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  1. Article ; Online: A four-year simulation of soil aquifer treatment using columns filled with San Gabriel Valley sand.

    Trussell, Bryan / Trussell, Shane / Qu, Yan / Gerringer, Fred / Stanczak, Sangam / Venezia, Teresa / Monroy, Israel / Bacaro, Fernanda / Trussell, Rhodes

    Water research

    2018  Volume 144, Page(s) 26–35

    Abstract: Two column pairs filled with 3.05-m of a sandy soil from the Upper San Gabriel Valley were operated ...

    Abstract Two column pairs filled with 3.05-m of a sandy soil from the Upper San Gabriel Valley were operated for a period of four and ½ years on municipal effluent from the San Jose Creek Water Reclamation Plant operated by the Sanitation Districts of Los Angeles County (LACSD). One column pair was fed filtered, chlorinated effluent (tertiary effluent) for the entire period. The other pair was fed ozonated secondary effluent for 8-mo, ozonated secondary effluent filtered through biological activated carbon (O
    MeSH term(s) Carbamazepine/chemistry ; Carbamazepine/isolation & purification ; Carbon/analysis ; Charcoal ; Dimethylnitrosamine/chemistry ; Dimethylnitrosamine/isolation & purification ; Groundwater/chemistry ; Recycling ; Soil/chemistry ; Waste Disposal, Fluid/methods ; Water Pollutants, Chemical/chemistry ; Water Pollutants, Chemical/isolation & purification ; Water Purification/instrumentation ; Water Purification/methods
    Chemical Substances Soil ; Water Pollutants, Chemical ; Charcoal (16291-96-6) ; Carbamazepine (33CM23913M) ; Carbon (7440-44-0) ; Dimethylnitrosamine (M43H21IO8R)
    Language English
    Publishing date 2018-07-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2018.07.012
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  2. Article ; Online: Acid-Promoted Multicomponent Tandem Cyclization to Synthesize Fully Substituted Oxazoles via Robinson-Gabriel-Type Reaction.

    Zhou, Rong-Rong / Cai, Qun / Li, Deng-Kui / Zhuang, Shi-Yi / Wu, Yan-Dong / Wu, An-Xin

    The Journal of organic chemistry

    2017  Volume 82, Issue 12, Page(s) 6450–6456

    Abstract: ... indicates that a classical Robinson-Gabriel reaction served as the key step for this tandem transformation. ...

    Abstract An acid-promoted multicomponent reaction for the synthesis of diverse fully substituted oxazole derivatives from simple and readily available arylglyoxal monohydrates, nitriles, and various C-nucleophiles has been developed. This protocol features wide functional group diversity which is capable of installing 4-hydroxycoumarin, 2-naphthol, and 1,3-cyclohexanedione motifs to oxazoles. Mechanistic analysis indicates that a classical Robinson-Gabriel reaction served as the key step for this tandem transformation.
    Language English
    Publishing date 2017-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.7b00763
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  3. Article: A four-year simulation of soil aquifer treatment using columns filled with San Gabriel Valley sand

    Trussell, Bryan / Trussell, Shane / Qu, Yan / Gerringer, Fred / Stanczak, Sangam / Venezia, Teresa / Monroy, Israel / Bacaro, Fernanda / Trussell, Rhodes

    Water research. 2018 Nov. 01, v. 144

    2018  

    Abstract: Two column pairs filled with 3.05-m of a sandy soil from the Upper San Gabriel Valley were operated ...

