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  1. Article: The Effect of Breastfeeding in the First Hour and Rooming-In of Low-Income, Multi-Ethnic Mothers on In-Hospital, One and Three Month High Breastfeeding Intensity.

    Noble, Lawrence / Hand, Ivan L / Noble, Anita

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 2

    Abstract: Despite the known benefits of exclusive breastfeeding, the value of Baby-Friendly Hospital Interventions in increasing breastfeeding rates has been challenged, particularly the interventions of breastfeeding in the first hour of life and rooming-in. This ...

    Abstract Despite the known benefits of exclusive breastfeeding, the value of Baby-Friendly Hospital Interventions in increasing breastfeeding rates has been challenged, particularly the interventions of breastfeeding in the first hour of life and rooming-in. This study aimed to measure the association of breastfeeding in the first hour of life and rooming-in with high breastfeeding intensity of low-income, multi-ethnic mothers intending to breastfeed. A prospective, longitudinal cohort study was performed on 149 postpartum mothers who intended to breastfeed their infants. Structured interviews were performed at birth and one and three months. Breastfeeding intensity was defined as the percentage of all feedings that were breast milk, and high breastfeeding intensity was defined as a breastfeeding intensity >80%. The data were analyzed by chi-square, t-test, binary logistic regression analysis, and multivariate logistic regression analysis. Breastfeeding in the first hour was associated with increased high breastfeeding intensity in the hospital (AOR = 11.6, 95% CI = 4.7-28.6) and at one month (AOR = 3.6, 95% CI = 1.6-7.7), but not at three months. Rooming-in was associated with increased high breastfeeding intensity in the hospital (AOR 9.3, 95% CI = 3.6-23.7) and at one month (AOR = 2.4 (1.1-5.3) and three months (AOR 2.7, 95% CI 1.2-6.3). Breastfeeding in the first hour and rooming-in are associated with increasing breastfeeding and should be incorporated into practice.
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10020313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early versus late caffeine and/or non-steroidal anti-inflammatory drugs (NSAIDS) for prevention of intermittent hypoxia-induced neuroinflammation in the neonatal rat.

    Batool, Myra / Cai, Charles L / Aranda, Jacob V / Hand, Ivan / Beharry, Kay D

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

    2024  

    Abstract: Preterm infants often experience frequent intermittent hypoxia (IH) episodes which are associated with neuroinflammation. We tested the hypotheses that early caffeine and/or non-steroidal inflammatory drugs (NSAIDs) confer superior therapeutic benefits ... ...

    Abstract Preterm infants often experience frequent intermittent hypoxia (IH) episodes which are associated with neuroinflammation. We tested the hypotheses that early caffeine and/or non-steroidal inflammatory drugs (NSAIDs) confer superior therapeutic benefits for protection against IH-induced neuroinflammation than late treatment. Newborn rats were exposed to IH or hyperoxia (50% O
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605533-3
    ISSN 1873-474X ; 0736-5748
    ISSN (online) 1873-474X
    ISSN 0736-5748
    DOI 10.1002/jdn.10321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Covid-19 and breastfeeding: what's the risk?

    Hand, Ivan L / Noble, Lawrence

    Journal of perinatology : official journal of the California Perinatal Association

    2020  Volume 40, Issue 10, Page(s) 1459–1461

    MeSH term(s) Betacoronavirus/isolation & purification ; Breast Feeding/adverse effects ; Breast Feeding/methods ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Female ; Humans ; Infant ; Infection Control/methods ; Infectious Disease Transmission, Vertical/prevention & control ; Male ; Milk, Human/virology ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-020-0738-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Covid-19 and breastfeeding

    Hand, Ivan L. / Noble, Lawrence

    Journal of Perinatology

    what’s the risk?

    2020  Volume 40, Issue 10, Page(s) 1459–1461

    Keywords Obstetrics and Gynaecology ; Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 645021-0
    ISSN 0743-8346
    ISSN 0743-8346
    DOI 10.1038/s41372-020-0738-6
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Routine Neuroimaging of the Preterm Brain.

    Hand, Ivan L / Shellhaas, Renée A / Milla, Sarah S

    Pediatrics

    2020  Volume 146, Issue 5

    Abstract: Neuroimaging of the preterm infant is a common assessment performed in the NICU. Timely and focused studies can be used for diagnostic, therapeutic, and prognostic information. However, significant variability exists among neonatal units as to which ... ...

