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  1. Article ; Online: Covid-19 and leptospirosis: Cytokine storm and the use of steroids.

    Ittyachen, Abraham M

    Tropical doctor

    2020  Volume 51, Issue 1, Page(s) 128–130

    Abstract: The majority of patients with Covid-19 have a good outcome. However, complications principally of acute respiratory distress syndrome (ARDS) and multiple-organ failure can occur rapidly. Leptospirosis, a zoonotic disease, is similar to Covid-19 in that ... ...

    Abstract The majority of patients with Covid-19 have a good outcome. However, complications principally of acute respiratory distress syndrome (ARDS) and multiple-organ failure can occur rapidly. Leptospirosis, a zoonotic disease, is similar to Covid-19 in that most infections are mild or asymptomatic and only a small number develop ARDS. Cytokine storm is considered to be the main incriminating factor in both. High dose steroids have been used to ameliorate the effects in leptospirosis, and similarly, reports suggest a benefit in Covid-19. SARS CoV-2 and leptospira, one a virus and the other a bacterium, are two species separated by millions of years of evolution, but producing illnesses with similar spectra, with cytokine storm being the common precipitating factor. As data are accrued from around the world, more light may be shed on features analogous to both pathways.
    MeSH term(s) Animals ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/virology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/etiology ; Humans ; Leptospira/pathogenicity ; Leptospirosis/complications ; Leptospirosis/drug therapy ; Leptospirosis/microbiology ; Male ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; SARS-CoV-2/pathogenicity ; Steroids/therapeutic use
    Chemical Substances Steroids
    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Letter
    ZDB-ID 193169-6
    ISSN 1758-1133 ; 0049-4755
    ISSN (online) 1758-1133
    ISSN 0049-4755
    DOI 10.1177/0049475520971425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Paradox of the cranial nerves

    Abraham M Ittyachen

    Current Medical Issues, Vol 19, Iss 4, Pp 282-

    Does the description of the facial nerve need a reinterpretation?

    2021  Volume 283

    Abstract: For years, generations of medical students were taught that in stroke, “;In a upper motor neuron (UMN) lesion, the upper part of the face is spared because this part of the face has bilateral representation while in a lower motor neuron (LMN) lesion, ... ...

    Abstract For years, generations of medical students were taught that in stroke, “;In a upper motor neuron (UMN) lesion, the upper part of the face is spared because this part of the face has bilateral representation while in a lower motor neuron (LMN) lesion, both parts of the face are involved.” Is this explanation apt ? Most of the fibers of the corticospinal tract decussate to the opposite side. But only 50% of the corticobulbar fibers decussate, meaning the muscles they supply receive fibers from both motor cortex (bilateral representation). Bilateral representation in the cortex is a perfect example of symmetry in the human body. An exception to this rule would be the lower part of the face which receives fibers from the contralateral cortex alone (unilateral representation). This goes against the general rule and so this represents the first paradox of the cranial nerves. The second paradox is entirely man made and is reversible. Should it not be, “;In a UMN lesion of the facial nerve, only the contralateral lower half of the face is affected, because this part of the face has unilateral representation only” and not “;In a UMN lesion of the facial nerve, the contralateral upper part of the face is spared because this part of the face has bilateral representation.” After all, is not bilateral representation the rule and unilateral representation the exception ?.
    Keywords cranial nerves ; facial nerve ; decussation of cranial nerves ; Medicine ; R
    Subject code 100
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Atypical case of infective endocarditis.

    Ittyachen, Abraham M / Peter, Ancy / Sukumaran, Anjely / Vinu, Joy

    BMJ case reports

    2023  Volume 16, Issue 5

    Abstract: A man in his late 40s presented to the emergency department with generalised tiredness and breathlessness. He was a known case of chronic obstructive pulmonary disease and also had a recent history of COVID-19. At arrival, he was in respiratory failure. ... ...

    Abstract A man in his late 40s presented to the emergency department with generalised tiredness and breathlessness. He was a known case of chronic obstructive pulmonary disease and also had a recent history of COVID-19. At arrival, he was in respiratory failure. Blood culture grew
    MeSH term(s) Male ; Humans ; COVID-19 ; Endocarditis, Bacterial/complications ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/microbiology ; Endocarditis/complications ; Endocarditis/diagnosis ; Mitral Valve/diagnostic imaging ; Echocardiography
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-254195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Copper beaten skull.

    Ittyachen, Abraham M / Anand, Rajeev

    BMJ case reports

    2019  Volume 12, Issue 8

    MeSH term(s) Adult ; Copper ; Cough ; Craniosynostoses/diagnostic imaging ; Humans ; Incidental Findings ; Male ; Radiography ; Skull/diagnostic imaging ; Tomography Scanners, X-Ray Computed ; Young Adult
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2019-08-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-230916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Covid-19 and leptospirosis, pulmonary involvement and response to steroids: A comparative observational study from a rural Tertiary care center in Kerala.

