux profile, and vice versa, for the kinetic analysis it uses in vivo tracer data to reveal the biochemical basis of the estimated metabolic fluxes.
    MeSH term(s) Algorithms ; Animals ; Cells/enzymology ; Isotope Labeling/methods ; Isotopes/metabolism ; Isotopes/pharmacokinetics ; Models, Biological ; Tissue Distribution
    Chemical Substances Isotopes
    Language English
    Publishing date 2006-10-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1471-2202
    ISSN (online) 1471-2202
    DOI 10.1186/1471-2202-7-S1-S7
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