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Article ; Online: Remote patient monitoring in peritoneal dialysis helps reduce risk of hospitalization during Covid-19 pandemic.

Scarpioni, Roberto / Manini, Alessandra / Chiappini, Paola

2020 Volume 33, Issue 6, Page(s) 1123–1124

MeSH term(s)	COVID-19/epidemiology ; Comorbidity ; Hospitalization/trends ; Humans ; Monitoring, Physiologic/methods ; Pandemics ; Peritoneal Dialysis/methods ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; SARS-CoV-2 ; Telemedicine/methods
Keywords	covid19
Language	English
Publishing date	2020-08-10
Publishing country	Italy
Document type	Editorial
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-020-00822-0
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Article: Renal involvement in autoinflammatory diseases and inflammasome-mediated chronic kidney damage.

Scarpioni, Roberto / Obici, Laura

Clinical and experimental rheumatology

2018 Volume 36 Suppl 110, Issue 1, Page(s) 54–60

Abstract: Unprovoked activation of innate immune pathways and increased secretion of interleukin (IL)-1β and IL-18 are responsible for the protean clinical manifestations and the marked inflammatory response that characterise most hereditary autoinflammatory ... ...

Abstract	Unprovoked activation of innate immune pathways and increased secretion of interleukin (IL)-1β and IL-18 are responsible for the protean clinical manifestations and the marked inflammatory response that characterise most hereditary autoinflammatory disorders. The kidney is a major target organ of this inflammatory process. The deposition of the acute-phase reactant serum amyloid A (SAA) as amyloid causes progressive glomerular and vascular damage and leads to organ failure. In this review we focus on the potential impact of hereditary autoinflammatory diseases on renal function, provide red flags that may guide the clinical suspicion of amyloid kidney damage and discuss the relevance of close renal monitoring for early diagnosis and prompt treatment. Moreover, NLRP3 inflammasome activation is increasingly recognised to play a key causative role in the pathogenesis of several chronic kidney diseases in which activation of caspase-1 and the proteolytic cleavage of IL-1β and IL-18 into their biologically active forms mediate glomerular and tubulointerstitial damage. Although much of the knowledge about the role of the inflammasome in kidney injury has been mostly gathered in experimental models, inhibition of IL-1 is also becoming an attractive potential therapeutic target in a variety of chronic renal disorders with a substantial inflammatory component.
MeSH term(s)	Hereditary Autoinflammatory Diseases/complications ; Hereditary Autoinflammatory Diseases/immunology ; Hereditary Autoinflammatory Diseases/metabolism ; Humans ; Inflammasomes/immunology ; Kidney Diseases/etiology ; Kidney Diseases/immunology ; Kidney Diseases/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/immunology ; Renal Insufficiency, Chronic/metabolism ; Serum Amyloid A Protein/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Serum Amyloid A Protein
Language	English
Publishing date	2018-01
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article ; Online: [West Nile Infection and Kidney Disease: Description of Two Clinical Cases in Peritoneal Dialysis Patients].

Scarpioni, Roberto / Valsania, Teresa / De Amicis, Sara / Rocca, Chiara / Blanco, Valentina / Varì, Maria / Frittoli, Michela / Albertazzi, Vittorio / Ricardi, Marco / Melfa, Luigi

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2024 Volume 41, Issue 1

Abstract: The West Nile Virus (WNV), an RNA arbovirus, has been transmitted by wild birds and conveyed by ticks and mosquitoes, with wide diffusion all over the world; it is not transmitted from human to human. It can give clinical symptoms only in a minority of ... ...

Abstract	The West Nile Virus (WNV), an RNA arbovirus, has been transmitted by wild birds and conveyed by ticks and mosquitoes, with wide diffusion all over the world; it is not transmitted from human to human. It can give clinical symptoms only in a minority of infected subjects such as fever, headache, muscle tiredness, visual disturbances, drowsiness, convulsions and muscle paralysis; in the most serious cases even potentially fatal encephalitis. In the literature there are few reports on WNV infection in patients with kidney diseases: here we report our experience on two patients on peritoneal dialysis infected by WNV with a revision of the literature.
MeSH term(s)	Animals ; Humans ; West Nile Fever/complications ; West Nile Fever/diagnosis ; West Nile Fever/veterinary ; West Nile virus/genetics ; Culicidae ; Birds ; Kidney Diseases
Language	Italian
Publishing date	2024-02-28
Publishing country	Italy
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article: Therapeutic tools for dyslipidemia in peritoneal dialysis patients.

