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Book: The resilience handbook

Kent, Martha / Davis, Mary C. / Reich, John W.

approaches to stress and trauma

2014

Author's details	ed. by Martha Kent, Mary C. Davis, and John W. Reich
Keywords	Resilience (Personality trait)
Language	English
Size	XIX, 318 S. : Ill., graph. Darst.
Publisher	Routledge
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT017663937
ISBN	978-0-415-69987-7 ; 978-0-415-81883-4 ; 9780203135303 ; 0-415-69987-8 ; 0-415-81883-4 ; 020313530X
Database	Catalogue ZB MED Medicine, Health

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2013 A 2320	available for loan (reading room)	Lesesaal EG

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Article ; Online: An update on the development of a bottlenose dolphin, Tursiops truncatus, immune reagent toolkit.

Sacco, Randy E / Jensen, Eric D / Sullivan, Yvonne B / LaBresh, Joanna / Davis, William C

Veterinary immunology and immunopathology

2024 Volume 272, Page(s) 110769

Abstract: There are extensive immunological reagents available for laboratory rodents and humans. However, for veterinary species there is a need for expansion of immunological toolkits, with this especially evident for marine mammals, such as cetaceans. In ... ...

Abstract	There are extensive immunological reagents available for laboratory rodents and humans. However, for veterinary species there is a need for expansion of immunological toolkits, with this especially evident for marine mammals, such as cetaceans. In addition to their use in a research setting, immune assays could be employed to monitor the health status of cetaceans and serve as an adjunct to available diagnostic tests. Such development of specific and sensitive immune assays will enhance the proper care and stewardship of wild and managed cetacean populations. Our goal is to provide immune reagents and immune assays for the research community, clinicians, and others involved in care of bottlenose dolphins. This review will provide an update on our development of a bottlenose dolphin immunological toolkit. The future availability and continued development of these reagents is critical for improving wild and managed bottlenose dolphin population health through enhanced assessment of their responses to alterations in the marine environment, including pathogens, and improve our ability to monitor their status following vaccination.
Language	English
Publishing date	2024-04-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	754160-0
ISSN	1873-2534 ; 0165-2427
ISSN (online)	1873-2534
ISSN	0165-2427
DOI	10.1016/j.vetimm.2024.110769
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Article ; Online: Progress in the development and use of monoclonal antibodies to study the evolution and function of the immune systems in the extant lineages of ungulates.

Davis, William C / Mahmoud, Asmaa H / Hulubei, Victoria / Hasan, Amany / Abdellrazeq, Gaber S

Veterinary immunology and immunopathology

2024 Volume 270, Page(s) 110730

Abstract: Details on the origin and function of the immune system are beginning to emerge from genomic studies tracing the origin of B and T cells and the major histocompatibility complex. This is being accomplished through identification of DNA sequences of ... ...

Abstract	Details on the origin and function of the immune system are beginning to emerge from genomic studies tracing the origin of B and T cells and the major histocompatibility complex. This is being accomplished through identification of DNA sequences of ancestral genes present in the genomes of lineages of vertebrates that have evolved from a common primordial ancestor. Information on the evolution of the composition and function of the immune system is being obtained through development of monoclonal antibodies (mAbs) specific for the MHC class I and II molecules and differentially expressed on leukocytes differentiation molecules (LDM). The mAbs have provided the tools needed to compare the similarities and differences in the phenotype and function of immune systems that have evolved during speciation. The majority of information currently available on evolution of the composition and function of the immune system is derived from study of the immune systems in humans and mice. As described in the present review, further information is beginning to emerge from comparative studies of the immune systems in the extant lineages of species present in the two orders of ungulates, Perissodactyla and Artiodactyla. Methods have been developed to facilitate comparative research across species on pathogens affecting animal and human health.
MeSH term(s)	Humans ; Animals ; Mice ; Antibodies, Monoclonal/genetics ; Mammals ; Major Histocompatibility Complex ; Genes, MHC Class I ; T-Lymphocytes
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2024-02-23
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	754160-0
ISSN	1873-2534 ; 0165-2427
ISSN (online)	1873-2534
ISSN	0165-2427
DOI	10.1016/j.vetimm.2024.110730
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Article ; Online: Association of semaglutide with risk of suicidal ideation in a real-world cohort.

Wang, William / Volkow, Nora D / Berger, Nathan A / Davis, Pamela B / Kaelber, David C / Xu, Rong

Nature medicine

2024 Volume 30, Issue 1, Page(s) 168–176

Abstract: Concerns over reports of suicidal ideation associated with semaglutide treatment, a glucagon-like peptide 1 receptor (GLP1R) agonist medication for type 2 diabetes (T2DM) and obesity, has led to investigations by European regulatory agencies. In this ... ...