    Abstract Neuroimaging of the preterm infant is a common assessment performed in the NICU. Timely and focused studies can be used for diagnostic, therapeutic, and prognostic information. However, significant variability exists among neonatal units as to which modalities are used and when imaging studies are obtained. Appropriate timing and selection of neuroimaging studies can help identify neonates with brain injury who may require therapeutic intervention or who may be at risk for neurodevelopmental impairment. This clinical report reviews the different modalities of imaging broadly available to the clinician. Evidence-based indications for each modality, optimal timing of examinations, and prognostic value are discussed.
    MeSH term(s) Brain/diagnostic imaging ; Cerebral Intraventricular Hemorrhage/diagnostic imaging ; Diagnostic Tests, Routine ; Humans ; Infant, Newborn ; Infant, Premature ; Leukomalacia, Periventricular/diagnostic imaging ; Neuroimaging/methods ; Practice Guidelines as Topic
    Language English
    Publishing date 2020-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-029082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Factors Influencing Neonatal Gut Microbiome and Health with a Focus on Necrotizing Enterocolitis.

    Beharry, Kay D / Latkowska, Magdalena / Valencia, Arwin M / Allana, Ahreen / Soto, Jatnna / Cai, Charles L / Golombek, Sergio / Hand, Ivan / Aranda, Jacob V

    Microorganisms

    2023  Volume 11, Issue 10

    Abstract: Maturational changes in the gut start in utero and rapidly progress after birth, with some functions becoming fully developed several months or years post birth including the acquisition of a full gut microbiome, which is made up of trillions of bacteria ...

    Abstract Maturational changes in the gut start in utero and rapidly progress after birth, with some functions becoming fully developed several months or years post birth including the acquisition of a full gut microbiome, which is made up of trillions of bacteria of thousands of species. Many factors influence the normal development of the neonatal and infantile microbiome, resulting in dysbiosis, which is associated with various interventions used for neonatal morbidities and survival. Extremely low gestational age neonates (<28 weeks' gestation) frequently experience recurring arterial oxygen desaturations, or apneas, during the first few weeks of life. Apnea, or the cessation of breathing lasting 15-20 s or more, occurs due to immature respiratory control and is commonly associated with intermittent hypoxia (IH). Chronic IH induces oxygen radical diseases of the neonate, including necrotizing enterocolitis (NEC), the most common and devastating gastrointestinal disease in preterm infants. NEC is associated with an immature intestinal structure and function and involves dysbiosis of the gut microbiome, inflammation, and necrosis of the intestinal mucosal layer. This review describes the factors that influence the neonatal gut microbiome and dysbiosis, which predispose preterm infants to NEC. Current and future management and therapies, including the avoidance of dysbiosis, the use of a human milk diet, probiotics, prebiotics, synbiotics, restricted antibiotics, and fecal transplantation, for the prevention of NEC and the promotion of a healthy gut microbiome are also reviewed. Interventions directed at boosting endogenous and/or exogenous antioxidant supplementation may not only help with prevention, but may also lessen the severity or shorten the course of the disease.
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11102528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vitamin K and the Newborn Infant.

    Hand, Ivan / Noble, Lawrence / Abrams, Steven A

    Pediatrics

    2022  Volume 149, Issue 3

    Abstract: Intramuscular administration of vitamin K for prevention of vitamin K deficiency bleeding (VKDB) has been a standard of care since the American Academy of Pediatrics recommended it in 1961. Despite the success of prevention of VKDB with vitamin K ... ...

    Abstract Intramuscular administration of vitamin K for prevention of vitamin K deficiency bleeding (VKDB) has been a standard of care since the American Academy of Pediatrics recommended it in 1961. Despite the success of prevention of VKDB with vitamin K administration, the incidence of VKDB appears to be on the rise. This increase in incidence of VKDB is attributable to parental refusal as well as lowered efficacy of alternate methods of administration. The aim of this statement is to discuss the current knowledge of prevention of VKDB with respect to the term and preterm infant and address parental concerns regarding vitamin K administration.
    MeSH term(s) Child ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; Infant, Premature ; Vitamin K ; Vitamin K Deficiency Bleeding/epidemiology ; Vitamin K Deficiency Bleeding/prevention & control
    Chemical Substances Vitamin K (12001-79-5)
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-056036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Factors Influencing Paternal Attachment Among Preterm Infants in an Urban Neonatal Intensive Care Unit.

    Taing, Rickey / Galescu, Ovidiu / Noble, Lawrence / Hand, Ivan L

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8476

    Abstract: The aim of this study is to elucidate factors that may influence paternal attachment to preterm infants in an urban hospital setting. Fathers of preterm infants admitted to a level III neonatal intensive care unit (NICU) were eligible for this study. The ...

