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  1. Article ; Online: Comments on Bruun, D.M. et al. Community-based recreational football: a novel approach to promote physical activity and quality of life in prostate cancer survivors. Int. J. Environ. Res. Public health 2014, 11, 5557-5585-time to raise our game.

    Parnell, Daniel / Pringle, Andy / McKenna, Jim / Zwolinsky, Stephen

    International journal of environmental research and public health

    2014  Volume 11, Issue 7, Page(s) 6842–6843

    MeSH term(s) Exercise ; Health Promotion/methods ; Humans ; Male ; Prostatic Neoplasms ; Quality of Life ; Soccer ; Survivors
    Language English
    Publishing date 2014-07-02
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph110706842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Haemoglobin mass responses and performance outcomes among high-performance swimmers following a 3-week live-high, train-high camp at 2320 m.

    Astridge, Daniel J / McKenna, Michael / Campbell, Adrian / Turner, Anthony P

    European journal of applied physiology

    2024  

    Abstract: ... weeks of LHTH at 2320 m, while characterising the training load periodisation strategy adopted during ...

    Abstract Aim: Greater quantification and characterisation of training load (TL) throughout Live-high, train-high (LHTH) altitude (ALT) training is required to identify periodisation strategies that may lead to physiological and performance improvements in swimmers.
    Purpose: This study aimed to examine the physiological responses and performance outcomes of 14 high-performance swimmers (FINA points: 836.0 ± 35.1) following 3 weeks of LHTH at 2320 m, while characterising the training load periodisation strategy adopted during the intervention.
    Methods: Haemoglobin (Hb) mass was measured pre-, 7 and 14 days post-ALT via CO rebreathing. Performance in each athlete's primary event at national standard meets were converted to FINA points and compared from pre-to-post-ALT. TL was quantified at sea level (SL) and ALT through session rating of perceived exertion (RPE), where duration of each session was multiplied by its RPE for each athlete, with all sessions totalled to give a weekly TL. Pre-to-post-ALT changes were evaluated using repeated-measures ANOVA.
    Results: Hb mass increased significantly from 798 ± 182 g pre-ALT to 828 ± 187 g at 7 days post (p = 0.013) and 833 ± 205 g 14 days post-ALT (p = 0.026). Weekly TL increased from SL (3179 ± 638 au) during week one (4797 ± 1349 au, p < 0.001) and week two (4373 ± 967 au, p < 0.001), but not week three (3511 ± 730 au, p = 0.149). No evidence of improved SL swimming performance was identified.
    Conclusion: A periodisation strategy characterised by a sharp spike in TL followed by a slight de-load towards the end of a LHTH intervention led to improved physiological characteristics but no change in the competitive performance of high-performance swimmers.
    Language English
    Publishing date 2024-03-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-024-05454-x
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: MiR-182 Is Upregulated in Prostate Cancer and Contributes to Tumor Progression by Targeting MITF.

    Stafford, M Y Cynthia / McKenna, Declan J

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Altered expression of microRNA-182-5p (miR-182) has been consistently linked with many cancers, but its specific role in prostate cancer remains unclear. In particular, its contribution to epithelial-to-mesenchymal transition (EMT) in this setting has ... ...

    Abstract Altered expression of microRNA-182-5p (miR-182) has been consistently linked with many cancers, but its specific role in prostate cancer remains unclear. In particular, its contribution to epithelial-to-mesenchymal transition (EMT) in this setting has not been well studied. Therefore, this paper profiles the expression of miR-182 in prostate cancer and investigates how it may contribute to progression of this disease. In vitro experiments on prostate cancer cell lines and in silico analyses of The Cancer Genome Atlas (TCGA) prostate adenocarcinoma (PRAD) datasets were performed. PCR revealed miR-182 expression was significantly increased in prostate cancer cell lines compared to normal prostate cells. Bioinformatic analysis of TCGA PRAD data similarly showed upregulation of miR-182 was significantly associated with prostate cancer and clinical markers of disease progression. Functional enrichment analysis confirmed a significant association of miR-182 and its target genes with EMT. The EMT-linked gene MITF (melanocyte inducing transcription factor) was subsequently shown to be a novel target of miR-182 in prostate cancer cells. Further TCGA analysis suggested miR-182 expression can be an indicator of patient outcomes and disease progression following therapy. In summary, this is the first study to report that miR-182 over-expression in prostate cancer may contribute to EMT by targeting MITF expression. We propose miR-182 as a potentially useful diagnostic and prognostic biomarker for prostate cancer and other malignancies.
    MeSH term(s) Male ; Humans ; MicroRNAs/metabolism ; Prostatic Neoplasms/metabolism ; Up-Regulation/genetics ; Disease Progression ; Epithelial-Mesenchymal Transition/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Movement ; Microphthalmia-Associated Transcription Factor/genetics ; Microphthalmia-Associated Transcription Factor/metabolism
    Chemical Substances MicroRNAs ; MITF protein, human ; Microphthalmia-Associated Transcription Factor ; Mirn182 microRNA, human
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031824
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  4. Article ; Online: Mass spectrometry of dendrimers.

