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  1. Article ; Online: Is a return to nature a piece of the health puzzle?

    Martel, Jan / Ojcius, David M

    Biomedical journal

    2023  Volume 46, Issue 1, Page(s) 8–10

    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is a return to nature a piece of the health puzzle?

    Jan Martel / David M. Ojcius

    Biomedical Journal, Vol 46, Iss 1, Pp 8-

    2023  Volume 10

    Keywords Electromagnetic pollution ; Free electrons ; Global atmospheric electrical circuit ; Grounding ; Schumann resonances ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Senescence: No country for old cells.

    Martel, Jan / Ojcius, David M / Young, John D

    Biomedical journal

    2023  Volume 47, Issue 2, Page(s) 100697

    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.100697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lifestyle interventions to delay senescence.

    Martel, Jan / Ojcius, David M / Young, John D

    Biomedical journal

    2023  Volume 47, Issue 2, Page(s) 100676

    Abstract: Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by ... ...

    Abstract Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by reducing the burden of senescence, less attention has been devoted to lifestyle interventions that produce similar effects. We describe here the effects of exercise, nutrition, caloric restriction, intermittent fasting, phytochemicals from natural products, prebiotics and probiotics, and adequate sleep on senescence in model organisms and humans. These interventions can be integrated within a healthy lifestyle to reduce senescence and inflammation and delay the consequences of aging.
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.100676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Treatment of Osteoid Osteoma.

    Dalili, Danoob / Dalili, Daniel E / Isaac, Amanda / Martel-Villagrán, José / Fritz, Jan

    Seminars in interventional radiology

    2023  Volume 40, Issue 1, Page(s) 100–105

    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0043-1767692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease.

    Martel, Jan / Chang, Shih-Hsin / Chevalier, Gaétan / Ojcius, David M / Young, John D

    Biomedical journal

    2023  Volume 46, Issue 1, Page(s) 48–59

    Abstract: Living organisms have evolved within the natural electromagnetic fields (EMFs) of the earth which comprise the global atmospheric electrical circuit, Schumann resonances (SRs) and the geomagnetic field. Research suggests that the circadian rhythm, which ... ...

    Abstract Living organisms have evolved within the natural electromagnetic fields (EMFs) of the earth which comprise the global atmospheric electrical circuit, Schumann resonances (SRs) and the geomagnetic field. Research suggests that the circadian rhythm, which controls several physiological functions in the human body, can be influenced by light but also by the earth's EMFs. Cyclic solar disturbances, including sunspots and seasonal weakening of the geomagnetic field, can affect human health, possibly by disrupting the circadian rhythm and downstream physiological functions. Severe disruption of the circadian rhythm increases inflammation which can induce fatigue, fever and flu-like symptoms in a fraction of the population and worsen existing symptoms in old and diseased individuals, leading to periodic spikes of infectious and chronic diseases. Possible mechanisms underlying sensing of the earth's EMFs involve entrainment via electrons and electromagnetic waves, light-dependent radical pair formation in retina cryptochromes, and paramagnetic magnetite nanoparticles. Factors such as electromagnetic pollution from wireless devices, base antennas and low orbit internet satellites, shielding by non-conductive materials used in shoes and buildings, and local geomagnetic anomalies may also affect sensing of the earth's EMFs by the human body and contribute to circadian rhythm disruption and disease development.
    MeSH term(s) Humans ; Electromagnetic Fields/adverse effects ; Circadian Rhythm
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Influence of electromagnetic fields on the circadian rhythm

    Jan Martel / Shih-Hsin Chang / Gaétan Chevalier / David M. Ojcius / John D. Young

    Biomedical Journal, Vol 46, Iss 1, Pp 48-

    Implications for human health and disease

    2023  Volume 59

    Abstract: Living organisms have evolved within the natural electromagnetic fields (EMFs) of the earth which comprise the global atmospheric electrical circuit, Schumann resonances (SRs) and the geomagnetic field. Research suggests that the circadian rhythm, which ... ...

