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  1. Article ; Online: Add mass spectrometry to the pandemic toolbox.

    Van Puyvelde, Bart / Dhaenens, Maarten

    eLife

    2021  Volume 10

    Abstract: A new protocol step improves robustness and ease-of-use for mass spectrometry in the clinic, opening the door to mass deployment to monitor infectious agents. ...

    Abstract A new protocol step improves robustness and ease-of-use for mass spectrometry in the clinic, opening the door to mass deployment to monitor infectious agents.
    MeSH term(s) COVID-19 ; Humans ; Mass Spectrometry ; Pandemics ; Proteomics ; SARS-CoV-2
    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.75471
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  2. Article ; Online: Add mass spectrometry to the pandemic toolbox

    Bart Van Puyvelde / Maarten Dhaenens

    eLife, Vol

    2021  Volume 10

    Abstract: A new protocol step improves robustness and ease-of-use for mass spectrometry in the clinic, opening the door to mass deployment to monitor infectious agents. ...

    Abstract A new protocol step improves robustness and ease-of-use for mass spectrometry in the clinic, opening the door to mass deployment to monitor infectious agents.
    Keywords SARS-CoV-2 ; Covid-19 ; public health ; proteomics ; diagnostics ; mass spectrometry ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Heartmate 3 implantation in small patients: CT-guided chest diameter assessment.

    Van Puyvelde, Joeri / Jacobs, Steven / Vlasselaers, Dirk / Meyns, Bart

    Interactive cardiovascular and thoracic surgery

    2022  Volume 34, Issue 5, Page(s) 939–940

    Abstract: In recent years, the Heartmate 3 (HM3) has largely replaced the use of other intracorporeal left ventricular assist devices in the adult field. Because the HM3 is larger than the Heartware Ventricular Assist Device, the general consensus was that for ... ...

    Abstract In recent years, the Heartmate 3 (HM3) has largely replaced the use of other intracorporeal left ventricular assist devices in the adult field. Because the HM3 is larger than the Heartware Ventricular Assist Device, the general consensus was that for small patients, the Heartware Ventricular Assist Device was the most appropriate implantable device option. Our goal was to describe our experiences with the successful implantation of the HM3 in 2 children, aged 9 and 11. We report on the chest cavity dimensions, as measured on computed tomography, that can be used to assess the feasibility of HM3 implantation in small patients.
    MeSH term(s) Adult ; Child ; Heart Failure/diagnostic imaging ; Heart Failure/surgery ; Heart-Assist Devices ; Humans ; Retrospective Studies ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivac009
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    Zs.A 5730: Show issues Location:
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  4. Article ; Online: How to perform focused transoesophageal echocardiography during extracorporeal cardiopulmonary resuscitation?

    Rosseel, Thomas / Van Puyvelde, Tim / Voigt, Jens-Uwe / Dauwe, Dieter / Meyns, Bart / Dewolf, Philippe / Vandenbriele, Christophe

    European heart journal. Cardiovascular Imaging

    2022  

    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeac205
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    Zs.A 5614: Show issues Location:
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  5. Article ; Online: Mitral valve replacement in children: balancing durability and risk with mechanical and bioprosthetic valves.

    Van Puyvelde, Joeri / Meyns, Bart / Rega, Filip / Gewillig, Marc / Eyskens, Benedicte / Heying, Ruth / Cools, Bjorn / Salaets, Thomas / Hellings, Peter-William / Meuris, Bart

    Interdisciplinary cardiovascular and thoracic surgery

    2024  Volume 38, Issue 3

    Abstract: Objectives: To investigate if there is still a place for bioprosthetic mitral valve replacement in children by comparing the prosthetic durability and transplant-free survival after bioprosthetic and mechanical mitral valve replacement.: Methods: We ... ...