    Abstract The aim of this study is to elucidate factors that may influence paternal attachment to preterm infants in an urban hospital setting. Fathers of preterm infants admitted to a level III neonatal intensive care unit (NICU) were eligible for this study. The Paternal Postnatal Attachment Scale (PPAS) is a questionnaire that invokes paternal attachment in five domains: patience, tolerance, pleasure, affection and pride. Clinical and demographic data were collected along with the PPAS to identify factors influencing paternal attachment. Infants studied were 28.1 ± 3.3 weeks gestational age with a birth weight of 1,070 ± 70 grams. Paternal age was 29.2 ± 6.6 years. Infants of fathers who scored in the lowest quartile of attachment were significantly smaller (756 ± 17 grams vs 1,210 ± 76 grams, p = 0.03) and more immature (26.4 ± 1.9 weeks vs 28.8 ± 3.5 weeks, p = 0.04) than infants of fathers with higher attachment scores. Subscores of patience and tolerance (p = 0.05) and pleasure in interaction (p = 0.01) were also significantly lower although there was no significant difference in subscores of affection and pride (p = 0.36). There were no significant differences between attachment scores for paternal age, educational level, marital status, number of children or breastfeeding status. Paternal attachment scores appear to be dependent on infant factors, such as birth weight and gestational age, rather than paternal or demographic factors.
    Language English
    Publishing date 2020-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pharmacodynamic Effects of Standard versus High Caffeine Doses in the Developing Brain of Neonatal Rats Exposed to Intermittent Hypoxia.

    Soontarapornchai, Kutilda / Cai, Charles L / Ahmad, Taimur / Aranda, Jacob V / Hand, Ivan / Beharry, Kay D

    International journal of molecular sciences

    2021  Volume 22, Issue 7

    Abstract: 1) Background: Caffeine citrate, at standard doses, is effective for reducing the incidence of apnea of prematurity (AOP) and may confer neuroprotection and decrease neonatal morbidities in extremely low gestational age neonates (ELGANs) requiring ... ...

    Abstract (1) Background: Caffeine citrate, at standard doses, is effective for reducing the incidence of apnea of prematurity (AOP) and may confer neuroprotection and decrease neonatal morbidities in extremely low gestational age neonates (ELGANs) requiring oxygen therapy. We tested the hypothesis that high-dose caffeine (HiC) has no adverse effects on the neonatal brain. (2) Methods: Newborn rat pups were randomized to room air (RA), hyperoxia (Hx) or neonatal intermittent hypoxia (IH), from birth (P0) to P14 during which they received intraperitoneal injections of LoC (20 mg/kg on P0; 5 mg/kg/day on P1-P14), HiC (80 mg/kg; 20 mg/kg), or equivalent volume saline. Blood gases, histopathology, myelin and neuronal integrity, and adenosine receptor reactivity were assessed. (3) Results: Caffeine treatment in Hx influenced blood gases more than treatment in neonatal IH. Exposure to neonatal IH resulted in hemorrhage and higher brain width, particularly in layer 2 of the cerebral cortex. Both caffeine doses increased brain width in RA, but layer 2 was increased only with HiC. HiC decreased oxidative stress more effectively than LoC, and both doses reduced apoptosis biomarkers. In RA, both caffeine doses improved myelination, but the effect was abolished in Hx and neonatal IH. Similarly, both doses inhibited adenosine 1A receptor in all oxygen environments, but adenosine 2A receptor was inhibited only in RA and Hx. (4) Conclusions: Caffeine, even at high doses, when administered in normoxia, can confer neuroprotection, evidenced by reductions in oxidative stress, hypermyelination, and increased Golgi bodies. However, varying oxygen environments, such as Hx or neonatal IH, may alter and modify pharmacodynamic actions of caffeine and may even override the benefits caffeine.
    MeSH term(s) Animals ; Animals, Newborn ; Apoptosis ; Biomarkers/metabolism ; Blood Gas Analysis ; Brain/drug effects ; Brain/growth & development ; Caffeine/administration & dosage ; Caffeine/pharmacology ; Cerebral Cortex/drug effects ; Drug Administration Schedule ; Female ; Hemorrhage/drug therapy ; Hyperoxia ; Hypoxia/drug therapy ; Male ; Oxidative Stress ; Oxygen/chemistry ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P1/metabolism
    Chemical Substances Biomarkers ; Receptors, Purinergic P1 ; Caffeine (3G6A5W338E) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22073473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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