    Abstract Two column pairs filled with 3.05-m of a sandy soil from the Upper San Gabriel Valley were operated for a period of four and 1⁄2 years on municipal effluent from the San Jose Creek Water Reclamation Plant operated by the Sanitation Districts of Los Angeles County (LACSD). One column pair was fed filtered, chlorinated effluent (tertiary effluent) for the entire period. The other pair was fed ozonated secondary effluent for 8-mo, ozonated secondary effluent filtered through biological activated carbon (O3/BAC) for 7-mo and tertiary effluent for 38-mo. Each column pair was operated in series, where the first column was operated for a shorter residence time and the second column for a longer residence time. Residence times tested were 5-d, 28-d, 30-d, 58-d, 60-d, 150-d and 180-d. For the last 38-mo, both pairs of columns had a residence time of 30-d in the first column and the total residence time of the two pairs was 150 and 180-d, respectively. Testing showed both of these pairs had the same long-term performance. The column pairs with a 150 to 180-d residence time, which were both fed tertiary effluent, reached an effluent total organic carbon (TOC) of 1.8 mg/L. Column pairs with a 28 to 30-d residence time, which were fed tertiary, ozonated, and O3/BAC effluent, reached effluent TOCs of 2.3, 2.1 and 1.8 mg/L respectively. In the latter, some TOC removal was shifted from the soil columns to the BAC. During the last 38 months of testing, using tertiary effluent as the source water, a series of sampling events was performed throughout the soil column system for N-nitrosodimethylamine (NDMA) and chemicals of emerging concern (CECs). NDMA was substantially reduced in all the columns, with a median value of 3 ng/L after 30-d and <2 ng/L after both 150 and 180-d. Twenty-one CECs were found in the majority of tertiary effluent samples, twelve of which were attenuated by the soil columns and the remaining were not. Chemicals found to be recalcitrant were 4-nonylphenol, acesulfame-k, carbamazepine, lidocaine, primidone, simazine, sucralose, sulfamethoxazole, and TCEP. Using excitation-emission matrix (EEM) techniques, soluble microbial products (SMP) peak characteristic of effluent organic matter (EfOM) is nearly eliminated after a 30-d hydraulic retention time (HRT) and completely eliminated in the 150/180-d samples. The intensity of the other peaks is significantly reduced as well, resulting in an EEM much like that of natural groundwater.
    Keywords N-nitrosodimethylamine ; acesulfame potassium ; activated carbon ; aquifers ; bacterial artificial chromosomes ; groundwater ; lidocaine ; organic carbon ; organic matter ; ozonation ; sand ; sandy soils ; sanitation ; simazine ; streams ; sucralose ; sulfamethoxazole ; water reuse
    Language English
    Dates of publication 2018-1101
    Size p. 26-35.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2018.07.012
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Acid-Promoted Multicomponent Tandem Cyclization to Synthesize Fully Substituted Oxazoles via Robinson–Gabriel-Type Reaction

    Zhou, Rong-Rong / Cai Qun / Li Deng-Kui / Wu An-Xin / Wu Yan-Dong / Zhuang Shi-Yi

    Journal of organic chemistry. 2017 June 16, v. 82, no. 12

    2017  

    Abstract: ... indicates that a classical Robinson–Gabriel reaction served as the key step for this tandem transformation. ...

    Abstract An acid-promoted multicomponent reaction for the synthesis of diverse fully substituted oxazole derivatives from simple and readily available arylglyoxal monohydrates, nitriles, and various C-nucleophiles has been developed. This protocol features wide functional group diversity which is capable of installing 4-hydroxycoumarin, 2-naphthol, and 1,3-cyclohexanedione motifs to oxazoles. Mechanistic analysis indicates that a classical Robinson–Gabriel reaction served as the key step for this tandem transformation.
    Keywords 2-naphthol ; 4-hydroxycoumarin ; cyclization reactions ; moieties ; nitriles ; organic chemistry ; oxazoles
    Language English
    Dates of publication 2017-0616
    Size p. 6450-6456.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021%2Facs.joc.7b00763
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  5. Article ; Online: Reactive arthritis in a patient with COVID-19 infection and pleural tuberculosis.

    Seet, Dominic / Yan, Gabriel / Cho, Jiacai

    Singapore medical journal

    2023  

    Language English
    Publishing date 2023-03-13
    Publishing country India
    Document type Letter
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2021-132
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  6. Article ; Online: A customized table-top aging simulation exercise to augment gerodontology teaching.

    Lee, Gabriel Keng Yan / Tada, Sayaka / Wong, Mun Loke

    Journal of dental education

    2024  

    Abstract: While aging simulation suits have been used in healthcare education to promote empathy for older adults, little has been published on learning outcomes specific to geriatric dental patients. We designed a seminar utilising a customised ageing simulation ... ...

    Abstract While aging simulation suits have been used in healthcare education to promote empathy for older adults, little has been published on learning outcomes specific to geriatric dental patients. We designed a seminar utilising a customised ageing simulation suit to help dental students empathise with several disabilties their older adult patients may face.
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410579-5
    ISSN 1930-7837 ; 0022-0337
    ISSN (online) 1930-7837
    ISSN 0022-0337
    DOI 10.1002/jdd.13452
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    Zs.A 428: Show issues Location:
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  7. Article ; Online: Transfusion-Transmitted Infections: Lessons From Dengue in Taiwan.