    Redding, McKenna J / Grayson, Scott M / Charles, Laurence

    Mass spectrometry reviews

    2024  

    Abstract: Mass spectrometry (MS) has become an essential technique to characterize dendrimers as it proved efficient at tackling analytical challenges raised by their peculiar onion-like structure. Owing to their chemical diversity, this review covers benefits of ... ...

    Abstract Mass spectrometry (MS) has become an essential technique to characterize dendrimers as it proved efficient at tackling analytical challenges raised by their peculiar onion-like structure. Owing to their chemical diversity, this review covers benefits of MS methods as a function of dendrimer classes, discussing advantages and limitations of ionization techniques, tandem mass spectrometry (MS/MS) strategies to determine the structure of defective species, as well as most recently demonstrated capabilities of ion mobility spectrometry (IMS) in the field. Complementarily, the well-defined structure of these macromolecules offers major advantages in the development of MS-based method, as reported in a second section reviewing uses of dendrimers as MS and IMS calibration standards and as multifunctional charge inversion reagents in gas phase ion/ion reactions.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1491946-1
    ISSN 1098-2787 ; 0277-7037
    ISSN (online) 1098-2787
    ISSN 0277-7037
    DOI 10.1002/mas.21876
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  5. Article ; Online: Articular Cartilage Chondroprogenitors: Isolation and Directed Differentiation.

    Khan, Ilyas M / McKenna, Joshua / Zhang, Yadan

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2598, Page(s) 29–44

    Abstract: Experimental data suggests that tissue-specific progenitors are present within hyaline articular cartilage with the potential to contribute to growth, maintenance, and repair. In this chapter, we show how colony-forming progenitor-like cells can be ... ...

    Abstract Experimental data suggests that tissue-specific progenitors are present within hyaline articular cartilage with the potential to contribute to growth, maintenance, and repair. In this chapter, we show how colony-forming progenitor-like cells can be isolated from bovine articular cartilage using differential adhesion to fibronectin. Furthermore, we describe the optimal conditions and factors required to differentiate these progenitor cells to produce hyaline articular cartilage.
    MeSH term(s) Cattle ; Animals ; Cartilage, Articular ; Chondrogenesis ; Chondrocytes ; Cell Differentiation ; Stem Cells ; Cells, Cultured
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2839-3_4
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  6. Article ; Online: Covalency-enabled Drug Discovery is Redefining Druggability

    Jeffrey M. McKenna / Rupert S. J. Proctor

    CHIMIA, Vol 77, Iss 7/

    2023  Volume 8

    Keywords Covalent ; Cysteine targeting ; Druggable proteins ; Proteomics ; Chemistry ; QD1-999
    Language German
    Publishing date 2023-08-01T00:00:00Z
    Publisher Swiss Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Work-Related Psychological Wellbeing and Conservative Christian Belief Among Methodist Circuit Ministers in Britain: Distinguishing Between Emotional Exhaustion and Satisfaction in Ministry.

    Francis, Leslie J / Haley, John M / McKenna, Ursula

    Journal of religion and health

    2022  Volume 62, Issue 3, Page(s) 1636–1657

    Abstract: Drawing on data provided by 803 Methodist circuit ministers serving in Great Britain, the present study was designed to test the association between conservative Christian belief and work-related psychological wellbeing as operationalised by the balanced ...