Scarpioni, Roberto

Journal of nephrology

2009 Volume 22, Issue 1, Page(s) 46–58

Abstract: Patients on peritoneal dialysis (PD) are at high cardiovascular (C-V) risk, and dyslipidemia, one of the major traditional C-V risk factors, is a common complication in chronic kidney disease. PD treatment may worsen lipid profile, because it confers a ... ...

Abstract	Patients on peritoneal dialysis (PD) are at high cardiovascular (C-V) risk, and dyslipidemia, one of the major traditional C-V risk factors, is a common complication in chronic kidney disease. PD treatment may worsen lipid profile, because it confers a more atherogenic state than hemodialysis. There is evidence that in the general population, lipid-lowering therapy reduces C-V mortality, both in terms of primary and secondary prevention. The association between dyslipidemia and C-V mortality in dialysis patients is not well defined, and hypocholesterolemia, related to malnutrition/inflammation, is a confounding factor. However, despite the unfavorable lipid profile in PD patients and their high C-V mortality rate, until now we have had no conclusive data that the treatment of dyslipidemia in PD patients might contribute to reducing C-V mortality. At the moment, following the ATPIII and K-DOQI recommendations in considering dialysis patients as high C-V risk patients seems a reasonable approach, awaiting new large trials in PD patients. The present therapeutic tools to treat dyslipidemia in PD patients, such as diet, fibrates, omega-3, statins, carnitine, phosphate binders and use of glucose-free dialysis bags, are considered, with attention to high-risk diabetic patients, with the possible use of intraperitoneal insulin. The data indicate a correctable nihilism in treating dyslipidemia in the general population, probably even exacerbated in PD patients. However, it will only be with the correction of all of the C-V risk factors, traditional and uremia-related ones, that in future we shall hope to observe the reduction of C-V death in PD patients.
MeSH term(s)	Chronic Disease ; Dyslipidemias/etiology ; Dyslipidemias/therapy ; Humans ; Kidney Diseases/complications ; Kidney Diseases/therapy ; Life Style ; Peritoneal Dialysis ; Risk Factors
Language	English
Publishing date	2009-01
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1121-8428 ; 1120-3625
ISSN (online)	1724-6059
ISSN	1121-8428 ; 1120-3625
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Article: A Rare Case of Coronavirus Disease 2019 Survival in an Elderly Patient With Atheroembolic Renal Disease.

Cavanna, Luigi / Zaffignani, Elena / Citterio, Chiara / De Amicis, Sara / Scarpioni, Roberto

Cureus

2021 Volume 13, Issue 3, Page(s) e14201

Abstract: Atheroembolic renal disease (AERD) is a life-threatening illness. Coronavirus disease 2019 (COVID-19) has a high mortality rate in older patients with comorbidities. We report the case of severe-type COVID-19 in an 82-year-old female with AERD. She was ... ...

Abstract	Atheroembolic renal disease (AERD) is a life-threatening illness. Coronavirus disease 2019 (COVID-19) has a high mortality rate in older patients with comorbidities. We report the case of severe-type COVID-19 in an 82-year-old female with AERD. She was treated with hydroxychloroquine-based therapy and overcame COVID-19. To our knowledge, this is the first report of a patient with AERD and COVID-19 pneumonia who overcame the infection and remains alive and well nine months following infection.
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.14201
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Article ; Online: Remote patient monitoring in peritoneal dialysis helps reduce risk of hospitalization during Covid-19 pandemic

Scarpioni, Roberto / Manini, Alessandra / Chiappini, Paola

Journal of Nephrology ; ISSN 1121-8428 1724-6059

2020

Keywords	Nephrology ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s40620-020-00822-0
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Article ; Online: Peritoneal videodialysis: first Italian audit.

Neri, Loris / Caria, Simonetta / Cannas, Katia / Scarpioni, Roberto / Manini, Alessandra / Cadoni, Chiara / Malandra, Rosella / Ullo, Ines / Rombolà, Giuseppe / Borzumati, Maurizio / Bonvegna, Francesca / Viglino, Giusto

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2022 Volume 39, Issue 4

Abstract: Conceived and developed since 2001 at the Alba Center, Videodialysis (VD) was used initially to prevent dropout in prevalent PD patients by guiding them in performing dialysis (VD-Caregiver). Subsequently, its use was extended to the clinical follow-up ... ...