    Yan, Gabriel / Tambyah, Paul

    The Journal of infectious diseases

    2022  Volume 225, Issue 9, Page(s) 1497–1499

    MeSH term(s) Blood Donors ; Dengue/blood ; Dengue/epidemiology ; Dengue/prevention & control ; Dengue Virus ; Disease Outbreaks ; Humans ; Incidence ; RNA ; Taiwan/epidemiology ; Transfusion Reaction/epidemiology
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac015
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  8. Article ; Online: Jarisch-Herxheimer reaction in a patient with Weil's disease.

    Ngiam, Jinghao Nicholas / Foo, Tiara Joy / Tan, Genevieve My / Phua, Jason / Lim, Hui Fang / Tambyah, Paul Anantharajah / Yan, Gabriel Zherong

    Singapore medical journal

    2024  

    Language English
    Publishing date 2024-01-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2022-196
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  9. Article ; Online: Addressing the overlooked: Integrating oral healthcare in a geriatric care system: Insights from Singapore.

    Tada, Sayaka / Lee, Gabriel Keng Yan / Tay, Chong Meng

    Community dentistry and oral epidemiology

    2023  

    Abstract: Oral health of the older population has long been overlooked in global healthcare agenda. Limited access to oral healthcare for dependent older adults results in poor oral health, negatively impacting their quality of life, nutrition and overall well- ... ...

    Abstract Oral health of the older population has long been overlooked in global healthcare agenda. Limited access to oral healthcare for dependent older adults results in poor oral health, negatively impacting their quality of life, nutrition and overall well-being. Especially for nations experiencing rapid ageing population, efforts must be urgently made to integrate oral healthcare services into the current healthcare system and policy. Singapore stands out as one of the most rapidly ageing nations in Southeast Asia, achieving remarkable progress in the healthcare field, as well as advancements in social modernization and economic growth. It now faces the growing burden of the dependent older population and is required to respond to the complex challenges associated with providing holistic eldercare services and ensuring the well-being of its ageing population. This narrative review offers an overview of Singapore's current healthcare policy and system development for the older population, with a specific focus on oral healthcare. The goal is to shed light on this underexplored area, highlighting the challenges that need to be tackled to improve the accessibility of oral health services for dependent older adults.
    Language English
    Publishing date 2023-12-14
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 189172-8
    ISSN 1600-0528 ; 0301-5661
    ISSN (online) 1600-0528
    ISSN 0301-5661
    DOI 10.1111/cdoe.12932
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  10. Article: The conformational landscape of human transthyretin revealed by cryo-EM.

    Basanta, Benjamin / Nugroho, Karina / Yan, Nicholas L / Kline, Gabriel M / Powers, Evan T / Tsai, Felix J / Wu, Mengyu / Hansel-Harris, Althea / Chen, Jason S / Forli, Stefano / Kelly, Jeffrey W / Lander, Gabriel C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Transthyretin (TTR) is a natively tetrameric thyroxine transporter found in blood and cerebrospinal fluid whose misfolding and aggregation causes transthyretin amyloidosis. A rational drug design campaign identified the small molecule tafamidis (Vyndaqel/ ...

    Abstract Transthyretin (TTR) is a natively tetrameric thyroxine transporter found in blood and cerebrospinal fluid whose misfolding and aggregation causes transthyretin amyloidosis. A rational drug design campaign identified the small molecule tafamidis (Vyndaqel/Vyndamax) as an effective stabilizer of the native TTR fold, and this aggregation inhibitor is regulatory agency-approved for the treatment of TTR amyloidosis. Despite 50 years of structural studies on TTR and this triumph of structure-based drug design, there remains a notable dearth of structural information available to understand ligand binding allostery and amyloidogenic TTR unfolding intermediates. We used single-particle cryo-electron microscopy (cryo-EM) to investigate the conformational landscape of this 55 kiloDalton tetramer in the absence and presence of one or two ligands, revealing inherent asymmetries in the tetrameric architecture and previously unobserved conformational states. These findings provide critical mechanistic insights into negatively cooperative ligand binding and the structural pathways responsible for TTR amyloidogenesis. This study underscores the capacity of cryo-EM to provide new insights into protein structures that have been historically considered too small to visualize and to identify pharmacological targets suppressed by the confines of the crystal lattice, opening uncharted territory in structure-based drug design.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.23.576879
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