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  1. Article ; Online: Axel Munthe: a physician's journey to San Michele.

    Mussap, C J

    Internal medicine journal

    2010  Volume 40, Issue 10, Page(s) 726–727

    MeSH term(s) Autobiography as Topic ; History, 19th Century ; History, 20th Century ; Humans ; Italy ; Physicians/history ; Sweden
    Language English
    Publishing date 2010-09-09
    Publishing country Australia
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/j.1445-5994.2010.02321.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  2. Article: Special Issue on "The Application of Metabolomics in Clinical Practice: Challenges and Opportunities".

    Mussap, Michele

    Metabolites

    2022  Volume 12, Issue 4

    Abstract: This Special Issue aimed to collect studies based on clinical applications of metabolomics in human disease [ ... ]. ...

    Abstract This Special Issue aimed to collect studies based on clinical applications of metabolomics in human disease [...].
    Language English
    Publishing date 2022-03-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12040296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical Laboratory Test Unit Homogeneity-an Urgent Need.

    Mussap, Michele

    JAMA internal medicine

    2020  Volume 180, Issue 12, Page(s) 1715–1716

    MeSH term(s) Clinical Laboratory Techniques ; Humans ; Laboratories, Clinical
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.3532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: The importance of laboratory medicine in the era of COVID-19 pandemic

    Michele Mussap

    Journal of Pediatric and Neonatal Individualized Medicine, Vol 9, Iss 2, Pp e090201-e

    a challenge for patients, pediatricians, obstetricians, and clinical pathologists

    2020  Volume 090201

    Abstract: The dramatic and rapid widespread of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is causing millions of infected subjects and thousand of deaths worldwide. The current global goal is to mitigate or suppress the burden of ... ...

    Abstract The dramatic and rapid widespread of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is causing millions of infected subjects and thousand of deaths worldwide. The current global goal is to mitigate or suppress the burden of COronaVIrus Disease 2019 (COVID-19) and to adopt effective targeted therapies. Laboratory tests include molecular diagnostics and viral antigens recognition for the identification of SARS-CoV-2 in human biological materials, serologic methods for detecting serum antibodies against SARS-CoV-2 and routine blood and urine tests. Many molecular tests, mainly based on real-time polymerase chain reaction (RT-PCR), have been developed after the publication of the SARS-CoV-2 full-length genome sequence; several factors may affect their accuracy, including inadequate sample collection, thermal inactivation, viral load, and cross-reactivity. In-vitro diagnostic (IVD) companies have developed serologic methods optimized on high throughput analytical platforms; however very few methods currently detect IgM and the accurate quantitative measurement of antibodies are not still ready. Sensitivity and specificity require robust validation; point of care (POC) lateral flow immunochromatographic assays are far to be highly sensitive and specific and data obtained by these methods should be evaluated with caution. The effectiveness of serologic tests depends on the appropriateness of test request too. Routine biochemical data in adults with COVID-19 reveal alterations of various tests, including lymphopenia, thrombocytopenia, hypoalbuminemia, and serum elevation of several biomarkers, including D-dimer, ferritin, C-reative protein (CRP), cytokines. Cardiac troponins and N-terminal pro-brain natriuretic peptide (NT-pro BNP) are predictors of adverse outcome and death. Vertical transmission of SARS-CoV-2 has been not yet demonstrated exhaustively. Regrettably, in pregnant women, newborns and children with COVID-19, very limited and confusing data hamper a definitive conclusion on the ...
    Keywords laboratory medicine ; sars-cov-2 ; covid-19 ; real-time polymerase chain reaction ; serologic tests ; routine laboratory tests ; pregnant women ; children ; newborns ; Medicine ; R ; Pediatrics ; RJ1-570 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Hygeia Press di Corridori Marinella
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: A ferroptosis-related ceRNA network for investigating the molecular mechanisms and the treatment of neonatal hypoxic-ischemic encephalopathy.

    Lu, Hongyi / Shen, Haiyan / Mao, Liming / Mussap, Michele / Song, Lei

    Translational pediatrics

    2024  Volume 13, Issue 1, Page(s) 119–136

    Abstract: Background: Neonatal hypoxic-ischemic brain damage (HIBD) is a clinical syndrome causing brain injury in newborns with obscure etiology. Increasing evidence suggests that ferroptosis plays a role in HIBD. This study aimed to clarify the key ferroptosis- ... ...