    Xavier, Vinod / Baby, Binitha / George, Joemon M / Ittyachen, Abraham M

    Journal of family medicine and primary care

    2022  Volume 11, Issue 1, Page(s) 294–298

    Abstract: Background: COVID-19 is an emerging infectious disease with a global outreach. Leptospirosis is a zoonotic disease mainly confined to tropical areas. In both cases, most of those affected are asymptomatic or have only mild respiratory disease. Those who ...

    Abstract Background: COVID-19 is an emerging infectious disease with a global outreach. Leptospirosis is a zoonotic disease mainly confined to tropical areas. In both cases, most of those affected are asymptomatic or have only mild respiratory disease. Those who turn critical develop acute respiratory distress syndrome (ARDS) and/or multiple-organ failure occurs rapidly, with high fatality.
    Methodology: This is a retrospective observational study from 2020 involving COVID-19 and leptospirosis patients. The data were collected using a semi-structured proforma, and analysis was performed using Easy R (EZR) software.
    Results: There were five patients with COVIDC-19 and four patients with leptospirosis; with pulmonary involvement. All the patients were males. There was no significant difference in age, the onset of pulmonary involvement, time of initiation of steroids, duration of steroids, and outcome between the two groups. However, in the case of COVID-19, it took a longer period for clearing of infiltrates.
    Conclusion: Though COVID-19 and leptospirosis are two different diseases, both of them show a similar life-saving response to steroids, the common factor in the pathogenesis being cytokine storm. Primary care physicians in tropical areas of the world should be aware of the similarities between these two diseases, especially the initial clinical presentation, the pathogenesis, and the response to steroids.
    Language English
    Publishing date 2022-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_1414_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Awareness of antibiotic resistance among medical students in Kerala State, India

    Anju P Reena / Abraham M Ittyachen

    Current Medical Issues, Vol 20, Iss 4, Pp 245-

    A cross-sectional study

    2022  Volume 252

    Abstract: Background: Antibiotic resistance is a natural phenomenon, but its misuse has expedited resistance. One of the best measures to tackle antibiotic resistance in the community would be to educate medical students and create awareness among them regarding ... ...

    Abstract Background: Antibiotic resistance is a natural phenomenon, but its misuse has expedited resistance. One of the best measures to tackle antibiotic resistance in the community would be to educate medical students and create awareness among them regarding antibiotic resistance. The objectives of this study were to assess the level of awareness of antibiotic resistance among undergraduate medical students and to determine the factors affecting the awareness. Materials and Methods: This is a cross-sectional study using a structured questionnaire among undergraduate medical students from the 1st year to the 4th year. Results: Three hundred and fifty-four undergraduate medical students from the 1st year to the 4th year were enrolled. More than 80% of students were from the 18–22-year age group, and more than half were female. Only 56.2% of participants had adequate awareness of antibiotic resistance. The academic year was not significantly associated with the awareness. Age and gender also had no significant association. Parent's education, parent's occupation, parents being medical practitioners and family income also had no significant association. Conclusion: Awareness levels regarding antibiotic resistance among medical students were slightly above 50%. Moreover, it seems to be a worldwide phenomenon too. Further studies are recommended to evaluate the practices and attitudes regarding the same. A “catch them young” policy would be a good step to tackle antimicrobial resistance at its inception itself. Moreover, it should start at the local level. Similar studies can be conducted among medical practitioners and health-care workers and at the community level.
    Keywords antibiotic resistance ; antibiotic stewardship ; medical education ; medical student ; nosocomial infection ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: An Investigation into the High Prevalence of Hepatitis B in a Rural Area of Kerala State, India: Hypothesis on

    Kuriakose, Mariamma / Ittyachen, Abraham M

    BioMed research international

    2018  Volume 2018, Page(s) 4612472

    Abstract: Objective: Since 2005 there have been several reports of hepatitis B outbreak in the state of Kerala in southern India. Objective of this study was to analyze such outbreaks and to explore hypothesis pertaining the transmission mode.: Methods: ... ...

    Abstract Objective: Since 2005 there have been several reports of hepatitis B outbreak in the state of Kerala in southern India. Objective of this study was to analyze such outbreaks and to explore hypothesis pertaining the transmission mode.
    Methods: Retrospective observational study involving cases of acute hepatitis B acquired between 1 January 2015 and 31 December 2015 and their family members residing in Mazhuvanoor village in Ernakulam district of Kerala State in southern India.
    Results: 59 houses were included in the survey. The number of patients diagnosed to have acute viral hepatitis B was 59. Majority (66.10%) were over 50 years old. There were no cases below the age of 15 years. All 59 patients claimed to have been bitten frequently by a fly which was identified as "deer fly" belonging to the genus
    Conclusion: Given the current understanding of mechanical transmission of pathogens in both humans and animals by insects belonging to the Tabanidae family which also includes
    MeSH term(s) Adolescent ; Adult ; Aged ; Animals ; Diptera/microbiology ; Female ; Hepatitis B/epidemiology ; Hepatitis B/transmission ; Humans ; India/epidemiology ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Rural Population ; Young Adult
    Language English
    Publishing date 2018-06-10
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/4612472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Aetiology of acute febrile illness: a multicentre study from the province of Kerala in southern India.