    Abstract Drawing on data provided by 803 Methodist circuit ministers serving in Great Britain, the present study was designed to test the association between conservative Christian belief and work-related psychological wellbeing as operationalised by the balanced affect model proposed by the Francis Burnout Inventory. After taking into account the effects of personal factors, psychological factors, contextual factors, and experience factors, holding conservative Christian belief was associated with a higher level of positive affect (satisfaction in ministry) but independent of negative affect (emotional exhaustion in ministry).
    MeSH term(s) Humans ; Protestantism ; United Kingdom ; Clergy/psychology ; Emotions ; Burnout, Professional/psychology ; Personal Satisfaction ; Job Satisfaction
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2017250-3
    ISSN 1573-6571 ; 0022-4197
    ISSN (online) 1573-6571
    ISSN 0022-4197
    DOI 10.1007/s10943-022-01637-y
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  8. Article: The Impact of COVID-19 on Alcohol Consumption.

    Allen, K / McKenna, R / Ryan, J / Quirke, M

    Irish medical journal

    2022  Volume 115, Issue 2, Page(s) 550

    MeSH term(s) Alcohol Drinking/epidemiology ; COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-02-17
    Publishing country Ireland
    Document type Letter
    ZDB-ID 193134-9
    ISSN 0332-3102 ; 0021-129X
    ISSN 0332-3102 ; 0021-129X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 148: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The Derivation and Use of HoxB8-Driven Conditionally Immortalized Macrophages.

    Lail, Shranjit S / McKenna, Neil / Yates, Robin M

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2692, Page(s) 109–120

    Abstract: The use of Hox-driven conditionally immortalized immune cells has significantly increased in biomedical research over the past 15 years. HoxB8-driven conditionally immortalized myeloid progenitor cells maintain their ability to differentiate into ... ...

    Abstract The use of Hox-driven conditionally immortalized immune cells has significantly increased in biomedical research over the past 15 years. HoxB8-driven conditionally immortalized myeloid progenitor cells maintain their ability to differentiate into functional macrophages. There are multiple benefits to this conditional immortalization strategy including the ability for unlimited propagation, genetic mutability, primary-like immune cells (macrophages, dendritic cells, and granulocytes) on demand, derivation from variety of mouse strains, and simple cryopreservation and reconstitution. In this chapter, we will discuss how to derive and use these HoxB8-conditionally immortalized myeloid progenitor cells.
    MeSH term(s) Mice ; Animals ; Cell Differentiation/genetics ; Homeodomain Proteins/genetics ; Macrophages ; Cell Line ; Myeloid Progenitor Cells
    Chemical Substances Homeodomain Proteins
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3338-0_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MiR-182 Is Upregulated in Prostate Cancer and Contributes to Tumor Progression by Targeting MITF

    M. Y. Cynthia Stafford / Declan J. McKenna

    International Journal of Molecular Sciences, Vol 24, Iss 1824, p

    2023  Volume 1824

    Abstract: Altered expression of microRNA-182-5p (miR-182) has been consistently linked with many cancers, but its specific role in prostate cancer remains unclear. In particular, its contribution to epithelial–to–mesenchymal transition (EMT) in this setting has ... ...

    Abstract Altered expression of microRNA-182-5p (miR-182) has been consistently linked with many cancers, but its specific role in prostate cancer remains unclear. In particular, its contribution to epithelial–to–mesenchymal transition (EMT) in this setting has not been well studied. Therefore, this paper profiles the expression of miR-182 in prostate cancer and investigates how it may contribute to progression of this disease. In vitro experiments on prostate cancer cell lines and in silico analyses of The Cancer Genome Atlas (TCGA) prostate adenocarcinoma (PRAD) datasets were performed. PCR revealed miR-182 expression was significantly increased in prostate cancer cell lines compared to normal prostate cells. Bioinformatic analysis of TCGA PRAD data similarly showed upregulation of miR-182 was significantly associated with prostate cancer and clinical markers of disease progression. Functional enrichment analysis confirmed a significant association of miR-182 and its target genes with EMT. The EMT-linked gene MITF (melanocyte inducing transcription factor) was subsequently shown to be a novel target of miR-182 in prostate cancer cells. Further TCGA analysis suggested miR-182 expression can be an indicator of patient outcomes and disease progression following therapy. In summary, this is the first study to report that miR-182 over-expression in prostate cancer may contribute to EMT by targeting MITF expression. We propose miR-182 as a potentially useful diagnostic and prognostic biomarker for prostate cancer and other malignancies.
    Keywords prostate cancer ; microRNA ; miR-182 ; epithelial-to-mesenchymal transition ; MITF ; biomarker ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570 ; 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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