    Abstract Objectives: To investigate if there is still a place for bioprosthetic mitral valve replacement in children by comparing the prosthetic durability and transplant-free survival after bioprosthetic and mechanical mitral valve replacement.
    Methods: We reviewed all mitral valve replacements in children between 1981 and 2020. Bioprosthetic mitral valve replacement cases were individually matched to mechanical mitral valve replacement cases. The incidence rate of a 2nd replacement was calculated using the cumulative incidence function that considered death or transplantation as a competing risk.
    Results: The median age at implantation was 3.6 years (interquartile range 0.8-7.9) for the bioprosthetic valve cohort (n = 28) and 3 years (interquartile range 1.3-7.8) for the mechanical valve cohort (n = 28). Seven years after bioprosthetic mitral valve replacement, the cumulative incidence of death or transplantation was 17.9% [95% confidence interval (CI) 6.3-34.1] and the cumulative incidence of a 2nd replacement was 63.6% (95% CI 39.9-80.1). Seven years after mechanical mitral valve replacement, the cumulative incidence of death or transplantation was 28.6% (95% CI 13.3-46) and the cumulative incidence of a 2nd replacement was 10.7% (95% CI 2.6-25.5). Fifteen years after mechanical mitral valve replacement, the cumulative incidence of death or transplantation was 33.6% (95% CI 16.2-52.1) and the cumulative incidence of a 2nd replacement was 41.1% (95% CI 18.4-62.7). The cumulative incidence curves for bioprosthetic and mechanical mitral valve replacement were statistically different for a 2nd valve replacement (P < 0.001) but not for death or transplantation (P = 0.33).
    Conclusions: There is no difference in transplant-free survival after bioprosthetic and mechanical mitral valve replacement in children. The lifespan of bioprosthetic mitral valves remains limited in children because of structural valve failure due to calcification. After 15 years, 40% of mechanical valves were replaced, primarily because of patient-prosthesis mismatch related to somatic growth.
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivae034
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  6. Article ; Online: Opioids in geriatric units in 14 Belgian hospitals: prevalence, dosage and associated factors.

    Janssens, Wim Henri / Van Den Noortgate, Nele J / Mouton, Veerle / Desmet, Peter / Van Puyvelde, Katrien / Steen, Elke / Maere, Caroline / Van Mulders, Katlijn / De Raes, Eva / Dekoninck, Julien / Kympers, Celine / Werbrouck, Bart / Delaere, Jozefien / Piers, Ruth D

    Annals of medicine

    2024  Volume 56, Issue 1, Page(s) 2310132

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Humans ; Aged ; Analgesics, Opioid/adverse effects ; Oxycodone/adverse effects ; Tramadol/adverse effects ; Cross-Sectional Studies ; Belgium/epidemiology ; Prevalence ; Fentanyl/adverse effects ; Morphine/adverse effects ; Buprenorphine/adverse effects ; Dementia/drug therapy ; Dementia/epidemiology ; Dementia/chemically induced
    Chemical Substances Analgesics, Opioid ; Oxycodone (CD35PMG570) ; Tramadol (39J1LGJ30J) ; Fentanyl (UF599785JZ) ; Morphine (76I7G6D29C) ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2024.2310132
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 680: Show issues Location:
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  7. Article ; Online: The Extent of Interlayer Bond Strength during Fused Filament Fabrication of Nylon Copolymers: An Interplay between Thermal History and Crystalline Morphology.

    Vaes, Dries / Coppens, Margot / Goderis, Bart / Zoetelief, Wim / Van Puyvelde, Peter

    Polymers

    2021  Volume 13, Issue 16

    Abstract: One of the main drawbacks of Fused Filament Fabrication is the often-inadequate mechanical performance of printed parts due to a lack of sufficient interlayer bonding between successively deposited layers. The phenomenon of interlayer bonding becomes ... ...

    Abstract One of the main drawbacks of Fused Filament Fabrication is the often-inadequate mechanical performance of printed parts due to a lack of sufficient interlayer bonding between successively deposited layers. The phenomenon of interlayer bonding becomes especially complex for semi-crystalline polymers, as, besides the extremely non-isothermal temperature history experienced by the extruded layers, the ongoing crystallization process will greatly complicate its analysis. This work attempts to elucidate a possible relation between the degree of crystallinity attained during printing by mimicking the experienced thermal history with Fast Scanning Chip Calorimetry, the extent of interlayer bonding by performing trouser tear fracture tests on printed specimens, and the resulting crystalline morphology at the weld interface through visualization with polarized light microscopy. Different printing conditions are defined, which all vary in terms of processing parameters or feedstock molecular weight. The concept of an equivalent isothermal weld time is utilized to validate whether an amorphous healing theory is capable of explaining the observed trends in weld strength. Interlayer bond strength was found to be positively impacted by an increased liquefier temperature and reduced feedstock molecular weight as predicted by the weld time. An increase in liquefier temperature of 40 °C brings about a tear energy value that is three to four times higher. The print speed was found to have a negligible effect. An elevated build plate temperature will lead to an increased degree of crystallinity, generally resulting in about a 1.5 times larger crystalline fraction compared to when printing occurs at a lower build plate temperature, as well as larger spherulites attained during printing, as it allows crystallization to occur at higher temperatures. Due to slower crystal growth, a lower tie chain density in the amorphous interlamellar regions is believed to be created, which will negatively impact interlayer bond strength.
    Language English
    Publishing date 2021-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13162677
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  8. Article ; Online: Fontan failure associated with a restrictive systemic ventricle.