    Abstract Background: Neonatal hypoxic-ischemic brain damage (HIBD) is a clinical syndrome causing brain injury in newborns with obscure etiology. Increasing evidence suggests that ferroptosis plays a role in HIBD. This study aimed to clarify the key ferroptosis-related genes (FRGs) of HIBD, construct a long non-coding RNA-microRNA-messenger RNA (lncRNA-miRNA-mRNA) network, and further investigate the pathogenesis of HIBD.
    Methods: Gene expression data were downloaded from the Gene Expression Omnibus and FerrDb databases. The differentially expressed lncRNAs and FRGs were screened, and the related miRNAs and mRNAs were predicted. The obtained mRNA was intersected with the differentially expressed FRGs (DE-FRGs) to identify the key DE-FRGs. Cell-type Identification by Estimating Relative Subsets of RNA Transcripts method was applied to analyze the immune cell infiltration level and the relationship between key genes and immune cells.
    Results: Gene differential expression analysis revealed that 1,178 lncRNAs, 207 miRNAs, and 647 mRNAs were differentially expressed in the blood of HIBD patients in comparison to healthy controls. The correlations of the lncRNAs, miRNAs, and mRNAs lead to the establishment of a competing endogenous RNA (ceRNA) network associated with ferroptosis in HIBD. Further validation using an external dataset and quantitative real-time polymerase chain reaction (PCR) analysis of brain tissues from hypoxic-ischemic encephalopathy rats confirmed the expression patterns of three key genes, including
    Conclusions: Our study established a ceRNA network, identified three key genes, and predicted four drugs that are associated with ferroptosis in HIBD, which provides new ideas for the investigation of the disease mechanisms and might facilitate the diagnosis and treatment of the disease.
    Language English
    Publishing date 2024-01-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Once upon a Time Oral Microbiota: A Cinderella or a Protagonist in Autism Spectrum Disorder?

    Mussap, Michele / Beretta, Paola / Esposito, Elena / Fanos, Vassilios

    Metabolites

    2023  Volume 13, Issue 12

    Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder evolving over the lifetime of individuals. The oral and gut microbial ecosystems are closely connected to each other and the brain and are potentially involved in neurodevelopmental diseases. ...

    Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder evolving over the lifetime of individuals. The oral and gut microbial ecosystems are closely connected to each other and the brain and are potentially involved in neurodevelopmental diseases. This narrative review aims to identify all the available evidence emerging from observational studies focused on the role of the oral microbiome in ASD. A literature search was conducted using PubMed and the Cochrane Library for relevant studies published over the last ten years. Overall, in autistic children, the oral microbiota is marked by the abundance of several microbial species belonging to the
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13121183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Metabolic Reprogramming of Immune Cells Following Vaccination: From Metabolites to Personalized Vaccinology.

    Mussap, Michele / Puddu, Melania / Fanos, Vassilios

    Current medicinal chemistry

    2023  Volume 31, Issue 9, Page(s) 1046–1068

    Abstract: Identifying metabolic signatures induced by the immune response to vaccines allows one to discriminate vaccinated from non-vaccinated subjects and decipher the molecular mechanisms associated with the host immune response. This review illustrates and ... ...

    Abstract Identifying metabolic signatures induced by the immune response to vaccines allows one to discriminate vaccinated from non-vaccinated subjects and decipher the molecular mechanisms associated with the host immune response. This review illustrates and discusses the results of metabolomics-based studies on the innate and adaptive immune response to vaccines, long-term functional reprogramming (immune memory), and adverse reactions. Glycolysis is not overexpressed by vaccines, suggesting that the immune cell response to vaccinations does not require rapid energy availability as necessary during an infection. Vaccines strongly impact lipids metabolism, including saturated or unsaturated fatty acids, inositol phosphate, and cholesterol. Cholesterol is strategic for synthesizing 25-hydroxycholesterol in activated macrophages and dendritic cells and stimulates the conversion of macrophages and T cells in M2 macrophage and Treg, respectively. In conclusion, the large-scale application of metabolomics enables the identification of candidate predictive biomarkers of vaccine efficacy/tolerability.
    MeSH term(s) Humans ; Immunity, Innate ; Vaccinology ; Vaccination ; Vaccines ; Cholesterol
    Chemical Substances Vaccines ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2023-05-11
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867330666230509110108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Conference proceedings: Metabolomics, laboratory medicine and infections in the newborn and child

    Fanos, Vassilios / Mussap, Michele

    28 - 29 October 2011, Cagliari, T Hotel

    (The journal of maternal-fetal & neonatal medicine ; 24, Suppl. 2)

    2011  

    Event/congress International Workshop on Neonatology (7, 2011, Cagliari)
    Author's details guest ed.: Vassilios Fanos ; Michele Mussap
    Series title The journal of maternal-fetal & neonatal medicine ; 24, Suppl. 2
    Collection
    Language English
    Size 66 S. : Ill., graph. Darst.
    Publisher Informa Healthcare
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT017050819
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 3510 -24,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  9. Article ; Online: Could metabolomics drive the fate of COVID-19 pandemic? A narrative review on lights and shadows.