Abstract	Concerns over reports of suicidal ideation associated with semaglutide treatment, a glucagon-like peptide 1 receptor (GLP1R) agonist medication for type 2 diabetes (T2DM) and obesity, has led to investigations by European regulatory agencies. In this retrospective cohort study of electronic health records from the TriNetX Analytics Network, we aimed to assess the associations of semaglutide with suicidal ideation compared to non-GLP1R agonist anti-obesity or anti-diabetes medications. The hazard ratios (HRs) and 95% confidence intervals (CIs) of incident and recurrent suicidal ideation were calculated for the 6-month follow-up by comparing propensity score-matched patient groups. The study population included 240,618 patients with overweight or obesity who were prescribed semaglutide or non-GLP1R agonist anti-obesity medications, with the findings replicated in 1,589,855 patients with T2DM. In patients with overweight or obesity (mean age 50.1 years, 72.6% female), semaglutide compared with non-GLP1R agonist anti-obesity medications was associated with lower risk for incident (HR = 0.27, 95% CI = 0.200.32-0.600.36) and recurrent (HR = 0.44, 95% CI = 0.32-0.60) suicidal ideation, consistent across sex, age and ethnicity stratification. Similar findings were replicated in patients with T2DM (mean age 57.5 years, 49.2% female). Our findings do not support higher risks of suicidal ideation with semaglutide compared with non-GLP1R agonist anti-obesity or anti-diabetes medications.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/complications ; Suicidal Ideation ; Retrospective Studies ; Overweight ; Obesity/complications ; Obesity/drug therapy ; Obesity/epidemiology ; Anti-Obesity Agents/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptides
Chemical Substances	semaglutide (53AXN4NNHX) ; Anti-Obesity Agents ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor ; Glucagon-Like Peptides (62340-29-8)
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-023-02672-2
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Article ; Online: Association of semaglutide with reduced incidence and relapse of cannabis use disorder in real-world populations: a retrospective cohort study.

Wang, William / Volkow, Nora D / Berger, Nathan A / Davis, Pamela B / Kaelber, David C / Xu, Rong

Molecular psychiatry

2024

Abstract: Cannabis is the most frequently used illicit drug in the United States with more than 45 million users of whom one-third suffer from a cannabis use disorder (CUD). Despite its high prevalence, there are currently no FDA-approved medications for CUD. ... ...

Abstract	Cannabis is the most frequently used illicit drug in the United States with more than 45 million users of whom one-third suffer from a cannabis use disorder (CUD). Despite its high prevalence, there are currently no FDA-approved medications for CUD. Patients treated with semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) approved for treating type 2 diabetes (T2D) and for weight management have reported reduced desire to drink and smoke. Preclinical studies have shown that semaglutide decreased nicotine and alcohol consumption. Preclinical and preliminary clinical evidence of semaglutide's potential beneficial effects on various substance use disorders led us to evaluate if it pertained to CUD. In this retrospective cohort study of electronic health records (EHRs) from the TriNetX Analytics Network, a global federated health research network of approximately 105.3 million patients from 61 large healthcare organizations in the US, we aimed to assess the associations of semaglutide with both incident and recurrent CUD diagnosis compared to non-GLP-1RA anti-obesity or anti-diabetes medications. Hazard ratio (HR) and 95% confidence intervals (CI) of incident and recurrent CUD were calculated for 12-month follow-up by comparing propensity-score matched patient cohorts. The study population included 85,223 patients with obesity who were prescribed semaglutide or non-GLP-1RA anti-obesity medications, with the findings replicated in 596,045 patients with T2D. In patients with obesity (mean age 51.3 years, 65.6% women), semaglutide compared with non-GLP-1RA anti-obesity medications was associated with lower risk for incident CUD in patients with no prior history CUD (HR: 0.56, 95% CI: 0.42-0.75), and recurrent CUD diagnosis in patients with a prior history CUD (HR: 0.62, 95% CI: 0.46-0.84). Consistent reductions were seen for patients stratified by gender, age group, race and in patients with and without T2D. Similar findings were replicated in the study population with T2D when comparing semaglutide with non-GLP-1RA anti-diabetes medications for incident CUD (HR: 0.40, 95% CI: 0.29-0.56) and recurrent CUD (HR: 0.66, 95% CI: 0.42-1.03). While these findings provide preliminary evidence of the potential benefit of semaglutide in CUD in real-world populations, further preclinical studies are warranted to understand the underlying mechanism and randomized clinical trials are needed to support its use clinically for CUD.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-024-02498-5
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Article ; Online: Spatially specific mechanisms and functions of the plant circadian clock.

Davis, William / Endo, Motomu / Locke, James C W

Plant physiology

2022 Volume 190, Issue 2, Page(s) 938–951

Abstract: Like many organisms, plants have evolved a genetic network, the circadian clock, to coordinate processes with day/night cycles. In plants, the clock is a pervasive regulator of development and modulates many aspects of physiology. Clock-regulated ... ...