    Abstract Living organisms have evolved within the natural electromagnetic fields (EMFs) of the earth which comprise the global atmospheric electrical circuit, Schumann resonances (SRs) and the geomagnetic field. Research suggests that the circadian rhythm, which controls several physiological functions in the human body, can be influenced by light but also by the earth's EMFs. Cyclic solar disturbances, including sunspots and seasonal weakening of the geomagnetic field, can affect human health, possibly by disrupting the circadian rhythm and downstream physiological functions. Severe disruption of the circadian rhythm increases inflammation which can induce fatigue, fever and flu-like symptoms in a fraction of the population and worsen existing symptoms in old and diseased individuals, leading to periodic spikes of infectious and chronic diseases. Possible mechanisms underlying sensing of the earth's EMFs involve entrainment via electrons and electromagnetic waves, light-dependent radical pair formation in retina cryptochromes, and paramagnetic magnetite nanoparticles. Factors such as electromagnetic pollution from wireless devices, base antennas and low orbit internet satellites, shielding by non-conductive materials used in shoes and buildings, and local geomagnetic anomalies may also affect sensing of the earth's EMFs by the human body and contribute to circadian rhythm disruption and disease development.
    Keywords Circadian rhythm ; Covid-19 pandemic ; Geomagnetic field ; Grounding ; Schumann resonances ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 535
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Treatment of Osteoid Osteoma

    Dalili, Danoob / Dalili, Daniel E. / Isaac, Amanda / Martel-Villagrán, José / Fritz, Jan

    Seminars in Interventional Radiology

    (Seminars in IR Portal Hypertension)

    2023  Volume 40, Issue 01, Page(s) 100–105

    Series title Seminars in IR Portal Hypertension
    Language English
    Publishing date 2023-02-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0043-1767692
    Database Thieme publisher's database

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  9. Article ; Online: Ectopic calcification and formation of mineralo-organic particles in arteries of diabetic subjects.

    Wu, Cheng-Yeu / Martel, Jan / Young, John D

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 8545

    Abstract: Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 ... ...

    Abstract Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 diabetes subjects for the presence of ectopic calcification and mineral particles using histology, electron microscopy and spectroscopy analyses. While arteries of healthy controls showed no calcification following von Kossa staining, arteries from 83% of diabetic individuals examined (19/23) revealed microscopic mineral deposits, mainly within the tunica media. Mineralo-organic particles containing calcium phosphate and proteins such as albumin, fetuin-A and apolipoprotein-A1 were detected in calcified arteries. Ectopic calcification and mineralo-organic particles were observed in a majority of diabetic patients and predominantly in arteries showing hyperplasia. While a low number of subjects was examined and information about disease severity and patient characteristics is lacking, these calcifications and mineralo-organic particles may represent signs of tissue dysfunction.
    MeSH term(s) Arteries/metabolism ; Arteries/pathology ; Arteriosclerosis/metabolism ; Arteriosclerosis/pathology ; Calcinosis/metabolism ; Calcinosis/pathology ; Calcium Phosphates/metabolism ; Case-Control Studies ; Diabetes Mellitus, Type 2/physiopathology ; Humans ; Minerals/chemistry ; Minerals/metabolism ; Organic Chemicals/chemistry ; Organic Chemicals/metabolism
    Chemical Substances Calcium Phosphates ; Minerals ; Organic Chemicals ; calcium phosphate (97Z1WI3NDX)
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-65276-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Phytochemicals as Prebiotics and Biological Stress Inducers.

    Martel, Jan / Ojcius, David M / Ko, Yun-Fei / Young, John D

    Trends in biochemical sciences

    2020  Volume 45, Issue 6, Page(s) 462–471

    Abstract: Phytochemicals in fruits and vegetables produce health benefits, but questions remain regarding their bioavailability, molecular targets, and mechanism of action. Here, we address these issues by considering the prebiotic and biological properties of ... ...

    Abstract Phytochemicals in fruits and vegetables produce health benefits, but questions remain regarding their bioavailability, molecular targets, and mechanism of action. Here, we address these issues by considering the prebiotic and biological properties of phytochemicals. A fraction of phytochemicals consumed orally passes through the gut lumen, where it modulates the composition of the gut microbiota and maintains intestinal integrity. Phytochemicals and microbiota-derived metabolites that are absorbed by the organism comprise compounds that, at low doses, induce stress resistance mechanisms, including autophagy, DNA repair, and expression of detoxifying and antioxidant enzymes. We propose that these mechanisms improve cellular and organ function and can account for the promiscuous bioactivities of phytochemicals, despite their limited bioavailability and extremely varied chemical structures.
    MeSH term(s) Biological Availability ; Gastrointestinal Microbiome ; Humans ; Phytochemicals/pharmacokinetics ; Phytochemicals/pharmacology ; Prebiotics ; Stress, Physiological/drug effects
    Chemical Substances Phytochemicals ; Prebiotics
    Language English
    Publishing date 2020-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2020.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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