    Andrews, Mekkattukunnel A / Ittyachen, Abraham M

    Tropical doctor

    2018  Volume 48, Issue 4, Page(s) 322–325

    Abstract: Acute febrile illness with varied aetiology but similar symptoms is common in tropical countries. This prospective, multicentre study was conducted in selected centres in the province of Kerala in India principally to analyse the aetiology of acute ... ...

    Abstract Acute febrile illness with varied aetiology but similar symptoms is common in tropical countries. This prospective, multicentre study was conducted in selected centres in the province of Kerala in India principally to analyse the aetiology of acute febrile illnesses in adult patients over the course of one year. Overall, 1324 patients were included in the study. The most common cause was dengue in 576 patients (43.5%). In 396 (29.9%), the exact aetiology could not be identified. Other causes, in order, were leptospirosis, enteric fever, malaria, respiratory tract infection, urinary tract infection and typhus. When such a wide variation with a significant number of 'indeterminate' cases exists, especially in such a small area and with limited resources, the onus is on public health authorities to draw up an 'easy-to-use algorithm' to tackle epidemics of febrile illness, particularly in the monsoon season.
    MeSH term(s) Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Dengue/complications ; Dengue/epidemiology ; Female ; Fever/epidemiology ; Fever/etiology ; Humans ; India/epidemiology ; Leptospirosis/complications ; Leptospirosis/epidemiology ; Malaria/complications ; Malaria/epidemiology ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Seasons ; Typhoid Fever/complications ; Young Adult
    Language English
    Publishing date 2018-08-20
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 193169-6
    ISSN 1758-1133 ; 0049-4755
    ISSN (online) 1758-1133
    ISSN 0049-4755
    DOI 10.1177/0049475518794572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Covid-19 and leptospirosis, pulmonary involvement and response to steroids

    Vinod Xavier / Binitha Baby / Joemon M George / Abraham M Ittyachen

    Journal of Family Medicine and Primary Care, Vol 11, Iss 1, Pp 294-

    A comparative observational study from a rural Tertiary care center in Kerala

    2022  Volume 298

    Abstract: Background: COVID-19 is an emerging infectious disease with a global outreach. Leptospirosis is a zoonotic disease mainly confined to tropical areas. In both cases, most of those affected are asymptomatic or have only mild respiratory disease. Those who ... ...

    Abstract Background: COVID-19 is an emerging infectious disease with a global outreach. Leptospirosis is a zoonotic disease mainly confined to tropical areas. In both cases, most of those affected are asymptomatic or have only mild respiratory disease. Those who turn critical develop acute respiratory distress syndrome (ARDS) and/or multiple-organ failure occurs rapidly, with high fatality. Methodology: This is a retrospective observational study from 2020 involving COVID-19 and leptospirosis patients. The data were collected using a semi-structured proforma, and analysis was performed using Easy R (EZR) software. Results: There were five patients with COVIDC-19 and four patients with leptospirosis; with pulmonary involvement. All the patients were males. There was no significant difference in age, the onset of pulmonary involvement, time of initiation of steroids, duration of steroids, and outcome between the two groups. However, in the case of COVID-19, it took a longer period for clearing of infiltrates. Conclusion: Though COVID-19 and leptospirosis are two different diseases, both of them show a similar life-saving response to steroids, the common factor in the pathogenesis being cytokine storm. Primary care physicians in tropical areas of the world should be aware of the similarities between these two diseases, especially the initial clinical presentation, the pathogenesis, and the response to steroids.
    Keywords ards ; covid-19 ; leptospirosis ; steroids ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Aches and Pains in a Patient With History of Prostatectomy: Extensive Skeletal Metastasis Picked up by Diffusion-Weighted Magnetic Resonance Imaging.

    Ittyachen, Abraham M / Radhakrishnan, Meera / Kuncheria, Thomas / Anand, Rajeev

    Journal of medical cases

    2020  Volume 11, Issue 9, Page(s) 275–278

    Abstract: A 64-year-old gentleman presented to the out-patient with complaints of generalized body ache. He had a history of prostate cancer for which robotic radical prostatectomy (RP) was done earlier. The levels of prostate specific antigen (PSA) and alkaline ... ...

    Abstract A 64-year-old gentleman presented to the out-patient with complaints of generalized body ache. He had a history of prostate cancer for which robotic radical prostatectomy (RP) was done earlier. The levels of prostate specific antigen (PSA) and alkaline phosphatase (ALP) were significantly elevated. Skeletal radiograph showed only few sclerotic foci. Magnetic resonance imaging whole-body diffusion-weighted image (MRI-WB-DWI) however revealed the presence of diffuse skeletal metastasis. In any elderly male who presents with generalized body pain, eliciting a good history should not be overlooked. With a history of prostate cancer, diffuse metastases should be high in the list of differential diagnosis. Though there are several imaging methods to detect metastases, MRI-WB-DWI is a welcome alternative to the established methods. Patients who undergo RP for prostate cancer should be counselled regarding the importance of follow-up of their PSA levels.
    Language English
    Publishing date 2020-08-06
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2586383-6
    ISSN 1923-4163 ; 1923-4155
    ISSN (online) 1923-4163
    ISSN 1923-4155
    DOI 10.14740/jmc3545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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