Abstract	Like many organisms, plants have evolved a genetic network, the circadian clock, to coordinate processes with day/night cycles. In plants, the clock is a pervasive regulator of development and modulates many aspects of physiology. Clock-regulated processes range from the correct timing of growth and cell division to interactions with the root microbiome. Recently developed techniques, such as single-cell time-lapse microscopy and single-cell RNA-seq, are beginning to revolutionize our understanding of this clock regulation, revealing a surprising degree of organ, tissue, and cell-type specificity. In this review, we highlight recent advances in our spatial view of the clock across the plant, both in terms of how it is regulated and how it regulates a diversity of output processes. We outline how understanding these spatially specific functions will help reveal the range of ways that the clock provides a fitness benefit for the plant.
MeSH term(s)	Arabidopsis/genetics ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Gene Expression Regulation, Plant ; Gene Regulatory Networks ; Plants/genetics
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1093/plphys/kiac236
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Book: Basic biostatistics for geneticists and epidemiologists

Elston, Robert C. / Johnson, William D.

a practical approach

2008

Author's details	Robert C. Elston ; William Johnson
Keywords	Biometry / methods ; Data Collection ; Genetics, Medical ; Epidemiologic Methods ; Biometry ; Genetics/Statistical methods ; Epidemiology/Statistical methods
Subject code	570.15195
Language	English
Size	X, 373 S. : Ill., graph. Darst.
Publisher	Wiley
Publishing place	Chichester
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT014935869
ISBN	978-0-470-02490-4 ; 0-470-02490-9 ; 978-0-470-02489-8 ; 0-470-02489-5
Database	Catalogue ZB MED Medicine, Health

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2008 A 5905	order for loan	Magazin

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Article ; Online: The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review.

Tucis, Davis / Hopkins, Georgina / Browne, William / James, Victoria / Onion, David / Fairclough, Lucy C

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: Allergies affect approximately 10-30% of people worldwide, with an increasing number of cases each year; however, the underlying mechanisms are still poorly understood. In recent years, extracellular vesicles (EVs) have been suggested to play a role in ... ...

Abstract	Allergies affect approximately 10-30% of people worldwide, with an increasing number of cases each year; however, the underlying mechanisms are still poorly understood. In recent years, extracellular vesicles (EVs) have been suggested to play a role in allergic sensitization and skew to a T helper type 2 (Th2) response. The aim of this review is to highlight the existing evidence of EV involvement in allergies. A total of 22 studies were reviewed; 12 studies showed EVs can influence a Th2 response, while 10 studies found EVs promoted a Th1 or Treg response. EVs can drive allergic sensitization through up-regulation of pro-Th2 cytokines, such as IL-4 and IL-13. In addition, EVs from MRSA can induce IgE hypersensitivity in mice towards MRSA. On the other hand, EVs can induce tolerance in the immune system; for example, pre-exposing OVA-loaded EVs prevented OVA sensitization in mice. The current literature thus suggests that EVs play an essential role in allergy. Further research utilizing human in vitro models and clinical studies is needed to give a reliable account of the role of EVs in allergy.
MeSH term(s)	Extracellular Vesicles/immunology ; Extracellular Vesicles/metabolism ; Animals ; Hypersensitivity/immunology ; Humans ; Th2 Cells/immunology ; Th2 Cells/metabolism ; Cytokines/metabolism ; Mice
Chemical Substances	Cytokines
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084492
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Article ; Online: Spatiotemporal dispersion compensation for a 200-THz noncollinear optical parametric amplifier.

Carbery, William P / Bizimana, Laurie A / Barclay, Matthew S / Wright, Nicholas D / Davis, Paul H / Knowlton, William B / Pensack, Ryan D / Arpin, Paul C / Turner, Daniel B

The Review of scientific instruments

2024 Volume 95, Issue 3

Abstract: A noncollinear optical parametric amplifier (NOPA) can produce few-cycle femtosecond laser pulses that are ideally suited for time-resolved optical spectroscopy measurements. However, the nonlinear-optical process giving rise to ultrabroadband pulses is ... ...

Abstract	A noncollinear optical parametric amplifier (NOPA) can produce few-cycle femtosecond laser pulses that are ideally suited for time-resolved optical spectroscopy measurements. However, the nonlinear-optical process giving rise to ultrabroadband pulses is susceptible to spatiotemporal dispersion problems. Here, we detail refinements, including chirped-pulse amplification (CPA) and pulse-front matching (PFM), that minimize spatiotemporal dispersion and thereby improve the properties of ultrabroadband pulses produced by a NOPA. The description includes a rationale behind the choices of optical and optomechanical components, as well as assessment protocols. We demonstrate these techniques using a 1 kHz, second-harmonic Ti:sapphire pump configuration, which produces ∼5-fs duration pulses that span from about 500 to 800 nm with a bandwidth of about 200 THz. To demonstrate the utility of the CPA-PFM-NOPA, we measure vibrational quantum beats in the transient-absorption spectrum of methylene blue, a dye molecule that serves as a reference standard.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0187338
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Article ; Online: Flow Cytometric Analysis of the Cytotoxic T-Cell Recall Response to

Elnaggar, Mahmoud M / Knowles, Donald P / Davis, William C / Fry, Lindsay M

Veterinary sciences

2021 Volume 8, Issue 6

Abstract: The apicomplexan hemoparasite, ...

Abstract	The apicomplexan hemoparasite,
Language	English
Publishing date	2021-06-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci8060114
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