    Mussap, Michele / Fanos, Vassilios

    Clinical chemistry and laboratory medicine

    2021  Volume 59, Issue 12, Page(s) 1891–1905

    Abstract: Human Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection activates a complex interaction host/virus, leading to the reprogramming of the host metabolism aimed at the energy supply for viral replication. Alterations of the host ... ...

    Abstract Human Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection activates a complex interaction host/virus, leading to the reprogramming of the host metabolism aimed at the energy supply for viral replication. Alterations of the host metabolic homeostasis strongly influence the immune response to SARS-CoV-2, forming the basis of a wide range of outcomes, from the asymptomatic infection to the onset of COVID-19 and up to life-threatening acute respiratory distress syndrome, vascular dysfunction, multiple organ failure, and death. Deciphering the molecular mechanisms associated with the individual susceptibility to SARS-CoV-2 infection calls for a system biology approach; this strategy can address multiple goals, including which patients will respond effectively to the therapeutic treatment. The power of metabolomics lies in the ability to recognize endogenous and exogenous metabolites within a biological sample, measuring their concentration, and identifying perturbations of biochemical pathways associated with qualitative and quantitative metabolic changes. Over the last year, a limited number of metabolomics- and lipidomics-based clinical studies in COVID-19 patients have been published and are discussed in this review. Remarkable alterations in the lipid and amino acid metabolism depict the molecular phenotype of subjects infected by SARS-CoV-2; notably, structural and functional data on the lipids-virus interaction may open new perspectives on targeted therapeutic interventions. Several limitations affect most metabolomics-based studies, slowing the routine application of metabolomics. However, moving metabolomics from bench to bedside cannot imply the mere determination of a given metabolite panel; rather, slotting metabolomics into clinical practice requires the conversion of metabolic patient-specific data into actionable clinical applications.
    MeSH term(s) Amino Acids/analysis ; Amino Acids/metabolism ; COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/virology ; Cytokines/analysis ; Eicosanoids/blood ; Humans ; Lipids/blood ; Metabolomics/methods ; Pandemics ; Phenylalanine/analysis ; Phenylalanine/metabolism ; SARS-CoV-2/isolation & purification
    Chemical Substances Amino Acids ; Cytokines ; Eicosanoids ; Lipids ; Phenylalanine (47E5O17Y3R)
    Language English
    Publishing date 2021-07-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2021-0414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 121: Show issues Location:
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  10. Article ; Online: An alternative perspective on how laboratory medicine can contribute to solve the health care crisis: a model to save costs by acquiring excellence in diagnostic systems.

    Mussap, Michele

    Clinica chimica acta; international journal of clinical chemistry

    2014  Volume 427, Page(s) 202–204

    Abstract: The rapid escalation in health care costs has led to the idea to deliver better care at lower costs, reshaping the responsibilities of the health care system to achieve the goal of creating value for the patient. The pressure for fiscal containment and ... ...

    Abstract The rapid escalation in health care costs has led to the idea to deliver better care at lower costs, reshaping the responsibilities of the health care system to achieve the goal of creating value for the patient. The pressure for fiscal containment and the progressive reduction in available health care resources originated very short term strategies consisting of abrupt reductions in expenditure, specifically in the provision of clinical pathology laboratory medicine services. However, the impact of laboratory test results on diagnostic and therapeutic interventions has increased enormously in the past decade, due to advances in personalized medicine and to the strictly correlated requirement to use new biomarkers with increasing sensitivity and specificity in clinical practice. In order to create savings by delivering better care there is the need to invest financial resources in purchasing high technology and new sophisticated tests and to promote the expertise of clinical pathologists and laboratory medicine professionals. This approach to creating value in patient health care is more productive and sustainable ethically, morally and economically as a long-term strategy. It can be successfully achieved by applying defined rules that make public-private cooperation clearer, skipping incompatible solutions such as transforming clinical laboratories to 'industrially productive premises', outsourcing laboratory medicine services and using central acquisition of diagnostic systems.
    MeSH term(s) Clinical Laboratory Services/economics ; Clinical Laboratory Techniques/economics ; Health Care Costs ; Humans
    Language English
    Publishing date 2014-01-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2013.09.034
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