    Van Puyvelde, Joeri / Verbeken, Erik / Gewillig, Marc / Meyns, Bart

    The Journal of thoracic and cardiovascular surgery

    2017  Volume 154, Issue 1, Page(s) e7–e8

    MeSH term(s) Adolescent ; Female ; Fontan Procedure ; Humans ; Postoperative Complications/etiology ; Treatment Failure ; Ventricular Dysfunction/complications
    Language English
    Publishing date 2017-02-15
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2017.02.016
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    Uk I Zs.104: Show issues Location:
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  9. Article ; Online: An experimental design to extract more information from MS-based histone studies.

    De Clerck, Laura / Willems, Sander / Daled, Simon / Van Puyvelde, Bart / Verhelst, Sigrid / Corveleyn, Laura / Deforce, Dieter / Dhaenens, Maarten

    Molecular omics

    2021  Volume 17, Issue 6, Page(s) 929–938

    Abstract: Histone-based chromatin organization paved the way for eukaryotic genome complexity. Because of their key role in information management, the histone posttranslational modifications (hPTM), which mediate their function, have evolved into an alphabet that ...

    Abstract Histone-based chromatin organization paved the way for eukaryotic genome complexity. Because of their key role in information management, the histone posttranslational modifications (hPTM), which mediate their function, have evolved into an alphabet that has more letters than there are amino acids, together making up the "histone code". The resulting combinatorial complexity is manifold higher than what is usually encountered in proteomics. Consequently, a considerably bigger part of the acquired MSMS spectra remains unannotated to date. Adapted search parameters can dig deeper into the dark histone ion space, but the lack of false discovery rate (FDR) control and the high level of ambiguity when searching combinatorial PTMs makes it very hard to assess whether the newly assigned ions are informative. Therefore, we propose an easily adoptable time-lapse enzymatic deacetylation (HDAC1) of a commercial histone extract as a quantify-first strategy that allows isolating ion populations of interest, when studying
    MeSH term(s) Histone Code ; Histones/metabolism ; Protein Processing, Post-Translational ; Proteomics ; Research Design
    Chemical Substances Histones
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2515-4184
    ISSN (online) 2515-4184
    DOI 10.1039/d1mo00201e
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  10. Article: Histone Sample Preparation for Bottom-Up Mass Spectrometry: A Roadmap to Informed Decisions.

    Daled, Simon / Willems, Sander / Van Puyvelde, Bart / Corveleyn, Laura / Verhelst, Sigrid / De Clerck, Laura / Deforce, Dieter / Dhaenens, Maarten

    Proteomes

    2021  Volume 9, Issue 2

    Abstract: Histone-based chromatin organization enabled eukaryotic genome complexity. This epigenetic control mechanism allowed for the differentiation of stable gene-expression and thus the very existence of multicellular organisms. This existential role in ... ...

    Abstract Histone-based chromatin organization enabled eukaryotic genome complexity. This epigenetic control mechanism allowed for the differentiation of stable gene-expression and thus the very existence of multicellular organisms. This existential role in biology makes histones one of the most complexly modified molecules in the biotic world, which makes these key regulators notoriously hard to analyze. We here provide a roadmap to enable fast and informed selection of a bottom-up mass spectrometry sample preparation protocol that matches a specific research question. We therefore propose a two-step assessment procedure: (i) visualization of the coverage that is attained for a given workflow and (ii) direct alignment between runs to assess potential pitfalls at the ion level. To illustrate the applicability, we compare four different sample preparation protocols while adding a new enzyme to the toolbox, i.e., RgpB (GingisREX
    Language English
    Publishing date 2021-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720995-7
    ISSN 2227-7382
    ISSN 2227-7382
    DOI 10.3390/proteomes9020017
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