Abstract	Conceived and developed since 2001 at the Alba Center, Videodialysis (VD) was used initially to prevent dropout in prevalent PD patients by guiding them in performing dialysis (VD-Caregiver). Subsequently, its use was extended to the clinical follow-up of critical patients (VD-Clinical), problems relating to transport to the Center (VD-Transport), and since 2016 for training/retraining all patients (VD-Training). Since 2017 other Centers have employed VD using modalities analyzed in this paper.
MeSH term(s)	Aged ; Aged, 80 and over ; Humans ; Italy ; Middle Aged ; Peritoneal Dialysis ; Peritonitis/epidemiology ; Peritonitis/etiology ; Renal Dialysis
Language	English
Publishing date	2022-08-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article: Acute hydrothorax in a peritoneal dialysis patient: long-term efficacy of autologous blood cell pleurodesis associated with small-volume peritoneal exchanges.

Scarpioni, Roberto

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2003 Volume 18, Issue 10, Page(s) 2200–1; author reply: 2201

MeSH term(s)	Acute Disease ; Catheters, Indwelling/adverse effects ; Erythrocyte Transfusion/methods ; Follow-Up Studies ; Humans ; Hydrothorax/etiology ; Hydrothorax/therapy ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Peritoneal Dialysis, Continuous Ambulatory/adverse effects ; Peritoneal Dialysis, Continuous Ambulatory/methods ; Peritoneum/physiology ; Pleurodesis/methods ; Risk Assessment ; Severity of Illness Index ; Transplantation, Autologous ; Treatment Outcome
Language	English
Publishing date	2003-10
Publishing country	England
Document type	Case Reports ; Comment ; Letter
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfg335
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Zs.MO 329: Show issues

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Article ; Online: Covid-19 and its impact on nephropathic patients: the experience at Ospedale "Guglielmo da Saliceto" in Piacenza.

Scarpioni, Roberto / Manini, Alessandra / Valsania, Teresa / De Amicis, Sara / Albertazzi, Vittorio / Melfa, Luigi / Ricardi, Marco / Rocca, Chiara

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2020 Volume 37, Issue 2

Abstract: Roberto Scarpioni and colleagues recount their experience with the Covid-19 epidemic ...

Abstract	Roberto Scarpioni and colleagues recount their experience with the Covid-19 epidemic at the Nephrology and Dialysis Center of the "Guglielmo da Saliceto" Hospital in Piacenza, where everybody is still fighting to this moment to contain the spread of the disease and face an increasingly unsustainable clinical situation. Piacenza is only 15 km away from the main cluster of cases in the country (Codogno, in the Lodi province) and, after the closure of the Hospital in Codogno, saw an escalation in the number of patients testing positive to Covid-19. The authors describe their efforts and the practices they adopted to contain the spread of the disease among inpatients visiting the hospital's Hemodialysis Clinic. They also reflect on some of the data available on the 25/03/2020, such as the number of patients testing positive and the mortality rate, unfortunately very high. Their aim is to help all colleagues that have yet to face this epidemic in its full force.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/prevention & control ; Humans ; Italy/epidemiology ; Kidney Diseases/complications ; Kidney Diseases/virology ; Pandemics/prevention & control ; Pneumonia, Viral/complications ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Secondary amyloidosis in autoinflammatory diseases and the role of inflammation in renal damage.

Scarpioni, Roberto / Ricardi, Marco / Albertazzi, Vittorio

World journal of nephrology

2015 Volume 5, Issue 1, Page(s) 66–75

Abstract: The release of proinflammatory cytokines during inflammation represents an attempt to respond to injury, but it may produce detrimental effects. The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response ...

Abstract	The release of proinflammatory cytokines during inflammation represents an attempt to respond to injury, but it may produce detrimental effects. The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury; the best-characterized inflammasome is the nod-like receptor protein-3 (NLRP3). Once activated, inflammasome leads to the active form of caspase-1, the enzyme required for the maturation of interleukin-1beta. Additional mechanisms bringing to renal inflammatory, systemic diseases and fibrotic processes were recently reported, via the activation of the inflammasome that consists of NLRP3, apoptosis associated speck-like protein and caspase-1. Several manuscripts seem to identify NLRP3 inflammasome as a possible therapeutic target in the treatment of progressive chronic kidney disease. Serum amyloid A (SAA), as acute-phase protein with also proinflammatory properties, has been shown to induce the secretion of cathepsin B and inflammasome components from human macrophages. SAA is a well recognised potent activator of the NLRP3. Here we will address our description on the involvement of the kidney in autoinflammatory diseases driven mainly by secondary, or reactive, AA amyloidosis with a particular attention on novel therapeutic approach which has to be addressed in suppressing underlying inflammatory disease and reducing the SAA concentration.
Language	English
Publishing date	2015-07-10
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2220-6124
ISSN	2220-6124
DOI	10.5527/wjn.v5.i1.66
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